Search Results - "MEIN, Charles A"

Glyphosate and its formulations Roundup Bioflow and RangerPro alter bacterial and fungal community composition in the rat caecum microbiome by Mesnage, Robin, Panzacchi, Simona, Bourne, Emma, Mein, Charles A., Perry, Melissa J., Hu, Jianzhong, Chen, Jia, Mandrioli, Daniele, Belpoggi, Fiorella, Antoniou, Michael N.

“…The potential health consequences of glyphosate-induced gut microbiome alterations have become a matter of intense debate. As part of a multifaceted study…”
Get full text

Vitamin D accelerates resolution of inflammatory responses during tuberculosis treatment by Coussens, Anna K., Wilkinson, Robert J., Hanifa, Yasmeen, Nikolayevskyy, Vladyslav, Elkington, Paul T., Islam, Kamrul, Timms, Peter M., Venton, Timothy R., Bothamley, Graham H., Packe, Geoffrey E., Darmalingam, Mathina, Davidson, Robert N., Milburn, Heather J., Baker, Lucy V., Barker, Richard D., Mein, Charles A., Bhaw-Rosun, Leena, Nuamah, Rosamond, Young, Douglas B., Drobniewski, Francis A., Griffiths, Christopher J., Martineau, Adrian R.

“…Calcidiol, the major circulating metabolite of vitamin D, supports induction of pleiotropic antimicrobial responses in vitro. Vitamin D supplementation…”
Get full text

Identification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis by Rakyan, Vardhman K, Beyan, Huriya, Down, Thomas A, Hawa, Mohammed I, Maslau, Siarhei, Aden, Deeqo, Daunay, Antoine, Busato, Florence, Mein, Charles A, Manfras, Burkhard, Dias, Kerith-Rae M, Bell, Christopher G, Tost, Jörg, Boehm, Bernhard O, Beck, Stephan, Leslie, R David

“…Monozygotic (MZ) twin pair discordance for childhood-onset Type 1 Diabetes (T1D) is ∼50%, implicating roles for genetic and non-genetic factors in the…”
Get full text

The genomic loci of specific human tRNA genes exhibit ageing-related DNA hypermethylation by Acton, Richard J., Yuan, Wei, Gao, Fei, Xia, Yudong, Bourne, Emma, Wozniak, Eva, Bell, Jordana, Lillycrop, Karen, Wang, Jun, Dennison, Elaine, Harvey, Nicholas C., Mein, Charles A., Spector, Tim D., Hysi, Pirro G., Cooper, Cyrus, Bell, Christopher G.

“…The epigenome has been shown to deteriorate with age, potentially impacting on ageing-related disease. tRNA, while arising from only ˜46 kb (<0.002% genome),…”
Get full text

Distinctive patterns of microRNA expression associated with karyotype in acute myeloid leukaemia by Dixon-McIver, Amanda, East, Phil, Mein, Charles A, Cazier, Jean-Baptiste, Molloy, Gael, Chaplin, Tracy, Andrew Lister, T, Young, Bryan D, Debernardi, Silvana

“…Acute myeloid leukaemia (AML) is the most common acute leukaemia in adults; however, the genetic aetiology of the disease is not yet fully understood. A…”
Get full text

A DNA methylation signature in the stress driver gene Fkbp5 indicates a neuropathic component in chronic pain by Maiarù, Maria, Acton, Richard J, Woźniak, Eva L, Mein, Charles A, Bell, Christopher G, Géranton, Sandrine M

“…Background Epigenetic changes can bring insight into gene regulatory mechanisms associated with disease pathogenicity, including chronicity and increased…”
Get full text

Genome-wide analysis of allelic expression imbalance in human primary cells by high-throughput transcriptome resequencing by Heap, Graham A., Yang, Jennie H.M., Downes, Kate, Healy, Barry C., Hunt, Karen A., Bockett, Nicholas, Franke, Lude, Dubois, Patrick C., Mein, Charles A., Dobson, Richard J., Albert, Thomas J., Rodesch, Matthew J., Clayton, David G., Todd, John A., van Heel, David A., Plagnol, Vincent

“…Many disease-associated variants identified by genome-wide association (GWA) studies are expected to regulate gene expression. Allele-specific expression (ASE)…”
Get full text

Ethnic variation in inflammatory profile in tuberculosis by Coussens, Anna K, Wilkinson, Robert J, Nikolayevskyy, Vladyslav, Elkington, Paul T, Hanifa, Yasmeen, Islam, Kamrul, Timms, Peter M, Bothamley, Graham H, Claxton, Alleyna P, Packe, Geoffrey E, Darmalingam, Mathina, Davidson, Robert N, Milburn, Heather J, Baker, Lucy V, Barker, Richard D, Drobniewski, Francis A, Mein, Charles A, Bhaw-Rosun, Leena, Nuamah, Rosamond A, Griffiths, Christopher J, Martineau, Adrian R

“…Distinct phylogenetic lineages of Mycobacterium tuberculosis (MTB) cause disease in patients of particular genetic ancestry, and elicit different patterns of…”
Get full text

ADAMS project: a genetic Association study in individuals from Diverse Ancestral backgrounds with Multiple Sclerosis based in the UK by Jacobs, Benjamin M, Schalk, Luisa, Dunne, Angie, Scalfari, Antonio, Nandoskar, Ashwini, Gran, Bruno, Mein, Charles A, Sellers, Charlotte, Spilker, Cord, Rog, David, Visentin, Elisa, Bezzina, Elizabeth Lindsey, Uzochukwu, Emeka, Tallantyre, Emma, Wozniak, Eva, Sacre, Eve, Hassan-Smith, Ghaniah, Ford, Helen L, Harris, Jade, Bradley, Joan, Breedon, Joshua, Brooke, Judith, Kreft, Karim L, Tuite Dalton, Katherine, George, Katila, Papachatzaki, Maria, O'Malley, Martin, Peter, Michelle, Mattoscio, Miriam, Rhule, Neisha, Evangelou, Nikos, Vinod, Nimisha, Quinn, Outi, Shamji, Ramya, Kaimal, Rashmi, Boulton, Rebecca, Tanveer, Riffat, Middleton, Rod, Murray, Roxanne, Bellfield, Ruth, Hoque, Sadid, Patel, Shakeelah, Raj, Sonia, Gumus, Stephanie, Mitchell, Stephanie, Sawcer, Stephen, Arun, Tarunya, Pogreban, Tatiana, Brown, Terri-Louise, Begum, Thamanna, Antoine, Veronica, Rashid, Waqar, Noyce, Alastair J, Silber, Eli, Morris, Huw, Giovannoni, Gavin, Dobson, Ruth

“…PurposeGenetic studies of multiple sclerosis (MS) susceptibility and severity have focused on populations of European ancestry. Studying MS genetics in other…”
Get full text

Multi-omics phenotyping of the gut-liver axis reveals metabolic perturbations from a low-dose pesticide mixture in rats by Mesnage, Robin, Teixeira, Maxime, Mandrioli, Daniele, Falcioni, Laura, Ibragim, Mariam, Ducarmon, Quinten Raymond, Zwittink, Romy Daniëlle, Amiel, Caroline, Panoff, Jean-Michel, Bourne, Emma, Savage, Emanuel, Mein, Charles A., Belpoggi, Fiorella, Antoniou, Michael N.

“…Health effects of pesticides are not always accurately detected using the current battery of regulatory toxicity tests. We compared standard histopathology and…”
Get full text

Comparison of transcriptome responses to glyphosate, isoxaflutole, quizalofop-p-ethyl and mesotrione in the HepaRG cell line by Mesnage, Robin, Biserni, Martina, Wozniak, Eva, Xenakis, Theodoros, Mein, Charles A., Antoniou, Michael N.

“…•We evaluated glyphosate, isoxaflutole, quizalofop-p-ethyl and mesotrione.•Gene expression alterations were measured in the HepaRG liver cell…”
Get full text

Multiparameter phenotyping of platelets and characterization of the effects of agonists using machine learning by Vadgama, Ami, Boot, James, Dark, Nicola, Allan, Harriet E., Mein, Charles A., Armstrong, Paul C., Warner, Timothy D.

“…Platelet function is driven by the expression of specialized surface markers. The concept of distinct circulating subpopulations of platelets has emerged in…”
Get full text

Integrated functional, gene expression and genomic analysis for the identification of cancer targets by Iorns, Elizabeth, Lord, Christopher J, Grigoriadis, Anita, McDonald, Sarah, Fenwick, Kerry, Mackay, Alan, Mein, Charles A, Natrajan, Rachael, Savage, Kay, Tamber, Narinder, Reis-Filho, Jorge S, Turner, Nicholas C, Ashworth, Alan

“…The majority of new drug approvals for cancer are based on existing therapeutic targets. One approach to the identification of novel targets is to perform…”
Get full text

Areca catechu-(Betel-nut)-induced whole transcriptome changes in a human monocyte cell line that may have relevance to diabetes and obesity; a pilot study by Cardosa, Shirleny R, Ogunkolade, B William, Lowe, Rob, Savage, Emanuel, Mein, Charles A, Boucher, Barbara J, Hitman, Graham A

“…Betel-nut consumption is the fourth most common addictive habit globally and there is good evidence linking the habit to obesity, type 2 diabetes (T2D) and the…”
Get full text

Homozygous Mutations in the 5′ Region of the JUP Gene Result in Cutaneous Disease but Normal Heart Development in Children by Cabral, Rita M., Liu, Lu, Hogan, Carol, Dopping-Hepenstal, Patricia J.C., Winik, Beatriz C., Asial, Raúl A., Dobson, Richard, Mein, Charles A., Baselaga, Patricia A., Mellerio, Jemima E., Nanda, Arti, Boente, Maria del Carmen, Kelsell, David P., McGrath, John A., South, Andrew P.

“…Desmosomes are intercellular adhesive junctions and attachment sites for the intermediate filament (IF) cytoskeleton, prominent in tissues subject to high…”
Get full text

A Variation in the Ghrelin Gene Increases Weight and Decreases Insulin Secretion in Tall, Obese Children by Korbonits, Márta, Gueorguiev, Maria, O’Grady, Eithne, Lecoeur, Cecile, Swan, Daniel C., Mein, Charles A., Weill, Jacques, Grossman, Ashley B., Froguel, Philippe

“…Ghrelin is a recently recognized gut-brain peptide originally derived from the gastric mucosa. It stimulates growth hormone release, increases appetite and…”
Get full text

ABCA12 Is the Major Harlequin Ichthyosis Gene by Thomas, Anna C., Cullup, Tom, Norgett, Elizabeth E., Hill, Tara, Barton, Stephanie, Dale, Beverly A., Sprecher, Eli, Sheridan, Eamonn, Taylor, Aileen E., Wilroy, Robert S., DeLozier, Celia, Burrows, Nigel, Goodyear, Helen, Fleckman, Philip, Stephens, Karen G., Mehta, Lakshmi, Watson, Rosemarie M., Graham, Robert, Wolf, Roni, Slavotinek, Anne, Martin, Madelena, Bourn, David, Mein, Charles A., O'Toole, Edel A., Kelsell, David P.

“…Harlequin ichthyosis (HI) is the most severe form of autosomal-recessive, congenital ichthyosis. Affected infants have markedly impaired barrier function and…”
Get full text

Functional analysis of tenocytes gene expression in tendon fascicles subjected to cyclic tensile strain by Maeda, Eijiro, Fleischmann, Christina, Mein, Charles A, Shelton, Julia C, Bader, Dan L, Lee, David A

“…Tenocytes are known to be mechanoresponsive and the present study tests the hypothesis that distinct mechanical stimulation regimes, associated with the…”
Get more information

Comparative Toxicogenomics of Glyphosate and Roundup Herbicides by Mammalian Stem Cell-Based Genotoxicity Assays and Molecular Profiling in Sprague-Dawley Rats by Mesnage, Robin, Ibragim, Mariam, Mandrioli, Daniele, Falcioni, Laura, Tibaldi, Eva, Belpoggi, Fiorella, Brandsma, Inger, Bourne, Emma, Savage, Emanuel, Mein, Charles A, Antoniou, Michael N

“…Abstract Whether glyphosate-based herbicides (GBHs) are more potent than glyphosate alone at activating cellular mechanisms, which drive carcinogenesis remain…”
Get full text

Alterations in small RNA profiles in liver following a subchronic exposure to a low-dose pesticide mixture in Sprague-Dawley rats by Mesnage, Robin, Mahmud, Nadiya, Mein, Charles A., Antoniou, Michael N.

“…•Small RNAs are biomarker to monitor health and track the development of diseases.•We report changes in small RNAs in the liver of rats exposed to a pesticide…”
Get full text