Search Results - "MEISSNER, P. N"

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    A systematic study of the clinical and biochemical expression of variegate porphyria in a large South African family by Hift, R.J., Meissner, D., Meissner, P.N.

    Published in British journal of dermatology (1951) (01-08-2004)
    “…Summary Background  Variegate porphyria (VP) is an autosomal dominant disorder associated with deficient haem synthesis. Recent reports indicate that the…”
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    Journal Article
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    Administration of oral activated charcoal in variegate porphyria results in a paradoxical clinical and biochemical deterioration by Hift, R.J., Todd, G., Meissner, P.N., Kirsch, R.E.

    Published in British journal of dermatology (1951) (01-12-2003)
    “…Summary Background  Porphyrinogens are the obligate intracellular precursors of haem. These compounds are, however, unstable and are easily oxidized to the…”
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    Journal Article
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    Molecular characterization of erythropoietic protoporphyria in South Africa by Parker, M., Corrigall, A.V., Hift, R.J., Meissner, P.N.

    Published in British journal of dermatology (1951) (01-07-2008)
    “…Summary Background  Erythropoietic protoporphyria (EPP) results from a partial deficiency of ferrochelatase (FECH). Clinical expression normally requires…”
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    Purification of and kinetic studies on a cloned protoporphyrinogen oxidase from the aerobic bacterium Bacillus subtilis by Corrigall, A V, Siziba, K B, Maneli, M H, Shephard, E G, Ziman, M, Dailey, T A, Dailey, H A, Kirsch, R E, Meissner, P N

    Published in Archives of biochemistry and biophysics (15-10-1998)
    “…The previously cloned and expressed protoporphyrinogen oxidase from Bacillus subtilis has been purified to homogeneity by Ni2+ affinity chromatography using a…”
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    Journal Article
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    Porphyria cutanea tarda: the etiological importance of mutations in the HFE gene and viral infection is population-dependent by Hift, R J, Corrigall, A V, Hancock, V, Kannemeyer, J, Kirsch, R E, Meissner, P N

    “…A number of factors, including increased iron stores and alcohol consumption, are known to be associated with the development of porphyria cutanea tarda (PCT)…”
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    Journal Article
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    Homozygous variegate porphyria: an evolving clinical syndrome by Hift, R. J., Meissner, P. N., Todd, G., Kirby, P., Bilsland, D., Collins, P., Ferguson, J., Moore, M. R.

    Published in Postgraduate Medical Journal (01-10-1993)
    “…Variegate porphyria is one of the most frequently encountered genetic conditions in South Africa. It is inherited as an autosomal dominant disease and in…”
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    Journal Article Book Review
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    Homozygous Variegate Porphyria in South Africa: Genotypic Analysis in Two Cases by Corrigall, A.V., Hift, R.J., Davids, L.M., Hancock, V., Meissner, D., Kirsch, R.E., Meissner, P.N.

    Published in Molecular genetics and metabolism (01-04-2000)
    “…Variegate porphyria is an autosomal dominant disorder of heme metabolism which results from decreased activity of the enzyme protoporphyrinogen oxidase…”
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    Journal Article
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    Hepatoerythropoietic porphyria precipitated by viral hepatitis by Hift, R J, Meissner, P N, Todd, G

    Published in Gut (01-11-1993)
    “…Porphyria cutanea tarda (PCT), the condition resulting from a deficiency of hepatic uroporphyrinogen decarboxylase activity, is the commonest form of…”
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    Journal Article
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    Identification of the First Variegate Porphyria Mutation in an Indigenous Black South African and Further Evidence for Heterogeneity in Variegate Porphyria by Corrigall, A.V., Hift, R.J., Davids, L.M., Hancock, V., Meissner, D., Kirsch, R.E., Meissner, P.N.

    Published in Molecular genetics and metabolism (01-05-2001)
    “…Variegate porphyria is an autosomal dominant disorder of haem metabolism resulting from reduced levels of the penultimate enzyme in the pathway,…”
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    Journal Article
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    The expression of protoporphyrinogen oxidase in human tissues by Corrigall, A V, Campbell, J A H, Siziba, K, Kirsch, R E, Meissner, P N

    “…Protoporphyrinogen oxidase is the penultimate enzyme in the haem biosynthetic pathway. In this study, the expression of protoporphyrinogen oxidase in a variety…”
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    Propofol as an i.v. anaesthetic induction agent in variegate porphyria by Meissner, P N, Harrison, G G, Hift, R J

    Published in British journal of anaesthesia : BJA (01-01-1991)
    “…The choice of an i.v. anaesthetic induction poses problems for the anaesthetist confronted with a patient with one of the acute porphyrias. We undertook a…”
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    Journal Article
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    The effect of oral activated charcoal on the course of congenital erythropoietic porphyria by Hift, R J, Meissner, P N, Kirsch, R E

    Published in British journal of dermatology (1951) (01-07-1993)
    “…The administration of oral activated charcoal to two patients with congenital erythropoietic porphyria has previously been reported to result in a marked…”
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    Journal Article
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    A R59W mutation in human protoporphyrinogen oxidase results in decreased enzyme activity and is prevalent in South Africans with variegate porphyria by Meissner, Peter N, Dailey, Tamara A, Hift, Richard J, Ziman, Mel, Corrigall, Anne V, Roberts, Andrew G, Meissner, Doreen M, Kirsch, Ralph E, Dailey, Harry A

    Published in Nature genetics (01-05-1996)
    “…Variegate porphyria (VP), a low-penetrant autosomal dominant inherited disorder of haem metabolism, is characterised by photosensitivity (Fig. 1) and a…”
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    Journal Article
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    Mapping of the variegate porphyria (VP) gene : contradictory evidence for linkage between VP and microsatellite markers at chromosome 14q32 by WARNICH, L, MEISSNER, P. N, HIFT, R. J, LOUW, J. H, VAN HEERDEN, C. J, RETIEF, A. E

    Published in Human genetics (01-05-1996)
    “…The gene for variegate porphyria (VP), an autosomal dominant disease with a high prevalance in South Africa, evidently due to a founder effect, was previously…”
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    Journal Article
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    Variegate porphyria in South Africa, 1688-1996 : new developments in an old disease by HIFT, R. J, MEISSNER, P. N, CORRIGALL, A. V, ZIMAN, M. R, PETERSEN, L. A, MEISSNER, D. M, DAVIDSON, B. P, SUTHERLAND, J, DAILEY, H. A, KIRSCH, R. E

    Published in SAMJ. South African medical journal (01-06-1997)
    “…Variegate porphyria, an autosomal dominant inherited trait resulting in decreased activity of protoporphyrinogen oxidase, the penultimate haem biosynthetic…”
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    Conference Proceeding Journal Article
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    Porphyrinogenicity of etomidate and ketamine as continuous infusions. Screening in the DDC-primed rat model by Harrison, G G, Moore, M R, Meissner, P N

    Published in British journal of anaesthesia : BJA (01-04-1985)
    “…The porphyrinogenicity of etomidate and ketamine administered as continuous i.v. infusions was screened in the DDC-primed rat model of latent variegate…”
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    Journal Article
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    Erythroid heme biosynthesis and its disorders by Dailey, Harry A, Meissner, Peter N

    “…Heme, which is composed of iron and the small organic molecule protoporphyrin, is an essential component of hemoglobin as well as a variety of physiologically…”
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    Journal Article