Search Results - "MELO DE OLIVEIRA, Gabriel"
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Overexpression of TcNTPDase-1 Gene Increases Infectivity in Mice Infected with Trypanosoma cruzi
Published in International journal of molecular sciences (24-11-2022)“…Ecto-nucleoside triphosphate diphosphohydrolases (NTPDases) are enzymes located on the surface of the T. cruzi plasma membrane, which hydrolyze a wide range of…”
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Combined treatment of heterocyclic analogues and benznidazole upon Trypanosoma cruzi in vivo
Published in PloS one (26-07-2011)“…Chagas disease caused by Trypanosoma cruzi is an important cause of mortality and morbidity in Latin America but no vaccines or safe chemotherapeutic agents…”
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Impact of autologous whole blood administration upon experimental mouse models of acute Trypanosoma cruzi infection
Published in The journal of venomous animals and toxins including tropical diseases (30-08-2018)“…Autologous whole blood (AWB) administration is described as alternative/complementary medical practice widely employed in medical and veterinary therapy…”
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Inhibitory insula-ACC projections modulate affective but not sensory aspects of neuropathic pain
Published in Molecular brain (21-08-2023)“…Abstract The insula and anterior cingulate cortex (ACC) are brain regions that undergo structural and functional reorganization in neuropathic pain states…”
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Vascular Growth Factor Inhibition with Bevacizumab Improves Cardiac Electrical Alterations and Fibrosis in Experimental Acute Chagas Disease
Published in Biology (Basel, Switzerland) (01-11-2023)“…Chagas disease (CD) caused by Trypanosoma cruzi is a neglected illness and a major reason for cardiomyopathy in endemic areas. The existing therapy generally…”
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Use of haloperidol and risperidone in highly aggressive Swiss Webster mice by applying the model of spontaneous aggression (MSA)
Published in Behavioural brain research (15-03-2016)“…•Animal model of spontaneous aggression is efficient to select aggressive individuals.•Haloperidol and risperidone were effective in reversal of aggressive…”
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Arylimidamide DB766, a Potential Chemotherapeutic Candidate for Chagas' Disease Treatment
Published in Antimicrobial Agents and Chemotherapy (01-07-2010)“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Acute experimental Trypanosoma cruzi infection: establishing a murine model that utilises non-invasive measurements of disease parameters
Published in Memórias do Instituto Oswaldo Cruz (01-03-2012)“…Trypanosoma cruzi infection has a large public health impact in Latin American countries. Although the transmission rates via blood transfusions and insect…”
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Absence of Fas-L aggravates renal injury in acute Trypanosoma cruzi infection
Published in Memórias do Instituto Oswaldo Cruz (01-12-2009)“…Trypanosoma cruzi infection induces diverse alterations in immunocompetent cells and organs, myocarditis and congestive heart failure. However, the…”
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Activity profile of two 5-nitroindazole derivatives over the moderately drug-resistant Trypanosoma cruzi Y strain (DTU TcII): in vitro and in vivo studies
Published in Parasitology (01-09-2020)“…In previous studies, we have identified several families of 5-nitroindazole derivatives as promising antichagasic prototypes. Among them,…”
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Impact of levamisole in co-administration with benznidazole on experimental Chagas disease
Published in Parasitology (01-07-2019)“…Levamisole (Lms) is an anthelminthic drug with immunomodulatory activity. Chagas disease (CD) is caused by Trypanosoma cruzi and there is very low access to…”
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Combination With Tomatidine Improves the Potency of Posaconazole Against Trypanosoma cruzi
Published in Frontiers in cellular and infection microbiology (04-03-2021)“…Azoles such as posaconazole (Posa) are highly potent against . However, when tested in chronic Chagas disease patients, a high rate of relapse after Posa…”
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7-Aryl-7-deazapurine 3′-deoxyribonucleoside derivative as a novel lead for Chagas’ disease therapy: in vitro and in vivo pharmacology
Published in JAC-antimicrobial resistance (01-12-2021)“…Abstract Background The protozoan Trypanosoma cruzi is auxotrophic for purines and causes Chagas’ disease (CD), a neglected illness affecting >6 million…”
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In Vitro and In Vivo Studies of the Trypanocidal Activity of a Diarylthiophene Diamidine against Trypanosoma cruzi
Published in Antimicrobial Agents and Chemotherapy (01-09-2008)“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Fas Ligand-Dependent Inflammatory Regulation in Acute Myocarditis Induced by Trypanosoma cruzi Infection
Published in The American journal of pathology (01-07-2007)“…Fas/Fas ligand (Fas-L) engagement, a potent inducer of apoptosis, is also important for cellular activation, regulation of effector and chemotactic activity,…”
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Applicability of the use of charcoal for the evaluation of intestinal motility in a murine model of Trypanosoma cruzi infection
Published in Parasitology research (1987) (01-03-2008)“…Chagas disease, caused by the protozoan Trypanosoma cruzi, remains a serious public health problem in Latin America. In relation to digestive problems, 4.5% of…”
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Trypanosoma cruzi: host selenium deficiency leads to higher mortality but similar parasitemia in mice
Published in Experimental parasitology (01-08-2002)“…Selenium is an essential trace element and its deficiency was implicated in heart diseases. We recently showed low Se levels in chronic chagasic patients with…”
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N6-modification of 7-Deazapurine nucleoside analogues as Anti-Trypanosoma cruzi and anti-Leishmania agents: Structure-activity relationship exploration and In vivo evaluation
Published in European journal of medicinal chemistry (05-03-2022)“…Chagas disease and leishmaniasis are two poverty-related neglected tropical diseases that cause high mortality and morbidity. Current treatments suffer from…”
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Dyslipidemia and cardiovascular risk in Afro-descendants: a study of the Quilombola communities in Maranhão, Brazil
Published in Revista brasileira de medicina de família e comunidade (30-09-2015)“…Objective: to evaluate the prevalence of cardiovascular risk factors associated with dyslipidemia in Quilombola communities in Maranhão, Brazil. Methods: a…”
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