Search Results - "MCLEAN, W"

One Remarkable Molecule: Filaggrin by Brown, Sara J., Irwin McLean, W.H.

“…The discovery, in 2006, that loss-of-function mutations in the filaggrin (FLG) gene are the cause of ichthyosis vulgaris—the most common disorder of…”
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Filaggrin Mutations Associated with Skin and Allergic Diseases by Irvine, Alan D, McLean, W.H. Irwin, Leung, Donald Y.M

“…Mutations in the filaggrin gene are associated with a broad range of skin and allergic diseases. The biology of this molecule and the role of mutations in its…”
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Levels of filaggrin degradation products are influenced by both filaggrin genotype and atopic dermatitis severity by Kezic, S., O’Regan, G. M., Yau, N., Sandilands, A., Chen, H., Campbell, L. E., Kroboth, K., Watson, R., Rowland, M., Irwin McLean, W. H., Irvine, A. D.

“…To cite this article: Kezic S, O’Regan GM, Yau N, Sandilands A, Chen H, Campbell LE, Kroboth K, Watson R, Rowland M, Irwin McLean WH, Irvine AD. Levels of…”
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Clumping Factor B Promotes Adherence of Staphylococcus aureus to Corneocytes in Atopic Dermatitis by Fleury, Orla M, McAleer, Maeve A, Feuillie, Cécile, Formosa-Dague, Cécile, Sansevere, Emily, Bennett, Désirée E, Towell, Aisling M, McLean, W H Irwin, Kezic, Sanja, Robinson, D Ashley, Fallon, Padraic G, Foster, Timothy J, Dufrêne, Yves F, Irvine, Alan D, Geoghegan, Joan A

“…skin infection is a frequent and recurrent problem in children with the common inflammatory skin disease atopic dermatitis (AD). colonizes the skin of the…”
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Filaggrin failure - from ichthyosis vulgaris to atopic eczema and beyond by McLean, W.H.I.

“…Summary The main proteinaceous component of the keratohyalin granules within the granular layer keratinocytes of the epidermis is the giant, repetitive…”
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Skin microbiome before development of atopic dermatitis: Early colonization with commensal staphylococci at 2 months is associated with a lower risk of atopic dermatitis at 1 year by Kennedy, Elizabeth A., BS, Connolly, Jennifer, MSc, Hourihane, Jonathan O'B., DM, Fallon, Padraic G., PhD, McLean, W.H. Irwin, DSc, FRS, Murray, Deirdre, PhD, Jo, Jay-Hyun, PhD, Segre, Julia A., PhD, Kong, Heidi H., MD, MHSc, Irvine, Alan D., MD, DSc

“…Background Disease flares of established atopic dermatitis (AD) are generally associated with a low-diversity skin microbiota and Staphylococcus aureus…”
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Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention by Simpson, Eric L., MD, MCR, Chalmers, Joanne R., PhD, Hanifin, Jon M., MD, Thomas, Kim S., PhD, Cork, Michael J., PhD, FRCP, McLean, W.H. Irwin, FRSE, FMedSci, Brown, Sara J., MRCP, MD, Chen, Zunqiu, MS, Chen, Yiyi, PhD, Williams, Hywel C., DSc, FMedSci

“…Background Atopic dermatitis (atopic eczema) is a chronic inflammatory skin disease that has reached epidemic proportions in children worldwide and is…”
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Filaggrin in the frontline: role in skin barrier function and disease by Sandilands, Aileen, Sutherland, Calum, Irvine, Alan D, McLean, W.H. Irwin

“…Recently, loss-of-function mutations in FLG, the human gene encoding profilaggrin and filaggrin, have been identified as the cause of the common skin condition…”
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A lack of premature termination codon read-through efficacy of PTC124 (Ataluren) in a diverse array of reporter assays by McElroy, Stuart P, Nomura, Toshifumi, Torrie, Leah S, Warbrick, Emma, Gartner, Ulrike, Wood, Gavin, McLean, W H Irwin

“…The drug molecule PTC124 (Ataluren) has been described as a read-through agent, capable of suppressing premature termination codons (PTCs) and restoring…”
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Atopic dermatitis is associated with an increased risk for rheumatoid arthritis and inflammatory bowel disease, and a decreased risk for type 1 diabetes by Schmitt, Jochen, MD, MPH, Schwarz, Kristin, MSc, Baurecht, Hansjörg, MSc, Hotze, Melanie, MSc, Fölster-Holst, Regina, MD, Rodríguez, Elke, PhD, Lee, Young A.E., MD, Franke, Andre, PhD, Degenhardt, Frauke, MSc, Lieb, Wolfgang, PhD, Gieger, Christian, PhD, Kabesch, Michael, MD, Nöthen, Markus M., MD, Irvine, Alan D., MD, McLean, W.H. Irwin, PhD, Deckert, Stefanie, MPH, Stephan, Victoria, Schwarz, Peter, MD, Aringer, Martin, MD, Novak, Natalija, MD, Weidinger, Stephan, MD, MaHM

“…Background Atopic dermatitis (AD) is characterized by epidermal barrier failure and immune-mediated inflammation. Evidence on AD as a potential risk factor for…”
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Atopic Dermatitis and Disease Severity Are the Main Risk Factors for Food Sensitization in Exclusively Breastfed Infants by Flohr, Carsten, Perkin, Michael, Logan, Kirsty, Marrs, Tom, Radulovic, Suzana, Campbell, Linda E., MacCallum, Stephanie F., Irwin McLean, W.H., Lack, Gideon

“…Filaggrin (FLG) loss-of-function skin barrier gene mutations are associated with atopic dermatitis (AD) and transepidermal water loss (TEWL). We investigated…”
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Keratin disorders: from gene to therapy by IRWIN MCLEAN, W. H, TARA MOORE, C. B

“…The term 'keratin' is generally accepted to refer to the epithelial keratins of soft and hard epithelial tissues such as: skin, cornea, hair and nail. Since…”
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Skin barrier dysfunction measured by transepidermal water loss at 2 days and 2 months predates and predicts atopic dermatitis at 1 year by Kelleher, Maeve, MB, Dunn-Galvin, Audrey, PhD, Hourihane, Jonathan O'B., DM, Murray, Deirdre, MD, Campbell, Linda E., BSc, McLean, W.H. Irwin, DSc, FRS, Irvine, Alan D., MD

“…Background Loss-of-function mutations in the skin barrier protein filaggrin ( FLG ) are a major risk for atopic dermatitis (AD). The pathogenic sequence of…”
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Skin barrier impairment at birth predicts food allergy at 2 years of age by Kelleher, Maeve M., MD, Dunn-Galvin, Audrey, PhD, Gray, Claire, RN, Murray, Deirdre M., MD, PhD, Kiely, Mairead, PhD, Kenny, Louise, PhD, McLean, W.H. Irwin, PhD, FRS, Irvine, Alan D., MD, PhD, Hourihane, Jonathan O'B., DM

“…Background Transcutaneous exposure to food allergens can lead to food sensitization (FS)/food allergy (FA). We measured skin barrier function in early infancy…”
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Filaggrin loss-of-function mutations are associated with enhanced expression of IL-1 cytokines in the stratum corneum of patients with atopic dermatitis and in a murine model of filaggrin deficiency by Kezic, Sanja, PhD, O’Regan, Gráinne M., MRCPI, Lutter, René, PhD, Jakasa, Ivone, PhD, Koster, Ellen S., PhD, Saunders, Sean, BSc, Caspers, Peter, PhD, Kemperman, Patrick M.J.H., MD, Puppels, Gerwin J., PhD, Sandilands, Aileen, PhD, Chen, Huijia, PhD, Campbell, Linda E., BSc, Kroboth, Karin, MSc, Watson, Rosemarie, MD, Fallon, Padraic G., PhD, McLean, W. H. Irwin, DSc, FMedSci, Irvine, Alan D., MD, FRCPI

“…Background Filaggrin (FLG) mutations result in reduced stratum corneum (SC) natural moisturizing factor (NMF) components and consequent increased SC pH…”
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Peanut allergy: Effect of environmental peanut exposure in children with filaggrin loss-of-function mutations by Brough, Helen A., MSc, FRCPCH, Simpson, Angela, MD, PhD, Makinson, Kerry, MSc, Hankinson, Jenny, PhD, Brown, Sara, MD, Douiri, Abdel, PhD, Belgrave, Danielle C.M., MSc, Penagos, Martin, MD, MSc, Stephens, Alick C., PhD, McLean, W.H. Irwin, PhD, DSc, FRSE, FMedSci, Turcanu, Victor, PhD, Nicolaou, Nicolaos, MD, PhD, Custovic, Adnan, MD, PhD, Lack, Gideon, MD, FRCPCH

“…Background Filaggrin (FLG) loss-of-function mutations lead to an impaired skin barrier associated with peanut allergy. Household peanut consumption is…”
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The persistence of atopic dermatitis and filaggrin ( FLG ) mutations in a US longitudinal cohort by Margolis, David J., MD, PhD, Apter, Andrea J., MD, MSc, Gupta, Jayanta, MD, PhD, Hoffstad, Ole, MS, Papadopoulos, Maryte, BA, Campbell, Linda E., BA, Sandilands, Aileen, PhD, McLean, W.H. Irwin, PhD, DSc, Rebbeck, Tim R., PhD, Mitra, Nandita, PhD

“…Background Atopic dermatitis (AD) is a common skin disease that is characterized by recurrent episodes of itching. Filaggrin ( FLG ) loss-of-function ( FLG…”
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Atopic dermatitis increases the effect of exposure to peanut antigen in dust on peanut sensitization and likely peanut allergy by Brough, Helen A., MSc, FRCPCH, Liu, Andrew H., MD, Sicherer, Scott, MD, Makinson, Kerry, MSc, Douiri, Abdel, PhD, Brown, Sara J., MD, Stephens, Alick C., PhD, Irwin McLean, W.H., PhD, DSc, FRSE, FMedSci, Turcanu, Victor, PhD, Wood, Robert A., MD, Jones, Stacie M., MD, Burks, Wesley, MD, Dawson, Peter, PhD, Stablein, Donald, PhD, Sampson, Hugh, MD, Lack, Gideon, MD

“…Background History and severity of atopic dermatitis (AD) are risk factors for peanut allergy. Recent evidence suggests that children can become sensitized to…”
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Gut microbiota development during infancy: Impact of introducing allergenic foods by Marrs, Tom, Jo, Jay-Hyun, Perkin, Michael R., Rivett, Damian W., Witney, Adam A., Bruce, Kenneth D., Logan, Kirsty, Craven, Joanna, Radulovic, Suzana, Versteeg, Serge A., van Ree, Ronald, McLean, W. H. Irwin, Strachan, David P., Lack, Gideon, Kong, Heidi H., Flohr, Carsten

“…The gut microbiota potentially plays an important role in the immunologic education of the host during early infancy. We sought to determine how the infant gut…”
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Systemic and stratum corneum biomarkers of severity in infant atopic dermatitis include markers of innate and T helper cell‐related immunity and angiogenesis by McAleer, M.A., Jakasa, I., Hurault, G., Sarvari, P., McLean, W.H.I., Tanaka, R.J., Kezic, S., Irvine, A.D.

“…Summary Background Biomarkers of atopic dermatitis (AD) are largely lacking, especially in infant AD. Those that have been examined to date have focused mostly…”
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