Search Results - "MEERMAN, John H. N"

Ultra high content image analysis and phenotype profiling of 3D cultured micro-tissues by Di, Zi, Klop, Maarten J D, Rogkoti, Vasiliki-Maria, Le Dévédec, Sylvia E, van de Water, Bob, Verbeek, Fons J, Price, Leo S, Meerman, John H N

“…In many situations, 3D cell cultures mimic the natural organization of tissues more closely than 2D cultures. Conventional methods for phenotyping such 3D…”
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Prediction of Ligand Binding Affinity and Orientation of Xenoestrogens to the Estrogen Receptor by Molecular Dynamics Simulations and the Linear Interaction Energy Method by van Lipzig, Marola M. H, ter Laak, Antonius M, Jongejan, Aldo, Vermeulen, Nico P. E, Wamelink, Mirjam, Geerke, Daan, Meerman, John. H. N

“…Exposure to environmental estrogens has been proposed as a risk factor for disruption of reproductive development and tumorigenesis of humans and wildlife…”
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Temporal and functional dynamics of the transcriptome during nerve growth factor-induced differentiation by Dijkmans, Thomas F, van Hooijdonk, Lenneke W.A, Schouten, Theo G, Kamphorst, Jessica T, Vellinga, Anette C.A, Meerman, John H.N, Fitzsimons, Carlos P, de Kloet, E. Ron, Vreugdenhil, Erno

“…The rat pheochromocytoma cell line (PC12) is an extensively used model to study neuronal differentiation. The initial signaling cascades triggered by nerve…”
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Detection of estrogenic potency in wastewater and surface water with three in vitro bioassays by Murk, Albertinka J., Legler, Juliette, van Lipzig, Marola M. H., Meerman, John H. N., Belfroid, Angelique C., Spenkelink, Albertus, van der Burg, Bart, Rijs, Gerard B. J., Vethaak, Dick

“…A study was performed to optimize sample preparation and application of three in vitro assays for measuring estrogenic potency in environmental extracts. The…”
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Automated analysis of NF-κB nuclear translocation kinetics in high-throughput screening by Di, Zi, Herpers, Bram, Fredriksson, Lisa, Yan, Kuan, van de Water, Bob, Verbeek, Fons J, Meerman, John H N

“…Nuclear entry and exit of the NF-κB family of dimeric transcription factors plays an essential role in regulating cellular responses to inflammatory stress…”
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Simultaneous determination of tyrosine, phenylalanine and deoxyguanosine oxidation products by liquid chromatography–tandem mass spectrometry as non-invasive biomarkers for oxidative damage by Orhan, Hilmi, Vermeulen, Nico P.E, Tump, Cornelis, Zappey, Herman, Meerman, John H.N

“…We developed an isotope dilution HPLC–atmospheric pressure chemical ionization–tandem mass spectrometry (HPLC–APCI–MS/MS) method for the simultaneous…”
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The Chemical Interaction between the Estrogen Receptor and Monohydroxybenzo[a]pyrene Derivatives Studied by Fluorescence Line-Narrowing Spectroscopy by Bader, Arjen N, van Dongen, Maarten M, van Lipzig, Marola M. H, Kool, Jeroen, Meerman, John H. N, Ariese, Freek, Gooijer, Cees

“…A novel approach is presented for studying the chemical interaction between receptor binding sites and ligands. Monohydroxylated polyaromatic compounds were…”
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Rapid On-line Profiling of Estrogen Receptor Binding Metabolites of Tamoxifen by Kool, Jeroen, Ramautar, Rawi, van Liempd, Sebastiaan M, Beckman, Joran, de Kanter, Frans J. J, Meerman, John H. N, Schenk, Tim, Irth, Hubertus, Commandeur, Jan N. M, Vermeulen, Nico P. E

“…Here we present a high-resolution screening (HRS) methodology for postcolumn on-line profiling of metabolites with affinity for the estrogen receptor α (ERα)…”
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Simulations of the Estrogen Receptor Ligand-Binding Domain:  Affinity of Natural Ligands and Xenoestrogens by Oostenbrink, B. Chris, Pitera, Jed W, van Lipzig, Marola M. H, Meerman, John H. N, van Gunsteren, Wilfred F

“…We have carried out molecular dynamics (MD) simulations and free energy calculations on the α-subtype of the human estrogen receptor ligand-binding domain (ERα…”
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IGF1R signaling drives antiestrogen resistance through PAK2/PIX activation in luminal breast cancer by Zhang, Yinghui, Wester, Lynn, He, Jichao, Geiger, Tamar, Moerkens, Marja, Siddappa, Ram, Helmijr, Jean A., Timmermans, Mieke M., Look, Maxime P., van Deurzen, Caroline H. M., Martens, John W. M., Pont, Chantal, de Graauw, Marjo, Danen, Erik H. J., Berns, Els M. J. J., Meerman, John H. N., Jansen, Maurice P. H. M., van de Water, Bob

“…Antiestrogen resistance in estrogen receptor positive (ER + ) breast cancer is associated with increased expression and activity of insulin-like growth factor…”
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Epidermal growth factor receptor signalling in human breast cancer cells operates parallel to estrogen receptor α signalling and results in tamoxifen insensitive proliferation by Moerkens, Marja, Zhang, Yinghui, Wester, Lynn, van de Water, Bob, Meerman, John H N

“…Tamoxifen resistance is a major problem in the treatment of estrogen receptor (ER) α -positive breast cancer patients. Although the mechanisms behind tamoxifen…”
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Bioactivation of Dibrominated Biphenyls by Cytochrome P450 Activity to Metabolites with Estrogenic Activity and Estrogen Sulfotransferase Inhibition Capacity by van Lipzig, Marola M. H, Commandeur, Jan N, de Kanter, Frans J. J, Damsten, Micaela C, Vermeulen, Nico P. E, Maat, Evelina, Groot, Ed J, Brouwer, Abraham, Kester, Monique H. A, Visser, Theo J, Meerman, John H. N

“…Exposure of humans and wildlife to xenobiotics, such as halogenated biphenyls, that interfere with the endogenous estrogen balance may lead to endocrine…”
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Online biochemical detection of glutathione-S-transferase P1-specific inhibitors in complex mixtures by Kool, Jeroen, Eggink, Mark, van Rossum, Huub, van Liempd, Sebastiaan M, van Elswijk, Danny A, Irth, Hubertus, Commandeur, Jan N M, Meerman, John H N, Vermeulen, Nico P E

“…A high-resolution screening (HRS) technology is described, which couples 2 parallel enzyme affinity detection (EAD) systems for substrates and inhibitors of…”
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Epidermal growth factor receptor signalling in human breast cancer cells operates parallel to estrogen receptor [alpha] signalling and results in tamoxifen insensitive proliferation by Moerkens, Marja, Zhang, Yinghui, Wester, Lynn, van de Water, Bob, Meerman, John HN

“…Doc number: 283 Abstract Background: Tamoxifen resistance is a major problem in the treatment of estrogen receptor (ER) α -positive breast cancer patients…”
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Systems biology approach identifies the kinase Csnk1a1 as a regulator of the DNA damage response in embryonic stem cells by Carreras Puigvert, Jordi, von Stechow, Louise, Siddappa, Ramakrishnaiah, Pines, Alex, Bahjat, Mahnoush, Haazen, Lizette C J M, Olsen, Jesper V, Vrieling, Harry, Meerman, John H N, Mullenders, Leon H F, van de Water, Bob, Danen, Erik H J

“…In pluripotent stem cells, DNA damage triggers loss of pluripotency and apoptosis as a safeguard to exclude damaged DNA from the lineage. An intricate DNA…”
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Quantification of urinary o,o'-dityrosine, a biomarker for oxidative damage to proteins, by high performance liquid chromatography with triple quadrupole tandem mass spectrometry. A comparison with ion-trap tandem mass spectrometry by Orhan, Hilmi, Coolen, Stefan, Meerman, John H N

“…We recently described an isotope dilution reversed-phase liquid chromatography-atmospheric pressure chemical ionization-ion-trap-tandem mass spectrometry…”
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Differential activation of promutagens by alloenzymes of human sulfotransferase 1A2 expressed in Salmonella typhimurium by MEINL, Walter, MEERMAN, John H. N, GLATT, Hansruedi

“…Various enzymatically formed sulfuric acid esters are chemically reactive and mutagenic. This metabolic activation pathway is not detected in standard in-vitro…”
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Development and validation of a microsomal online cytochrome P450 bioreactor coupled to solid-phase extraction and reversed-phase liquid chromatography by van Liempd, Sebastiaan M., Kool, Jeroen, Reinen, Jelle, Schenk, Tim, Meerman, John H.N., Irth, Hubertus, Vermeulen, Nico P.E.

“…The development and validation of an online cytochrome P450 (CYP)-based bioreactor coupled to automated solid-phase extraction (SPE) and gradient HPLC…”
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Development of a novel cytochrome p450 bioaffinity detection system coupled online to gradient reversed-phase high-performance liquid chromatography by Kool, Jeroen, van Liempd, Sebastiaan M, Ramautar, Rawi, Schenk, Tim, Meerman, John H N, Irth, Hubertus, Commandeur, Jan N M, Vermeulen, Nico P E

“…A high-resolution screening platform, coupling online affinity detection for mammalian cytochrome P450s (Cyt P450s) to gradient reversed-phase high-performance…”
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Influence of N-Substitution of 7-Methoxy-4-(aminomethyl)-coumarin on Cytochrome P450 Metabolism and Selectivity by VENHORST, Jennifer, ONDERWATER, Rob C. A, MEERMAN, John H. N, COMMANDEUR, Jan N. M, VERMEULEN, Nico P. E

“…A series of six structural analogs of 7-methoxy-4-(aminomethyl)-coumarin (MAMC), a recently developed high-throughput substrate of P450 2D6 (CYP2D6), was…”
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