Search Results - "MEEKER, K"

Tracking the clonal origin of lethal prostate cancer by Haffner, Michael C, Mosbruger, Timothy, Esopi, David M, Fedor, Helen, Heaphy, Christopher M, Walker, David A, Adejola, Nkosi, Gürel, Meltem, Hicks, Jessica, Meeker, Alan K, Halushka, Marc K, Simons, Jonathan W, Isaacs, William B, De Marzo, Angelo M, Nelson, William G, Yegnasubramanian, Srinivasan

“…Recent controversies surrounding prostate cancer overtreatment emphasize the critical need to delineate the molecular features associated with progression to…”
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Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway by Lovejoy, Courtney A, Li, Wendi, Reisenweber, Steven, Thongthip, Supawat, Bruno, Joanne, de Lange, Titia, De, Saurav, Petrini, John H J, Sung, Patricia A, Jasin, Maria, Rosenbluh, Joseph, Zwang, Yaara, Weir, Barbara A, Hatton, Charlie, Ivanova, Elena, Macconaill, Laura, Hanna, Megan, Hahn, William C, Lue, Neal F, Reddel, Roger R, Jiao, Yuchen, Kinzler, Kenneth, Vogelstein, Bert, Papadopoulos, Nickolas, Meeker, Alan K

“…The Alternative Lengthening of Telomeres (ALT) pathway is a telomerase-independent pathway for telomere maintenance that is active in a significant subset of…”
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Tumor‐infiltrating mesenchymal stem cells: Drivers of the immunosuppressive tumor microenvironment in prostate cancer? by Krueger, Timothy E., Thorek, Daniel L. J., Meeker, Alan K., Isaacs, John T., Brennen, W. Nathaniel

“…Background Prostate cancer is characterized by T‐cell exclusion, which is consistent with their poor responses to immunotherapy. In addition, T‐cells…”
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Paucity of PD-L1 expression in prostate cancer: innate and adaptive immune resistance by Martin, A M, Nirschl, T R, Nirschl, C J, Francica, B J, Kochel, C M, van Bokhoven, A, Meeker, A K, Lucia, M S, Anders, R A, DeMarzo, A M, Drake, C G

“…BACKGROUND: Primary prostate cancers are infiltrated with programmed death-1 (PD-1) expressing CD8+ T-cells. However, in early clinical trials, men with…”
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The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma by Diplas, Bill H., He, Xujun, Brosnan-Cashman, Jacqueline A., Liu, Heng, Chen, Lee H., Wang, Zhaohui, Moure, Casey J., Killela, Patrick J., Loriaux, Daniel B., Lipp, Eric S., Greer, Paula K., Yang, Rui, Rizzo, Anthony J., Rodriguez, Fausto J., Friedman, Allan H., Friedman, Henry S., Wang, Sizhen, He, Yiping, McLendon, Roger E., Bigner, Darell D., Jiao, Yuchen, Waitkus, Matthew S., Meeker, Alan K., Yan, Hai

“…The majority of glioblastomas can be classified into molecular subgroups based on mutations in the TERT promoter ( TERTp ) and isocitrate dehydrogenase 1 or 2…”
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Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers by Haffner, Michael C, Chaux, Alcides, Meeker, Alan K, Esopi, David M, Gerber, Jonathan, Pellakuru, Laxmi G, Toubaji, Antoun, Argani, Pedram, Iacobuzio-Donahue, Christine, Nelson, William G, Netto, George J, De Marzo, Angelo M, Yegnasubramanian, Srinivasan

“…DNA methylation at the 5-position of cytosines (5 mC) represents an important epigenetic modification involved in tissue differentiation and is frequently…”
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ATRX loss induces multiple hallmarks of the alternative lengthening of telomeres (ALT) phenotype in human glioma cell lines in a cell line-specific manner by Brosnan-Cashman, Jacqueline A, Yuan, Ming, Graham, Mindy K, Rizzo, Anthony J, Myers, Kaylar M, Davis, Christine, Zhang, Rebecca, Esopi, David M, Raabe, Eric H, Eberhart, Charles G, Heaphy, Christopher M, Meeker, Alan K

“…Cancers must maintain their telomeres at lengths sufficient for cell survival. In several cancer subtypes, a recombination-like mechanism termed alternative…”
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Role of telomere dysfunction in cardiac failure in Duchenne muscular dystrophy by Mourkioti, Foteini, Kustan, Jackie, Kraft, Peggy, Day, John W., Zhao, Ming-Ming, Kost-Alimova, Maria, Protopopov, Alexei, DePinho, Ronald A., Bernstein, Daniel, Meeker, Alan K., Blau, Helen M.

“…Duchenne muscular dystrophy (DMD), the most common inherited muscular dystrophy of childhood, leads to death due to cardiorespiratory failure. Paradoxically,…”
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Inactivating ARID1A Tumor Suppressor Enhances TERT Transcription and Maintains Telomere Length in Cancer Cells by Rahmanto, Yohan Suryo, Jung, Jin-Gyoung, Wu, Ren-Chin, Kobayashi, Yusuke, Heaphy, Christopher M., Meeker, Alan K., Wang, Tian-Li, Shih, Ie-Ming

“…ARID1A is a tumor suppressor gene that belongs to the switch/sucrose non-fermentable chromatin remodeling gene family. It is mutated in many types of human…”
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Significant Human β-Cell Turnover Is Limited to the First Three Decades of Life as Determined by in Vivo Thymidine Analog Incorporation and Radiocarbon Dating by Perl, S, Kushner, J. A, Buchholz, B. A, Meeker, A. K, Stein, G. M, Hsieh, M, Kirby, M, Pechhold, S, Liu, E. H, Harlan, D. M, Tisdale, J. F

“…Aims: Diabetes mellitus results from an absolute or relative deficiency of insulin-producing pancreatic β-cells. The turnover rate of adult human β-cells…”
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MYC drives overexpression of telomerase RNA (hTR/TERC) in prostate cancer by Baena‐Del Valle, Javier A, Zheng, Qizhi, Esopi, David M, Rubenstein, Michael, Hubbard, Gretchen K, Moncaliano, Maria C, Hruszkewycz, Andrew, Vaghasia, Ajay, Yegnasubramanian, Srinivasan, Wheelan, Sarah J, Meeker, Alan K, Heaphy, Christopher M, Graham, Mindy K, De Marzo, Angelo M

“…Telomerase consists of at least two essential elements, an RNA component hTR or TERC that contains the template for telomere DNA addition and a catalytic…”
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Association between statin drug use and peripheral blood leukocyte telomere length in the National Health and Nutrition Examination Survey 1999–2002: a cross-sectional study by Tran, Phuong T., Meeker, Alan K., Platz, Elizabeth A.

“…To evaluate the association between statin drug use and peripheral blood leukocyte telomere length in a U.S. nationally representative sample of adults. We…”
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DAXX promotes centromeric stability independently of ATRX by preventing the accumulation of R-loop-induced DNA double-stranded breaks by Pinto, Lia M, Pailas, Alexandros, Bondarchenko, Max, Sharma, Abhishek Bharadwaj, Neumann, Katrin, Rizzo, Anthony J, Jeanty, Céline, Nicot, Nathalie, Racca, Carine, Graham, Mindy K, Naughton, Catherine, Liu, Yaqun, Chen, Chun-Long, Meakin, Paul J, Gilbert, Nick, Britton, Sébastien, Meeker, Alan K, Heaphy, Christopher M, Larminat, Florence, Van Dyck, Eric

“…Maintaining chromatin integrity at the repetitive non-coding DNA sequences underlying centromeres is crucial to prevent replicative stress, DNA breaks and…”
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Loss of ATRX or DAXX expression and concomitant acquisition of the alternative lengthening of telomeres phenotype are late events in a small subset of MEN-1 syndrome pancreatic neuroendocrine tumors by de Wilde, Roeland F, Heaphy, Christopher M, Maitra, Anirban, Meeker, Alan K, Edil, Barish H, Wolfgang, Christopher L, Ellison, Trevor A, Schulick, Richard D, Molenaar, I Quintus, Valk, Gerlof D, Vriens, Menno R, Borel Rinkes, Inne H M, Offerhaus, G Johan A, Hruban, Ralph H, Matsukuma, Karen E

“…Approximately 45% of sporadic well-differentiated pancreatic neuroendocrine tumors harbor mutations in either ATRX (alpha thalassemia/mental retardation…”
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Investigation of miR-21, miR-141, and miR-221 expression levels in prostate adenocarcinoma for associated risk of recurrence after radical prostatectomy by Zheng, Qizhi, Peskoe, Sarah B., Ribas, Judit, Rafiqi, Fatema, Kudrolli, Tarana, Meeker, Alan K., De Marzo, Angelo M., Platz, Elizabeth A., Lupold, Shawn E.

“…BACKGROUND MicroRNAs (miRNAs) are small non‐coding RNAs that regulate a broad array of cellular and disease processes. Several miRNAs are differentially…”
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Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells by Konishi, Hiroyuki, Mohseni, Morassa, Tamaki, Akina, Garay, Joseph P, Croessmann, Sarah, Karnan, Sivasundaram, Ota, Akinobu, Wong, Hong Yuen, Konishi, Yuko, Karakas, Bedri, Tahir, Khola, Abukhdeir, Abde M, Gustin, John P, Cidado, Justin, Wang, Grace M, Cosgrove, David, Cochran, Rory, Jelovac, Danijela, Higgins, Michaela J, Arena, Sabrina, Hawkins, Lauren, Lauring, Josh, Gross, Amy L, Heaphy, Christopher M, Hosokawa, Yositaka, Gabrielson, Edward, Meeker, Alan K, Visvanathan, Kala, Argani, Pedram, Bachman, Kurtis E, Park, Ben Ho

“…Biallelic inactivation of cancer susceptibility gene BRCA1 leads to breast and ovarian carcinogenesis. Paradoxically, BRCA1 deficiency in mice results in early…”
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Evaluation of telomere length in human cardiac tissues using cardiac quantitative FISH by Sharifi-Sanjani, Maryam, Meeker, Alan K, Mourkioti, Foteini

“…This protocol describes how to measure telomere length in archival human cardiac tissues using cardiac quantitative fluorescent in situ hybridization (CQ-FISH)…”
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Genomic analysis identifies frequent deletions of Dystrophin in olfactory neuroblastoma by Gallia, Gary L., Zhang, Ming, Ning, Yi, Haffner, Michael C., Batista, Denise, Binder, Zev A., Bishop, Justin A., Hann, Christine L., Hruban, Ralph H., Ishii, Masaru, Klein, Alison P., Reh, Douglas D., Rooper, Lisa M., Salmasi, Vafi, Tamargo, Rafael J., Wang, Qing, Williamson, Tara, Zhao, Tianna, Zou, Ying, Meeker, Alan K., Agrawal, Nishant, Vogelstein, Bert, Kinzler, Kenneth W., Papadopoulos, Nickolas, Bettegowda, Chetan

“…Olfactory neuroblastoma (ONB) is a rare malignant neoplasm arising in the upper portion of the sinonasal cavity. To better understand the genetic bases for…”
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Molecular and Morphologic Correlates of the Alternative Lengthening of Telomeres Phenotype in High-Grade Astrocytomas by Nguyen, Doreen N., Heaphy, Christopher M., de Wilde, Roeland F., Orr, Brent A., Odia, Yazmin, Eberhart, Charles G., Meeker, Alan K., Rodriguez, Fausto J.

“…Recent studies suggest that the telomere maintenance mechanism known as alternative lengthening of telomeres (ALT) is relatively more common in specific glioma…”
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Telomere Length Abnormalities Occur Early in the Initiation of Epithelial Carcinogenesis by MEEKER, Alan K, HICKS, Jessica L, IACOBUZIO-DONAHUE, Christine A, MONTGOMERY, Elizabeth A, WESTRA, William H, CHAN, Theresa Y, RONNETT, Brigitte M, DE MARZO, Angelo M

“…Purpose: Telomeres help maintain chromosomal integrity. Dysfunctional telomeres can cause genetic instability in vitro and an increased cancer incidence in…”
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