Search Results - "MEHRA, Smriti"

Increased Expression of P-Glycoprotein and Doxorubicin Chemoresistance of Metastatic Breast Cancer Is Regulated by miR-298 by Bao, Lili, Hazari, Sidhartha, Mehra, Smriti, Kaushal, Deepak, Moroz, Krzysztof, Dash, Srikanta

“…MicroRNAs (miRNAs) are short, noncoding RNA molecules that regulate the expression of a number of genes involved in cancer; therefore, they offer great…”
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Myeloid cell interferon responses correlate with clearance of SARS-CoV-2 by Singh, Dhiraj K., Aladyeva, Ekaterina, Das, Shibali, Singh, Bindu, Esaulova, Ekaterina, Swain, Amanda, Ahmed, Mushtaq, Cole, Journey, Moodley, Chivonne, Mehra, Smriti, Schlesinger, Larry S., Artyomov, Maxim N., Khader, Shabaana A., Kaushal, Deepak

“…Emergence of mutant SARS-CoV-2 strains associated with an increased risk of COVID-19-related death necessitates better understanding of the early viral…”
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The immunoregulatory landscape of human tuberculosis granulomas by McCaffrey, Erin F., Donato, Michele, Keren, Leeat, Chen, Zhenghao, Delmastro, Alea, Fitzpatrick, Megan B., Gupta, Sanjana, Greenwald, Noah F., Baranski, Alex, Graf, William, Kumar, Rashmi, Bosse, Marc, Fullaway, Christine Camacho, Ramdial, Pratista K., Forgó, Erna, Jojic, Vladimir, Van Valen, David, Mehra, Smriti, Khader, Shabaana A., Bendall, Sean C., van de Rijn, Matt, Kalman, Daniel, Kaushal, Deepak, Hunter, Robert L., Banaei, Niaz, Steyn, Adrie J. C., Khatri, Purvesh, Angelo, Michael

“…Tuberculosis (TB) in humans is characterized by formation of immune-rich granulomas in infected tissues, the architecture and composition of which are thought…”
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Robust IgM responses following intravenous vaccination with Bacille Calmette–Guérin associate with prevention of Mycobacterium tuberculosis infection in macaques by Irvine, Edward B., O’Neil, Anthony, Darrah, Patricia A., Shin, Sally, Choudhary, Alok, Li, Wenjun, Honnen, William, Mehra, Smriti, Kaushal, Deepak, Gideon, Hannah Priyadarshini, Flynn, JoAnne L., Roederer, Mario, Seder, Robert A., Pinter, Abraham, Fortune, Sarah, Alter, Galit

“…Development of an effective tuberculosis (TB) vaccine has suffered from an incomplete understanding of the correlates of protection against Mycobacterium…”
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Transcriptional Response of Mycobacterium tuberculosis to Cigarette Smoke Condensate by Willemse, Danicke, Moodley, Chivonne, Mehra, Smriti, Kaushal, Deepak

“…Smoking is known to be an added risk factor for tuberculosis (TB), with nearly a quarter of the TB cases attributed to cigarette smokers in the 22 countries…”
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LAG3 Expression in Active Mycobacterium tuberculosis Infections by Phillips, Bonnie L, Mehra, Smriti, Ahsan, Muhammad H, Selman, Moises, Khader, Shabaana A, Kaushal, Deepak

“…Mycobacterium tuberculosis (MTB) is a highly successful pathogen because of its ability to persist in human lungs for long periods of time. MTB modulates…”
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In-Vivo Gene Signatures of Mycobacterium tuberculosis in C3HeB/FeJ Mice by Gautam, Uma Shankar, Mehra, Smriti, Kaushal, Deepak

“…Despite considerable progress in understanding the pathogenesis of Mycobacterium tuberculosis (Mtb), development of new therapeutics and vaccines against it…”
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System-wide identification of myeloid markers of TB disease and HIV-induced reactivation in the macaque model of Mtb infection and Mtb/SIV co-infection by Gough, Maya, Singh, Dhiraj K, Singh, Bindu, Kaushal, Deepak, Mehra, Smriti

“…( ) has developed specialized mechanisms to parasitize its host cell, the macrophage. These mechanisms allow it to overcome killing by oxidative burst and…”
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High Turnover of Tissue Macrophages Contributes to Tuberculosis Reactivation in Simian Immunodeficiency Virus-Infected Rhesus Macaques by Kuroda, Marcelo J, Sugimoto, Chie, Cai, Yanhui, Merino, Kristen M, Mehra, Smriti, Araínga, Mariluz, Roy, Chad J, Midkiff, Cecily C, Alvarez, Xavier, Didier, Elizabeth S, Kaushal, Deepak

“…Tuberculosis (TB) and human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) profoundly affect the immune system and synergistically…”
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Abnormal Tryptophan Metabolism in HIV and Mycobacterium tuberculosis Infection by Wang, Xiaolei, Mehra, Smriti, Kaushal, Deepak, Veazey, Ronald S, Xu, Huanbin

“…Host metabolism has recently gained more attention for its roles in physiological functions and pathologic conditions. Of these, metabolic tryptophan disorders…”
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A Mycobacterium tuberculosis sigma factor network responds to cell-envelope damage by the promising anti-mycobacterial thioridazine by Dutta, Noton K, Mehra, Smriti, Kaushal, Deepak

“…Novel therapeutics are urgently needed to control tuberculosis (TB). Thioridazine (THZ) is a candidate for the therapy of multidrug and extensively…”
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Antiretroviral therapy timing impacts latent tuberculosis infection reactivation in a Mycobacterium tuberculosis/SIV coinfection model by Sharan, Riti, Ganatra, Shashank R, Bucsan, Allison N, Cole, Journey, Singh, Dhiraj K, Alvarez, Xavier, Gough, Maya, Alvarez, Cynthia, Blakley, Alyssa, Ferdin, Justin, Thippeshappa, Rajesh, Singh, Bindu, Escobedo, Ruby, Shivanna, Vinay, Dick, Jr, Edward J, Hall-Ursone, Shannan, Khader, Shabaana A, Mehra, Smriti, Rengarajan, Jyothi, Kaushal, Deepak

“…Studies using the nonhuman primate model of Mycobacterium tuberculosis/simian immunodeficiency virus coinfection have revealed protective CD4+ T…”
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Immune Responses in Lung Granulomas during Mtb/HIV Co-Infection: Implications for Pathogenesis and Therapy by Kaushal, Deepak, Singh, Dhiraj K, Mehra, Smriti

“…HIV and TB are the cause of significant worldwide mortality and pose a grave danger to the global public health. TB is the leading cause of death in…”
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Isoniazid and rifapentine treatment effectively reduces persistent M. tuberculosis infection in macaque lungs by Sharan, Riti, Ganatra, Shashank R, Singh, Dhiraj K, Cole, Journey, Foreman, Taylor W, Thippeshappa, Rajesh, Peloquin, Charles A, Shivanna, Vinay, Gonzalez, Olga, Day, Cheryl L, Gandhi, Neel R, Dick, Jr, Edward J, Hall-Ursone, Shannan, Mehra, Smriti, Schlesinger, Larry S, Rengarajan, Jyothi, Kaushal, Deepak

“…A once-weekly oral dose of isoniazid and rifapentine for 3 months (3HP) is recommended by the CDC for treatment of latent tuberculosis infection (LTBI). The…”
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Granuloma Correlates of Protection Against Tuberculosis and Mechanisms of Immune Modulation by Mycobacterium tuberculosis by Mehra, Smriti, Alvarez, Xavier, Didier, Peter J., Doyle, Lara A., Blanchard, James L., Lackner, Andrew A., Kaushal, Deepak

“…Background. The BCG vaccine is ineffective against adult tuberculosis. Hence, new antituberculosis vaccines are needed. Correlates of protection against…”
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Myeloid-Derived Suppressor Cells Mediate T Cell Dysfunction in Nonhuman Primate TB Granulomas by Singh, Bindu, Singh, Dhiraj K, Ganatra, Shashank R, Escobedo, Ruby A, Khader, Shabaana, Schlesinger, Larry S, Kaushal, Deepak, Mehra, Smriti

“…Myeloid-derived suppressor cells (MDSCs) represent an innate immune cell population comprised of immature myeloid cells and myeloid progenitors with very…”
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The Mycobacterium tuberculosis Rv2745c plays an important role in responding to redox stress by McGillivray, Amanda, Golden, Nadia Abrahams, Gautam, Uma Shankar, Mehra, Smriti, Kaushal, Deepak

“…Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is the leading cause of death from an infectious disease worldwide. Over the course of its life…”
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Impact of SIV infection on mycobacterial lipid-reactive T cell responses in Bacillus Calmette-Guérin (BCG) inoculated macaques by Walker, Edith M, Merino, Kristen M, Slisarenko, Nadia, Grasperge, Brooke F, Mehra, Smriti, Roy, Chad J, Kaushal, Deepak, Rout, Namita

“…Although BCG vaccine protects infants from tuberculosis (TB), it has limited efficacy in adults against pulmonary TB. Further, HIV coinfection significantly…”
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Early treatment with anti-α4β7 antibody facilitates increased gut macrophage maturity in SIV-infected rhesus macaques by Johnson, Samuel D., Knight, Lindsey A., Kumar, Narendra, Olwenyi, Omalla A., Thurman, Michellie, Mehra, Smriti, Mohan, Mahesh, Byrareddy, Siddappa N.

“…Despite advances in combination antiretroviral therapy (cART), people living with HIV (PLWH) continue to experience gastrointestinal dysfunction. Infusions of…”
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LAG-3 potentiates the survival of Mycobacterium tuberculosis in host phagocytes by modulating mitochondrial signaling in an in-vitro granuloma model by Phillips, Bonnie L, Gautam, Uma S, Bucsan, Allison N, Foreman, Taylor W, Golden, Nadia A, Niu, Tianhua, Kaushal, Deepak, Mehra, Smriti

“…CD4+ T-cell mediated Th1 immune responses are critical for immunity to TB. The immunomodulatory protein, lymphocyte activation gene-3 (LAG-3) decreases…”
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