Search Results - "MCVICAR, D. W"

Myeloid specific human CD33 is an inhibitory receptor with differential ITIM function in recruiting the phosphatases SHP-1 and SHP-2 by PAUL, S. P, TAYLOR, L. S, STANSBURY, E. K, MCVICAR, D. W

“…CD33 is a myeloid specific member of the sialic acid-binding receptor family and is expressed highly on myeloid progenitor cells but at much lower levels in…”
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Interaction of IL-2R$\beta$ and $\gamma_c$ Chains with Jak1 and Jak3: Implications for XSCID and XCID by Russell, Sarah M., Johnston, James A., Noguchi, Masayuki, Kawamura, Masaru, Bacon, Chris M., Friedmann, Michael, Berg, Maria, McVicar, Daniel W., Witthuhn, Bruce A., Silvennoinen, Olli, Goldman, Armond S., Schmalstieg, Frank C., Ihle, James N., O'Shea, John J., Leonard, Warren J.

“…Interleukin-2 (IL-2) signaling requires the dimerization of the IL-2 receptor $\beta$ (IL-2R$\beta$) and common $\gamma$ ($\gamma_c$) chains. Mutations of…”
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Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2 by Johnston, James A, Kawamura, Masaru, Kirken, Robert A, Chen, Yi-Qing, Blake, Trevor B, Shibuya, Kyoichi, Ortaldo, John R, McVicar, Daniel W, O'Shea, John J

“…Interleukin-2 is an autocrine growth factor for T cells which also activates other cells including B cells and natural killer cells. The subunits of the…”
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Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12 by Bacon, C M, McVicar, D W, Ortaldo, J R, Rees, R C, O'Shea, J J, Johnston, J A

“…Interleukin (IL-12) has many effects on the function of natural killer and T cells, and is important in the control of cell-mediated immunity. IL-2 and IL-12…”
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Alterations in Signal Transduction Molecules in T Lymphocytes from Tumor-Bearing Mice by Mizoguchi, Hiromoto, O'Shea, John J., Longo, Dan L., Loeffler, Cynthia M., McVicar, Daniel W., Ochoa, Augusto C.

“…Impaired immune responses occur frequently in cancer patients or in tumor-bearing mice, but the mechanisms of the tumor-induced immune defects remain poorly…”
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Interaction of a dengue virus NS1‐derived peptide with the inhibitory receptor KIR3DL1 on natural killer cells by Townsley, E., O'Connor, G., Cosgrove, C., Woda, M., Co, M., Thomas, S. J., Kalayanarooj, S., Yoon, I.‐K., Nisalak, A., Srikiatkhachorn, A., Green, S., Stephens, H. A. F., Gostick, E., Price, D. A., Carrington, M., Alter, G., McVicar, D. W., Rothman, A. L., Mathew, A.

“…Summary Killer immunoglobulin‐like receptors (KIRs) interact with human leucocyte antigen (HLA) class I ligands and play a key role in the regulation and…”
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Molecular Cloning of L-JAK, a Janus Family Protein-Tyrosine Kinase Expressed in Natural Killer Cells and Activated Leukocytes by Kawamura, Masaru, McVicar, Daniel W., Johnston, James A., Blake, Trevor B., Chen, Yi-Qing, Lal, Brajesh K., Lloyd, Andrew R., Kelvin, David J., Staples, J. Erin, Ortaldo, John R., O'Shea, John J.

“…Protein-tyrosine kinases (PTKs) are critical enzymes for receptor-mediated signaling in lymphocytes. Because natural killer (NK) cells are large granular…”
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Analysis of Ly49 gene transcripts in mature NK cells supports a role for the Pro1 element in gene activation, not gene expression by McCullen, M V, Li, H, Cam, M, Sen, S K, McVicar, D W, Anderson, S K

“…The variegated expression of murine Ly49 loci has been associated with the probabilistic behavior of an upstream promoter active in immature cells, the Pro1…”
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Activation of Human Peripheral Blood T Lymphocytes by Pharmacological Induction of Protein-Tyrosine Phosphorylation by O'Shea, John J., McVicar, Daniel W., Bailey, Trevor L., Burns, Chris, Smyth, Mark J.

“…Protein-tyrosine kinase and protein-tyrosine phosphatase (PTPase) activities are essential for T-cell antigen receptor-mediated signaling. To assess the…”
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Identification of RANTES receptors on human monocytic cells : competition for binding and desensitization by homologous chemotactic cytokines by JI MING WANG, MCVICAR, D. W, OPPENHEIM, J. J, KELVIN, D. J

“…RANTES (regulated on activation, normal T expressed and secreted) is a member of the chemotactic cytokine (chemokine) beta subfamily. High affinity receptors…”
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Regulation of JAK3 expression and activation in human B cells and B cell malignancies by Tortolani, PJ, Lal, BK, Riva, A, Johnston, JA, Chen, YQ, Reaman, GH, Beckwith, M, Longo, D, Ortaldo, JR, Bhatia, K

“…Members of the Janus family (JAK) of protein tyrosine kinases are critical enzymes in signaling pathways via hematopoietin receptors. We have cloned JAK3,…”
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Induction of DAP12 phosphorylation, calcium mobilization, and cytokine secretion by Ly49H by Gosselin, Pierre, Mason, Llewellyn H., Willette‐Brown, Jami, Ortaldo, John R., McVicar, Daniel W., Anderson, Stephen K.

“…The ability of several Ly49 family members to inhibit natural killer (NK) cell functions through recruitment of SHP‐1 phosphatase has been reported. In…”
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Thrombopoietin Induces Tyrosine Phosphorylation and Activation of the Janus Kinase, JAK2 by Tortolani, P.Justin, Johnston, James A., Bacon, Chris M., McVicar, Daniel W., Shimosaka, Akihiro, Linnekin, Diana, Longo, Dan L., O'Shea, John J.

“…Thrombopoietin (TPO) is a recently characterized growth and differentiation factor for megakaryocytes and platelets that exerts its effects via the receptor,…”
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Regulation of NK cells through the 80-kDa TNFR (CD120b) by Mason, A T, McVicar, D W, Smith, C A, Young, H A, Ware, C F, Ortaldo, J R

“…By using monoclonal antibody specific for tumor necrosis factor receptor80 (TNFR80) (CD120b) and TNFR60 (CD120a), we determined which receptor transduces the…”
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A role for protein tyrosine kinase activity in natural cytotoxicity as well as antibody-dependent cellular cytotoxicity. Effects of herbimycin A by O'Shea, JJ, McVicar, DW, Kuhns, DB, Ortaldo, JR

“…NK cells, CD3- large granular lymphocytes, have diverse means by which they lyse targets, including antibody-dependent cellular cytotoxicity. The low affinity…”
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Tyrosine Phosphorylation Disrupts Elongin Interaction and Accelerates SOCS3 Degradation by Haan, Serge, Ferguson, Paul, Sommer, Ulrike, Hiremath, Meena, McVicar, Daniel W., Heinrich, Peter C., Johnston, James A., Cacalano, Nicholas A.

“…The suppressors of cytokine signaling (SOCS) are negative feedback inhibitors of cytokine and growth factor-induced signal transduction. The C-terminal SOCS…”
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T cell activation via the disialoganglioside GD3: analysis of signal transduction by Ortaldo, John R., Mason, Anna T., Longo, Dan L., Beckwith, Margaret, Creekmore, Stephen P., McVicar, Daniel W.

“…The monoclonal antibody (mAb) R24 is a murine immunoglobulin G3 (IgG3) that reacts with the GD3 disialoganglioside present on melanoma cells as well as a…”
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Molecular cloning of lsk, a carboxyl-terminal src kinase (csk) related gene, expressed in leukocytes by McVicar, D W, Lal, B K, Lloyd, A, Kawamura, M, Chen, Y Q, Zhang, X, Staples, J E, Ortaldo, J R, O'Shea, J J

“…Regulation of the activity of src-family kinases is thought to occur, in part, through the phosphorylation of conserved carboxyl-terminal tyrosine residues…”
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Pathogen-Specific Loss of Host Resistance in Mice Lacking the IFN-γ -Inducible Gene IGTP by Taylor, Gregory A., Collazo, Carmen M., Yap, George S., Nguyen, Khuong, Gregorio, Theresa A., Taylor, Lynn S., Eagleson, Bryn, Secrest, Lisa, Southon, Eileen A., Reid, Susan W., Tessarollo, Lino, Bray, Mike, McVicar, Dan W., Komschlies, Kristin L., Young, Howard A., Biron, Christine A., Sher, Alan, George F. Vande Woude

“…interferon-γ (IFN-γ) is critical for defense against pathogens, but the molecules that mediate its antimicrobial responses are largely unknown. IGTP is the…”
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The ever-expanding Ly49 gene family: repertoire and signaling by Anderson, Stephen K., Ortaldo, John R., McVicar, Daniel W.

“…The mouse lectin‐related Ly49 family and the human killer cell Ig‐like receptor (KIR) family represent structurally distinct, yet functionally analogous, class…”
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