Search Results - "MCPHERSON, David D"

Liposome-Based Carriers for CRISPR Genome Editing by Yin, Xing, Harmancey, Romain, McPherson, David D, Kim, Hyunggun, Huang, Shao-Ling

“…The CRISPR-based genome editing technology, known as clustered regularly interspaced short palindromic repeats (CRISPR), has sparked renewed interest in gene…”
Get full text

A Two-Step Transcriptome Analysis of the Human Heart Reveals Broad and Disease-Responsive Expression of Ectopic Olfactory Receptors by Ashraf, Sadia, Frazier, O. Howard, Carranza, Sylvia, McPherson, David D, Taegtmeyer, Heinrich, Harmancey, Romain

“…G-protein-coupled receptors (GPCRs) are critical regulators of cardiac physiology and a key therapeutic target for the treatment of heart disease. Ectopic…”
Get full text

In vitro characterization of sonothrombolysis and echocontrast agents to treat ischemic stroke by Shekhar, Himanshu, Kleven, Robert T., Peng, Tao, Palaniappan, Arunkumar, Karani, Kunal B., Huang, Shaoling, McPherson, David D., Holland, Christy K.

“…The development of adjuvant techniques to improve thrombolytic efficacy is important for advancing ischemic stroke therapy. We characterized octafluoropropane…”
Get full text

Personalized Computational Modeling of Mitral Valve Prolapse: Virtual Leaflet Resection by Rim, Yonghoon, Choi, Ahnryul, McPherson, David D, Kim, Hyunggun

“…Posterior leaflet prolapse following chordal elongation or rupture is one of the primary valvular diseases in patients with degenerative mitral valves (MVs)…”
Get full text

Initiating and imaging cavitation from infused echo contrast agents through the EkoSonic catheter by Kennedy, Sonya R., Lafond, Maxime, Haworth, Kevin J., Escudero, Daniel Suarez, Ionascu, Dan, Frierson, Brion, Huang, Shaoling, Klegerman, Melvin E., Peng, Tao, McPherson, David D., Genstler, Curtis, Holland, Christy K.

“…Ultrasound-enhanced delivery of therapeutic-loaded echogenic liposomes is under development for vascular applications using the EkoSonic Endovascular System…”
Get full text

Biomechanical Evaluation of Mitral Valve Repair: Virtual Chordal Transposition to Restore Anterior Leaflet Prolapse by Jeong, Soohwan, Kim, Seong-Min, Hong, Woojae, Ko, Minsung, McPherson, David D, Kim, Hyunggun

“…Surgical management of an anterior leaflet prolapse remains comparatively challenging and has led to the lack of any firmly established standard repair…”
Get full text

Broadband Attenuation Measurements of Phospholipid-Shelled Ultrasound Contrast Agents by Raymond, Jason L, Haworth, Kevin J, Bader, Kenneth B, Radhakrishnan, Kirthi, Griffin, Joseph K, Huang, Shao-Ling, McPherson, David D, Holland, Christy K

“…Abstract The aim of this study was to characterize the frequency-dependent acoustic attenuation of three phospholipid-shelled ultrasound contrast agents…”
Get full text

Co-Delivery of Therapeutics and Bioactive Gas Using a Novel Liposomal Platform for Enhanced Treatment of Acute Arterial Injury by Huang, Shao-Ling, Moody, Melanie R, Yin, Xing, McPherson, David D, Kim, Hyunggun

“…Atherosclerosis is a complex, multi-stage disease characterized by pathological changes across the vascular wall. Endothelial dysfunction, inflammation,…”
Get full text

Frequency of Nonalcoholic Fatty Liver Disease and Subclinical Atherosclerosis Among Young Mexican Americans by Gill, Clarence, MD, Vatcheva, Kristina P., PhD, Pan, Jen-Jung, MD, Smulevitz, Beverly, BS, McPherson, David D., MD, Fallon, Michael, MD, McCormick, Joseph B., MD, Fisher-Hoch, Susan P., MD, Laing, Susan T., MD

“…Abstract Non-alcoholic fatty liver disease (NAFLD) is considered the hepatic manifestation of the metabolic syndrome, whose criteria are risk factors for…”
Get full text

Efficient Gene Editing for Heart Disease via ELIP-Based CRISPR Delivery System by Yin, Xing, Harmancey, Romain, Frierson, Brion, Wu, Jean G, Moody, Melanie R, McPherson, David D, Huang, Shao-Ling

“…Liposomes as carriers for CRISPR/Cas9 complexes represent an attractive approach for cardiovascular gene therapy. A critical barrier to this approach remains…”
Get full text

Nitric Oxide-Loaded Echogenic Liposomes for Nitric Oxide Delivery and Inhibition of Intimal Hyperplasia by Huang, Shao-Ling, MD, PhD, Kee, Patrick H., MD, PhD, Kim, Hyunggun, PhD, Moody, Melanie R., MS, Chrzanowski, Stephen M, MacDonald, Robert C., PhD, McPherson, David D., MD

“…Objectives We sought to develop a new bioactive gas-delivery method by the use of echogenic liposomes (ELIP) as the gas carrier. Background Nitric oxide (NO)…”
Get full text

Enhanced Cerebroprotection of Xenon-Loaded Liposomes in Combination with rtPA Thrombolysis for Embolic Ischemic Stroke by Peng, Tao, Booher, Keith, Moody, Melanie R, Yin, Xing, Aronowski, Jaroslaw, McPherson, David D, Savitz, Sean I, Kim, Hyunggun, Huang, Shao-Ling

“…Xenon (Xe) has shown great potential as a stroke treatment due to its exceptional ability to protect brain tissue without inducing side effects. We have…”
Get full text

Improving transcatheter aortic valve interventional predictability via fluid-structure interaction modelling using patient-specific anatomy by Govindarajan, Vijay, Kolanjiyil, Arun, Johnson, Nils P, Kim, Hyunggun, Chandran, Krishnan B, McPherson, David D

“…Transcatheter aortic valve replacement (TAVR) is now a standard treatment for high-surgical-risk patients with severe aortic valve stenosis. TAVR is being…”
Get full text

Storage Stability of Atheroglitatide, an Echogenic Liposomal Formulation of Pioglitazone Targeted to Advanced Atheroma with a Fibrin-Binding Peptide by Klegerman, Melvin E, Peng, Tao, Huang, Shao-Ling, Frierson, Brion, Moody, Melanie R, Kim, Hyunggun, McPherson, David D

“…We have conducted a stability study of a complex liposomal pharmaceutical product, Atheroglitatide (AGT), stored at three temperatures, 4, 24, and 37 °C, for…”
Get full text

Simultaneous submission of seven CTSA proposals: UM1, K12, R25, T32-predoctoral, T32-postdoctoral, and RC2: strategies, evaluation, and lessons learned by Lema, Carolina, Cheng, Kwai Wa, Anderson, Delanderia M, Miller, Charles C, Karp, Daniel D, McPherson, David D, Kolar, Satya Sree N

“…Translation is the process of turning observations in the research laboratory, clinic, and community into interventions that improve people's health. The…”
Get full text

Association of Visceral Adipose Tissue and Subclinical Atherosclerosis in US-Born Mexican Americans but not First Generation Immigrants by Gill, Clarence, Lee, Miryoung, Vatcheva, Kristina P, Rianon, Nahid, Smulevitz, Beverly, McPherson, David D, McCormick, Joseph B, Fisher-Hoch, Susan P, Laing, Susan T

“…Background Excess visceral adipose tissue (VAT) is a primary driver for the cardiometabolic complications of obesity; VAT-associated cardiovascular disease…”
Get full text

Ultrasound-Enhanced Thrombolytic Effect of Tissue Plasminogen Activator–Loaded Echogenic Liposomes in an In Vivo Rabbit Aorta Thrombus Model—Brief Report by Laing, Susan T, Moody, Melanie, Smulevitz, Beverly, Kim, Hyunggun, Kee, Patrick, Huang, Shaoling, Holland, Christy K, McPherson, David D

“…OBJECTIVE—Ultrasound enhances thrombolysis when combined with a thrombolytic and a contrast agent. This study aimed to evaluate the thrombolytic effect of our…”
Get full text

Clinical Status and Cardiovascular Risk Profile of Adults with a History of Juvenile Dermatomyositis by Eimer, Micah J., MD, Brickman, Wendy J., MD, Seshadri, Roopa, PhD, Ramsey-Goldman, Rosalind, MD, McPherson, David D., MD, Smulevitz, Beverly, BS, Stone, Neil J., MD, Pachman, Lauren M., MD

“…Objective A pilot study of adults who had onset of juvenile dermatomyositis (JDM) in childhood, before current therapeutic approaches, to characterize JDM…”
Get full text

Ultrasound-Triggered Release of Recombinant Tissue-Type Plasminogen Activator from Echogenic Liposomes by Smith, Denise A.B, Vaidya, Sampada S, Kopechek, Jonathan A, Huang, Shao-Ling, Klegerman, Melvin E, McPherson, David D, Holland, Christy K

“…Abstract Echogenic liposomes (ELIP) were developed as ultrasound-triggered targeted drug or gene delivery vehicles ( Lanza et al. 1997 ; Huang et al. 2001 )…”
Get full text

A Method to Co-Encapsulate Gas and Drugs in Liposomes for Ultrasound-Controlled Drug Delivery by Huang, Shao-Ling, McPherson, David D, MacDonald, Robert C

“…Abstract We describe a novel method for the facile production of gas-containing liposomes with simultaneous drug encapsulation. Liposomes of phospholipid and…”
Get full text