Translocation t(1;3)(p36.3;q25) is a nonrandom aberration in epithelioid hemangioendothelioma

The cytogenetic findings for two epithelioid hemangioendotheliomas are reported. An identical chromosomal translocation involving chromosomes 1 and 3 [t(1;3)(p36.3;q25)] was detected in both cases of epithelioid hemangioendothelioma, possibly representing a characteristic rearrangement for this hist...

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Bibliographic Details
Published in:	The American journal of surgical pathology Vol. 25; no. 5; pp. 684 - 687
Main Authors:	MENDLICK, Matthew R, NELSON, Marilu, PICKERING, Diane, JOHANSSON, Sonny L, SEEMAYER, Thomas A, NEFF, James R, VERGARA, Gerardo, ROSENTHAL, Howard, BRIDGE, Julia A
Format:	Journal Article
Language:	English
Published:	Hagerstown, MD Lippincott Williams & Wilkins 01-05-2001
Subjects:	Adult Biological and medical sciences Biomarkers, Tumor - analysis Chromosomes, Human, Pair 1 Chromosomes, Human, Pair 3 Clone Cells Dermatology Female Hemangioendothelioma, Epithelioid - chemistry Hemangioendothelioma, Epithelioid - genetics Hemangioendothelioma, Epithelioid - pathology Humans Immunohistochemistry Karyotyping Liver Neoplasms - chemistry Liver Neoplasms - genetics Liver Neoplasms - pathology Medical sciences Middle Aged Neoplasm Proteins - analysis Platelet Endothelial Cell Adhesion Molecule-1 - analysis Soft Tissue Neoplasms - chemistry Soft Tissue Neoplasms - genetics Soft Tissue Neoplasms - pathology Translocation, Genetic Tumors of the skin and soft tissue. Premalignant lesions Chromosomal aberration Human Immunohistochemistry Epithelioid hemangioendothelioma Cardiovascular disease Chromosome 3 Chromosome 1 Vascular disease Case study Pathology Cytogenetics Abnormal chromosome Tumor Adult Female Soft tissue Chromosome translocation
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Summary:	The cytogenetic findings for two epithelioid hemangioendotheliomas are reported. An identical chromosomal translocation involving chromosomes 1 and 3 [t(1;3)(p36.3;q25)] was detected in both cases of epithelioid hemangioendothelioma, possibly representing a characteristic rearrangement for this histopathologic entity. The presence of clonal karyotypic abnormalities supports a neoplastic origin for the epithelioid variant of hemangioendothelioma. Identification of the 1;3 translocation may be useful diagnostically. Should additional studies confirm these data, this could lead to the identification of the gene(s) central to this neoplastic process.
Bibliography:	ObjectType-Case Study-3 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-2
ISSN:	0147-5185 1532-0979
DOI:	10.1097/00000478-200105000-00019