Search Results - "MELNIK, Svitlana"

Impact of c-MYC expression on proliferation, differentiation, and risk of neoplastic transformation of human mesenchymal stromal cells by Melnik, Svitlana, Werth, Nadine, Boeuf, Stephane, Hahn, Eva-Maria, Gotterbarm, Tobias, Anton, Martina, Richter, Wiltrud

“…Mesenchymal stromal cells isolated from bone marrow (MSC) represent an attractive source of adult stem cells for regenerative medicine. However, thorough…”
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The Warburg Trap: A Novel Therapeutic Approach for Targeting Osteosarcoma by Fellenberg, Joerg, Losch, Sarina, Tripel, Elena, Lehner, Burkhard, Melnik, Svitlana

“…Although urgently needed, no significant improvements in osteosarcoma (OS) therapy have been achieved within the last decades. Here, we present a new…”
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The proteomes of transcription factories containing RNA polymerases I, II or III by Melnik, Svitlana, Deng, Binwei, Papantonis, Argyris, Baboo, Sabyasachi, Carr, Ian M, Cook, Peter R

“…The question of whether transcription factories containing RNA polymerases exist has been controversial, owing to the fact that they have not been isolated…”
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MiR-218 affects hypertrophic differentiation of human mesenchymal stromal cells during chondrogenesis via targeting RUNX2, MEF2C, and COL10A1 by Melnik, Svitlana, Gabler, Jessica, Dreher, Simon I, Hecht, Nicole, Hofmann, Nina, Großner, Tobias, Richter, Wiltrud

“…Human mesenchymal stromal cells (MSC) hold hopes for cartilage regenerative therapy due to their chondrogenic differentiation potential. However, undesirable…”
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Transcription factories, chromatin loops, and the dysregulation of gene expression in malignancy by Deng, Binwei, Melnik, Svitlana, Cook, Peter R

“…Abstract Pathologists recognize and classify cancers according to nuclear morphology, but there remains little scientific explanation of why malignant nuclei…”
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MiR-181a Targets RSPO2 and Regulates Bone Morphogenetic Protein – WNT Signaling Crosstalk During Chondrogenic Differentiation of Mesenchymal Stromal Cells by Melnik, Svitlana, Hofmann, Nina, Gabler, Jessica, Hecht, Nicole, Richter, Wiltrud

“…Mechanisms of WNT and bone morphogenetic protein (BMP) signaling crosstalk is in the focus of multiple biological studies, and it also has been discovered to…”
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Differentially methylated regions within lung cancer risk loci are enriched in deregulated enhancers by Laplana, Marina, Bieg, Matthias, Faltus, Christian, Melnik, Svitlana, Bogatyrova, Olga, Gu, Zuguang, Muley, Thomas, Meister, Michael, Dienemann, Hendrik, Herpel, Esther, Amos, Christopher I., Schlesner, Matthias, Eils, Roland, Plass, Christoph, Risch, Angela

“…Genome-wide association studies (GWAS) have identified SNPs linked with lung cancer risk. Our aim was to discover the genes, non-coding RNAs, and regulatory…”
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Extracellular Vesicles in Musculoskeletal Pathologies and Regeneration by Herrmann, Marietta, Diederichs, Solvig, Melnik, Svitlana, Riegger, Jana, Trivanović, Drenka, Li, Shushan, Jenei-Lanzl, Zsuzsa, Brenner, Rolf E, Huber-Lang, Markus, Zaucke, Frank, Schildberg, Frank A, Grässel, Susanne

“…The incidence of musculoskeletal diseases is steadily increasing with aging of the population. In the past years, extracellular vesicles (EVs) have gained…”
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Isolation of the protein and RNA content of active sites of transcription from mammalian cells by Melnik, Svitlana, Caudron-Herger, Maïwen, Brant, Lilija, Carr, Ian M, Rippe, Karsten, Cook, Peter R, Papantonis, Argyris

“…Transcription factories contain all three mammalian RNA polymerases, each actively transcribing a different subset of genes. This protocol describes how to…”
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C/EBPβ Induces Chromatin Opening at a Cell-Type-Specific Enhancer by Plachetka, Annette, Chayka, Olesya, Wilczek, Carola, Melnik, Svitlana, Bonifer, Constanze, Klempnauer, Karl-Heinz

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Developmentally Regulated Recruitment of Transcription Factors and Chromatin Modification Activities to Chicken Lysozyme cis-Regulatory Elements In Vivo by Lefevre, Pascal, Melnik, Svitlana, Wilson, Nicola, Riggs, Arthur D., Bonifer, Constanze

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Differentiation-dependent Alterations in Histone Methylation and Chromatin Architecture at the Inducible Chicken Lysozyme Gene by Lefevre, Pascal, Lacroix, Claire, Tagoh, Hiromi, Hoogenkamp, Maarten, Melnik, Svitlana, Ingram, Richard, Bonifer, Constanze

“…It is now well established that locus-wide chromatin remodeling and dynamic alterations of histone modifications are required for the developmentally regulated…”
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c-FMS chromatin structure and expression in normal and leukaemic myelopoiesis by FOLLOWS, George Alexander, TAGOH, Hiromi, RICHARDS, Stephen John, MELNIK, Svitlana, DICKINSON, Helen, DE WYNTER, Erica, LEFEVRE, Pascal, MORGAN, Gareth John, BONIFER, Constanze

“…The macrophage colony-stimulating factor receptor is encoded by the c-FMS gene, and it has been suggested that altered regulation of c-FMS expression may…”
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A novel RNA binding surface of the TAM domain of TIP5/BAZ2A mediates epigenetic regulation of rRNA genes by Anosova, Irina, Melnik, Svitlana, Tripsianes, Konstantinos, Kateb, Fatiha, Grummt, Ingrid, Sattler, Michael

“…The chromatin remodeling complex NoRC, comprising the subunits SNF2h and TIP5/BAZ2A, mediates heterochromatin formation at major clusters of repetitive…”
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Cancer cell specific inhibition of Wnt/β-catenin signaling by forced intracellular acidification by Melnik, Svitlana, Dvornikov, Dmytro, Müller-Decker, Karin, Depner, Sofia, Stannek, Peter, Meister, Michael, Warth, Arne, Thomas, Michael, Muley, Tomas, Risch, Angela, Plass, Christoph, Klingmüller, Ursula, Niehrs, Christof, Glinka, Andrey

“…Use of the diabetes type II drug Metformin is associated with a moderately lowered risk of cancer incidence in numerous tumor entities. Studying the molecular…”
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Simple and Efficient Identification of Rare Recessive Pathologically Important Sequence Variants from Next Generation Exome Sequence Data by Carr, Ian M., Morgan, Joanne, Watson, Christopher, Melnik, Svitlana, Diggle, Christine P., Logan, Clare V., Harrison, Sally M., Taylor, Graham R., Pena, Sergio D.J., Markham, Alexander F., Alkuraya, Fowzan S., Black, Graeme C.M., Ali, Manir, Bonthron, David T.

“…ABSTRACT Massively parallel (“next generation”) DNA sequencing (NGS) has quickly become the method of choice for seeking pathogenic mutations in rare…”
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Dynamic reorganization of chromatin structure and selective DNA demethylation prior to stable enhancer complex formation during differentiation of primary hematopoietic cells in vitro by Tagoh, Hiromi, Melnik, Svitlana, Lefevre, Pascal, Chong, Suyinn, Riggs, Arthur D., Bonifer, Constanze

“…In order to gain insights in the true molecular mechanisms involved in cell fate decisions, it is important to study the molecular details of gene activation…”
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C/EBPbeta induces chromatin opening at a cell-type-specific enhancer by Plachetka, Annette, Chayka, Olesya, Wilczek, Carola, Melnik, Svitlana, Bonifer, Constanze, Klempnauer, Karl-Heinz

“…We have used the chicken mim-1 gene as a model to study the mechanisms by which transcription factors gain initial access to their target sites in compacted…”
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