Search Results - "MEMPEL, Thorsten R"

Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop by Marangoni, Francesco, Zhakyp, Ademi, Corsini, Michela, Geels, Shannon N., Carrizosa, Esteban, Thelen, Martin, Mani, Vinidhra, Prüßmann, Jasper N., Warner, Ross D., Ozga, Aleksandra J., Di Pilato, Mauro, Othy, Shivashankar, Mempel, Thorsten R.

“…Foxp3+ T regulatory (Treg) cells promote immunological tumor tolerance, but how their immune-suppressive function is regulated in the tumor microenvironment…”
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CXCR3 Chemokine Receptor-Ligand Interactions in the Lymph Node Optimize CD4+ T Helper 1 Cell Differentiation by Groom, Joanna R., Richmond, Jillian, Murooka, Thomas T., Sorensen, Elizabeth W., Sung, Jung Hwan, Bankert, Katherine, von Andrian, Ulrich H., Moon, James J., Mempel, Thorsten R., Luster, Andrew D.

“…Differentiation of naive CD4+ T cells into T helper (Th) cells is a defining event in adaptive immunity. The cytokines and transcription factors that control…”
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The transcription factor NFAT promotes exhaustion of activated CD8⁺ T cells by Martinez, Gustavo J, Pereira, Renata M, Äijö, Tarmo, Kim, Edward Y, Marangoni, Francesco, Pipkin, Matthew E, Togher, Susan, Heissmeyer, Vigo, Zhang, Yi Chen, Crotty, Shane, Lamperti, Edward D, Ansel, K Mark, Mempel, Thorsten R, Lähdesmäki, Harri, Hogan, Patrick G, Rao, Anjana

“…During persistent antigen stimulation, CD8(+) T cells show a gradual decrease in effector function, referred to as exhaustion, which impairs responses in the…”
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SCS macrophages suppress melanoma by restricting tumor-derived vesicle–B cell interactions by Pucci, Ferdinando, Garris, Christopher, Lai, Charles P., Newton, Andita, Pfirschke, Christina, Engblom, Camilla, Alvarez, David, Sprachman, Melissa, Evavold, Charles, Magnuson, Angela, von Andrian, Ulrich H., Glatz, Katharina, Breakefield, Xandra O., Mempel, Thorsten R., Weissleder, Ralph, Pittet, Mikael J.

“…Tumor-derived extracellular vesicles (tEVs) are important signals in tumor–host cell communication, yet it remains unclear how endogenously produced tEVs…”
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The Transcription Factor NFAT Exhibits Signal Memory during Serial T Cell Interactions with Antigen-Presenting Cells by Marangoni, Francesco, Murooka, Thomas T., Manzo, Teresa, Kim, Edward Y., Carrizosa, Esteban, Elpek, Natalie M., Mempel, Thorsten R.

“…Interactions with antigen-presenting cells (APCs) interrupt T cell migration through tissues and trigger signaling pathways that converge on the activation…”
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Directly visualized glioblastoma-derived extracellular vesicles transfer RNA to microglia/macrophages in the brain by van der Vos, Kristan E, Abels, Erik R, Zhang, Xuan, Lai, Charles, Carrizosa, Esteban, Oakley, Derek, Prabhakar, Shilpa, Mardini, Osama, Crommentuijn, Matheus H W, Skog, Johan, Krichevsky, Anna M, Stemmer-Rachamimov, Anat, Mempel, Thorsten R, El Khoury, Joseph, Hickman, Suzanne E, Breakefield, Xandra O

“…To understand the ability of gliomas to manipulate their microenvironment, we visualized the transfer of vesicles and the effects of tumor-released…”
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Antigen Availability Determines CD8+ T Cell-Dendritic Cell Interaction Kinetics and Memory Fate Decisions by Henrickson, Sarah E., Perro, Mario, Loughhead, Scott M., Senman, Balimkiz, Stutte, Susanne, Quigley, Michael, Alexe, Gabriela, Iannacone, Matteo, Flynn, Michael P., Omid, Shaida, Jesneck, Jonathan L., Imam, Sabrina, Mempel, Thorsten R., Mazo, Irina B., Haining, W. Nicholas, von Andrian, Ulrich H.

“…T cells are activated by antigen (Ag)-bearing dendritic cells (DCs) in lymph nodes in three phases. The duration of the initial phase of transient, serial DC-T…”
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Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection by Sewald, Xaver, Ladinsky, Mark S., Uchil, Pradeep D., Beloor, Jagadish, Pi, Ruoxi, Herrmann, Christin, Motamedi, Nasim, Murrooka, Thomas T., Brehm, Michael A., Greiner, Dale L., Shultz, Leonard D., Mempel, Thorsten R., Bjorkman, Pamela J., Kumar, Priti, Mothes, Walther

“…Dendritic cells can capture and transfer retroviruses in vitro across synaptic cell-cell contacts to uninfected cells, a process called trans-infection…”
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Combining precision oncology and immunotherapy by targeting the MALT1 protease by Mempel, Thorsten R, Krappmann, Daniel

“…An innovative strategy for cancer therapy is to combine the inhibition of cancer cell-intrinsic oncogenic signaling with cancer cell-extrinsic immunological…”
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Conduits Mediate Transport of Low-Molecular-Weight Antigen to Lymph Node Follicles by Roozendaal, Ramon, Mempel, Thorsten R., Pitcher, Lisa A., Gonzalez, Santiago F., Verschoor, Admar, Mebius, Reina E., von Andrian, Ulrich H., Carroll, Michael C.

“…To track drainage of lymph-borne small and large antigens (Ags) into the peripheral lymph nodes and subsequent encounter by B cells and follicular dendritic…”
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A single glycan on IgE is indispensable for initiation of anaphylaxis by Shade, Kai-Ting C, Platzer, Barbara, Washburn, Nathaniel, Mani, Vinidhra, Bartsch, Yannic C, Conroy, Michelle, Pagan, Jose D, Bosques, Carlos, Mempel, Thorsten R, Fiebiger, Edda, Anthony, Robert M

“…Immunoglobulin ε (IgE) antibodies are the primary mediators of allergic diseases, which affect more than 1 in 10 individuals worldwide. IgE specific for…”
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Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo by Lamphier, Marc, Zheng, Wanjun, Latz, Eicke, Spyvee, Mark, Hansen, Hans, Rose, Jeffrey, Genest, Melinda, Yang, Hua, Shaffer, Christina, Zhao, Yan, Shen, Yongchun, Liu, Carrie, Liu, Diana, Mempel, Thorsten R, Rowbottom, Christopher, Chow, Jesse, Twine, Natalie C, Yu, Melvin, Gusovsky, Fabian, Ishizaka, Sally T

“…The discovery that circulating nucleic acid-containing complexes in the serum of autoimmune lupus patients can stimulate B cells and plasmacytoid dendritic…”
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T cell-intrinsic S1PR1 regulates endogenous effector T-cell egress dynamics from lymph nodes during infection by Benechet, Alexandre P., Menon, Manisha, Xu, Daqi, Samji, Tasleem, Maher, Leigh, Murooka, Thomas T., Mempel, Thorsten R., Sheridan, Brian S., Lemoine, Francois M., Khanna, Kamal M.

“…Viral clearance requires effector T-cell egress from the draining lymph node (dLN). The mechanisms that regulate the complex process of effector T-cell egress…”
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In Vivo Imaging of Tumor-Propagating Cells, Regional Tumor Heterogeneity, and Dynamic Cell Movements in Embryonal Rhabdomyosarcoma by Ignatius, Myron S., Chen, Eleanor, Elpek, Natalie M., Fuller, Adam Z., Tenente, Inês M., Clagg, Ryan, Liu, Sali, Blackburn, Jessica S., Linardic, Corinne M., Rosenberg, Andrew E., Nielsen, Petur G., Mempel, Thorsten R., Langenau, David M.

“…Embryonal rhabdomyosarcoma (ERMS) is an aggressive pediatric sarcoma of muscle. Here, we show that ERMS-propagating potential is confined to myf5+ cells and…”
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Definition of Germinal-Center B Cell Migration In Vivo Reveals Predominant Intrazonal Circulation Patterns by Hauser, Anja E., Junt, Tobias, Mempel, Thorsten R., Sneddon, Michael W., Kleinstein, Steven H., Henrickson, Sarah E., von Andrian, Ulrich H., Shlomchik, Mark J., Haberman, Ann M.

“…Proliferation, mutation, and selection in the germinal center (GC) are thought to occur in distinct microanatomical compartments—the dark zone (DZ) and the…”
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HIV-1-Induced Small T Cell Syncytia Can Transfer Virus Particles to Target Cells through Transient Contacts by Symeonides, Menelaos, Murooka, Thomas T, Bellfy, Lauren N, Roy, Nathan H, Mempel, Thorsten R, Thali, Markus

“…HIV-1 Env mediates fusion of viral and target cell membranes, but it can also mediate fusion of infected (producer) and target cells, thus triggering the…”
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Atypical complement receptor C5aR2 transports C5a to initiate neutrophil adhesion and inflammation by Miyabe, Yoshishige, Miyabe, Chie, Mani, Vinidhra, Mempel, Thorsten R, Luster, Andrew D

“…Chemoattractant-induced arrest of circulating leukocytes and their subsequent diapedesis is a fundamental component of inflammation. However, how…”
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A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediated egress by Nombela-Arrieta, César, Mempel, Thorsten R, Soriano, Silvia F, Mazo, Irina, Wymann, Matthias P, Hirsch, Emilio, Martínez-A, Carlos, Fukui, Yoshinori, von Andrian, Ulrich H, Stein, Jens V

“…Recent observations using multiphoton intravital microscopy (MP-IVM) have uncovered an unexpectedly high lymphocyte motility within peripheral lymph nodes…”
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Dendritic cells as shepherds of T cell immunity in cancer by Pittet, Mikael J., Di Pilato, Mauro, Garris, Christopher, Mempel, Thorsten R.

“…In cancer patients, dendritic cells (DCs) in tumor-draining lymph nodes can present antigens to naive T cells in ways that break immunological tolerance. The…”
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Behavior of Endogenous Tumor-Associated Macrophages Assessed In Vivo Using a Functionalized Nanoparticle by Leimgruber, Antoine, Berger, Cedric, Cortez-Retamozo, Virna, Etzrodt, Martin, Newton, Andita P., Waterman, Peter, Figueiredo, Jose Luiz, Kohler, Rainer H., Elpek, Natalie, Mempel, Thorsten R., Swirski, Filip K., Nahrendorf, Matthias, Weissleder, Ralph, Pittet, Mikael J.

“…Tumor-associated macrophages (TAMs) invade the tumor stroma in many cancers, yet their role is incompletely understood. To visualize and better understand…”
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