Search Results - "MELDRUM, D. R"

K+ regulates Ca2+ to drive inflammasome signaling: dynamic visualization of ion flux in live cells by Yaron, J R, Gangaraju, S, Rao, M Y, Kong, X, Zhang, L, Su, F, Tian, Y, Glenn, H L, Meldrum, D R

“…P2X 7 purinergic receptor engagement with extracellular ATP induces transmembrane potassium and calcium flux resulting in assembly of the NLRP3 inflammasome in…”
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Lifestyle and metabolic approaches to maximizing erectile and vascular health by Meldrum, D R, Gambone, J C, Morris, M A, Esposito, K, Giugliano, D, Ignarro, L J

“…Oxidative stress and inflammation, which disrupt nitric oxide (NO) production directly or by causing resistance to insulin, are central determinants of…”
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TNF-alpha mediates obstruction-induced renal tubular cell apoptosis and proapoptotic signaling by Misseri, R, Meldrum, D R, Dinarello, C A, Dagher, P, Hile, K L, Rink, R C, Meldrum, K K

“…Obstruction of the upper urinary tract induces a progressive loss in renal mass through apoptotic renal cell death. Although TNF-alpha has been implicated in…”
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Blastocyst culture and transfer: analysis of results and parameters affecting outcome in two in vitro fertilization programs by Schoolcraft, W B, Gardner, D K, Lane, M, Schlenker, T, Hamilton, F, Meldrum, D R

“…To determine whether previously described advanced blastocyst development and high implantation rates are confirmed in an expanded multicenter trial…”
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K(+) regulates Ca(2+) to drive inflammasome signaling: dynamic visualization of ion flux in live cells by Yaron, J R, Gangaraju, S, Rao, M Y, Kong, X, Zhang, L, Su, F, Tian, Y, Glenn, H L, Meldrum, D R

“…P2X7 purinergic receptor engagement with extracellular ATP induces transmembrane potassium and calcium flux resulting in assembly of the NLRP3 inflammasome in…”
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Female reproductive aging--ovarian and uterine factors by Meldrum, D R

“…To review published data on ovarian and uterine aging in the human female. Literature review. Studies examining the effect of age on oocyte quality and uterine…”
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Oral sulfonylurea hypoglycemic agents prevent ischemic preconditioning in human myocardium : Two paradoxes revisited by CLEVELAND, J. C, MELDRUM, D. R, CAIN, B. S, BANERJEE, A, HARKEN, A. H

“…Patients receiving oral hypoglycemic agents for diabetes mellitus are at increased risk of cardiovascular mortality. Oral hypoglycemic agents are inhibitors of…”
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Success rate with repeated cycles of in vitro fertilization-embryo transfer by Meldrum, D R, Silverberg, K M, Bustillo, M, Stokes, L

“…To analyze data from a large multicenter study to determine whether pregnancy and delivery rates decrease with repeated IVF-ET cycles. Multicenter…”
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A Novel Model of Ischemia in Renal Tubular Cells Which Closely Parallels in Vivo Injury by Meldrum, K.K., Meldrum, D.R., Hile, K.L., Burnett, A.L., Harken, A.H.

“…Purpose. Renal ischemia-reperfusion (IR) injury is a devastating clinical problem. While effective animal models have been developed to investigate this…”
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p38 MAPK mediates renal tubular cell TNF-alpha production and TNF-alpha-dependent apoptosis during simulated ischemia by Meldrum, K K, Meldrum, D R, Hile, K L, Yerkes, E B, Ayala, A, Cain, M P, Rink, R C, Casale, A J, Kaefer, M A

“…Ischemia causes renal tubular cell loss through apoptosis; however, the mechanisms of this process remain unclear. Using the renal tubular epithelial cell line…”
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Heat shock prevents simulated ischemia-induced apoptosis in renal tubular cells via a PKC-dependent mechanism by Meldrum, K K, Meldrum, D R, Sezen, S F, Crone, J K, Burnett, A L

“…Heat shock produces cellular tolerance to a variety of adverse conditions; however, the protective effect of heat shock on renal cell ischemic injury remains…”
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Mechanisms of Cardiac Preconditioning: Ten Years after the Discovery of Ischemic Preconditioning by Meldrum, Daniel R.

“…Cardiac preconditioning describes the phenomenon by which transient ischemia induces myocardial protection against subsequent ischemia and reperfusion injury…”
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Role of TNF in Mediating Renal Insufficiency Following Cardiac Surgery: Evidence of a Postbypass Cardiorenal Syndrome by Meldrum, Daniel R., Donnahoo, Kirstan K.

“…Recent evidence has implicated proinflammatory mediators such as TNF-α in the pathophysiology of ischemia-reperfusion (I/R) injury. Clinically, serum levels of…”
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Lower pregnancy rate with premature luteinization during pituitary suppression with leuprolide acetate by Schoolcraft, W, Sinton, E, Schlenker, T, Huynh, D, Hamilton, F, Meldrum, D R

“…The relationship of the circulating level of progesterone (P) on the day of human chorionic gonadotropin (hCG) injection to occurrence of clinical pregnancy…”
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TNF-alpha neutralization ameliorates obstruction-induced renal fibrosis and dysfunction by Meldrum, K K, Misseri, R, Metcalfe, P, Dinarello, C A, Hile, K L, Meldrum, D R

“…Upper urinary tract obstruction results in tubulointerstitial fibrosis and a progressive decline in renal function. Although several inflammatory mediators…”
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Early and delayed preconditioning: differential mechanisms and additive protection by Meldrum, D R, Cleveland, Jr, J C, Rowland, R T, Banerjee, A, Harken, A H, Meng, X

“…The purposes of this study were to determine whether 1) 24-h endotoxin (ETX) pretreatment induces delayed ("second window") myocardial protection against…”
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Human SERCA2a levels correlate inversely with age in senescent human myocardium by Cain, Brian S, Meldrum, Daniel R, Joo, Kyung S, Wang, Ju-Feng, Meng, Xianzhong, Cleveland, Joseph C, Banerjee, Anirban, Harken, Alden H

“…Objectives. This study sought to characterize functional impairment after simulated ischemia-reperfusion (I/R) or Ca2+bolus in senescent human myocardium and…”
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Tumor necrosis factor in the heart by Meldrum, D R

“…The heart is a tumor necrosis factor (TNF)-producing organ. Both myocardial macrophages and cardiac myocytes themselves synthesize TNF. Accumulating evidence…”
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Cardiopulmonary Bypass Renders Patients at Risk for Multiple Organ Failure via Early Neutrophil Priming and Late Neutrophil Disability by Partrick, David A., Moore, Ernest E., Fullerton, David A., Barnett, Carlton C., Meldrum, Daniel R., Silliman, Christopher C.

“…Background. Cardiopulmonary bypass (CPB) is associated with a systemic inflammatory response syndrome (SIRS) and these patients are recognized to be at…”
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Cardiac preconditioning with calcium: Clinically accessible myocardial protection by Meldrum, Daniel R., Cleveland, Joseph C., Sheridan, Brett C., Rowland, Robert T., Banerjee, Anirban, Harken, Alden H.

“…Cardiac preconditioning is mediated by protein kinase C. Although endogenous calcium is a potent stimulus of protein kinase C, it remains unknown whether…”
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