Search Results - "MENON, RAMKUMAR"

Epithelial to mesenchymal transition (EMT) of feto-maternal reproductive tissues generates inflammation: a detrimental factor for preterm birth by Menon, Ramkumar

“…Human pregnancy is a delicate and complex process where multiorgan interactions between two independent systems, the mother, and her fetus, maintain pregnancy…”
Get full text

Initiation of human parturition: signaling from senescent fetal tissues via extracellular vesicle mediated paracrine mechanism by Menon, Ramkumar

“…A better understanding of the underlying mechanisms by which signals from the fetus initiate human parturition is required. Our recent findings support the…”
Get full text

Placental exosomes: A proxy to understand pregnancy complications by Jin, Jin, Menon, Ramkumar

“…Exosomes (30‐ to 150‐nm particles), originating from multivesicular bodies by the invagination of the endosomal membrane, are communication channels between…”
Get full text

Preterm prelabor rupture of the membranes: A disease of the fetal membranes by Menon, Ramkumar, Richardson, Lauren S.

“…Preterm prelabor rupture of the membranes (pPROM) remains a significant obstetric problem that affects 3–4% of all pregnancies and precedes 40–50% of all…”
Get full text

Proliferative, Migratory, and Transition Properties Reveal Metastate of Human Amnion Cells by Richardson, Lauren, Menon, Ramkumar

“…Amnion epithelial cell (AEC) shedding causes microfractures in human placental membranes during gestation. However, microfractures are healed to maintain…”
Get full text

Exosomes Cause Preterm Birth in Mice: Evidence for Paracrine Signaling in Pregnancy by Sheller-Miller, Samantha, Trivedi, Jayshil, Yellon, Steven M., Menon, Ramkumar

“…Endocrine factors and signals of fetal organ maturation are reported determinants of birth timing. To test the hypothesis that paracrine signaling by exosomes…”
Get full text

Cyclic-recombinase-reporter mouse model to determine exosome communication and function during pregnancy by Sheller-Miller, Samantha, Choi, Kyungsun, Choi, Chulhee, Menon, Ramkumar

“…During pregnancy, feto-maternal communication can be mediated through extracellular vesicles, specifically exosomes, 30- to 150-nm particles released from each…”
Get full text

Organ-On-Chip Technology: The Future of Feto-Maternal Interface Research? by Richardson, Lauren, Kim, Sungjin, Menon, Ramkumar, Han, Arum

“…The placenta and fetal membrane act as a protective barrier throughout pregnancy while maintaining communication and nutrient exchange between the baby and the…”
Get full text

Progesterone receptor membrane components: key regulators of fetal membrane integrity by Lozovyy, Violetta, Richardson, Lauren, Saade, George, Menon, Ramkumar

“…Pro-pregnancy hormone progesterone (P4) helps to maintain a quiescent status of uterine tissues during gestation. However, P4's functional role in maintaining…”
Get full text

Reversible EMT and MET mediate amnion remodeling during pregnancy and labor by Richardson, Lauren S, Taylor, Robert N, Menon, Ramkumar

“…The amnion is remodeled during pregnancy to protect the growing fetus it contains, and it is particularly dynamic just before and during labor. By combining…”
Get more information

p38 Mitogen activated protein kinase (MAPK): a new therapeutic target for reducing the risk of adverse pregnancy outcomes by Menon, Ramkumar, Papaconstantinou, John

“…Spontaneous preterm birth (PTB) and preterm premature rupture of the membranes (pPROM) remain as a major clinical and therapeutic problem for intervention and…”
Get more information

Circulating Exosomal miRNA Profile During Term and Preterm Birth Pregnancies: A Longitudinal Study by Menon, Ramkumar, Debnath, Chirantan, Lai, Andrew, Guanzon, Dominic, Bhatnagar, Shinjini, Kshetrapal, Pallavi K, Sheller-Miller, Samantha, Salomon, Carlos

“…Abstract Despite decades of research in the field of human reproduction, the mechanisms responsible for human parturition still remain elusive. The objective…”
Get full text

Epithelial to mesenchymal transition (EMT) of feto-maternal reproductive tissues generates inflammation: a detrimental factor for preterm birth by Menon, Ramkumar

“…Human pregnancy is a delicate and complex process where multiorgan interactions between two independent systems, the mother, and her fetus, maintain pregnancy…”
Get full text

Oxidative stress-induced TGF-beta/TAB1-mediated p38MAPK activation in human amnion epithelial cells by Richardson, Lauren, Dixon, Christopher Luke, Aguilera-Aguirre, Leopoldo, Menon, Ramkumar

“…Term and preterm parturition are associated with oxidative stress (OS)-induced p38 mitogenactivated protein kinase (p38MAPK)-mediated fetal tissue…”
Get full text

Amniotic Fluid Exosome Proteomic Profile Exhibits Unique Pathways of Term and Preterm Labor by Dixon, C Luke, Sheller-Miller, Samantha, Saade, George R, Fortunato, Stephen J, Lai, Andrew, Palma, Carlos, Guanzon, Dominic, Salomon, Carlos, Menon, Ramkumar

“…Our objective was to determine the amniotic fluid-derived exosomal proteomic profile in patients who had spontaneous preterm birth (PTB) or preterm premature…”
Get full text

Amnion-Epithelial-Cell-Derived Exosomes Demonstrate Physiologic State of Cell under Oxidative Stress by Sheller, Samantha, Papaconstantinou, John, Urrabaz-Garza, Rheanna, Richardson, Lauren, Saade, George, Salomon, Carlos, Menon, Ramkumar

“…At term, the signals of fetal maturity and feto-placental tissue aging prompt uterine readiness for delivery by transitioning quiescent myometrium to an active…”
Get full text

Amnion epithelial cell–derived exosomes induce inflammatory changes in uterine cells by Hadley, Emily E., Sheller-Miller, Samantha, Saade, George, Salomon, Carlos, Mesiano, Sam, Taylor, Robert N., Taylor, Brandie D., Menon, Ramkumar

“…Fetal endocrine signals are generally considered to contribute to the timing of birth and the initiation of labor. Fetal tissues under oxidative stress release…”
Get full text

Damage-Associated molecular pattern markers HMGB1 and cell-Free fetal telomere fragments in oxidative-Stressed amnion epithelial cell-Derived exosomes by Sheller-Miller, Samantha, Urrabaz-Garza, Rheanna, Saade, George, Menon, Ramkumar

“…•Oxidative stress induces primary amnion cells to undergo cellular senescence.•Senescence results in damage-associated molecular pattern (DAMPs)…”
Get full text

Extracellular vesicle mediated feto-maternal HMGB1 signaling induces preterm birth by Radnaa, Enkhtuya, Richardson, Lauren S, Sheller-Miller, Samantha, Baljinnyam, Tuvshintugs, de Castro Silva, Mariana, Kumar Kammala, Ananth, Urrabaz-Garza, Rheanna, Kechichian, Talar, Kim, Sungjin, Han, Arum, Menon, Ramkumar

“…Preterm birth (PTB; <37 weeks of gestation) impacts ∼11% of all pregnancies and contributes to 1 million neonatal deaths worldwide annually. An understanding…”
Get more information

Intraamniotic Inflammation in Women with Preterm Prelabor Rupture of Membranes by Musilova, Ivana, Kutová, Radka, Pliskova, Lenka, Stepan, Martin, Menon, Ramkumar, Jacobsson, Bo, Kacerovsky, Marian

“…To characterize subgroups of preterm prelabor rupture of membranes (PPROM) and short-term neonatal outcomes based on the presence and absence of intraamniotic…”
Get full text