Search Results - "MELTZER, M. S"

Activated macrophages destroy intracellular Leishmania major amastigotes by an L-arginine-dependent killing mechanism by Green, SJ, Meltzer, MS, Hibbs, JB, Jr, Nacy, CA

“…Macrophages infected with amastigotes of Leishmania major and treated with IFN-gamma in vitro develop potent antimicrobial activities that eliminate the…”
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Growth of Francisella tularensis LVS in macrophages: the acidic intracellular compartment provides essential iron required for growth by Fortier, A.H. (EntreMed, Inc., Rockville, MD.), Leiby, D.A, Narayanan, R.B, Asafoadjei, E, Crawford, R.M, Nacy, C.A, Meltzer, M.S

“…Murine macrophages supported exponential intracellular growth of Francisella tularensis LVS in vitro with a doubling time of 4 to 6 h. LVS was internalized and…”
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Live vaccine strain of Francisella tularensis: infection and immunity in mice by FORTIER, A. H, SLAYTER, M. V, ZIEMBA, R, MELTZER, M. S, NACY, C. A

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Cytokine-induced synthesis of nitrogen oxides in macrophages: a protective host response to Leishmania and other intracellular pathogens by Green, S J, Nacy, C A, Meltzer, M S

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Cytoplasmic assembly and accumulation of human immunodeficiency virus types 1 and 2 in recombinant human colony-stimulating factor-1-treated human monocytes: an ultrastructural study by ORENSTEIN, J. M, MELTZER, M. S, PHIPPS, T, GENDELMAN, H. E

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Leishmania major amastigotes initiate the L-arginine-dependent killing mechanism in IFN-gamma-stimulated macrophages by induction of tumor necrosis factor-alpha by Green, SJ, Crawford, RM, Hockmeyer, JT, Meltzer, MS, Nacy, CA

“…Macrophages exposed to IFN-gamma and infected with amastigotes of Leishmania major develop the capacity to eliminate the intracellular pathogen. This…”
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Enhanced HIV replication in macrophage colony-stimulating factor- treated monocytes by Kalter, DC, Nakamura, M, Turpin, JA, Baca, LM, Hoover, DL, Dieffenbach, C, Ralph, P, Gendelman, HE, Meltzer, MS

“…Monocytes cultured 7 to 10 days in recombinant human macrophage CSF (MCSF) were greater than 400-fold more susceptible to HIV infection than an equal number of…”
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Neutralization of gamma interferon and tumor necrosis factor alpha blocks in vivo synthesis of nitrogen oxides from L-arginine and protection against Francisella tularensis infection in Mycobacterium bovis BCG-treated mice by GREEN, S. J, NACY, C. A, SCHREIBER, R. D, GRANGER, D. L, CRAWFORD, R. M, MELTZER, M. S, FORTIER, A. H

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B cell stimulatory factor-1 (interleukin 4) activates macrophages for increased tumoricidal activity and expression of Ia antigens by Crawford, RM, Finbloom, DS, Ohara, J, Paul, WE, Meltzer, MS

“…Macrophages are activated by lymphokines (LK) to kill tumor cell and microbial targets. Interferon-gamma (IFN) is the major LK activity in conventional,…”
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The macrophage in the persistence and pathogenesis of HIV infection by Gendelman, H E, Orenstein, J M, Baca, L M, Weiser, B, Burger, H, Kalter, D C, Meltzer, M S

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A selective defect of interferon α production in human immunodeficiency virus-infected monocytes by GENDELMAN, H. E, FRIEDMAN, R. M, JOE, S, BACA, L. M, TURPIN, J. A, DVEKSLER, G, MELTZER, M. S, DIEFFENBACH, C

“…Interferon alpha (IFN-alpha) induces significant antiretroviral activities that affect the ability of human immunodeficiency virus (HIV) to infect and…”
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Role of mononuclear phagocytes in the pathogenesis of human immunodeficiency virus infection by MELTZER, M. S, SKILLMAN, D. R, GOMATOS, P. J, KALTER, D. C, GENDELMAN, H. E

“…We have presented evidence in this review for the following: (a) Macrophages are likely the first cell infected by HIV. Recovery of HIV from macrophages has…”
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Regulation of activated macrophage antimicrobial activities. Identification of lymphokines that cooperate with IFN-gamma for induction of resistance to infection by Belosevic, M, Davis, CE, Meltzer, MS, Nacy, CA

“…Macrophages exposed to lymphokines (LK) before exposure to parasites develop the capacity to resist infection with amastigotes of Leishmania major. Activity of…”
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Regulation of interferon-alpha-inducible cellular genes in human immunodeficiency virus-infected monocytes by Baca, L M, Genis, P, Kalvakolanu, D, Sen, G, Meltzer, M S, Zhou, A, Silverman, R, Gendelman, H E

“…Cellular mechanisms that control susceptibility to opportunistic infection in human immunodeficiency virus (HIV)-infected individuals remain poorly understood…”
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Phase I Trial of Interferon Alfa-n3 in Early-Stage Human Immunodeficiency Virus Type 1 Disease: Evidence for Drug Safety, Tolerance, and Antiviral Activity by Skillman, Donald R., Malone, Joseph L., Decker, Catherine F., Wagner, Kenneth F., Mapou, Robert L., Liao, Mei-June, Testa, Douglas, Meltzer, Monte S.

“…The safety and tolerance of interferon alfa-n3 (IFN-αn3) was tested in 20 adults with asymptomatic human immunodeficiency virus type 1 (HIV-l) infection (>400…”
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Loss of infectivity by progeny virus from alpha interferon-treated human immunodeficiency virus type 1-infected T cells is associated with defective assembly of envelope gp120 by HANSEN, B. D, NARA, P. L, MAHESHWARI, R. K, SIDHU, G. S, BERNBAUM, J. G, HOEKZEMA, D, MELTZER, M. S, GENDELMAN, H. E

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Mononuclear phagocytes as targets, tissue reservoirs, and immunoregulatory cells in human immunodeficiency virus disease by Meltzer, M S, Gendelman, H E

“…We have presented evidence in this review for the following: 1. Macrophages are likely the first cell infected by HIV. Studies document recovery of HIV into…”
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Enhanced HIV-1 replication in retinoid-treated monocytes. Retinoid effects mediated through mechanisms related to cell differentiation and to a direct transcriptional action on viral gene expression by Turpin, JA, Vargo, M, Meltzer, MS

“…Vitamin A and other retinoids have profound effects on macrophage differentiation and function. Such effects could alter interactions between HIV and tissue…”
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Interferons in the persistence, pathogenesis, and treatment of HIV infection by Francis, M L, Meltzer, M S, Gendelman, H E

“…Interferon (IFN) plays an important role in the treatment and pathogenesis of HIV disease. Recent studies show beneficial effects of IFN alpha in the treatment…”
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Regulation of HIV replication in infected monocytes by IFN-alpha. Mechanisms for viral restriction by Gendelman, HE, Baca, LM, Turpin, J, Kalter, DC, Hansen, B, Orenstein, JM, Dieffenbach, CW, Friedman, RM, Meltzer, MS

“…In a survey of 15 different virus isolates, no IFN-alpha or IFN-beta activity was detected in culture fluids of HIV-infected T cells or monocytes. Exogenous…”
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