Search Results - "MENON, Rajasree"

A new neutrophil subset promotes CNS neuron survival and axon regeneration by Sas, Andrew R., Carbajal, Kevin S., Jerome, Andrew D., Menon, Rajasree, Yoon, Choya, Kalinski, Ashley L., Giger, Roman J., Segal, Benjamin M.

“…Transected axons typically fail to regenerate in the central nervous system (CNS), resulting in chronic neurological disability in individuals with traumatic…”
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Regulation of heterotopic ossification by monocytes in a mouse model of aberrant wound healing by Sorkin, Michael, Huber, Amanda K., Hwang, Charles, Carson, William F., Menon, Rajasree, Li, John, Vasquez, Kaetlin, Pagani, Chase, Patel, Nicole, Li, Shuli, Visser, Noelle D., Niknafs, Yashar, Loder, Shawn, Scola, Melissa, Nycz, Dylan, Gallagher, Katherine, McCauley, Laurie K., Xu, Jiajia, James, Aaron W., Agarwal, Shailesh, Kunkel, Stephen, Mishina, Yuji, Levi, Benjamin

“…Heterotopic ossification (HO) is an aberrant regenerative process with ectopic bone induction in response to musculoskeletal trauma, in which mesenchymal stem…”
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High-Throughput Screening Enhances Kidney Organoid Differentiation from Human Pluripotent Stem Cells and Enables Automated Multidimensional Phenotyping by Czerniecki, Stefan M., Cruz, Nelly M., Harder, Jennifer L., Menon, Rajasree, Annis, James, Otto, Edgar A., Gulieva, Ramila E., Islas, Laura V., Kim, Yong Kyun, Tran, Linh M., Martins, Timothy J., Pippin, Jeffrey W., Fu, Hongxia, Kretzler, Matthias, Shankland, Stuart J., Himmelfarb, Jonathan, Moon, Randall T., Paragas, Neal, Freedman, Benjamin S.

“…Organoids derived from human pluripotent stem cells are a potentially powerful tool for high-throughput screening (HTS), but the complexity of organoid…”
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Single-cell analysis of progenitor cell dynamics and lineage specification in the human fetal kidney by Menon, Rajasree, Otto, Edgar A, Kokoruda, Austin, Zhou, Jian, Zhang, Zidong, Yoon, Euisik, Chen, Yu-Chih, Troyanskaya, Olga, Spence, Jason R, Kretzler, Matthias, Cebrián, Cristina

“…The mammalian kidney develops through reciprocal interactions between the ureteric bud and the metanephric mesenchyme to give rise to the entire collecting…”
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An eQTL Landscape of Kidney Tissue in Human Nephrotic Syndrome by Gillies, Christopher E., Putler, Rosemary, Menon, Rajasree, Otto, Edgar, Yasutake, Kalyn, Nair, Viji, Hoover, Paul, Lieb, David, Li, Shuqiang, Eddy, Sean, Fermin, Damian, McNulty, Michelle T., Sedor, John, Dell, Katherine, Schachere, Marleen, Lemley, Kevin, Whitted, Lauren, Srivastava, Tarak, Haney, Connie, Sethna, Christine, Grammatikopoulos, Kalliopi, Appel, Gerald, Toledo, Michael, Greenbaum, Laurence, Wang, Chia-shi, Lee, Brian, Adler, Sharon, Nast, Cynthia, LaPage, Janine, Athavale, Ambarish, Neu, Alicia, Boynton, Sara, Fervenza, Fernando, Hogan, Marie, Lieske, John C., Chernitskiy, Vladimir, Kaskel, Frederick, Kumar, Neelja, Flynn, Patricia, Kopp, Jeffrey, Castro-Rubio, Eveleyn, Blake, Jodi, Trachtman, Howard, Zhdanova, Olga, Modersitzki, Frank, Vento, Suzanne, Lafayette, Richard, Mehta, Kshama, Gadegbeku, Crystal, Johnstone, Duncan, Cattran, Daniel, Hladunewich, Michelle, Reich, Heather, Ling, Paul, Romano, Martin, Fornoni, Alessia, Barisoni, Laura, Bidot, Carlos, Kretzler, Matthias, Gipson, Debbie, Williams, Amanda, Pitter, Renee, Nachman, Patrick, Grubbs, Sandra, Froment, Anne, Holzman, Lawrence, Meyers, Kevin, Kallem, Krishna, Cerecino, Fumei, Sambandam, Kamal, Brown, Elizabeth, Johnson, Natalie, Jefferson, Ashley, Hingorani, Sangeeta, Tuttle, Kathleen, Curtin, Laura, Dismuke, S., Cooper, Ann, Freedman, Barry, Lin, Jen Jar, Gray, Stefanie, Barisoni, Larua, Gillespie, Brenda, Mariani, Laura, Sampson, Matthew G., Song, Peter, Troost, Johnathan, Zee, Jarcy, Herreshoff, Emily, Kincaid, Colleen, Lienczewski, Chrysta, Mainieri, Tina, Abbott, Kevin, Roy, Cindy, Urv, Tiina, Brooks, John, Hacohen, Nir, Kretzler, Matthias, Wen, Xiaoquan, Sampson, Matthew G.

“…Expression quantitative trait loci (eQTL) studies illuminate the genetics of gene expression and, in disease research, can be particularly illuminating when…”
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Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen by Salem, Rany M, Todd, Jennifer N, Sandholm, Niina, Cole, Joanne B, Chen, Wei-Min, Andrews, Darrell, Pezzolesi, Marcus G, McKeigue, Paul M, Hiraki, Linda T, Qiu, Chengxiang, Nair, Viji, Di Liao, Chen, Cao, Jing Jing, Valo, Erkka, Onengut-Gumuscu, Suna, Smiles, Adam M, McGurnaghan, Stuart J, Haukka, Jani K, Harjutsalo, Valma, Brennan, Eoin P, van Zuydam, Natalie, Ahlqvist, Emma, Doyle, Ross, Ahluwalia, Tarunveer S, Lajer, Maria, Hughes, Maria F, Park, Jihwan, Skupien, Jan, Spiliopoulou, Athina, Liu, Andrew, Menon, Rajasree, Boustany-Kari, Carine M, Kang, Hyun M, Nelson, Robert G, Klein, Ronald, Klein, Barbara E, Lee, Kristine E, Gao, Xiaoyu, Mauer, Michael, Maestroni, Silvia, Caramori, Maria Luiza, de Boer, Ian H, Miller, Rachel G, Guo, Jingchuan, Boright, Andrew P, Tregouet, David, Gyorgy, Beata, Snell-Bergeon, Janet K, Maahs, David M, Bull, Shelley B, Canty, Angelo J, Palmer, Colin N A, Stechemesser, Lars, Paulweber, Bernhard, Weitgasser, Raimund, Sokolovska, Jelizaveta, Rovīte, Vita, Pīrāgs, Valdis, Prakapiene, Edita, Radzeviciene, Lina, Verkauskiene, Rasa, Panduru, Nicolae Mircea, Groop, Leif C, McCarthy, Mark I, Gu, Harvest F, Möllsten, Anna, Falhammar, Henrik, Brismar, Kerstin, Martin, Finian, Rossing, Peter, Costacou, Tina, Zerbini, Gianpaolo, Marre, Michel, Hadjadj, Samy, McKnight, Amy J, Forsblom, Carol, McKay, Gareth, Godson, Catherine, Maxwell, A Peter, Kretzler, Matthias, Susztak, Katalin, Colhoun, Helen M, Krolewski, Andrzej, Paterson, Andrew D, Groop, Per-Henrik, Rich, Stephen S, Hirschhorn, Joel N, Florez, Jose C

“…Although diabetic kidney disease demonstrates both familial clustering and single nucleotide polymorphism heritability, the specific genetic factors…”
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SGLT2 inhibitors mitigate kidney tubular metabolic and mTORC1 perturbations in youth-onset type 2 diabetes by Schaub, Jennifer A, AlAkwaa, Fadhl M, McCown, Phillip J, Naik, Abhijit S, Nair, Viji, Eddy, Sean, Menon, Rajasree, Otto, Edgar A, Demeke, Dawit, Hartman, John, Fermin, Damian, O'Connor, Christopher L, Subramanian, Lalita, Bitzer, Markus, Harned, Roger, Ladd, Patricia, Pyle, Laura, Pennathur, Subramaniam, Inoki, Ken, Hodgin, Jeffrey B, Brosius, 3rd, Frank C, Nelson, Robert G, Kretzler, Matthias, Bjornstad, Petter

“…The molecular mechanisms of sodium-glucose cotransporter-2 (SGLT2) inhibitors (SGLT2i) remain incompletely understood. Single-cell RNA sequencing and…”
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Molecular Characterization of Membranous Nephropathy by Sealfon, Rachel, Mariani, Laura, Avila-Casado, Carmen, Nair, Viji, Menon, Rajasree, Funk, Julien, Wong, Aaron, Lerner, Gabriel, Hayashi, Norifumi, Troyanskaya, Olga, Kretzler, Matthias, Beck, Jr, Laurence H

“…Molecular characterization of nephropathies may facilitate pathophysiologic insight, development of targeted therapeutics, and transcriptome-based disease…”
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Systematically differentiating functions for alternatively spliced isoforms through integrating RNA-seq data by Eksi, Ridvan, Li, Hong-Dong, Menon, Rajasree, Wen, Yuchen, Omenn, Gilbert S, Kretzler, Matthias, Guan, Yuanfang

“…Integrating large-scale functional genomic data has significantly accelerated our understanding of gene functions. However, no algorithm has been developed to…”
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Proteomic Characterization of Novel Alternative Splice Variant Proteins in Human Epidermal Growth Factor Receptor 2/neu-Induced Breast Cancers by MENON, Rajasree, OMENN, Gilbert S

“…Multifaceted alternative splicing in cancer cells greatly diversifies protein structure independently of genome changes, but the characterization of…”
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Endoplasmic reticulum-associated degradation is required for nephrin maturation and kidney glomerular filtration function by Yoshida, Sei, Wei, Xiaoqiong, Zhang, Gensheng, O'Connor, Christopher L, Torres, Mauricio, Zhou, Zhangsen, Lin, Liangguang, Menon, Rajasree, Xu, Xiaoxi, Zheng, Wenyue, Xiong, Yi, Otto, Edgar, Tang, Chih-Hang Anthony, Hua, Rui, Verma, Rakesh, Mori, Hiroyuki, Zhang, Yang, Hu, Chih-Chi Andrew, Liu, Ming, Garg, Puneet, Hodgin, Jeffrey B, Sun, Shengyi, Bitzer, Markus, Qi, Ling

“…Podocytes are key to the glomerular filtration barrier by forming a slit diaphragm between interdigitating foot processes; however, the molecular details and…”
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A new class of protein cancer biomarker candidates: Differentially expressed splice variants of ERBB2 (HER2/neu) and ERBB1 (EGFR) in breast cancer cell lines by Omenn, Gilbert S., Guan, Yuanfang, Menon, Rajasree

“…Combined RNA-Seq and proteomics analyses reveal striking differential expression of splice isoforms of key proteins in important cancer pathways and networks…”
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Micro-dissection and integration of long and short reads to create a robust catalog of kidney compartment-specific isoforms by Li, Hongyang, Eksi, Ridvan, Yi, Daiyao, Godfrey, Bradley, Mathew, Lisa R, O'Connor, Christopher L, Bitzer, Markus, Kretzler, Matthias, Menon, Rajasree, Guan, Yuanfang

“…Studying isoform expression at the microscopic level has always been a challenging task. A classical example is kidney, where glomerular and…”
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Association of urinary EGF, FABP3, and VCAM1 levels with the progression of early diabetic kidney disease by Keller, Felix, Denicolò, Sara, Leierer, Johannes, Kruus, Maren, Heinzel, Andreas, Kammer, Michael, Ju, Wenjun, Nair, Viji, Burdet, Frederic, Ibberson, Mark, Menon, Rajasree, Otto, Edgar, Choi, Ye Ji, Pyle, Laura, Ladd, Patricia, Bjornstad, Petter M., Eder, Susanne, Rosivall, Laszlo, Mark, Patrick Barry, Wiecek, Andrzej, Heerspink, Hiddo J. Lamber, Kretzler, Matthias, Oberbauer, Rainer, Mayer, Gert, Perco, Paul

“…Introduction Diabetic kidney disease (DKD) is a common cause of chronic kidney disease with around 25-40% of patients with diabetes being affected. The course…”
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Exosomes Derived from IL-10-Treated Dendritic Cells Can Suppress Inflammation and Collagen-Induced Arthritis by Kim, Seon-Hee, Lechman, Eric R, Bianco, Nicole, Menon, Rajasree, Keravala, Annahita, Nash, Joan, Mi, Zhibao, Watkins, Simon C, Gambotto, Andrea, Robbins, Paul D

“…We have demonstrated previously that local, adenoviral-mediated gene transfer of viral IL-10 to a single joint of rabbits and mice with experimental arthritis…”
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Identification of kidney cell types in scRNA-seq and snRNA-seq data using machine learning algorithms by Tisch, Adam, Madapoosi, Siddharth, Blough, Stephen, Rosa, Jan, Eddy, Sean, Mariani, Laura, Naik, Abhijit, Limonte, Christine, McCown, Philip, Menon, Rajasree, Rosas, Sylvia E., Parikh, Chirag R., Kretzler, Matthias, Mahfouz, Ahmed, Alakwaa, Fadhl

“…Single-cell RNA sequencing (scRNA-seq) and single-nucleus RNA sequencing (snRNA-seq) provide valuable insights into the cellular states of kidney cells…”
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Exosomes Derived from Genetically Modified DC Expressing FasL Are Anti-inflammatory and Immunosuppressive by Kim, Seon Hee, Bianco, Nicole, Menon, Rajasree, Lechman, Eric R, Shufesky, William J, Morelli, Adrian E, Robbins, Paul D

“…We previously have demonstrated the ability of primary murine bone marrow-derived DC (BM-DC), genetically modified by adenoviral infection to express FasL, to…”
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Cross-validation of SARS-CoV-2 responses in kidney organoids and clinical populations by Helms, Louisa, Marchiano, Silvia, Stanaway, Ian B, Hsiang, Tien-Ying, Juliar, Benjamin A, Saini, Shally, Zhao, Yan Ting, Khanna, Akshita, Menon, Rajasree, Alakwaa, Fadhl, Mikacenic, Carmen, Morrell, Eric D, Wurfel, Mark M, Kretzler, Matthias, Harder, Jennifer L, Murry, Charles E, Himmelfarb, Jonathan, Ruohola-Baker, Hannele, Bhatraju, Pavan K, Gale, Jr, Michael, Freedman, Benjamin S

“…Kidneys are critical target organs of COVID-19, but susceptibility and responses to infection remain poorly understood. Here, we combine SARS-CoV-2 variants…”
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Urinary EGF and MCP-1 and risk of CKD after cardiac surgery by Menez, Steven, Ju, Wenjun, Menon, Rajasree, Moledina, Dennis G, Thiessen Philbrook, Heather, McArthur, Eric, Jia, Yaqi, Obeid, Wassim, Mansour, Sherry G, Koyner, Jay L, Shlipak, Michael G, Coca, Steven G, Garg, Amit X, Bomback, Andrew S, Kellum, John A, Kretzler, Matthias, Parikh, Chirag R

“…BACKGROUNDAssessment of chronic kidney disease (CKD) risk after acute kidney injury (AKI) is based on limited markers primarily reflecting glomerular function…”
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Identification of Novel Alternative Splice Isoforms of Circulating Proteins in a Mouse Model of Human Pancreatic Cancer by MENON, Rajasree, QING ZHANG, YAN ZHANG, FERMIN, Damian, BARDEESY, Nabeel, DEPINHO, Ronald A, CHUNXIA LU, HANASH, Samir M, OMENN, Gilbert S, STATES, David J

“…To assess the potential of tumor-associated, alternatively spliced gene products as a source of biomarkers in biological fluids, we have analyzed a large data…”
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