Search Results - "MELCANGI, Roberto C"

Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease by Barron, Anna M, Garcia-Segura, Luis M, Caruso, Donatella, Jayaraman, Anusha, Lee, Joo-Won, Melcangi, Roberto C, Pike, Christian J

“…Ligands of the translocator protein (TSPO) elicit pleiotropic neuroprotective effects that represent emerging treatment strategies for several…”
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Age-related changes in neuroactive steroid levels in 3xTg-AD mice by Caruso, Donatella, Barron, Anna M, Brown, Meghan A, Abbiati, Federico, Carrero, Paloma, Pike, Christian J, Garcia-Segura, Luis M, Melcangi, Roberto C

“…Abstract Although neuroactive steroids exert neuroprotective actions in different experimental models of neurodegenerative diseases, including those of…”
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Steroids and glial cell function by Garcia-Segura, Luis M., Melcangi, Roberto C.

“…Hormonal and locally produced steroids act in the nervous system as neuroendocrine regulators, as trophic factors and as neuromodulators and have a major…”
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Lack of Sterol Regulatory Element Binding Factor-1c Imposes Glial Fatty Acid Utilization Leading to Peripheral Neuropathy by Cermenati, Gaia, Audano, Matteo, Giatti, Silvia, Carozzi, Valentina, Porretta-Serapiglia, Carla, Pettinato, Emanuela, Ferri, Cinzia, D’Antonio, Maurizio, De Fabiani, Emma, Crestani, Maurizio, Scurati, Samuele, Saez, Enrique, Azcoitia, Iñigo, Cavaletti, Guido, Garcia-Segura, Luis-Miguel, Melcangi, Roberto C., Caruso, Donatella, Mitro, Nico

“…Myelin is a membrane characterized by high lipid content to facilitate impulse propagation. Changes in myelin fatty acid (FA) composition have been associated…”
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Diabetes-induced myelin abnormalities are associated with an altered lipid pattern: protective effects of LXR activation by Cermenati, Gaia, Abbiati, Federico, Cermenati, Solei, Brioschi, Elisabetta, Volonterio, Alessandro, Cavaletti, Guido, Saez, Enrique, De Fabiani, Emma, Crestani, Maurizio, Garcia-Segura, Luis M., Melcangi, Roberto C., Caruso, Donatella, Mitro, Nico

“…Diabetic peripheral neuropathy (DPN) is characterized by myelin abnormalities; however, the molecular mechanisms underlying such deficits remain obscure. To…”
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Neuroactive steroids and the peripheral nervous system: An update by Giatti, Silvia, Romano, Simone, Pesaresi, Marzia, Cermenati, Gaia, Mitro, Nico, Caruso, Donatella, Tetel, Marc J., Garcia-Segura, Luis Miguel, Melcangi, Roberto C.

“…In the present review we summarize observations to date supporting the concept that neuroactive steroids are synthesized in the peripheral nervous system,…”
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Neuroprotective Effect of Progesterone in MPTP-Treated Male Mice by Bourque, Mélanie, Morissette, Marc, Al Sweidi, Sara, Caruso, Donatella, Melcangi, Roberto C, Di Paolo, Thérèse

“…Numerous studies have reported on the neuroprotective activity of estradiol, whereas the effect of the other ovarian steroid, progesterone, is much less…”
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Sex-dimorphic changes in neuroactive steroid levels after chronic experimental autoimmune encephalomyelitis by Caruso, Donatella, D'Intino, Giulia, Giatti, Silvia, Maschi, Omar, Pesaresi, Marzia, Calabrese, Donato, Garcia-Segura, Luis-Miguel, Calza, Laura, Melcangi, Roberto C

“…J. Neurochem. (2010) 114, 921-932. Our previous observations have shown that neuroactive steroid levels in the brain are affected by acute experimental…”
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LXR and TSPO as new therapeutic targets to increase the levels of neuroactive steroids in the central nervous system of diabetic animals by Mitro, Nico, Cermenati, Gaia, Giatti, Silvia, Abbiati, Federico, Pesaresi, Marzia, Calabrese, Donato, Garcia-Segura, Luis Miguel, Caruso, Donatella, Melcangi, Roberto C.

“…► Ro5-4864 and GW3965 increase neuroactive steroid levels in the CNS areas of diabetic animals. ► Pattern of induction was different among the three CNS areas…”
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Evaluation of neuroactive steroid levels by liquid chromatography–tandem mass spectrometry in central and peripheral nervous system: Effect of diabetes by Caruso, Donatella, Scurati, Samuele, Maschi, Omar, De Angelis, Leonardo, Roglio, Ilaria, Giatti, Silvia, Garcia-Segura, Luis Miguel, Melcangi, Roberto C.

“…The nervous system is a target for physiological and protective effects of neuroactive steroids. Consequently, the assessment of their levels in nervous…”
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Gender effect on neurodegeneration and myelin markers in an animal model for multiple sclerosis by Massella, Alessandro, D'Intino, Giulia, Fernández, Mercedes, Sivilia, Sandra, Lorenzini, Luca, Giatti, Silvia, Melcangi, Roberto C, Calzà, Laura, Giardino, Luciana

“…Multiple sclerosis (MS) varies considerably in its incidence and progression in females and males. In spite of clinical evidence, relatively few studies have…”
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Neuroactive steroids, neurosteroidogenesis and sex by Giatti, Silvia, Garcia-Segura, Luis M, Barreto, George E, Melcangi, Roberto C

“…The nervous system is a target and a source of steroids. Neuroactive steroids are steroids that target neurons and glial cells. They include hormonal steroids…”
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Docetaxel-induced peripheral neuropathy: protective effects of dihydroprogesterone and progesterone in an experimental model by Roglio, Ilaria, Bianchi, Roberto, Camozzi, Francesca, Carozzi, Valentina, Cervellini, Ilaria, Crippa, Donatella, Lauria, Giuseppe, Cavaletti, Guido, Melcangi, Roberto C.

“…Peripheral neurotoxicity is a frequent complication limiting docetaxel chemotherapy in patients with cancer. We developed an experimental model that closely…”
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Effects of paroxetine treatment and its withdrawal on neurosteroidogenesis by Giatti, Silvia, Diviccaro, Silvia, Cioffi, Lucia, Falvo, Eva, Caruso, Donatella, Melcangi, Roberto C.

“…Selective serotonin reuptake inhibitors (SSRI) show high efficacy in treating depression, however during treatment side effects, like for instance sexual…”
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Lipids in the nervous system: From biochemistry and molecular biology to patho-physiology by Cermenati, Gaia, Mitro, Nico, Audano, Matteo, Melcangi, Roberto C., Crestani, Maurizio, De Fabiani, Emma, Caruso, Donatella

“…Lipids in the nervous system accomplish a great number of key functions, from synaptogenesis to impulse conduction, and more. Most of the lipids of the nervous…”
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Levels and actions of neuroactive steroids in the nervous system under physiological and pathological conditions: Sex-specific features by Melcangi, Roberto C., Giatti, Silvia, Garcia-Segura, Luis M.

“…•Neuroactive steroids are involved in the physiological regulation of brain function.•Neuroactive steroids participate in the control of mood, behavior and…”
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Sex differences in steroid levels and steroidogenesis in the nervous system: Physiopathological role by Giatti, Silvia, Diviccaro, Silvia, Serafini, Melania Maria, Caruso, Donatella, Garcia-Segura, Luis Miguel, Viviani, Barbara, Melcangi, Roberto C.

“…•Neuroactive steroid levels and neurosteroidogenesis show sex-dimorphic features.•Neurodegenerative and psychiatric disorders show sex-dimorphic…”
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Paroxetine effects in adult male rat colon: Focus on gut steroidogenesis and microbiota by Diviccaro, Silvia, Giatti, Silvia, Cioffi, Lucia, Falvo, Eva, Piazza, Rocco, Caruso, Donatella, Melcangi, Roberto C.

“…Paroxetine, a selective serotonin reuptake inhibitor (SSRI), is prescribed to treat psychiatric disorders, although an off-label SSRI use is also for…”
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Structural and molecular brain sexual differences: A tool to understand sex differences in health and disease by Panzica, GianCarlo, Melcangi, Roberto C.

“…•Sexually dimorphic circuits are present in many parts of the nervous system.•Sex differences span from large structures to very subtle neurochemical…”
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Neuroactive steroids and the new decade by Panzica, Giancarlo, Melcangi, Roberto C.

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