Search Results - "MEESTERS, Christian"

Estimating reliability: A comparison of Cronbach's α, McDonald's ωt and the greatest lower bound by Malkewitz, Camila Paola, Schwall, Philipp, Meesters, Christian, Hardt, Jochen

“…Cronbach's alpha as a reliability estimate for a set of items has been repeatedly criticised. Using McDonald's omega or the Greatest Lower Bound (GLB) has been…”
Get full text

Coronavirus Inhibitors Targeting nsp16 by Omer, Ejlal A, Abdelfatah, Sara, Riedl, Max, Meesters, Christian, Hildebrandt, Andreas, Efferth, Thomas

“…During the past three decades, humans have been confronted with different new coronavirus outbreaks. Since the end of the year 2019, COVID-19 threatens the…”
Get full text

A chemical inhibitor of jasmonate signaling targets JAR1 in Arabidopsis thaliana by Meesters, Christian, Mönig, Timon, Oeljeklaus, Julian, Krahn, Daniel, Westfall, Corey S, Hause, Bettina, Jez, Joseph M, Kaiser, Markus, Kombrink, Erich

“…Jasmonate derivatives regulate numerous defense and developmental pathways in plants. A chemical screen in Arabidopsis thaliana identifies jarin-1 as an…”
Get full text

Potential Coronaviral Inhibitors of the Nucleocapsid Protein Identified In Silico and In Vitro from a Large Natural Product Library by Pohler, Alexandra, Abdelfatah, Sara, Riedl, Max, Meesters, Christian, Hildebrandt, Andreas, Efferth, Thomas

“…The nucleocapsid protein (NP) is one of the main proteins out of four structural proteins of coronaviruses including the severe acute respiratory syndrome…”
Get full text

Identification of Antagonistic Action of Pyrrolizidine Alkaloids in Muscarinic Acetylcholine Receptor M1 by Computational Target Prediction Analysis by Abdalfattah, Sara, Knorz, Caroline, Ayoobi, Akhtar, Omer, Ejlal A, Rosellini, Matteo, Riedl, Max, Meesters, Christian, Efferth, Thomas

“…Pyrrolizidine alkaloids (PAs) are one of the largest distributed classes of toxins in nature. They have a wide range of toxicity, such as hepatotoxicity,…”
Get full text

Research data management for bioimaging: the 2021 NFDI4BIOIMAGE community survey [version 1; peer review: 2 approved] by Schmidt, Christian, Hanne, Janina, Moore, Josh, Meesters, Christian, Ferrando-May, Elisa, Weidtkamp-Peters, Stefanie

“…Background Knowing the needs of the bioimaging community with respect to research data management (RDM) is essential for identifying measures that enable the…”
Get full text

Comparative analysis of MAMP-induced calcium influx in Arabidopsis seedlings and protoplasts by Maintz, Jens, Cavdar, Meltem, Tamborski, Janina, Kwaaitaal, Mark, Huisman, Rik, Meesters, Christian, Kombrink, Erich, Panstruga, Ralph

“…Rapid transient elevation of cytoplasmic calcium (Ca(2+)) levels in plant cells is an early signaling event triggered by many environmental cues including…”
Get full text

Research data management for bioimaging: the 2021 NFDI4BIOIMAGE community survey [version 2; peer review: 2 approved] by Schmidt, Christian, Hanne, Janina, Moore, Josh, Meesters, Christian, Ferrando-May, Elisa, Weidtkamp-Peters, Stefanie

“…Background Knowing the needs of the bioimaging community with respect to research data management (RDM) is essential for identifying measures that enable the…”
Get full text

Quick, "imputation-free" meta-analysis with proxy-SNPs by Meesters, Christian, Leber, Markus, Herold, Christine, Angisch, Marina, Mattheisen, Manuel, Drichel, Dmitriy, Lacour, André, Becker, Tim

“…Meta-analysis (MA) is widely used to pool genome-wide association studies (GWASes) in order to a) increase the power to detect strong or weak genotype effects…”
Get full text

Is activated hemocyanin instead of phenoloxidase involved in immune response in woodlice? by Jaenicke, Elmar, Fraune, Sebastian, May, Sandra, Irmak, Pinar, Augustin, Rene, Meesters, Christian, Decker, Heinz, Zimmer, Martin

“…In the Common woodlouse Porcellio scaber (Crustacea: Isopoda: Oniscidea), experimental immune challenge did not induce the expression of pro-phenoloxidase…”
Get full text

Estimating person parameters via item response model and simple sum score in small samples with few polytomous items: A simulation study by Schwall, Philipp, Meesters, Christian, Hardt, Jochen

“…Background: The Item Response Theory (IRT) is becoming increasingly popular for item analysis. Theoretical considerations and simulation studies suggest that…”
Get full text

The HPC Certification Forum: Toward a Globally Acknowledged HPC Certification by Kunkel, Julian, Filinger, Weronika, Meesters, Christian, Gerbes, Anja, Broude Geva, Sharon, Colbry, Dirk

“…The goal of the HPC Certification Forum is to categorize, define, and examine competencies expected from proficient HPC practitioners. The community-led forum…”
Get full text

Genome-wide Association Study Identifies Genetic Variation in Neurocan as a Susceptibility Factor for Bipolar Disorder by Cichon, Sven, Mühleisen, Thomas W., Degenhardt, Franziska A., Mattheisen, Manuel, Miró, Xavier, Strohmaier, Jana, Steffens, Michael, Meesters, Christian, Herms, Stefan, Weingarten, Moritz, Priebe, Lutz, Haenisch, Britta, Alexander, Michael, Vollmer, Jennifer, Breuer, René, Schmäl, Christine, Tessmann, Peter, Moebus, Susanne, Wichmann, H.-Erich, Schreiber, Stefan, Müller-Myhsok, Bertram, Lucae, Susanne, Jamain, Stéphane, Leboyer, Marion, Bellivier, Frank, Etain, Bruno, Henry, Chantal, Kahn, Jean-Pierre, Heath, Simon, Hamshere, Marian, O'Donovan, Michael C., Owen, Michael J., Craddock, Nick, Schwarz, Markus, Vedder, Helmut, Kammerer-Ciernioch, Jutta, Reif, Andreas, Sasse, Johanna, Bauer, Michael, Hautzinger, Martin, Wright, Adam, Mitchell, Philip B., Schofield, Peter R., Montgomery, Grant W., Medland, Sarah E., Gordon, Scott D., Martin, Nicholas G., Gustafsson, Omar, Andreassen, Ole, Djurovic, Srdjan, Sigurdsson, Engilbert, Steinberg, Stacy, Stefansson, Hreinn, Stefansson, Kari, Kapur-Pojskic, Lejla, Oruc, Liliana, Rivas, Fabio, Mayoral, Fermín, Chuchalin, Alexander, Babadjanova, Gulja, Tiganov, Alexander S., Pantelejeva, Galina, Abramova, Lilia I., Grigoroiu-Serbanescu, Maria, Diaconu, Carmen C., Czerski, Piotr M., Hauser, Joanna, Zimmer, Andreas, Lathrop, Mark, Schulze, Thomas G., Wienker, Thomas F., Schumacher, Johannes, Maier, Wolfgang, Propping, Peter, Rietschel, Marcella, Nöthen, Markus M.

“…We conducted a genome-wide association study (GWAS) and a follow-up study of bipolar disorder (BD), a common neuropsychiatric disorder. In the GWAS, we…”
Get full text

Considerations for designing chemical screening strategies in plant biology by Serrano, Mario, Kombrink, Erich, Meesters, Christian

“…Traditionally, biologists regularly used classical genetic approaches to characterize and dissect plant processes. However, this strategy is often impaired by…”
Get full text

Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32 by STEFFEN, Michael Steffen, LEU, Costin, LA NEVE, Angela, CRICHIUTTI, Giovanni, DE KOVEL, Carolien G. F, TRENITE, Dorothée Kasteleijn-Nolst, DE HAAN, Gerrit-Jan, LINDHOUT, Dick, GAUS, Verena, SCHMITZ, Bettina, JANZ, Dieter, WEBER, Yvonne G, RUPPERT, Ann-Kathrin, BECKER, Felicitas, LERCHE, Holger, STEINHOFF, Bernhard J, KLEEFUSS-LIE, Ailing A, KUNZ, Wolfram S, SURGES, Rainer, ELGER, Christian E, MUHLE, Hiltrud, VON SPICZAK, Sarah, OSTERTAG, Philipp, ZARA, Federico, HELBIG, Ingo, STEPHANI, Ulrich, MØLLER, Rikke S, HJALGRIM, Helle, DIBBENS, Leanne M, BELLOWS, Susannah, OLIVER, Karen, MULLEN, Saul, SCHEFFER, Ingrid E, BERKOVIC, Samuel F, STRIANO, Pasquale, EVERETT, Kate V, GARDINER, Mark R, MARINI, Carla, GUERRINI, Renzo, LEHESJOKI, Anna-Elina, SIREN, Auli, ROBBIANO, Angela, CAPOVILLA, Giuseppe, TINUPER, Paolo, GAMBARDELLA, Antonio, BIANCHI, Amedeo

“…Genetic generalized epilepsies (GGEs) have a lifetime prevalence of 0.3% and account for 20-30% of all epilepsies. Despite their high heritability of 80%, the…”
Get full text

Structural characterization of the α-hemolysin monomer from Staphylococcus aureus by Meesters, Christian, Brack, Antje, Hellmann, Nadja, Decker, Heinz

“…α‐Hemolysin from Staphylococcus aureus is secreted as a water‐soluble monomer and assembles on membranes to oligomerize into a homo‐heptameric, water‐filled…”
Get full text

Hemocyanin conformational changes associated with SDS-induced phenol oxidase activation by Baird, Sharon, Kelly, Sharon M., Price, Nicholas C., Jaenicke, Elmar, Meesters, Christian, Nillius, Dorothea, Decker, Heinz, Nairn, Jacqueline

“…The enzymatic activity of phenoloxidase is assayed routinely in the presence of SDS. Similar assay conditions elicit phenoloxidase activity in another type 3…”
Get full text

Methylation of L1Hs promoters is lower on the inactive X, has a tendency of being higher on autosomes in smaller genomes and shows inter-individual variability at some loci by Singer, Heike, Walier, Maja, Nüsgen, Nicole, Meesters, Christian, Schreiner, Felix, Woelfle, Joachim, Fimmers, Rolf, Wienker, Thomas, Kalscheuer, Vera M., Becker, Tim, Schwaab, Rainer, Oldenburg, Johannes, El-Maarri, Osman

“…LINE-1 repeats account for ∼17% of the human genome. Little is known about their individual methylation patterns, because their repetitive, almost identical…”
Get full text

Significance Levels in Genome‐Wide Interaction Analysis (GWIA) by Becker, Tim, Herold, Christine, Meesters, Christian, Mattheisen, Manuel, Baur, Max P.

“…Summary Interaction between genetic variants is hypothesized to be one of several putative explanations for the ‘case of missing heritability.’ Therefore,…”
Get full text

Genome-wide association study and mouse expression data identify a highly conserved 32 kb intergenic region between WNT3 and WNT9b as possible susceptibility locus for isolated classic exstrophy of the bladder by Reutter, Heiko, Draaken, Markus, Pennimpede, Tracie, Wittler, Lars, Brockschmidt, Felix F, Ebert, Anne-Karolin, Bartels, Enrika, Rösch, Wolfgang, Boemers, Thomas M, Hirsch, Karin, Schmiedeke, Eberhard, Meesters, Christian, Becker, Tim, Stein, Raimund, Utsch, Boris, Mangold, Elisabeth, Nordenskjöld, Agneta, Barker, Gillian, Kockum, Christina Clementsson, Zwink, Nadine, Holmdahl, Gundula, Läckgren, Göran, Jenetzky, Ekkehart, Feitz, Wouter F J, Marcelis, Carlo, Wijers, Charlotte H W, Van Rooij, Iris A L M, Gearhart, John P, Herrmann, Bernhard G, Ludwig, Michael, Boyadjiev, Simeon A, Nöthen, Markus M, Mattheisen, Manuel

“…Bladder exstrophy-epispadias complex (BEEC), the severe end of the urorectal malformation spectrum, has a profound impact on continence as well as sexual and…”
Get full text