Search Results - "MENGER, Laurie"

Immunogenic Tumor Cell Death for Optimal Anticancer Therapy: The Calreticulin Exposure Pathway by ZITVOGEL, Laurence, KEPP, Oliver, SENOVILLA, Laura, MENGER, Laurie, CHAPUT, Nathalie, KROEMER, Guido

“…In response to some chemotherapeutic agents such as anthracyclines and oxaliplatin, cancer cells undergo immunogenic apoptosis, meaning that their corpses are…”
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A common transcriptomic program acquired in the thymus defines tissue residency of MAIT and NKT subsets by Salou, Marion, Legoux, François, Gilet, Jules, Darbois, Aurélie, du Halgouet, Anastasia, Alonso, Ruby, Richer, Wilfrid, Goubet, Anne-Gaëlle, Daviaud, Céline, Menger, Laurie, Procopio, Emanuele, Premel, Virginie, Lantz, Olivier

“…Mucosal-associated invariant T (MAIT) cells are abundant T cells with unique specificity for microbial metabolites. MAIT conservation along evolution indicates…”
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Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice by Michaud, Mickaël, Martins, Isabelle, Sukkurwala, Abdul Qader, Adjemian, Sandy, Ma, Yuting, Pellegatti, Patrizia, Shen, Shensi, Kepp, Oliver, Scoazec, Marie, Mignot, Grégoire, Rello-Varona, Santiago, Tailler, Maximilien, Menger, Laurie, Vacchelli, Erika, Galluzzi, Lorenzo, Ghiringhelli, François, di Virgilio, Francesco, Zitvogel, Laurence, Kroemer, Guido

“…Antineoplastic chemotherapies are particularly efficient when they elicit immunogenic cell death, thus provoking an anticancer immune response. Here we…”
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Molecular determinants of immunogenic cell death elicited by anticancer chemotherapy by Kepp, Oliver, Galluzzi, Lorenzo, Martins, Isabelle, Schlemmer, Frederic, Adjemian, Sandy, Michaud, Mickael, Sukkurwala, Abdul Qader, Menger, Laurie, Zitvogel, Laurence, Kroemer, Guido

“…The success of some chemo- and radiotherapeutic regimens relies on the induction of immunogenic tumor cell death and on the induction of an anticancer immune…”
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Surface-exposed calreticulin in the interaction between dying cells and phagocytes by Martins, Isabelle, Kepp, Oliver, Galluzzi, Lorenzo, Senovilla, Laura, Schlemmer, Frederic, Adjemian, Sandy, Menger, Laurie, Michaud, Mickael, Zitvogel, Laurence, Kroemer, Guido

“…Phagocytosis is essential for pathogen elimination and for the removal of apoptotic corpses, a process that has been long considered immunologically silent…”
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Optimized protocol to generate genome-wide inactivated Cas9-expressing murine T cells by Laprie-Sentenac, Marguerite, Cretet-Rodeschini, Clara, Menger, Laurie

“…In vivo genome-wide CRISPR screens in primary T cells allow the systematic and unbiased identification of non-redundant regulatory mechanisms shaping immune…”
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Premortem autophagy determines the immunogenicity of chemotherapy-induced cancer cell death by Martins, Isabelle, Michaud, Mickaël, Sukkurwala, Abdul Qader, Adjemian, Sandy, Ma, Yuting, Shen, Shensi, Kepp, Oliver, Menger, Laurie, Vacchelli, Erika, Galluzzi, Lorenzo, Zitvogel, Laurence, Kroemer, Guido

“…One particular strategy to render anticancer therapies efficient consists of converting the patient's own tumor cells into therapeutic vaccines, via the…”
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Single-cell transcriptomics reveals shared immunosuppressive landscapes of mouse and human neuroblastoma by Costa, Ana, Thirant, Cécile, Kramdi, Amira, Pierre-Eugène, Cécile, Louis-Brennetot, Caroline, Blanchard, Orphée, Surdez, Didier, Gruel, Nadege, Lapouble, Eve, Pierron, Gaëlle, Sitbon, Deborah, Brisse, Hervé, Gauthier, Arnaud, Fréneaux, Paul, Bohec, Mylène, Raynal, Virginie, Baulande, Sylvain, Leclere, Renaud, Champenois, Gabriel, Nicolas, Andre, Meseure, Didier, Bellini, Angela, Marabelle, Aurelien, Geoerger, Birgit, Mechta-Grigoriou, Fatima, Schleiermacher, Gudrun, Menger, Laurie, Delattre, Olivier, Janoueix-Lerosey, Isabelle

“…BackgroundHigh-risk neuroblastoma is a pediatric cancer with still a dismal prognosis, despite multimodal and intensive therapies. Tumor microenvironment…”
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Loss-of-function alleles of P2RX7 and TLR4 fail to affect the response to chemotherapy in non-small cell lung cancer by Vacchelli, Erika, Galluzzi, Lorenzo, Rousseau, Vanessa, Rigoni, Alice, Tesniere, Antoine, Delahaye, Nicolas, Schlemmer, Fre´de´ric, Menger, Laurie, Sukkurwala, Abdul Qader, Adjemian, Sandy, Martins, Isabelle, Michaud, Mickaël, Dunant, Ariane, Kepp, Oliver, Brambilla, Elisabeth, Soria, Jean-Charles, Zitvogel, Laurence, Kroemer, Guido

“…The success of anticancer chemotherapy relies at least in part on the induction of an immune response against tumor cells. Thus, tumors growing on mice that…”
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Tissue-resident FOLR2+ macrophages associate with CD8+ T cell infiltration in human breast cancer by Nalio Ramos, Rodrigo, Missolo-Koussou, Yoann, Gerber-Ferder, Yohan, Bromley, Christian P., Bugatti, Mattia, Núñez, Nicolas Gonzalo, Tosello Boari, Jimena, Richer, Wilfrid, Menger, Laurie, Denizeau, Jordan, Sedlik, Christine, Caudana, Pamela, Kotsias, Fiorella, Niborski, Leticia L., Viel, Sophie, Bohec, Mylène, Lameiras, Sonia, Baulande, Sylvain, Lesage, Laëtitia, Nicolas, André, Meseure, Didier, Vincent-Salomon, Anne, Reyal, Fabien, Dutertre, Charles-Antoine, Ginhoux, Florent, Vimeux, Lene, Donnadieu, Emmanuel, Buttard, Bénédicte, Galon, Jérôme, Zelenay, Santiago, Vermi, William, Guermonprez, Pierre, Piaggio, Eliane, Helft, Julie

“…Macrophage infiltration is a hallmark of solid cancers, and overall macrophage infiltration correlates with lower patient survival and resistance to therapy…”
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Crosstalk between ER stress and immunogenic cell death by Kepp, Oliver, Menger, Laurie, Vacchelli, Erika, Locher, Clara, Adjemian, Sandy, Yamazaki, Takahiro, Martins, Isabelle, Sukkurwala, Abdul Qader, Michaud, Michael, Senovilla, Laura, Galluzzi, Lorenzo, Kroemer, Guido, Zitvogel, Laurence

“…Abstract Preclinical and clinical findings suggest that tumor-specific immune responses may be responsible – at least in part – for the clinical success of…”
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Trial watch: Cardiac glycosides and cancer therapy by Menger, Laurie, Vacchelli, Erika, Kepp, Oliver, Eggermont, Alexander, Tartour, Eric, Zitvogel, Laurence, Kroemer, Guido, Galluzzi, Lorenzo

“…Cardiac glycosides (CGs) are natural compounds sharing the ability to operate as potent inhibitors of the plasma membrane Na + /K + -ATPase, hence…”
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Anticancer Chemotherapy-Induced Intratumoral Recruitment and Differentiation of Antigen-Presenting Cells by Ma, Yuting, Adjemian, Sandy, Mattarollo, Stephen R., Yamazaki, Takahiro, Aymeric, Laetitia, Yang, Heng, Portela Catani, João Paulo, Hannani, Dalil, Duret, Helene, Steegh, Kim, Martins, Isabelle, Schlemmer, Frederic, Michaud, Mickaël, Kepp, Oliver, Sukkurwala, Abdul Qader, Menger, Laurie, Vacchelli, Erika, Droin, Nathalie, Galluzzi, Lorenzo, Krzysiek, Roman, Gordon, Siamon, Taylor, Philip R., Van Endert, Peter, Solary, Eric, Smyth, Mark J., Zitvogel, Laurence, Kroemer, Guido

“…The therapeutic efficacy of anthracyclines relies on antitumor immune responses elicited by dying cancer cells. How chemotherapy-induced cell death leads to…”
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Negative immune checkpoints on T lymphocytes and their relevance to cancer immunotherapy by Śledzińska, Anna, Menger, Laurie, Bergerhoff, Katharina, Peggs, Karl S., Quezada, Sergio A.

“…The term ‘inhibitory checkpoint’ refers to the broad spectrum of co-receptors expressed by T cells that negatively regulate T cell activation thus playing a…”
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TALEN-Mediated Inactivation of PD-1 in Tumor-Reactive Lymphocytes Promotes Intratumoral T-cell Persistence and Rejection of Established Tumors by Menger, Laurie, Sledzinska, Anna, Bergerhoff, Katharina, Vargas, Frederick Arce, Smith, Julianne, Poirot, Laurent, Pule, Martin, Hererro, Javier, Peggs, Karl S, Quezada, Sergio A

“…Despite the promising efficacy of adoptive cell therapies (ACT) in melanoma, complete response rates remain relatively low and outcomes in other cancers are…”
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Cardiac glycosides exert anticancer effects by inducing immunogenic cell death by Menger, Laurie, Vacchelli, Erika, Adjemian, Sandy, Martins, Isabelle, Ma, Yuting, Shen, Shensi, Yamazaki, Takahiro, Sukkurwala, Abdul Qader, Michaud, Mickaël, Mignot, Grégoire, Schlemmer, Frederic, Sulpice, Eric, Locher, Clara, Gidrol, Xavier, Ghiringhelli, François, Modjtahedi, Nazanine, Galluzzi, Lorenzo, André, Fabrice, Zitvogel, Laurence, Kepp, Oliver, Kroemer, Guido

“…Some successful chemotherapeutics, notably anthracyclines and oxaliplatin, induce a type of cell stress and death that is immunogenic, hence converting the…”
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Tumor-intrinsic sensitivity to the pro-apoptotic effects of IFN-γ is a major determinant of CD4 + CAR T-cell antitumor activity by Boulch, Morgane, Cazaux, Marine, Cuffel, Alexis, Guerin, Marion V, Garcia, Zacarias, Alonso, Ruby, Lemaître, Fabrice, Beer, Alexander, Corre, Béatrice, Menger, Laurie, Grandjean, Capucine L, Morin, Florence, Thieblemont, Catherine, Caillat-Zucman, Sophie, Bousso, Philippe

“…CD4 T cells and CD4 chimeric antigen receptor (CAR) T cells display highly variable antitumor activity in preclinical models and in patients; however, the…”
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TALEN-mediated genetic inactivation of the glucocorticoid receptor in cytomegalovirus-specific T cells by Menger, Laurie, Gouble, Agnes, Marzolini, Maria A.V., Pachnio, Annette, Bergerhoff, Katharina, Henry, Jake Y., Smith, Julianne, Pule, Martin, Moss, Paul, Riddell, Stanley R., Quezada, Sergio A., Peggs, Karl S.

“…Cytomegalovirus (CMV) infection is responsible for substantial morbidity and mortality after allogeneic hematopoietic stem cell transplant. T-cell immunity is…”
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Anticancer activity of cardiac glycosides: At the frontier between cell-autonomous and immunological effects by Kepp, Oliver, Menger, Laurie, Vacchelli, Erika, Adjemian, Sandy, Martins, Isabelle, Ma, Yuting, Sukkurwala, Abdul Qader, Michaud, Mickaël, Galluzzi, Lorenzo, Zitvogel, Laurence, Kroemer, Guido

“…Retrospective clinical data indicate that cardiac glycosides (CGs), notably digoxin, prolong the survival of carcinoma patients treated with conventional…”
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Acute Influenza Infection Promotes Lung Tumor Growth by Reprogramming the Tumor Microenvironment by Garmendia, Irati, Varthaman, Aditi, Marmier, Solenne, Angrini, Mahmud, Matchoua, Ingrid, Darbois-Delahousse, Aurelie, Josseaume, Nathalie, Foy, Pierre-Emmanuel, Roumenina, Lubka T, Naouar, Naïra, Meylan, Maxime, Sibéril, Sophie, Russick, Jules, Joubert, Pierre-Emmanuel, Leroy, Karen, Damotte, Diane, Mansuet-Lupo, Audrey, Wislez, Marie, Alifano, Marco, Menger, Laurie, Garcia-Verdugo, Ignacio, Sallenave, Jean-Michel, Lantz, Olivier, Petitprez, Florent, Cremer, Isabelle

“…One billion people worldwide get flu every year, including patients with non-small cell lung cancer (NSCLC). However, the impact of acute influenza A virus…”
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