Search Results - "MELOTTE, Veerle"

The enteric nervous system in gastrointestinal disease etiology by Holland, Amy Marie, Bon-Frauches, Ana Carina, Keszthelyi, Daniel, Melotte, Veerle, Boesmans, Werend

“…A highly conserved but convoluted network of neurons and glial cells, the enteric nervous system (ENS), is positioned along the wall of the gut to coordinate…”
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Analysis of DNA methylation in cancer: location revisited by Koch, Alexander, Joosten, Sophie C., Feng, Zheng, de Ruijter, Tim C., Draht, Muriel X., Melotte, Veerle, Smits, Kim M., Veeck, Jurgen, Herman, James G., Van Neste, Leander, Van Criekinge, Wim, De Meyer, Tim, van Engeland, Manon

“…Changes in DNA methylation in cancer have been heralded as promising targets for the development of powerful diagnostic, prognostic, and predictive biomarkers…”
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The emerging role of GATA transcription factors in development and disease by Lentjes, Marjolein H F M, Niessen, Hanneke E C, Akiyama, Yoshimitsu, de Bruïne, Adriaan P, Melotte, Veerle, van Engeland, Manon

“…The GATA family of transcription factors consists of six proteins (GATA1-6) which are involved in a variety of physiological and pathological processes…”
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N-myc downstream regulated gene (NDRG) family: diverse functions, multiple applications by Melotte, Veerle, Qu, Xianghu, Ongenaert, Maté, van Criekinge, Wim, de Bruïne, Adriaan P, Baldwin, H. Scott, van Engeland, Manon

“…The N-myc downstream regulated gene (NDRG) family of proteins consists of 4 members, NDRG1-4, which are well conserved through evolution. The first member to…”
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Nervous NDRGs: the N-myc downstream–regulated gene family in the central and peripheral nervous system by Schonkeren, Simone L., Massen, Maartje, van der Horst, Raisa, Koch, Alexander, Vaes, Nathalie, Melotte, Veerle

“…The N-Myc downstream-regulated gene (NDRG) family consists of four members ( NDRG1 , NDRG2 , NDRG3 , NDRG4 ) that are differentially expressed in various…”
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WHO grade I meningiomas that show regrowth after gamma knife radiosurgery often show 1p36 loss by Damen, Pim J. J., Bulthuis, Vincent J., Hanssens, Patrick E. J., Lie, Suan Te, Fleischeuer, Ruth, Melotte, Veerle, Wouters, Kim A., Ruland, Andrea, Beckervordersandforth, Jan, Speel, Ernst Jan M.

“…WHO grade I meningiomas occasionally show regrowth after radiosurgical treatment, which cannot be predicted by clinical features. There is increasing evidence…”
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The CpG Island Methylator Phenotype: What's in a Name? by HUGHES, Laura A. E, MELOTTE, Veerle, VAN CRIEKINGE, Wim, AHUJA, Nita, HERMAN, James G, WEIJENBERG, Matty P, VAN ENGELAND, Manon, DE SCHRIJVER, Joachim, DE MAAT, Michiel, SMIT, Vincent T. H. B. M, BOVEE, Judith V. M. G, FRENCH, Pim J, VAN DEN BRANDT, Piet A, SCHOUTEN, Leo J, DE MEYER, Tim

“…Although the CpG island methylator phenotype (CIMP) was first identified and has been most extensively studied in colorectal cancer, the term "CIMP" has been…”
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Differences in enteric neuronal density in the NSE-Noggin mouse model across institutes by Schonkeren, Simone L., Thijssen, Meike S., Idris, Musa, Wouters, Kim, de Vaan, Joëlle, Teubner, Andreas, Gijbels, Marion J., Boesmans, Werend, Melotte, Veerle

“…The enteric nervous system (ENS) is a large and complex part of the peripheral nervous system, and it is vital for gut homeostasis. To study the ENS, different…”
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KRAS status is related to histological phenotype in gastric cancer: results from a large multicentre study by Hewitt, Lindsay C., Saito, Yuichi, Wang, Tan, Matsuda, Yoko, Oosting, Jan, Silva, Arnaldo N. S., Slaney, Hayley L., Melotte, Veerle, Hutchins, Gordon, Tan, Patrick, Yoshikawa, Takaki, Arai, Tomio, Grabsch, Heike I.

“…Background Gastric cancer (GC) is histologically a very heterogeneous disease, and the temporal development of different histological phenotypes remains…”
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Cost-effectiveness of High-performance Biomarker Tests vs Fecal Immunochemical Test for Noninvasive Colorectal Cancer Screening by Lansdorp-Vogelaar, Iris, Goede, S. Lucas, Bosch, Linda J.W., Melotte, Veerle, Carvalho, Beatriz, van Engeland, Manon, Meijer, Gerrit A., de Koning, Harry J., van Ballegooijen, Marjolein

“…Biomarker assays could increase the accuracy of noninvasive detection of colorectal cancer (CRC); fecal immunochemical tests (FITs) are estimated to miss…”
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Promoter hypermethylation of neural-related genes is compatible with stemness in solid cancers by Idris, Musa, Coussement, Louis, Alves, Maria M, De Meyer, Tim, Melotte, Veerle

“…DNA hypermethylation is an epigenetic feature that modulates gene expression, and its deregulation is observed in cancer. Previously, we identified a…”
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A Four-Gene Promoter Methylation Marker Panel Consisting of GREM1, NEURL, LAD1, and NEFH Predicts Survival of Clear Cell Renal Cell Cancer Patients by van Vlodrop, Iris J H, Joosten, Sophie C, De Meyer, Tim, Smits, Kim M, Van Neste, Leander, Melotte, Veerle, Baldewijns, Marcella M L L, Schouten, Leo J, van den Brandt, Piet A, Jeschke, Jana, Yi, Joo Mi, Schuebel, Kornel E, Ahuja, Nita, Herman, James G, Aarts, Maureen J, Bosman, Fred T, Van Criekinge, Wim, van Engeland, Manon

“…The currently used prognostic models for patients with nonmetastatic clear cell renal cell carcinoma (ccRCC) are based on clinicopathologic features and might…”
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Prognostic DNA methylation markers for renal cell carcinoma: a systematic review by Joosten, Sophie C, Deckers, Ivette AG, Aarts, Maureen J, Hoeben, Ann, van Roermund, Joep G, Smits, Kim M, Melotte, Veerle, van Engeland, Manon, Tjan-Heijnen, Vivianne C

“…Despite numerous published prognostic methylation markers for renal cell carcinoma (RCC), none of these have yet changed patient management. Our aim is to…”
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GATA4 and GATA5 are Potential Tumor Suppressors and Biomarkers in Colorectal Cancer by Hellebrekers, Debby M E I, Lentjes, Marjolein H F M, van den Bosch, Sandra M, Melotte, Veerle, Wouters, Kim A D, Daenen, Kathleen L J, Smits, Kim M, Akiyama, Yoshimitsu, Yuasa, Yasuhito, Sanduleanu, Silvia, Khalid-de Bakker, Carolina A J, Jonkers, Daisy, Weijenberg, Matty P, Louwagie, Joost, van Criekinge, Wim, Carvalho, Beatriz, Meijer, Gerrit A, Baylin, Stephen B, Herman, James G, de Bruïne, Adriaan P, van Engeland, Manon

“…Purpose: The transcription factors GATA4 and GATA5 are involved in gastrointestinal development and are inactivated by promoter hypermethylation in colorectal…”
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Prognostic DNA methylation markers for sporadic colorectal cancer: a systematic review by Draht, Muriel X G, Goudkade, Danny, Koch, Alexander, Grabsch, Heike I, Weijenberg, Matty P, van Engeland, Manon, Melotte, Veerle, Smits, Kim M

“…Biomarkers that can predict the prognosis of colorectal cancer (CRC) patients and that can stratify high-risk early stage patients from low-risk early stage…”
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Chronic Intra-Uterine Ureaplasma parvum Infection Induces Injury of the Enteric Nervous System in Ovine Fetuses by Heymans, Cathelijne, de Lange, Ilse H, Hütten, Matthias C, Lenaerts, Kaatje, de Ruijter, Nadine J E, Kessels, Lilian C G A, Rademakers, Glenn, Melotte, Veerle, Boesmans, Werend, Saito, Masatoshi, Usuda, Haruo, Stock, Sarah J, Spiller, Owen B, Beeton, Michael L., Payne, Matthew S, Kramer, Boris W, Newnham, John P, Jobe, Alan H, Kemp, Matthew W, van Gemert, Wim G, Wolfs, Tim G A M

“…Chorioamnionitis, inflammation of the fetal membranes during pregnancy, is often caused by intra-amniotic (IA) infection with single or multiple microbes…”
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Histological intratumoral heterogeneity in pretreatment esophageal cancer biopsies predicts survival benefit from neoadjuvant chemotherapy: results from the UK MRC OE02 trial by Davarzani, Naser, Hewitt, Lindsay C, Hale, Matthew D, Melotte, Veerle, Nankivell, Matthew, Hutchins, Gordon G A, Cunningham, David, Allum, William H, Langley, Ruth E, Jolani, Shahab, Grabsch, Heike I

“…Summary Despite the use of multimodal treatment, survival of esophageal cancer (EC) patients remains poor. One proposed explanation for the relatively poor…”
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Unbiased characterization of the larval zebrafish enteric nervous system at a single cell transcriptomic level by Kuil, Laura E., Kakiailatu, Naomi J.M., Windster, Jonathan D., Bindels, Eric, Zink, Joke T.M., van der Zee, Gaby, Hofstra, Robert M.W., Shepherd, Iain T., Melotte, Veerle, Alves, Maria M.

“…The enteric nervous system (ENS) regulates many gastrointestinal functions including peristalsis, immune regulation and uptake of nutrients. Defects in the ENS…”
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Identification of epigenetically silenced genes in tumor endothelial cells by HELLEBREKERS, Debby M. E. I, MELOTTE, Veerle, VIRE, Emmanuelle, LANGENKAMP, Elise, MOLEMA, Grietje, FUKS, Francois, HERMAN, James G, VAN CRIEKINGE, Wim, GRIFFIOEN, Arjan W, VAN ENGELAND, Manon

“…Tumor angiogenesis requires intricate regulation of gene expression in endothelial cells. We recently showed that DNA methyltransferase (DNMT) and histone…”
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Emerging evidence for CHFR as a cancer biomarker: from tumor biology to precision medicine by Derks, Sarah, Cleven, Arjen H. G., Melotte, Veerle, Smits, Kim M., Brandes, Johann C., Azad, Nilofer, van Criekinge, Wim, de Bruïne, Adriaan P., Herman, James G., van Engeland, Manon

“…Novel insights in the biology of cancer have switched the paradigm of a “one-size-fits-all” cancer treatment to an individualized biology-driven treatment…”
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