Search Results - "MCLAREN, A. W"

An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials by Henderson, C J, Kapelyukh, Y, Scheer, N, Rode, A, McLaren, A W, MacLeod, A K, Lin, D, Wright, J, Stanley, L A, Wolf, C R

“…Species differences in drug metabolism and disposition can confound the extrapolation of in vivo PK data to man and also profoundly compromise drug efficacy…”
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Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics by FORRESTER, L. M, HENDERSON, C. J, WOLF, C. R, GLANCEY, M. J, BACK, D. J, PARK, B. K, BALL, S. E, KITTERINGHAM, N. R, MCLAREN, A. W, MILES, J. S, SKETT, P

“…Cytochrome P450s play a central role in the metabolism and disposition of an extremely wide range of drugs and chemical carcinogens. Individual differences in…”
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Identification of the human liver cytochrome P-450 responsible for coumarin 7-hydroxylase activity by Miles, J S, McLaren, A W, Forrester, L M, Glancey, M J, Lang, M A, Wolf, C R

“…1. We have constructed a full-length human liver cytochrome P450IIA cDNA from a partial-length clone by oligonucleotide-directed mutagenesis, and subcloned it…”
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Involvement of Jun and Fos proteins in regulating transcriptional activation of the human pi class glutathione S-transferase gene in multidrug-resistant MCF7 breast cancer cells by MOFFAT, G. J, MCLAREN, A. W, WOLF, C. R

“…Elevated levels of the human pi class glutathione S-transferase (GSTP1-1) have been implicated in the development of antineoplastic drug resistance. Using…”
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Inactivation of the Hepatic Cytochrome P450 System by Conditional Deletion of Hepatic Cytochrome P450 Reductase by Henderson, Colin J, Otto, Diana M E, Carrie, Dianne, Magnuson, Mark A, McLaren, Aileen W, Rosewell, Ian, Wolf, C Roland

“…Cytochrome P450 (CYP) monooxygenases catalyze the oxidation of a large number of endogenous compounds and the majority of ingested environmental chemicals,…”
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Alternative splicing in the human cytochrome P450IIB6 gene generates a high level of aberrant messages by MILES, J. S, MCLAREN, A. W, WOLF, C. R

“…Polymorphisms within the human cytochrome P450 system can have severe clinical consequences and have been associated with adverse drug side effects and…”
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A novel human cytochrome P450 gene (P450IIB): chromosomal localization and evidence for alternative splicing by MILES, J. S, SPURR, N. K, GOUGH, A. C, JOWETT, T, MCLAREN, A. W, BROOK, J. D, WOLF, C. R

“…We have isolated from a single human liver cDNA library two clones which are highly homologous (78% over the coding region) to the major…”
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Pi-class glutathione S-transferase: regulation and function by Henderson, Colin J., McLaren, Aileen W., Moffat, Graeme J., Bacon, E.Jane, Wolf, C.Roland

“…Our laboratory has been involved in the study of Glutathione S-transferase pi (GST pi) for many years, both in terms of regulation of gene expression and in…”
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Characterization of the human cytochrome P4502D6 promoter. A potential role for antagonistic interactions between members of the nuclear receptor family by Cairns, W, Smith, C A, McLaren, A W, Wolf, C R

“…The functional mapping of the human cytochrome P4502D6 (CYP2D6) promoter in HepG2 cells revealed the presence of both positive and negative regulatory…”
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Alternative splicing in the human cytochrome P450IIB6 gene: use of a cryptic exon within intron 3 and splice acceptor site within exon 4 by MILES, J. S, MCLAREN, A. W, GONZALEZ, F. J, WOLF, C. R

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Sp1-mediated Transcriptional Activation of the Human Pi Class Glutathione S-Transferase Promoter (∗) by Moffat, Graeme J., McLaren, Aileen W., Wolf, C. Roland

“…Previous studies in this laboratory have identified an essential AP-1 recognition sequence (C1 region; −69 to −63) in the human Pi class glutathione…”
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Functional Characterization of the Transcription Silencer Element Located within the Human Pi Class Glutathione S-Transferase Promoter by Moffat, Graeme J., McLaren, Aileen W., Wolf, C. Roland

“…We have previously demonstrated enhanced transcriptional activity of the human Pi class glutathione S-transferase (GSTP1) promoter in a multidrug-resistant…”
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Close linkage of the human cytochrome P450IIA and P450IIB gene subfamilies: implications for the assignment of substrate specificity by MILES, J. S, BICKMORE, W, BROOK, J. D, MCLAREN, A. W, MEEHAN, R, WOLF, C. R

“…We have isolated from human liver libraries two cytochrome P450 cDNA clones (lambda MP14 and lambda MP3) which are highly similar (83% over the coding region)…”
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Transcriptional and post-transcriptional mechanisms can regulate cell-specific expression of the human Pi-class glutathione S-transferase gene by Moffat, G J, McLaren, A W, Wolf, C R

“…Previous studies from this laboratory have identified transcriptional mechanisms that are utilized to increase expression of the human glutathione…”
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A novel human cytochrome P4S0 gene (P450IIB): chromosomal localization and evidence for alternative splicing by Miles, J. S, Spurr, N. K., Gough, A. C., Jowett, T., McLaren, A. W., Brook, J.D., Wolf, C.R.

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Knockout Mice in Xenobiotic Metabolism by Henderson, Colin J., Otto, Diana M. E., McLaren, Aileen W., Carrie, Dianne, Roland Wolf, C.

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Relative expression of cytochrome P 450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics by Forrester, L M, Henderson, C J, Glancey, M J, Back, D J, Park, B K, Ball, S E, Kitteringham, N R, McLaren, A W, Miles, J S, Skett, P, Wolf, C R

“…Cytochrome P450s play a central role in the metabolism and disposition of an extremely wide range of drugs and chemical carcinogens. Individual differences in…”
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Mean platelet volume is a useful parameter: a reproducible routine method using a modified Coulter Thrombocytometer by Bancroft, A J, Abel, E W, Mclaren, M, Belch, J J

“…The principal physiological function of platelets is to promote haemostasis but they also contribute to thrombosis and atherogenesis. Platelet volume is a…”
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