Search Results - "MCNEILLY, ALISON D."

Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status by Cameron, Amy R, Morrison, Vicky L, Levin, Daniel, Mohan, Mohapradeep, Forteath, Calum, Beall, Craig, McNeilly, Alison D, Balfour, David J.K, Savinko, Terhi, Wong, Aaron K.F, Viollet, Benoit, Sakamoto, Kei, Fagerholm, Susanna C, Foretz, Marc, Lang, Chim C, Rena, Graham

“…RATIONALE:The diabetes mellitus drug metformin is under investigation in cardiovascular disease, but the molecular mechanisms underlying possible benefits are…”
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Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2) by Sharma, Ritu S, Harrison, David J, Kisielewski, Dorothy, Cassidy, Diane M, McNeilly, Alison D, Gallagher, Jennifer R, Walsh, Shaun V, Honda, Tadashi, McCrimmon, Rory J, Dinkova-Kostova, Albena T, Ashford, Michael L.J, Dillon, John F, Hayes, John D

“…Background & Aims Nonalcoholic steatohepatitis (NASH) is associated with oxidative stress. We surmised that pharmacologic activation of NF-E2 p45-related…”
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Neurodevelopmental defects in a mouse model of O-GlcNAc transferase intellectual disability by Authier, Florence, Ondruskova, Nina, Ferenbach, Andrew T, McNeilly, Alison D, van Aalten, Daan M F

“…The addition of O-linked β-N-acetylglucosamine (O-GlcNAc) to proteins (referred to as O-GlcNAcylation) is a modification that is crucial for vertebrate…”
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Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice by Meakin, Paul J, Harper, Alex J, Hamilton, D Lee, Gallagher, Jennifer, McNeilly, Alison D, Burgess, Laura A, Vaanholt, Lobke M, Bannon, Kirsten A, Latcham, Judy, Hussain, Ishrut, Speakman, John R, Howlett, David R, Ashford, Michael L J

“…Insulin resistance and impaired glucose homoeostasis are important indicators of Type 2 diabetes and are early risk factors of AD (Alzheimer's disease). An…”
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Inhibition of glycogen synthase kinase-3 enhances NRF2 protein stability, nuclear localisation and target gene transcription in pancreatic beta cells by Patibandla, Chinmai, van Aalten, Lidy, Dinkova-Kostova, Albena T., Honda, Tadashi, Cuadrado, Antonio, Fernández-Ginés, Raquel, McNeilly, Alison D., Hayes, John D., Cantley, James, Sutherland, Calum

“…Accumulation of reactive oxygen species (i.e., oxidative stress) is a leading cause of beta cell dysfunction and apoptosis in diabetes. NRF2 (NF-E2 p45-related…”
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The genetic association of the transcription factor NPAT with glycemic response to metformin involves regulation of fuel selection by Chen, Changwei, Gallagher, Jennifer R, Tarlton, Jamie, van Aalten, Lidy, Bray, Susan E, Ashford, Michael L J, McCrimmon, Rory J, Pearson, Ewan R, McNeilly, Alison D, Sutherland, Calum

“…The biguanide, metformin, is the first-choice therapeutic agent for type-2 diabetes, although the mechanisms that underpin metformin clinical efficacy remain…”
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Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice by Meakin, Paul J., Jalicy, Susan M., Montagut, Gemma, Allsop, David J. P., Cavellini, Daniella L., Irvine, Stuart W., McGinley, Christopher, Liddell, Mary K., McNeilly, Alison D., Parmionova, Karolina, Liu, Yu-Ru, Bailey, Charlotte L. S., Dale, J. Kim, Heisler, Lora K., McCrimmon, Rory J., Ashford, Michael L. J.

“…Obesity places an enormous medical and economic burden on society. The principal driver appears to be central leptin resistance with hyperleptinemia…”
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Metformin increases the uptake of glucose into the gut from the circulation in high-fat diet-fed male mice, which is enhanced by a reduction in whole-body Slc2a2 expression by Morrice, Nicola, Vainio, Susanne, Mikkola, Kirsi, van Aalten, Lidy, Gallagher, Jennifer R., Ashford, Michael L.J., McNeilly, Alison D., McCrimmon, Rory J., Grosfeld, Alexandra, Serradas, Patricia, Koffert, Jukka, Pearson, Ewan R., Nuutila, Pirjo, Sutherland, Calum

“…Metformin is the first line therapy recommended for type 2 diabetes. However, the precise mechanism of action remains unclear and up to a quarter of patients…”
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Central deficiency of IL-6Ra in mice impairs glucose-stimulated insulin secretion by McNeilly, Alison D., Yianakas, Adonis, Gallagher, Jennifer G., Tarlton, Jamie, Ashford, Michael LJ, McCrimmon, Rory J.

“…IL-6 is an important contributor to glucose and energy homeostasis through changes in whole-body glucose disposal, insulin sensitivity, food intake and energy…”
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Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice by Muha, Villo, Williamson, Ritchie, Hills, Rachel, McNeilly, Alison D, McWilliams, Thomas G, Alonso, Jana, Schimpl, Marianne, Leney, Aneika C, Heck, Albert J R, Sutherland, Calum, Read, Kevin D, McCrimmon, Rory J, Brooks, Simon P, van Aalten, Daan M F

“…O-GlcNAcylation is an abundant post-translational modification in the nervous system, linked to both neurodevelopmental and neurodegenerative disease. However,…”
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High‐intensity training as a novel treatment for impaired awareness of hypoglycaemia in type 1 diabetes [HIT4HYPOS]: Protocol for a randomized parallel‐group study by Farrell, Catriona M., McNeilly, Alison D., West, Daniel, McCrimmon, Rory J.

“…Aim This pilot study aimed to investigate whether a 4‐week programme of intermittent high‐intensity training (HIT) will improve counterregulatory responses and…”
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Impaired hypoglycaemia awareness in type 1 diabetes: lessons from the lab by McNeilly, Alison D., McCrimmon, Rory J.

“…Hypoglycaemia remains the most common metabolic adverse effect of insulin and sulfonylurea therapy in diabetes. Repeated exposure to hypoglycaemia leads to a…”
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243-LB: C5a Receptor (C5aR1) Antagonism Ameliorates Saturated Fatty Acid–Induced Mitochondrial Dysfunction in Skeletal Muscle Cells by SHAH, DINESH S., MCNEILLY, ALISON D., MCCRIMMON, RORY J., HUNDAL, HARI

“…The complement system is an integral component of the innate immune response and plays a vital role in adaptive immunity. Activation of the system produces…”
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Hypoglycaemia: Still the main drawback of insulin 100 years on: “From man to mouse” by Merchant, Heather J., McNeilly, Alison D.

“…One hundred years on from the initial discovery of insulin, we take this opportunity to reflect on the scientific discoveries that have improved so many lives…”
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Is high‐frequency ultrasound a useful process to add value to out of specification strawberries, raspberries and blackberries industrially? by Hooper, Matthew, McNeilly, Alison D., Schaschke, Carl, Wilkin, Jonathan D.

“…Summary Bioactive ingredients can be extracted from surplus soft fruits to add value to them as a fortification ingredient in many new products…”
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The C5aR1 complement receptor: A novel immunomodulator of insulin action in skeletal muscle by Shah, Dinesh S, McNeilly, Alison D, McCrimmon, Rory J, Hundal, Harinder S

“…The complement system constitutes an integral component of the innate immune system and plays a critical role in adaptive immunity. Activation of this system…”
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Correction: Cold-induced dishabituation in rodents exposed to recurrent hypoglycaemia by Vickneson, Keeran, Blackburn, Jessica, Gallagher, Jennifer R., Evans, Mark L., de Galan, Bastiaan E., Pedersen-Bjergaard, Ulrik, Thorens, Bernard, McNeilly, Alison D., McCrimmon, Rory J.

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Experimental Models of Impaired Hypoglycaemia-Associated Counter-Regulation by Sankar, Adhithya, Khodai, Tansi, McNeilly, Alison D., McCrimmon, Rory J., Luckman, Simon M.

“…Impaired awareness of hypoglycaemia (IAH) affects around a quarter of patients with diabetes who receive insulin treatment. This condition is characterised by…”
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Real-time Continuous Glucose Monitoring During a Hyperinsulinemic-Hypoglycemic Clamp Significantly Underestimates the Degree of Hypoglycemia by Farrell, Catriona M, McNeilly, Alison D, Hapca, Simona M, McCrimmon, Rory J

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1837-P: Central IL-6 Receptor Deficiency Impairs Pancreatic Insulin Secretion by MCNEILLY, ALISON D., GALLAGHER, JENNIFER, MCCRIMMON, RORY J.

“…Inflammation has become a major mechanism linking obesity to type 2 diabetes (T2D). The pleiotropic cytokine, Interleukin 6 (IL-6) is pro-inflammatory and…”
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