Search Results - "MEENA SACHDEVA"

Fatty Acid Biosynthesis in Pseudomonas aeruginosa Is Initiated by the FabY Class of β-Ketoacyl Acyl Carrier Protein Synthases by Yuan, Yanqiu, Sachdeva, Meena, Leeds, Jennifer A, Meredith, Timothy C

“…The prototypical type II fatty acid synthesis (FAS) pathway in bacteria utilizes two distinct classes of β-ketoacyl synthase (KAS) domains to assemble…”
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Discovery of LFF571: An Investigational Agent for Clostridium difficile Infection by LaMarche, Matthew J, Leeds, Jennifer A, Amaral, Adam, Brewer, Jason T, Bushell, Simon M, Deng, Gejing, Dewhurst, Janetta M, Ding, Jian, Dzink-Fox, JoAnne, Gamber, Gabriel, Jain, Akash, Lee, Kwangho, Lee, Lac, Lister, Troy, McKenney, David, Mullin, Steve, Osborne, Colin, Palestrant, Deborah, Patane, Michael A, Rann, Elin M, Sachdeva, Meena, Shao, Jian, Tiamfook, Stacey, Trzasko, Anna, Whitehead, Lewis, Yifru, Aregahegn, Yu, Donghui, Yan, Wanlin, Zhu, Qingming

“…Clostridium difficile (C. difficile) is a Gram positive, anaerobic bacterium that infects the lumen of the large intestine and produces toxins. This results in…”
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Subinhibitory concentrations of LFF571 reduce toxin production by Clostridium difficile by Sachdeva, Meena, Leeds, Jennifer A

“…LFF571 is a novel semisynthetic thiopeptide antibacterial that is undergoing investigation for safety and efficacy in patients with moderate Clostridium…”
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Discovery of Novel Antibiotics as Covalent Inhibitors of Fatty Acid Synthesis by Wang, Jia, Ye, Xiaoping, Yang, Xiaohan, Cai, Youyan, Wang, Shengjun, Tang, Jieyu, Sachdeva, Meena, Qian, Yu, Hu, Wenhao, Leeds, Jennifer A, Yuan, Yanqiu

“…The steady increase in the prevalence of multidrug-resistant Staphylococcus aureus has made the search for novel antibiotics to combat this clinically…”
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In vitro selection, via serial passage, of Clostridium difficile mutants with reduced susceptibility to fidaxomicin or vancomycin by Leeds, Jennifer A, Sachdeva, Meena, Mullin, Steve, Barnes, S Whitney, Ruzin, Alexey

“…Current treatments for Clostridium difficile infection include vancomycin, metronidazole and fidaxomicin. LFF571 is an experimental agent undergoing evaluation…”
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Loss of cerebrovascular autoregulation in experimental meningitis in rabbits by TUREEN, J. H, DWORKIN, R. J, KENNEDY, S. L, MEENA SACHDEVA, SANDE, M. A

“…The present study was designed to determine whether cerebrovascular autoregulation is intact in experimental meningitis and to examine the relationship between…”
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Development and Optimization of a Higher-Throughput Bacterial Compound Accumulation Assay by Widya, Marcella, Pasutti, William D, Sachdeva, Meena, Simmons, Robert L, Tamrakar, Pramila, Krucker, Thomas, Six, David A

“…The Gram-negative bacterial permeability barrier, coupled with efflux, raises formidable challenges to antibiotic drug discovery. The absence of efficient…”
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Fatty Acid Biosynthesis in Pseudomonas aeruginosa Is Initiated by the FabY Class of [Beta]-Ketoacyl Acyl Carrier Protein Synthases by Yuan, Yanqiu, Sachdeva, Meena, Leeds, Jennifer A, Meredith, Timothy C

“…The prototypical type II fatty acid synthesis (FAS) pathway in bacteria utilizes two distinct classes of β-ketoacyl synthase (KAS) domains to assemble…”
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Antibacterial Optimization of 4-Aminothiazolyl Analogues of the Natural Product GE2270 A: Identification of the Cycloalkylcarboxylic Acids by LaMarche, Matthew J, Leeds, Jennifer A, Amaral, Kerri, Brewer, Jason T, Bushell, Simon M, Dewhurst, Janetta M, Dzink-Fox, JoAnne, Gangl, Eric, Goldovitz, Julie, Jain, Akash, Mullin, Steve, Neckermann, Georg, Osborne, Colin, Palestrant, Deborah, Patane, Michael A, Rann, Elin M, Sachdeva, Meena, Shao, Jian, Tiamfook, Stacey, Whitehead, Lewis, Yu, Donghui

“…4-Aminothiazolyl analogues of the antibiotic natural product GE2270 A (1) were designed, synthesized, and optimized for their activity against Gram positive…”
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Benzothioxalone derivatives as novel inhibitors of UDP-N-acetylglucosamine enolpyruvyl transferases (MurA and MurZ) by Miller, Keith, Dunsmore, Colin J., Leeds, Jennifer A., Patching, Simon G., Sachdeva, Meena, Blake, Katy L., Stubbings, William J., Simmons, Katie J., Henderson, Peter J. F., De Los Angeles, Joe, Fishwick, Colin W. G., Chopra, Ian

“…Objectives We sought to identify and characterize new inhibitors of MurA and MurZ, which are enzymes involved in the early stages of bacterial peptidoglycan…”
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Efficient DNA Sequence Identification: A Classification Approach Integrating Gaussian RBM by Gulati, Chahat, Barman, Biswajit, Balde, Govind Hanmantrao, Rexy V, Arul Mary, Sachdeva, Meena, Patil, Harshal

“…Using machine learning techniques, this article examines cancer patients' DNA sequences. Cancer is certainly one of the most common and devastating diseases in…”
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Predicting Financial Market Movements Through Time Series Analysis and Advanced Machine Learning Algorithms by Reddy, B Amarnath, Kathiriya, Harsh, Thapliyal, Nitin, Vasuki, S., Sachdeva, Meena, Shobana, A.

“…A novel approach for forecasting the movements of financial markets is presented in this research. It combines Auto Regressive Integrated Moving Average…”
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Teicoplanin pharmacokinetics and bioavailability during peritoneal dialysis by Brouard, R J, Kapusnik, J E, Gambertoglio, J G, Schoenfeld, P Y, Sachdeva, M, Freel, K, Tozer, T N

“…The pharmacokinetics of teicoplanin in serum and dialysate were examined in a crossover study after intravenous and intraperitoneal administration of a 3 mg/kg…”
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Discovery of human antibodies against the C5aR target using phage display technology by Huang, Lili, Sato, Aaron K., Sachdeva, Meena, Fleming, Tony, Townsend, Susan, Dransfield, Daniel T.

“…Phage display technologies have been increasingly utilized for the generation of therapeutic, imaging and purification reagents for a number of biological…”
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Discovery of high-affinity peptide binders to BLyS by phage display by Fleming, Tony J., Sachdeva, Meena, Delic, Marko, Beltzer, James, Wescott, Charles R., Devlin, Mary, Lander, Robert C., Nixon, Andrew E., Roschke, Viktor, Hilbert, David M., Sexton, Daniel J.

“…B lymphocyte stimulator (BLyS) is a tumor necrosis factor (TNF) family member and a key regulator of B cell responses. We employed a phage display‐based…”
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Binding of β-Lactam Antibiotics to Penicillin-Binding Proteins in Methicillin-Resistant Staphylococcus aureus by Chambers, Henry F., Sachdeva, Meena

“…Binding affinity of penicillin-binding proteins (PBP) of Staphylococcus aureus for several β-lactam antibiotics was examined in a methicillin-susceptible…”
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Binding Affinity for Penicillin-Binding Protein 2a Correlates with in vivo Activity of β-Lactam Antibiotics against Methicillin-Resistant Staphylococcus aureus by Chambers, Henry F., Sachdeva, Meena, Kennedy, Steve

“…The β-lactam antibiotics ticarcillin, nafcillin, imipenem, and ampicillin, which differ in antibacterial activity against methicillin-resistant strains of…”
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Binding Affinity for Penicillin-Binding Protein 2a Correlates with In Activity of β-Lactan Antibiotics against Methicillin-Resistant Staphylococcus aureus by Chambers, Henry F., Sachdeva, Meena, Kennedy, Steve

“…The β-lactam antibiotics ticarcillin, nafcillin, imipenem, and ampicillin, which differ in antibacterial activity against methicillin-resistant strains of…”
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Toxicity in Neuronal Cells Caused by Cerebrospinal Fluid from Pneumococcal and Gram-Negative Meningitis by Täuber, Martin G., Sachdeva, Meena, Kennedy, Stephen L., Loetscher, Hansruedi, Lesslauer, Werner

“…To identify neurotoxic factors in meningitis, a neuronal cell line (HN33.1) was exposed to cerebrospinal fluid (CSF) obtained from rabbits with pneumococcal…”
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Toxicity in Neuronal Cells Caused by Cerebrospinal Fluid from Pneumococcaland Gram-Negative Meningitis by Täuber, Martin G., Sachdeva, Meena, Kennedy, Stephen L., Loetscher, Hansruedi, Lesslauer, Werner

“…To identify neurotoxic factors in meningitis, a neuronal cell line (HN33.1) was exposed to cerebrospinal fluid (CSF) obtained from rabbits with pneumococcal…”
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