Search Results - "MEDINA, Pedro P"

OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma by Slack, Frank J, Medina, Pedro P, Nolde, Mona

“…MicroRNAs (miRNAs) belong to a recently discovered class of small RNA molecules that regulate gene expression at the post-transcriptional level. miRNAs have…”
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MicroRNAs and cancer: An overview by Medina, Pedro P., Slack, Frank J.

“…MicroRNAs (miRNAs) are a recently discovered class of small RNA molecules that negatively regulate gene expression at the post-transcriptional level. MiRNAs…”
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SWI/SNF complexes in hematological malignancies: biological implications and therapeutic opportunities by Andrades, Alvaro, Peinado, Paola, Alvarez-Perez, Juan Carlos, Sanjuan-Hidalgo, Juan, García, Daniel J, Arenas, Alberto M, Matia-González, Ana M, Medina, Pedro P

“…Hematological malignancies are a highly heterogeneous group of diseases with varied molecular and phenotypical characteristics. SWI/SNF (SWItch/Sucrose…”
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FGF Regulates TGF-β Signaling and Endothelial-to-Mesenchymal Transition via Control of let-7 miRNA Expression by Chen, Pei-Yu, Qin, Lingfeng, Barnes, Carmen, Charisse, Klaus, Yi, Tai, Zhang, Xinbo, Ali, Rahmat, Medina, Pedro P., Yu, Jun, Slack, Frank J., Anderson, Daniel G., Kotelianski, Victor, Wang, Fen, Tellides, George, Simons, Michael

“…Maintenance of normal endothelial function is critical to various aspects of blood vessel function, but its regulation is poorly understood. In this study, we…”
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Activation-induced cytidine deaminase causes recurrent splicing mutations in diffuse large B-cell lymphoma by Benitez-Cantos, Maria S, Cano, Carlos, Cuadros, Marta, Medina, Pedro P

“…Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma. A major mutagenic process in DLBCL is aberrant somatic hypermutation (aSHM) by…”
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Maslinic Acid, a Natural Triterpene, Induces a Death Receptor-Mediated Apoptotic Mechanism in Caco-2 p53-Deficient Colon Adenocarcinoma Cells by Reyes-Zurita, Fernando J, Rufino-Palomares, Eva E, García-Salguero, Leticia, Peragón, Juan, Medina, Pedro P, Parra, Andrés, Cascante, Marta, Lupiáñez, José A

“…Maslinic acid (MA) is a natural triterpene present in high concentrations in the waxy skin of olives. We have previously reported that MA induces apoptotic…”
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SMARCA4 deficient tumours are vulnerable to KDM6A/UTX and KDM6B/JMJD3 blockade by Romero, Octavio A., Vilarrubi, Andrea, Alburquerque-Bejar, Juan J., Gomez, Antonio, Andrades, Alvaro, Trastulli, Deborah, Pros, Eva, Setien, Fernando, Verdura, Sara, Farré, Lourdes, Martín-Tejera, Juan F., Llabata, Paula, Oaknin, Ana, Saigi, Maria, Piulats, Josep M., Matias-Guiu, Xavier, Medina, Pedro P., Vidal, August, Villanueva, Alberto, Sanchez-Cespedes, Montse

“…Despite the genetic inactivation of SMARCA4 , a core component of the SWI/SNF-complex commonly found in cancer, there are no therapies that effectively target…”
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Genome-wide CRISPR interference screen identifies long non-coding RNA loci required for differentiation and pluripotency by Haswell, Jeffrey R, Mattioli, Kaia, Gerhardinger, Chiara, Maass, Philipp G, Foster, Daniel J, Peinado, Paola, Wang, Xiaofeng, Medina, Pedro P, Rinn, John L, Slack, Frank J

“…Although many long non-coding RNAs (lncRNAs) exhibit lineage-specific expression, the vast majority remain functionally uncharacterized in the context of…”
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Frequent BRG1/SMARCA4-inactivating mutations in human lung cancer cell lines by Medina, Pedro P, Romero, Octavio A, Kohno, Takashi, Montuenga, Luis M, Pio, Ruben, Yokota, Jun, Sanchez-Cespedes, Montse

“…Components of the SWI/SNF chromatin-remodeling complex, such as INI1, are inactivated in human cancer and, thus, act as tumor suppressors. Here we screened for…”
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DNA-Repair Gene Polymorphisms Predict Favorable Clinical Outcome Among Patients With Advanced Squamous Cell Carcinoma of the Head and Neck Treated With Cisplatin-Based Induction Chemotherapy by Quintela-Fandino, Miguel, Hitt, Ricardo, Medina, Pedro P, Gamarra, Soledad, Manso, Luis, Cortes-Funes, Hernan, Sanchez-Cespedes, Montserrat

“…Cisplatin kills tumor cells through DNA cross linking. Alterations in the function of DNA repair genes may affect DNA repair proficiency and influence cancer…”
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The SRY-HMG box gene, SOX4, is a target of gene amplification at chromosome 6p in lung cancer by Medina, Pedro P., Castillo, Sandra D., Blanco, Sandra, Sanz-Garcia, Marta, Largo, Cristina, Alvarez, Sara, Yokota, Jun, Gonzalez-Neira, Ana, Benitez, Javier, Clevers, Hans C., Cigudosa, Juan C., Lazo, Pedro A., Sanchez-Cespedes, Montse

“…The search for oncogenes is becoming increasingly important in cancer genetics because they are suitable targets for therapeutic intervention. To identify…”
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Expression inactivation of SMARCA4 by microRNAs in lung tumors by Coira, Isabel F, Rufino-Palomares, Eva E, Romero, Octavio A, Peinado, Paola, Metheetrairut, Chanatip, Boyero-Corral, Laura, Carretero, Julian, Farez-Vidal, Esther, Cuadros, Marta, Reyes-Zurita, Fernando J, Lupiáñez, Jose A, Sánchez-Cespedes, Montse, Slack, Frank J, Medina, Pedro P

“…SMARCA4 is the catalytic subunit of the SWI/SNF chromatin-remodeling complex, which alters the interactions between DNA and histones and modifies the…”
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Involvement of the chromatin-remodeling factor BRG1/SMARCA4 in human cancer by Medina, Pedro P., Sanchez-Cespedes, Montse

“…The SWI/SNF complex is a chromatin-remodeling complex that uses the energy of ATP hydrolysis to modify chromatin structure in order to regulate gene…”
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Wiping DNA Methylation: Wip1 Regulates Genomic Fluidity on Cancer by Muñoz-Lopez, Martin, Medina, Pedro P., Garcia-Perez, Jose L.

“…Wip1 phosphatase plays an important role in cancer by inactivating p53 and INK4a/ARF pathways. In this issue of Cancer Cell, Filipponi and colleagues further…”
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BCL7A is silenced by hypermethylation to promote acute myeloid leukemia by Patiño-Mercau, Juan Rodrigo, Baliñas-Gavira, Carlos, Andrades, Alvaro, Benitez-Cantos, Maria S, Rot, Ana Ercegovič, Rodriguez, Maria Isabel, Álvarez-Pérez, Juan Carlos, Cuadros, Marta, Medina, Pedro P

“…Recent massive sequencing studies have revealed that SWI/SNF complexes are among the most frequently altered functional entities in solid tumors. However, the…”
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Genetic and Epigenetic screening for gene alterations of the chromatin-remodeling factor, SMARCA4/BRG1, in lung tumors by Medina, Pedro P., Carretero, Julian, Fraga, Mario F., Esteller, Manel, Sidransky, David, Sanchez-Cespedes, Montserrat

“…The SMARCA4/BRG1 gene product is a component of the SWI‐SNF chromatin‐remodeling complex and regulates gene expression by disrupting histone‐DNA contacts in an…”
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Recurrent splice site mutations affect key diffuse large B-cell lymphoma genes by Andrades, Alvaro, Álvarez-Pérez, Juan Carlos, Patiño-Mercau, Juan Rodrigo, Cuadros, Marta, Baliñas-Gavira, Carlos, Medina, Pedro P.

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Clinical applications of DNA methylation profiling in lung cancer by Castro-Gonzalez, Sergio, Cuadros, Marta, Medina, Pedro P.

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The SWI/SNF complex regulates the expression of miR-222, a tumor suppressor microRNA in lung adenocarcinoma by Peinado, Paola, Andrades, Alvaro, Martorell-Marugán, Jordi, Haswell, Jeffrey R, Slack, Frank J, Carmona-Sáez, Pedro, Medina, Pedro P

“…Abstract SWitch/Sucrose Non-Fermentable (SWI/SNF) chromatin remodeling complexes are key epigenetic regulators that are recurrently mutated in cancer. Most…”
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EZH2 endorses cell plasticity to non-small cell lung cancer cells facilitating mesenchymal to epithelial transition and tumour colonization by Gallardo, Amador, Molina, Aldara, Asenjo, Helena G., Lopez-Onieva, Lourdes, Martorell-Marugán, Jordi, Espinosa-Martinez, Mencia, Griñan-Lison, Carmen, Alvarez-Perez, Juan Carlos, Cara, Francisca E., Navarro-Marchal, Saul A., Carmona-Sáez, Pedro, Medina, Pedro P., Marchal, Juan Antonio, Granados-Principal, Sergio, Sánchez-Pozo, Antonio, Landeira, David

“…Reversible transition between the epithelial and mesenchymal states are key aspects of carcinoma cell dissemination and the metastatic disease, and thus,…”
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