Search Results - "MELLOR, Joseph C"

A framework for exhaustively mapping functional missense variants by Weile, Jochen, Sun, Song, Cote, Atina G, Knapp, Jennifer, Verby, Marta, Mellor, Joseph C, Wu, Yingzhou, Pons, Carles, Wong, Cassandra, van Lieshout, Natascha, Yang, Fan, Tasan, Murat, Tan, Guihong, Yang, Shan, Fowler, Douglas M, Nussbaum, Robert, Bloom, Jesse D, Vidal, Marc, Hill, David E, Aloy, Patrick, Roth, Frederick P

“…Although we now routinely sequence human genomes, we can confidently identify only a fraction of the sequence variants that have a functional impact. Here, we…”
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Numerous Conserved and Divergent MicroRNAs Expressed by Herpes Simplex Viruses 1 and 2 by JURAK, Igor, KRAMER, Martha F, MELLOR, Joseph C, VAN LINT, Alison L, ROTH, Frederick P, KNIPE, David M, COEN, Donald M

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Pooled‐matrix protein interaction screens using Barcode Fusion Genetics by Yachie, Nozomu, Petsalaki, Evangelia, Mellor, Joseph C, Weile, Jochen, Jacob, Yves, Verby, Marta, Ozturk, Sedide B, Li, Siyang, Cote, Atina G, Mosca, Roberto, Knapp, Jennifer J, Ko, Minjeong, Yu, Analyn, Gebbia, Marinella, Sahni, Nidhi, Yi, Song, Tyagi, Tanya, Sheykhkarimli, Dayag, Roth, Jonathan F, Wong, Cassandra, Musa, Louai, Snider, Jamie, Liu, Yi‐Chun, Yu, Haiyuan, Braun, Pascal, Stagljar, Igor, Hao, Tong, Calderwood, Michael A, Pelletier, Laurence, Aloy, Patrick, Hill, David E, Vidal, Marc, Roth, Frederick P

“…High‐throughput binary protein interaction mapping is continuing to extend our understanding of cellular function and disease mechanisms. However, we remain…”
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Application of Data Mining to “Big Data” Acquired in Audiology: Principles and Potential by Mellor, Joseph C., Stone, Michael A., Keane, John

“…The ubiquity and cheapness of miniature low-power sensors, digital processing, and large amounts of storage contained in small packages has heralded the…”
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Mapping DNA damage‐dependent genetic interactions in yeast via party mating and barcode fusion genetics by Díaz‐Mejía, J Javier, Celaj, Albi, Mellor, Joseph C, Coté, Atina, Balint, Attila, Ho, Brandon, Bansal, Pritpal, Shaeri, Fatemeh, Gebbia, Marinella, Weile, Jochen, Verby, Marta, Karkhanina, Anna, Zhang, YiFan, Wong, Cassandra, Rich, Justin, Prendergast, D'Arcy, Gupta, Gaurav, Öztürk, Sedide, Durocher, Daniel, Brown, Grant W, Roth, Frederick P

“…Condition‐dependent genetic interactions can reveal functional relationships between genes that are not evident under standard culture conditions…”
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Reverse Chemical Genetics: Comprehensive Fitness Profiling Reveals the Spectrum of Drug Target Interactions by Wong, Lai H, Sinha, Sunita, Bergeron, Julien R, Mellor, Joseph C, Giaever, Guri, Flaherty, Patrick, Nislow, Corey

“…The emergence and prevalence of drug resistance demands streamlined strategies to identify drug resistant variants in a fast, systematic and cost-effective…”
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Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways by Das, Jishnu, Vo, Tommy V, Wei, Xiaomu, Mellor, Joseph C, Tong, Virginia, Degatano, Andrew G, Wang, Xiujuan, Wang, Lihua, Cordero, Nicolas A, Kruer-Zerhusen, Nathan, Matsuyama, Akihisa, Pleiss, Jeffrey A, Lipkin, Steven M, Yoshida, Minoru, Roth, Frederick P, Yu, Haiyuan

“…The fission yeast Schizosaccharomyces pombe has more metazoan-like features than the budding yeast Saccharomyces cerevisiae, yet it has similarly facile…”
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Genome-wide functional analysis of human 5' untranslated region introns by Cenik, Can, Derti, Adnan, Mellor, Joseph C, Berriz, Gabriel F, Roth, Frederick P

“…Approximately 35% of human genes contain introns within the 5' untranslated region (UTR). Introns in 5'UTRs differ from those in coding regions and 3'UTRs with…”
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NGS barcode sequencing in taxonomy and diagnostics, an application in " Candida " pathogenic yeasts with a metagenomic perspective by Colabella, Claudia, Corte, Laura, Roscini, Luca, Bassetti, Matteo, Tascini, Carlo, Mellor, Joseph C, Meyer, Wieland, Robert, Vincent, Vu, Duong, Cardinali, Gianluigi

“…Species identification of yeasts and other Fungi is currently carried out with Sanger sequences of selected molecular markers, mainly from the ribosomal DNA…”
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Predictome: a database of putative functional links between proteins by Mellor, Joseph C, Yanai, Itai, Clodfelter, Karl H, Mintseris, Julian, DeLisi, Charles

“…The current deluge of genomic sequences has spawned the creation of tools capable of making sense of the data. Computational and high-throughput experimental…”
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Reconstitution of human RNA interference in budding yeast by Suk, Kyoungho, Choi, Jihye, Suzuki, Yo, Ozturk, Sedide B, Mellor, Joseph C, Wong, Koon Ho, MacKay, Joanna L, Gregory, Richard I, Roth, Frederick P

“…Although RNA-mediated interference (RNAi) is a widely conserved process among eukaryotes, including many fungi, it is absent from the budding yeast…”
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Deciphering Protein Network Organization Using Phylogenetic Profile Groups by Wu, Jie, Mellor, Joseph C., Lisi, Charles De

“…Phylogenetic profiling is now an effective computational method to detect functional associations between proteins. The method links two proteins in accordance…”
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Identifying functional links between genes using conserved chromosomal proximity by Yanai, Itai, Mellor, Joseph C., DeLisi, Charles

“…Conservation of proximity of a pair of genes across multiple genomes generally indicates that their functions could be linked. Here, we present a systematic…”
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Constructing Networks with Correlation Maximization Methods by Mellor, Joseph C., Wu, Jie, Lisi, Charles De

“…Problems of inference in systems biology are ideally reduced to formulations which can efficiently represent the features of interest. In the case of…”
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546-P: Deep Learning Predictions of Diabetic Retinopathy Associated with Progression of Renal Disease in Type 1 Diabetes by MELLOR, JOSEPH C., STORKEY, AMOS J., COLHOUN, HELEN, MCKEIGUE, PAUL M.

“…Background and Aims: We considered if deep learning (DL) models trained to predict diabetic retinopathy (DR) are also useful for prediction of renal disease in…”
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Circuits of the cell by Mellor, Joseph C., DeLisi, Charles

“…Networks of gene regulation control many aspects of cellular biology, ranging from development and differentiation to the cell cycle and apoptosis. However,…”
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