Search Results - "MEDEIROS, RUI"

ASCT2 and LAT1 Contribution to the Hallmarks of Cancer: From a Molecular Perspective to Clinical Translation by Lopes, Catarina, Pereira, Carina, Medeiros, Rui

“…The role of the amino acid transporters ASCT2 and LAT1 in cancer has been explored throughout the years. In this review, we report their impact on the…”
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Hallmarks of HPV carcinogenesis: The role of E6, E7 and E5 oncoproteins in cellular malignancy by Estêvão, Diogo, Costa, Natália Rios, Gil da Costa, Rui M., Medeiros, Rui

“…Human papillomavirus (HPV) is the most common sexually transmitted infectious agent worldwide, being also responsible for 5% of all human cancers. The…”
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RAD52 Functions in Homologous Recombination and Its Importance on Genomic Integrity Maintenance and Cancer Therapy by Nogueira, Augusto, Fernandes, Mara, Catarino, Raquel, Medeiros, Rui

“…Genomes are continually subjected to DNA damage whether they are induced from intrinsic physiological processes or extrinsic agents. Double-stranded breaks…”
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Cancer cachexia and its pathophysiology: links with sarcopenia, anorexia and asthenia by Peixoto da Silva, Sara, Santos, Joana M.O., Costa e Silva, Maria Paula, Gil da Costa, Rui M., Medeiros, Rui

“…Cancer cachexia is a multifactorial syndrome characterized by a progressive loss of skeletal muscle mass, along with adipose tissue wasting, systemic…”
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Hyaluronic Acid-Based Nanomaterials Applied to Cancer: Where Are We Now? by Machado, Vera, Morais, Mariana, Medeiros, Rui

“…Cancer cells normally develop the ability to rewire or reprogram themselves to become resistant to treatments that were previously effective. Despite progress…”
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Plasmatic MicroRNAs and Treatment Outcomes of Patients with Metastatic Castration-Resistant Prostate Cancer: A Hospital-Based Cohort Study and In Silico Analysis by Silva, Jani, Tavares, Valéria, Afonso, Ana, Garcia, Juliana, Cerqueira, Fátima, Medeiros, Rui

“…Prostate cancer (PCa) is one of the most common malignancies among men worldwide. Inevitably, all advanced PCa patients develop metastatic castration-resistant…”
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ceRNA Network of lncRNA/miRNA as Circulating Prognostic Biomarkers in Non-Hodgkin Lymphomas: Bioinformatic Analysis and Assessment of Their Prognostic Value in an NHL Cohort by Fernandes, Mara, Marques, Herlander, Teixeira, Ana Luísa, Medeiros, Rui

“…Research has been focusing on identifying novel biomarkers to better stratify non-Hodgkin lymphoma patients based on prognosis. Studies have demonstrated that…”
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In Vitro Models for Cancer-Associated Cachexia: The Complex Modelling of a Multiorgan Syndrome by Meireles, Isabel, Medeiros, Rui, Cerqueira, Fátima

“…Cancer-associated cachexia is a multifactorial syndrome characterised by systemic inflammation and hypermetabolism that affects different tissues and organs…”
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Paradigm Shift: A Comprehensive Review of Ovarian Cancer Management in an Era of Advancements by Tavares, Valéria, Marques, Inês Soares, Melo, Inês Guerra de, Assis, Joana, Pereira, Deolinda, Medeiros, Rui

“…Ovarian cancer (OC) is the female genital malignancy with the highest lethality. Patients present a poor prognosis mainly due to the late clinical presentation…”
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Canine Mammary Tumors: Comparison of Classification and Grading Methods in a Survival Study by Canadas, Ana, França, Miguel, Pereira, Cristina, Vilaça, Raquel, Vilhena, Hugo, Tinoco, Flora, Silva, Maria João, Ribeiro, Jorge, Medeiros, Rui, Oliveira, Pedro, Dias-Pereira, Patrícia, Santos, Marta

“…Histopathology remains the cornerstone for diagnosing canine mammary tumors (CMTs). Recently, 2 classification systems (the World Health Organization [WHO]…”
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Venous thromboembolism-related genetic determinant F11 rs4253417 is a potential prognostic factor in ischaemic stroke by Tavares, Valéria, Assis, Joana, Pinto, Ricardo, Freitas-Silva, Margarida, Medeiros, Rui

“…Ischaemic stroke (IS) and venous thromboembolism (VTE) are two forms of thromboembolism that, although distinct, seem to share numerous risk factors…”
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ABCB1 C1236T, G2677TA and C3435T genetic polymorphisms and antidepressant response phenotypes: results from a portuguese major depressive disorder cohort by Santos, Marlene, Lima, Luís, Carvalho, Serafim, Brandão, Andreia, Barroso, Fátima, Cruz, Agostinho, Medeiros, Rui

“…P-glycoprotein (P-GP) is a transporter molecule expressed on the apical surface of capillary endothelial cells of the Blood–Brain Barrier (BBB), whose activity…”
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Contribution of Endothelial Dysfunction to Cancer Susceptibility and Progression: A Comprehensive Narrative Review on the Genetic Risk Component by de Melo, Inês Guerra, Tavares, Valéria, Pereira, Deolinda, Medeiros, Rui

“…Venous thromboembolism (VTE) is a challenging clinical obstacle in oncological settings, marked by elevated incidence rates and resulting morbidity and…”
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Role of key TYMS polymorphisms on methotrexate therapeutic outcome in portuguese rheumatoid arthritis patients by Lima, Aurea, Seabra, Vítor, Bernardes, Miguel, Azevedo, Rita, Sousa, Hugo, Medeiros, Rui

“…Therapeutic outcome of rheumatoid arthritis (RA) patients treated with methotrexate (MTX) can be modulated by thymidylate synthase (TS) levels, which may be…”
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Thrombogenesis-associated genetic determinants as predictors of thromboembolism and prognosis in cervical cancer by Neto, Beatriz Vieira, Tavares, Valéria, da Silva, José Brito, Liz-Pimenta, Joana, Marques, Inês Soares, Carvalho, Luísa, Salgado, Lurdes, Pereira, Deolinda, Medeiros, Rui

“…Venous thromboembolism (VTE) is a leading cause of death among cancer patients. Khorana score (KS) is the most studied tool to predict cancer-related VTE,…”
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Renin-Angiotensin System in Lung Tumor and Microenvironment Interactions by Catarata, Maria Joana, Ribeiro, Ricardo, Oliveira, Maria José, Robalo Cordeiro, Carlos, Medeiros, Rui

“…The mechanistic involvement of the renin-angiotensin system (RAS) reaches beyond cardiovascular physiopathology. Recent knowledge pinpoints a pleiotropic role…”
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Antimicrobial Activity of Dimeric Flavonoids by Lopes, Inês, Campos, Carla, Medeiros, Rui, Cerqueira, Fátima

“…Distributed throughout the environment are various microorganisms such as bacteria, fungi, parasites, and viruses. Although many are part of the human…”
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The Impact of BDNF , NTRK2 , NGFR , CREB1 , GSK3B , AKT , MAPK1 , MTOR , PTEN , ARC, and SYN1 Genetic Polymorphisms in Antidepressant Treatment Response Phenotypes by Santos, Marlene, Lima, Luis, Carvalho, Serafim, Mota-Pereira, Jorge, Pimentel, Paulo, Maia, Dulce, Correia, Diana, Barroso, M Fátima, Gomes, Sofia, Cruz, Agostinho, Medeiros, Rui

“…This study aimed to investigate the influence of genetic variants in neuroplasticity-related genes on antidepressant treatment phenotypes. The BDNF-TrkB…”
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Connecting Gene Variation to Treatment Outcomes in Metastatic Castration-Resistant Prostate Adenocarcinoma: Insights into Second-Generation Androgen Receptor Axis-Targeted Therapies by Vaz-Ferreira, Ana, Tavares, Valéria, de Melo, Inês Guerra, Rodrigues, Patrícia Rafaela, Afonso, Ana, Maurício, Maria Joaquina, Medeiros, Rui

“…Prostate cancer (PC) is one of the most commonly diagnosed tumours among men. Second-generation androgen receptor axis-targeted (ARAT) agents, namely…”
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Genetic Variations in Prostaglandin E2 Pathway Identified as Susceptibility Biomarkers for Gastric Cancer in an Intermediate Risk European Country by Lopes, Catarina, Pereira, Carina, Farinha, Mónica, Medeiros, Rui, Dinis-Ribeiro, Mário

“…The cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) pathway exerts deleterious pleiotropic effects in inflammation-induced gastric carcinogenesis. We aimed to…”
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