Search Results - "MELLADO, W"

Induction of Cyclophosphamide-Resistance by Aldehyde-Dehydrogenase Gene Transfer by Magni, Michele, Shammah, Suzy, Schiró, Raffaella, Mellado, Wilfredo, Dalla-Favera, Riccardo, Gianni, A. Massimo

“…The identification of genes inducing resistance to anticancer chemotherapeutic agents and their introduction into hematopoietic cells represents a promising…”
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Antisense ATM gene therapy: a strategy to increase the radiosensitivity of human tumors by Guha, C, Guha, U, Tribius, S, Alfieri, A, Casper, D, Chakravarty, P, Mellado, W, Pandita, T K, Vikram, B

“…Atm, the gene mutated in ataxia-telangiectasia (AT) patients, is an essential component of the signal transduction pathway that responds to DNA damage due to…”
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Astrocyte Process Growth Induction by Actin Breakdown by Baorto, David M., Mellado, Wilfredo, Shelanski, Michael L.

“…cAMP analogues such as dibutyryl cAMP (dBcAMP) have been shown to induce the formation of processes in cultured primary astrocytes. We observe that the…”
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Phosphorylation of the multidrug resistance associated glycoprotein by Mellado, Wilfredo, Horwitz, Susan Band

“…Drug-resistant cell lines derived from the mouse macrophage-like cell line J774.2 express the multidrug resistance phenotype which includes the overexpression…”
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Activated CREB Is Sufficient to Overcome Inhibitors in Myelin and Promote Spinal Axon Regeneration In Vivo by Gao, Ying, Deng, Kangwen, Hou, Jianwei, Bryson, J.Barney, Barco, Angel, Nikulina, Elena, Spencer, Tim, Mellado, Wilfredo, Kandel, Eric R., Filbin, Marie T.

“…Inhibitors in myelin play a major role in preventing spontaneous axonal regeneration after CNS injury. Elevation of cAMP overcomes this inhibition, in a…”
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Taxol: mechanisms of action and resistance by Horwitz, S B, Lothstein, L, Manfredi, J J, Mellado, W, Parness, J, Roy, S N, Schiff, P B, Sorbara, L, Zeheb, R

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MAG Induces Regulated Intramembrane Proteolysis of the p75 Neurotrophin Receptor to Inhibit Neurite Outgrowth by Domeniconi, Marco, Zampieri, Niccolò, Spencer, Tim, Hilaire, Melissa, Mellado, Wilfredo, Chao, Moses V., Filbin, Marie T.

“…The three known inhibitors of axonal regeneration present in myelin—MAG, Nogo, and OMgp—all interact with the same receptor complex to effect inhibition via…”
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Arginase I and Polyamines Act Downstream from Cyclic AMP in Overcoming Inhibition of Axonal Growth MAG and Myelin In Vitro by Cai, Dongming, Deng, Kangwen, Mellado, Wilfredo, Lee, Junghee, Ratan, Rajiv R, Filbin, Marie T

“…Elevation of cAMP can overcome myelin inhibitors to encourage regeneration of the CNS. We show that a consequence of elevated cAMP is the synthesis of…”
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Neurotrophins Elevate cAMP to Reach a Threshold Required to Overcome Inhibition by MAG through Extracellular Signal-Regulated Kinase-Dependent Inhibition of Phosphodiesterase by Gao, Ying, Nikulina, Elena, Mellado, Wilfredo, Filbin, Marie T

“…Inhibitors of regeneration in myelin, such as myelin-associated glycoprotein (MAG), play an important role in preventing regeneration after CNS injury…”
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BDNF activates CaMKIV and PKA in parallel to block MAG-mediated inhibition of neurite outgrowth by Spencer, Timothy K., Mellado, Wilfredo, Filbin, Marie T.

“…The environment of the adult CNS prevents axonal regeneration after injury. This inhibition of axonal regeneration can be blocked by elevating cAMP…”
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BCL-6 and the molecular pathogenesis of B-cell lymphoma by Dalla-Favera, R, Ye, B H, Lo Coco, F, Chang, C C, Cechova, K, Zhang, J, Migliazza, A, Mellado, W, Niu, H, Chaganti, S

“…The results presented identify the first genetic lesion associated with DLCL, the most clinically relevant form of NHL. Although no proof yet exists of a role…”
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Tubulin carbamoylation. Functional amino groups in microtubule assembly by Mellado, W, Slebe, J C, Maccioni, R B

“…The characteristics of the carbamoylation of pig brain tubulin were examined by using the modification conditions with cyanate described previously [Mellado,…”
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Influence of ATM function on telomere metabolism by SMILENOV, L. B, MORGAN, S. E, MELLADO, W, SAWANT, S. G, KASTAN, M. B, PANDITA, T. K

“…The ATM gene product, which is defective in the cancer-prone disorder ataxia telangiectasia, has been implicated in mitogenic signal transduction, chromosome…”
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Isoacceptor glycine tRNA species during bovine myocardium development by Meza, L, Vera, J C, Mellado, W, Concha, I

“…The isoacceptor patterns of glycyl-tRNAs from fetal bovine myocardium during development, and of adult cardiac muscle, have been studied by reverse-phase…”
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Paclitaxel sensitivity correlates with p53 status and DNA fragmentation, but not G2/M accumulation by Rakovitch, E, Mellado, W, Hall, E J, Pandita, T K, Sawant, S, Geard, C R

“…The antitumor agent paclitaxel (Taxol) has been shown to arrest cells in mitosis through microtubule stabilization and to induce apoptosis. The tumor…”
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High molecular weight tau : preferential localization in the peripheral nervous system by GEORGIEFF, I. S, LIEM, R. K. H, MELLADO, W, NUNEZ, J, SHELANSKI, M. L

“…Using epitope mapping we have demonstrated that a high molecular weight protein (Mr approximately 115 x 10(3)) present in brain and spinal cord is a member of…”
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Molecular cloning and chromosomal localization of chinese hamster telomeric protein chTRF1. Its potential role in chromosomal instability by SMILENOV, L. B, MELLADO, W, RAO, P. H, SAWANT, S. G, UMBRICHT, C. B, SUKUMAR, S, PANDITA, T. K

“…Chinese hamster cells frequently have altered karyotypes. To investigate the basis of recent observations that karyotypic alterations are related to telomeric…”
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Azidopine photoaffinity labeling of multidrug resistance-associated glycoproteins by Yang, C P, Mellado, W, Horwitz, S B

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Penclomedine-induced DNA fragmentation and p53 accumulation correlate with reproductive cell death in colorectal carcinoma cells with altered p53 status by Rakovitch, E, Mellado, W, Hall, E J, Sawant, S G, Geard, C R, Newman, R A, Pandita, T K

“…Penclomedine, a synthetic pyridine derivative, has documented antitumor activity and is being investigated in clinical trials. Its mechanism of action is…”
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Preparation and biological activity of taxol acetates by Mellado, W, Magri, N F, Kingston, D G, Garcia-Arenas, R, Orr, G A, Horwitz, S B

“…Synthesis and biological activity of 2'-acetyltaxol and 7-acetyltaxol are reported. Activity is measured in vivo by cytotoxicity toward the macrophage-like…”
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