Search Results - "MCSHANE, Teresa M"

Updates on managing advanced breast cancer with palbociclib combination therapy by McShane, Teresa M., Wolfe, Thomas A., Ryan, Joanne C.

“…Background: The objective of this study was to review the pharmacology, efficacy, and safety of palbociclib, a first-in-class cyclin-dependent kinase 4/6…”
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Dynamic Contrast-Enhanced Magnetic Resonance Imaging As a Pharmacodynamic Measure of Response After Acute Dosing of AG-013736, an Oral Angiogenesis Inhibitor, in Patients With Advanced Solid Tumors: Results From a Phase I Study by LIU, Glenn, RUGO, Hope S, CHARNSANGAVEJ, Chusilp, PARK, John W, ASHTON, Edward A, STEINFELDT, Heidi M, PITHAVALA, Yazdi K, REICH, Steven D, HERBST, Roy S, WILDING, George, MCSHANE, Teresa M, EVELHOCH, Jeffrey L, NG, Chaan, JACKSON, Edward, KELCZ, Frederick, YEH, Benjamin M, LEE, Fred T

“…Identifying suitable markers of biologic activity is important when assessing novel compounds such as angiogenesis inhibitors to optimize the dose and schedule…”
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Reproducibility of Perfusion Parameters in Dynamic Contrast-Enhanced MRI of Lung and Liver Tumors: Effect on Estimates of Patient Sample Size in Clinical Trials and on Individual Patient Responses by Ng, Chaan S, Raunig, David L, Jackson, Edward F, Ashton, Edward A, Kelcz, Frederick, Kim, Kevin B, Kurzrock, Razelle, McShane, Teresa M

“…Dynamic contrast-enhanced MRI (DCE-MRI) is a potentially useful noninvasive technique for assessing tissue perfusion, particularly in the context of solid…”
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AG-013736, a novel inhibitor of VEGF receptor tyrosine kinases, inhibits breast cancer growth and decreases vascular permeability as detected by dynamic contrast-enhanced magnetic resonance imaging by Wilmes, Lisa J, Pallavicini, Maria G, Fleming, Lisa M, Gibbs, Jessica, Wang, Donghui, Li, Ka-Loh, Partridge, Savannah C, Henry, Roland G, Shalinsky, David R, Hu-Lowe, Dana, Park, John W, McShane, Teresa M, Lu, Ying, Brasch, Robert C, Hylton, Nola M

“…Abstract Dynamic contrast-enhanced MRI (DCE-MRI) was used to noninvasively evaluate the effects of AG-03736, a novel inhibitor of vascular endothelial growth…”
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Development and Use of Biomarkers in Oncology Drug Development by Floyd, Eugenia, Mcshane, Teresa M.

“…Successful development and use of biomarkers will improve the productivity of oncology drug development. Recognition of the importance of biomarkers for…”
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Heterogeneity in the angiogenic response of a BT474 human breast cancer to a novel vascular endothelial growth factor-receptor tyrosine kinase inhibitor: Assessment by voxel analysis of dynamic contrast-enhanced MRI by Li, Ka-Loh, Wilmes, Lisa J., Henry, Roland G., Pallavicini, Maria G., Park, John W., Hu-Lowe, Dana D., McShane, Teresa M., Shalinsky, David R., Fu, Y-J, Brasch, Robert C., Hylton, Nola M.

“…Purpose To investigate the heterogeneity in the angiogenic response of a human breast cancer xenograft to a novel vascular endothelial growth factor…”
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Effects of Lifelong Moderate Caloric Restriction on Levels of Neuropeptide Y, Proopiomelanocortin, and Galanin mRNA by McShane, Teresa M., Wilson, Melinda E., Wise, Phyllis M.

“…We are interested in how neuropeptides that regulate both food intake and reproductive function change with age and how life-prolonging moderate caloric…”
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Influence of Food Restriction on Neuropeptide-Y, Proopiomelanocortin, and Luteinizing Hormone-Releasing Hormone Gene Expression in Sheep Hypothalami1 by McShane, Teresa M., Petersen, Sandra L., McCrone, Sue, Keisler, D. H.

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Life-long moderate caloric restriction prolongs reproductive life span in rats without interrupting estrous cyclicity: effects on the gonadotropin-releasing hormone/luteinizing hormone axis by McShane, T.M. (University of Kentucky College of Medicine, Lexington, KY.), Wise, P.M

“…Restricting food intake to 60% that of ad libitum-fed rats results in an extended life span, reduced incidence of age-related diseases, and delayed…”
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Effects of Dietary Energy on Ovarian Function, Estrogen Suppression of Luteinizing Hormone and Follicle-Stimulating Hormone, and Competency of the Gonadotropin Surge1 by McShane, Teresa M., Keisler, D. H.

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Neuropeptide-Y neurons projectioning to the medial septum-diagonal band do not have access to fenestrated capillaries in the rat brain by McShane, T M, Wise, P M, Jennes, L

“…The aims of this study were to (1) determine the localization of neuropeptide-Y (NPY)-containing perikarya which project to the medial septum-diagonal band…”
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Central Actions of Neuropeptide-Y May Provide a Neuromodulatory Link between Nutrition and Reproduction1 by Mcshane, Teresa M., May, Tammy, Miner, Jess L., Keisler, D. H.

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