Search Results - "MEGGER, Dominik A."

Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours by Nwosu, Zeribe C, Battello, Nadia, Rothley, Melanie, Piorońska, Weronika, Sitek, Barbara, Ebert, Matthias P, Hofmann, Ute, Sleeman, Jonathan, Wölfl, Stefan, Meyer, Christoph, Megger, Dominik A, Dooley, Steven

“…Although metabolism is profoundly altered in human liver cancer, the extent to which experimental models, e.g. cell lines, mimic those alterations is…”
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Label-free Proteomic Analysis of Exosomes Derived from Inducible Hepatitis B Virus-Replicating HepAD38 Cell Line by Jia, Xiaofang, Chen, Jieliang, Megger, Dominik A., Zhang, Xiaonan, Kozlowski, Maya, Zhang, Lijun, Fang, Zhong, Li, Jin, Chu, Qiaofang, Wu, Min, Li, Yaming, Sitek, Barbara, Yuan, Zhenghong

“…Hepatitis B virus (HBV) infection is a major health problem worldwide. Recent evidence suggests that some viruses can manipulate the infection process by…”
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Comparison of label-free and label-based strategies for proteome analysis of hepatoma cell lines by Megger, Dominik A., Pott, Leona L., Ahrens, Maike, Padden, Juliet, Bracht, Thilo, Kuhlmann, Katja, Eisenacher, Martin, Meyer, Helmut E., Sitek, Barbara

“…Within the past decade numerous methods for quantitative proteome analysis have been developed of which all exhibit particular advantages and disadvantages…”
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The PD-1/PD-L1 Pathway Affects the Expansion and Function of Cytotoxic CD8 + T Cells During an Acute Retroviral Infection by David, Paul, Megger, Dominik A, Kaiser, Tamara, Werner, Tanja, Liu, Jia, Chen, Lieping, Sitek, Barbara, Dittmer, Ulf, Zelinskyy, Gennadiy

“…Cytotoxic CD8 T lymphocytes (CTL) efficiently control acute virus infections but can become exhausted when a chronic infection develops. The checkpoint…”
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Deciphering of the Human Interferon-Regulated Proteome by Mass Spectrometry-Based Quantitative Analysis Reveals Extent and Dynamics of Protein Induction and Repression by Megger, Dominik A, Philipp, Jos, Le-Trilling, Vu Thuy Khanh, Sitek, Barbara, Trilling, Mirko

“…Interferons (IFNs) are pleotropic cytokines secreted upon encounter of pathogens and tumors. Applying their antipathogenic, antiproliferative, and immune…”
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Proteomic Differences Between Hepatocellular Carcinoma and Nontumorous Liver Tissue Investigated by a Combined Gel-based and Label-free Quantitative Proteomics Study by Megger, Dominik A., Bracht, Thilo, Kohl, Michael, Ahrens, Maike, Naboulsi, Wael, Weber, Frank, Hoffmann, Andreas-Claudius, Stephan, Christian, Kuhlmann, Katja, Eisenacher, Martin, Schlaak, Jörg F., Baba, Hideo A., Meyer, Helmut E., Sitek, Barbara

“…Proteomics-based clinical studies have been shown to be promising strategies for the discovery of novel biomarkers of a particular disease. Here, we present a…”
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Quantitative Tissue Proteomics Analysis Reveals Versican as Potential Biomarker for Early-Stage Hepatocellular Carcinoma by Naboulsi, Wael, Megger, Dominik A, Bracht, Thilo, Kohl, Michael, Turewicz, Michael, Eisenacher, Martin, Voss, Don Marvin, Schlaak, Jörg F, Hoffmann, Andreas-Claudius, Weber, Frank, Baba, Hideo A, Meyer, Helmut E, Sitek, Barbara

“…Hepatocellular carcinoma (HCC) is one of the most aggressive tumors, and the treatment outcome of this disease is improved when the cancer is diagnosed at an…”
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Immunohistochemical Markers Distinguishing Cholangiocellular Carcinoma (CCC) from Pancreatic Ductal Adenocarcinoma (PDAC) Discovered by Proteomic Analysis of Microdissected Cells by Padden, Juliet, Ahrens, Maike, Kälsch, Julia, Bertram, Stefanie, Megger, Dominik A., Bracht, Thilo, Eisenacher, Martin, Kocabayoglu, Peri, Meyer, Helmut E., Sipos, Bence, Baba, Hideo A., Sitek, Barbara

“…Cholangiocellular carcinoma (CCC) and pancreatic ductal adenocarcinoma (PDAC) are two highly aggressive cancer types that arise from epithelial cells of the…”
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Combination immunotherapy with anti-PD-L1 antibody and depletion of regulatory T cells during acute viral infections results in improved virus control but lethal immunopathology by David, Paul, Drabczyk-Pluta, Malgorzata, Pastille, Eva, Knuschke, Torben, Werner, Tanja, Honke, Nadine, Megger, Dominik A, Akhmetzyanova, Ilseyar, Shaabani, Namir, Eyking-Singer, Annette, Cario, Elke, Kershaw, Olivia, Gruber, Achim D, Tenbusch, Matthias, Dietze, Kirsten K, Trilling, Mirko, Liu, Jia, Schadendorf, Dirk, Streeck, Hendrik, Lang, Karl S, Xie, Youhua, Zimmer, Lisa, Sitek, Barbara, Paschen, Annette, Westendorf, Astrid M, Dittmer, Ulf, Zelinskyy, Gennadiy

“…Combination immunotherapy (CIT) is currently applied as a treatment for different cancers and is proposed as a cure strategy for chronic viral infections…”
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A Mass Spectrometry-Based Profiling of Interactomes of Viral DDB1- and Cullin Ubiquitin Ligase-Binding Proteins Reveals NF-κB Inhibitory Activity of the HIV-2-Encoded Vpx by Landsberg, Christine D, Megger, Dominik A, Hotter, Dominik, Rückborn, Meike U, Eilbrecht, Mareike, Rashidi-Alavijeh, Jassin, Howe, Sebastian, Heinrichs, Stefan, Sauter, Daniel, Sitek, Barbara, Le-Trilling, Vu Thuy Khanh, Trilling, Mirko

“…Viruses and hosts are situated in a molecular arms race. To avoid morbidity and mortality, hosts evolved antiviral restriction factors. These restriction…”
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NHS-based Tandem Mass Tagging of Proteins at the Level of Whole Cells: A Critical Evaluation in Comparison to Conventional TMT-Labeling Approaches for Quantitative Proteome Analysis by MEGGER, Dominik A., POTT, Leona L., ROSOWSKI, Kristin, ZÜLCH, Birgit, TAUTGES, Stephanie, BRACHT, Thilo, SITEK, Barbara

“…Tandem mass tags (TMT) are usually introduced at the levels of isolated proteins or peptides. Here, for the first time, we report the labeling of whole cells…”
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Conformational Change Induced by Metal-Ion-Binding to DNA Containing the Artificial 1,2,4-Triazole Nucleoside by Böhme, Dominik, Düpre, Nicole, Megger, Dominik A, Müller, Jens

“…A conformational switch can be induced upon the addition of transition-metal ions to oligonucleotides that contain a row of successive artificial nucleobases…”
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Correction to: Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours by Nwosu, Zeribe C, Battello, Nadia, Rothley, Melanie, Piorońska, Weronika, Sitek, Barbara, Ebert, Matthias P, Hofmann, Ute, Sleeman, Jonathan, Wölfl, Stefan, Meyer, Christoph, Megger, Dominik A, Dooley, Steven

“…In the publication of this article (1), there is an error in Fig. 5b. This has now been updated in the original article (1)…”
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Acid sphingomyelinase deficiency in Western diet-fed mice protects against adipocyte hypertrophy and diet-induced liver steatosis by Sydor, Svenja, Sowa, Jan-Peter, Megger, Dominik A, Schlattjan, Martin, Jafoui, Sami, Wingerter, Lena, Carpinteiro, Alexander, Baba, Hideo A, Bechmann, Lars P, Sitek, Barbara, Gerken, Guido, Gulbins, Erich, Canbay, Ali

“…Abstract Objective Alterations in sphingolipid and ceramide metabolism have been associated with various diseases, including nonalcoholic fatty liver disease…”
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Label-free quantification in clinical proteomics by Megger, Dominik A., Bracht, Thilo, Meyer, Helmut E., Sitek, Barbara

“…Nowadays, proteomic studies no longer focus only on identifying as many proteins as possible in a given sample, but aiming for an accurate quantification of…”
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Label-Free Proteomic Analysis of Exosomes Secreted from THP-1-Derived Macrophages Treated with IFN‑α Identifies Antiviral Proteins Enriched in Exosomes by Yao, Zhenlan, Jia, Xiaofang, Megger, Dominik A, Chen, Jieliang, Liu, Yuyi, Li, Jianhua, Sitek, Barbara, Yuan, Zhenghong

“…Exosomes are extracellular vesicles that function in intercellular communication. We have previously reported that exosomes play an important role in the…”
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CalibraCurve: A Tool for Calibration of Targeted MS‐Based Measurements by Kohl, Michael, Stepath, Markus, Bracht, Thilo, Megger, Dominik A, Sitek, Barbara, Marcus, Katrin, Eisenacher, Martin

“…Targeted proteomics techniques allow accurate quantitative measurements of analytes in complex matrices with dynamic linear ranges that span up to 4–5 orders…”
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A metal-mediated base pair that discriminates between the canonical pyrimidine nucleobases by Jash, Biswarup, Scharf, Philipp, Sandmann, Nikolas, Fonseca Guerra, Célia, Megger, Dominik A, Müller, Jens

“…A nucleoside analogue comprising the ligand 1 -imidazo[4,5- ][1,10]phenanthroline ( ) was applied to develop a molecular beacon capable of discriminating the…”
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Permissive HLA-DPB1 mismatches in HCT depend on immunopeptidome divergence and editing by HLA-DM by Meurer, Thuja, Crivello, Pietro, Metzing, Maximilian, Kester, Michel, Megger, Dominik A., Chen, Weiqiang, van Veelen, Peter A., van Balen, Peter, Westendorf, Astrid M., Homa, Georg, Layer, Sophia E., Turki, Amin T., Griffioen, Marieke, Horn, Peter A., Sitek, Barbara, Beelen, Dietrich W., Falkenburg, J. H. Frederik, Arrieta-Bolaños, Esteban, Fleischhauer, Katharina

“…In hematopoietic cell transplantation (HCT), permissive HLA-DPB1 mismatches between patients and their unrelated donors are associated with improved outcomes…”
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Structurally related hydrazone-based metal complexes with different antitumor activities variably induce apoptotic cell death by Megger, Dominik A, Rosowski, Kristin, Radunsky, Christian, Kösters, Jutta, Sitek, Barbara, Müller, Jens

“…Three new complexes bearing the tridentate hydrazone-based ligand 2-(2-(1-(pyridin-2-yl)ethylidene)hydrazinyl)pyridine (L) were synthesized and structurally…”
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