Search Results - "MCPHAIL, Linda C."

Phospholipase D2-derived phosphatidic acid binds to and activates ribosomal p70 S6 kinase independently of mTOR by Lehman, Nicholas, Ledford, Bill, Di Fulvio, Mauricio, Frondorf, Kathleen, McPhail, Linda C, Gomez-Cambronero, Julian

“…The product of phospholipase D (PLD) enzymatic action in cell membranes, phosphatidic acid (PA), regulates kinases implicated in NADPH oxidase activation, as…”
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Phorbol myristate acetate induces neutrophil NADPH-oxidase activity by two separate signal transduction pathways: dependent or independent of phosphatidylinositol 3-kinase by Karlsson, Anna, Nixon, Jennifer B., McPhail, Linda C.

“…The neutrophil NADPH‐oxidase can be activated by protein kinase C (PKC) agonists such as phorbol myristate acetate (PMA), resulting in superoxide anion…”
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Creation of a genetic system for analysis of the phagocyte respiratory burst: high-level reconstitution of the NADPH oxidase in a nonhematopoietic system by Price, Marianne O., McPhail, Linda C., Lambeth, J. David, Han, Chang-Hoon, Knaus, Ulla G., Dinauer, Mary C.

“…The phagocyte nicotinamide adenine dinucleotide phosphate (reduced form) (NADPH) oxidase was functionally reconstituted in monkey kidney COS-7 cells by…”
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Phosphorylation of p22phox on Threonine 147 Enhances NADPH Oxidase Activity by Promoting p47phox Binding by Lewis, Eric M., Sergeant, Susan, Ledford, Bill, Stull, Natalie, Dinauer, Mary C., McPhail, Linda C.

“…NADPH oxidase comprises both cytosolic and membrane-bound subunits, which, when assembled and activated, initiate the transfer of electrons from NADPH to…”
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Mutations in the PX−SH3A Linker of p47phox Decouple PI(3,4)P2 Binding from NADPH Oxidase Activation by SHEN, Kai, SERGEANT, Susan, HANTGAN, Roy R., MCPHAIL, Linda C., HORITA, David A.

“…NADPH oxidase is essential in the human innate immune response. p47 (phox), a cytosolic NADPH oxidase component, plays a regulatory role in the activation of…”
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Characterization of Surface Structure and p47phox SH3 Domain-Mediated Conformational Changes for Human Neutrophil Flavocytochrome b by TAYLOR, Ross M., LORD, Connie I., RIESSELMAN, Marcia H., GRIPENTROG, Jeannie M., LETO, Thomas L., MCPHAIL, Linda C., BERDICHEVSKY, Yevgeny, PICK, Edgar, JESAITIS, Algirdas J.

“…The heterodimeric, integral membrane protein flavocytochrome b (Cyt b) is the catalytic core of the phagocyte NADPH oxidase and generates superoxide which…”
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Anionic amphiphile and phospholipid-induced conformational changes in human neutrophil flavocytochrome b observed by fluorescence resonance energy transfer by Taylor, Ross M, Foubert, Thomas R, Burritt, James B, Baniulis, Danas, McPhail, Linda C, Jesaitis, Algirdas J

“…The integral membrane protein flavocytochrome b (Cyt b) comprises the catalytic core of the human phagocyte NADPH oxidase complex and serves to initiate a…”
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The NOXO1β PX Domain Preferentially Targets PtdIns(4,5)P2 and PtdIns(3,4,5)P3 by Davis, Nicole Y., McPhail, Linda C., Horita, David A.

“…NOXO1β [NOXO1 (Nox organizer 1) β] is a cytosolic protein that, in conjunction with NOXA1 (Nox activator 1), regulates generation of reactive oxygen species by…”
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Phosphorylation of p22 on Threonine 147 Enhances NADPH Oxidase Activity by Promoting p47 Binding by Lewis, Eric M., Sergeant, Susan, Ledford, Bill, Stull, Natalie, Dinauer, Mary C., McPhail, Linda C.

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Membrane Targeting by APPL1 and APPL2: Dynamic Scaffolds that Oligomerize and Bind Phosphoinositides by Chial, Heidi J, Wu, Ruping, Ustach, Carolyn V, McPhail, Linda C, Mobley, William C, Chen, Yong Q

“…Human adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (APPL1) and adaptor protein, phosphotyrosine interaction, PH…”
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X-linked chronic granulomatous disease secondary to skewed X chromosome inactivation in a female with a novel CYBB mutation and late presentation by Lewis, Eric M, Singla, Manav, Sergeant, Susan, Koty, Patrick P, McPhail, Linda C

“…Abstract Chronic granulomatous disease (CGD) is characterized by defects in the superoxide producing enzyme NADPH oxidase causing phagocytes to improperly…”
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Angeli's salt counteracts the vasoactive effects of elevated plasma hemoglobin by Solomon, Steven B., Bellavia, Landon, Sweeney, Daniel, Piknova, Barbora, Perlegas, Andreas, Helms, Christine C., Ferreyra, Gabriela A., Bruce King, S., Raat, Nicolaas J.H., Kern, Steven J., Sun, Junfeng, McPhail, Linda C., Schechter, Alan N., Natanson, Charles, Gladwin, Mark T., Kim-Shapiro, Daniel B.

“…Plasma hemoglobin (Hb) released during intravascular hemolysis has been associated with numerous deleterious effects that may stem from increased nitric oxide…”
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Effect of splice-site mutations in X-linked chronic granulomatous disease by McPhail, Linda C

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Measurement of phospholipid metabolism in intact neutrophils by Sergeant, Susan, McPhail, Linda C

“…Phospholipid metabolizing enzymes are important participants in neutrophil signal transduction pathways. The methods discussed herein describe assays for…”
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Phosphatidic Acid and Diacylglycerol Directly Activate NADPH Oxidase by Interacting with Enzyme Components by Palicz, Anita, Foubert, Thomas R., Jesaitis, Algirdas J., Marodi, Laszlo, McPhail, Linda C.

“…The enzyme NADPH oxidase is regulated by phospholipase D in intact neutrophils and is activated by phosphatidic acid (PA) plus diacylglycerol (DG) in cell-free…”
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Protein Kinase C (PKC) Isoforms Translocate to Triton-Insoluble Fractions in Stimulated Human Neutrophils: Correlation of Conventional PKC with Activation of NADPH Oxidase by Nixon, Jennifer B, McPhail, Linda C

“…The responses of human neutrophils (PMN) involve reorganization and phosphorylation of cytoskeletal components. We investigated the translocation of protein…”
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Measurement of phospholipid metabolism in intact neutrophils by Sergeant, Susan, McPhail, Linda C

“…Phospholipid-metabolizing enzymes are important participants in neutrophil signal transduction pathways. The methods discussed herein describe assays for…”
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Backbone 1H, 15N, and 13C resonance assignments for the NOXO1β PX domain by Davis, Nicole Y., McPhail, Linda C., Horita, David A.

“…NOXO1 (Nox Organizer 1) is a homolog of the NAPDH oxidase protein p47 phox . NADPH oxidases transfer electrons from NADPH to molecular oxygen, generating the…”
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Characterization of Surface Structure and p47 phox SH3 Domain-Mediated Conformational Changes for Human Neutrophil Flavocytochrome b by Taylor, Ross M, Lord, Connie I, Riesselman, Marcia H, Gripentrog, Jeannie M, Leto, Thomas L, McPhail, Linda C, Berdichevsky, Yevgeny, Pick, Edgar, Jesaitis, Algirdas J

“…The heterodimeric, integral membrane protein flavocytochrome b (Cyt b) is the catalytic core of the phagocyte NADPH oxidase and generates superoxide which…”
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Cell-Free Activation of Neutrophil NADPH Oxidase by a Phosphatidic Acid-Regulated Protein Kinase by McPhail, Linda C., Qualliotine-Mann, Diane, Waite, Kristin A.

“…The phosphorylation-dependent mechanisms regulating activation of the human neutrophil respiratory-burst enzyme, NADPH oxidase, have not been elucidated. We…”
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