Search Results - "MEHLE, Andrew"

Fiat Luc: Bioluminescence Imaging Reveals In Vivo Viral Replication Dynamics by Mehle, Andrew

“…  [...]inherent animal-to-animal variability introduces significant confounding effects, resulting in studies that require hundreds of animals to acquire…”
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Unusual influenza A viruses in bats by Mehle, Andrew

“…Influenza A viruses infect a remarkably diverse number of hosts. Two completely new influenza A virus subtypes were recently discovered in bats, dramatically…”
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Adaptive strategies of the influenza virus polymerase for replication in humans by Mehle, Andrew, Doudna, Jennifer A

“…Transmission of influenza viruses into the human population requires surmounting barriers to cross-species infection. Changes in the influenza polymerase…”
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Highly Sensitive Real-Time In Vivo Imaging of an Influenza Reporter Virus Reveals Dynamics of Replication and Spread by Tran, Vy, Moser, Lindsey A, Poole, Daniel S, Mehle, Andrew

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The later stages of viral infection: An undiscovered country of host dependency factors by King, Cason R, Mehle, Andrew

“…By linking individual perturbation of genes across a genome to some measurable phenotypic output, such as viral gene expression, these experiments quickly…”
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Differential Splicing of ANP32A in Birds Alters Its Ability to Stimulate RNA Synthesis by Restricted Influenza Polymerase by Baker, Steven F., Ledwith, Mitchell P., Mehle, Andrew

“…Adaptation of viruses to their hosts can result in specialization and a restricted host range. Species-specific polymorphisms in the influenza virus polymerase…”
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Flu's cues: Exploiting host post-translational modifications to direct the influenza virus replication cycle by Dawson, Anthony R, Mehle, Andrew

“…Ac, acetylation; ADPr, ADP-ribosylation; cRNA, plus-sense genomic RNA; dsRNA, double-stranded RNA; Glycos., N-linked glycosylation; ISG15, ISGylation; Nedd8,…”
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Visualizing real-time influenza virus infection, transmission and protection in ferrets by Karlsson, Erik A., Meliopoulos, Victoria A., Savage, Chandra, Livingston, Brandi, Mehle, Andrew, Schultz-Cherry, Stacey

“…Influenza transmission efficiency in ferrets is vital for risk-assessment studies. However, the inability to monitor viral infection and transmission dynamics…”
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An inhibitory activity in human cells restricts the function of an avian-like influenza virus polymerase by Mehle, Andrew, Doudna, Jennifer A

“…Transmission of avian influenza virus into human populations has the potential to cause pandemic outbreaks. A major determinant of species tropism is the…”
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ANP32B, or not to be, that is the question for influenza virus by Baker, Steven F, Mehle, Andrew

“…The evolutionary history of ANP32 proteins impacts how influenza virus jumps from birds to mammals…”
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Alternative splicing liberates a cryptic cytoplasmic isoform of mitochondrial MECR that antagonizes influenza virus by Baker, Steven F, Meistermann, Helene, Tzouros, Manuel, Baker, Aaron, Golling, Sabrina, Polster, Juliane Siebourg, Ledwith, Mitchell P, Gitter, Anthony, Augustin, Angelique, Javanbakht, Hassan, Mehle, Andrew

“…Viruses must balance their reliance on host cell machinery for replication while avoiding host defense. Influenza A viruses are zoonotic agents that frequently…”
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Obesity Outweighs Protection Conferred by Adjuvanted Influenza Vaccination by Karlsson, Erik A, Hertz, Tomer, Johnson, Cydney, Mehle, Andrew, Krammer, Florian, Schultz-Cherry, Stacey

“…Obesity is a risk factor for developing severe influenza virus infection, making vaccination of utmost importance for this high-risk population. However,…”
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Reassortment and Mutation of the Avian Influenza Virus Polymerase PA Subunit Overcome Species Barriers by MEHLE, Andrew, DUGAN, Vivien G, TAUBENBERGER, Jeffery K, DOUDNA, Jennifer A

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Influenza A virus undergoes compartmentalized replication in vivo dominated by stochastic bottlenecks by Amato, Katherine A., Haddock, Luis A., Braun, Katarina M., Meliopoulos, Victoria, Livingston, Brandi, Honce, Rebekah, Schaack, Grace A., Boehm, Emma, Higgins, Christina A., Barry, Gabrielle L., Koelle, Katia, Schultz-Cherry, Stacey, Friedrich, Thomas C., Mehle, Andrew

“…Transmission of influenza A viruses (IAV) between hosts is subject to numerous physical and biological barriers that impose genetic bottlenecks, constraining…”
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Multiple unfolded protein response pathways cooperate to link cytosolic dsDNA release to stimulator of interferon gene activation by Hu, Tiancheng, Liu, Yiping, Fleck, Jeremy, King, Cason, Schalk, Elaine, Zhang, Zhenyu, Mehle, Andrew, Smith, Judith A

“…The double-stranded DNA (dsDNA) sensor STING has been increasingly implicated in responses to "sterile" endogenous threats and pathogens without nominal DNA or…”
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Phosphorylation controls RNA binding and transcription by the influenza virus polymerase by Dawson, Anthony R, Wilson, Gary M, Freiberger, Elyse C, Mondal, Arindam, Coon, Joshua J, Mehle, Andrew, Pekosz, Andrew, Shih, Shin-Ru

“…The influenza virus polymerase transcribes and replicates the viral genome. The proper timing and balance of polymerase activity is important for successful…”
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Vif Overcomes the Innate Antiviral Activity of APOBEC3G by Promoting Its Degradation in the Ubiquitin-Proteasome Pathway by Mehle, Andrew, Strack, Bettina, Ancuta, Petronela, Zhang, Chengsheng, McPike, Mark, Gabuzda, Dana

“…Viruses must overcome diverse intracellular defense mechanisms to establish infection. The Vif (virion infectivity factor) protein of human immunodeficiency…”
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Phosphorylation at the homotypic interface regulates nucleoprotein oligomerization and assembly of the influenza virus replication machinery by Mondal, Arindam, Potts, Gregory K, Dawson, Anthony R, Coon, Joshua J, Mehle, Andrew

“…Negative-sense RNA viruses assemble large ribonucleoprotein (RNP) complexes that direct replication and transcription of the viral genome. Influenza virus RNPs…”
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A Zinc-binding Region in Vif Binds Cul5 and Determines Cullin Selection by Mehle, Andrew, Thomas, Elaine R., Rajendran, Kottampatty S., Gabuzda, Dana

“…Human immunodeficiency virus-1 (HIV-1) Vif overcomes the anti-viral activity of APOBEC3G by targeting it for ubiquitination via a Cullin 5-ElonginB-ElonginC…”
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Inhibitors of peptidyl proline isomerases as antivirals in hepatitis C and other viruses by Striker, Rob, Mehle, Andrew

“…  [...]disordered proteins are enriched in the viral proteome and are common features to a large number of viruses. [...]HCV is not only the most common reason…”
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