Search Results - "MCKNIGHT, BARBARA"

Circulating Sphingolipids, Insulin, HOMA-IR, and HOMA-B: The Strong Heart Family Study by Lemaitre, Rozenn N, Yu, Chaoyu, Hoofnagle, Andrew, Hari, Nair, Jensen, Paul N, Fretts, Amanda M, Umans, Jason G, Howard, Barbara V, Sitlani, Colleen M, Siscovick, David S, King, Irena B, Sotoodehnia, Nona, McKnight, Barbara

“…Experimental studies suggest ceramides may play a role in insulin resistance. However, the relationships of circulating ceramides and related sphingolipids…”
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Behavior of QQ-plots and genomic control in studies of gene-environment interaction by Voorman, Arend, Lumley, Thomas, McKnight, Barbara, Rice, Kenneth

“…Genome-wide association studies of gene-environment interaction (GxE GWAS) are becoming popular. As with main effects GWAS, quantile-quantile plots (QQ-plots)…”
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A comprehensive evaluation of the genetic architecture of sudden cardiac arrest by Ashar, Foram N, Mitchell, Rebecca N, Albert, Christine M, Newton-Cheh, Christopher, Brody, Jennifer A, Müller-Nurasyid, Martina, Moes, Anna, Meitinger, Thomas, Mak, Angel, Huikuri, Heikki, Junttila, M Juhani, Goyette, Philippe, Pulit, Sara L, Pazoki, Raha, Tanck, Michael W, Blom, Marieke T, Zhao, XiaoQing, Havulinna, Aki S, Jabbari, Reza, Glinge, Charlotte, Tragante, Vinicius, Escher, Stefan A, Chakravarti, Aravinda, Ehret, Georg, Coresh, Josef, Li, Man, Prineas, Ronald J, Franco, Oscar H, Kwok, Pui-Yan, Lumley, Thomas, Dumas, Florence, McKnight, Barbara, Rotter, Jerome I, Lemaitre, Rozenn N, Heckbert, Susan R, O’Donnell, Christopher J, Hwang, Shih-Jen, Tardif, Jean-Claude, VanDenburgh, Martin, Uitterlinden, André G, Hofman, Albert, Stricker, Bruno H C, de Bakker, Paul I W, Franks, Paul W, Jansson, Jan-Hakan, Asselbergs, Folkert W, Halushka, Marc K, Maleszewski, Joseph J, Tfelt-Hansen, Jacob, Engstrøm, Thomas, Salomaa, Veikko, Virmani, Renu, Kolodgie, Frank, Wilde, Arthur A M, Tan, Hanno L, Bezzina, Connie R, Eijgelsheim, Mark, Rioux, John D, Jouven, Xavier, Kääb, Stefan, Psaty, Bruce M, Siscovick, David S, Arking, Dan E, Sotoodehnia, Nona

“…Abstract Aims Sudden cardiac arrest (SCA) accounts for 10% of adult mortality in Western populations. We aim to identify potential loci associated with SCA and…”
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Plasma phospholipid very-long-chain saturated fatty acids and incident diabetes in older adults: the Cardiovascular Health Study by Lemaitre, Rozenn N, Fretts, Amanda M, Sitlani, Colleen M, Biggs, Mary L, Mukamal, Kenneth, King, Irena B, Song, Xiaoling, Djoussé, Luc, Siscovick, David S, McKnight, Barbara, Sotoodehnia, Nona, Kizer, Jorge R, Mozaffarian, Dariush

“…Background: Circulating saturated fatty acids (SFAs) are integrated biomarkers of diet and metabolism that may influence the pathogenesis of diabetes. In…”
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Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium by Lemaitre, Rozenn N, Tanaka, Toshiko, Tang, Weihong, Manichaikul, Ani, Foy, Millennia, Kabagambe, Edmond K, Nettleton, Jennifer A, King, Irena B, Weng, Lu-Chen, Bhattacharya, Sayanti, Bandinelli, Stefania, Bis, Joshua C, Rich, Stephen S, Jacobs, Jr, David R, Cherubini, Antonio, McKnight, Barbara, Liang, Shuang, Gu, Xiangjun, Rice, Kenneth, Laurie, Cathy C, Lumley, Thomas, Browning, Brian L, Psaty, Bruce M, Chen, Yii-Der I, Friedlander, Yechiel, Djousse, Luc, Wu, Jason H Y, Siscovick, David S, Uitterlinden, André G, Arnett, Donna K, Ferrucci, Luigi, Fornage, Myriam, Tsai, Michael Y, Mozaffarian, Dariush, Steffen, Lyn M

“…Long-chain n-3 polyunsaturated fatty acids (PUFAs) can derive from diet or from α-linolenic acid (ALA) by elongation and desaturation. We investigated the…”
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Plasma ceramides containing saturated fatty acids are associated with risk of type 2 diabetes by Fretts, Amanda M., Jensen, Paul N., Hoofnagle, Andrew N., McKnight, Barbara, Howard, Barbara V., Umans, Jason, Sitlani, Colleen M., Siscovick, David S., King, Irena B., Djousse, Luc, Sotoodehnia, Nona, Lemaitre, Rozenn N.

“…Recent studies suggest that the type of saturated fatty acid bound to sphingolipids influences the biological activity of those sphingolipids. However, it is…”
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Associations of circulating very-long-chain saturated fatty acids and incident type 2 diabetes: a pooled analysis of prospective cohort studies by Fretts, Amanda M, Imamura, Fumiaki, Marklund, Matti, Micha, Renata, Wu, Jason H Y, Murphy, Rachel A, Chien, Kuo-Liong, McKnight, Barbara, Tintle, Nathan, Forouhi, Nita G, Qureshi, Waqas T, Virtanen, Jyrki K, Wong, Kerry, Wood, Alexis C, Lankinen, Maria, Rajaobelina, Kalina, Harris, Tamara B, Djoussé, Luc, Harris, Bill, Wareham, Nick J, Steffen, Lyn M, Laakso, Markku, Veenstra, Jenna, Samieri, Cécilia, Brouwer, Ingeborg A, Yu, Chaoyu Ian, Koulman, Albert, Steffen, Brian T, Helmer, Catherine, Sotoodehnia, Nona, Siscovick, David, Gudnason, Vilmundur, Wagenknecht, Lynne, Voutilainen, Sari, Tsai, Michael Y, Uusitupa, Matti, Kalsbeek, Anya, Berr, Claudine, Mozaffarian, Dariush, Lemaitre, Rozenn N

“…Saturated fatty acids (SFAs) of different chain lengths have unique metabolic and biological effects, and a small number of recent studies suggest that higher…”
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Relationship between group dynamics and spatial distribution of African elephants in a semi‐arid environment by McKnight, Barbara L

“…Group dynamics related to distribution of African elephants in the semi‐arid environment of Tsavo East National Park, Kenya was studied between 2007 and 2010…”
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CYP2J2 Modulates Diverse Transcriptional Programs in Adult Human Cardiomyocytes by Evangelista, Eric A., Aliwarga, Theresa, Sotoodehnia, Nona, Jensen, Paul N., McKnight, Barbara, Lemaitre, Rozenn N., Totah, Rheem A., Gharib, Sina A.

“…CYP2J2, a member of the Cytochrome P450 family of enzymes, is the most abundant epoxygenase in the heart and has multifunctional properties including…”
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Longitudinal Plasma Measures of Trimethylamine N-Oxide and Risk of Atherosclerotic Cardiovascular Disease Events in Community-Based Older Adults by Lee, Yujin, Nemet, Ina, Wang, Zeneng, Lai, Heidi T M, de Oliveira Otto, Marcia C, Lemaitre, Rozenn N, Fretts, Amanda M, Sotoodehnia, Nona, Budoff, Matthew, DiDonato, Joseph A, McKnight, Barbara, Tang, W H Wilson, Psaty, Bruce M, Siscovick, David S, Hazen, Stanley L, Mozaffarian, Dariush

“…Background Trimethylamine N-oxide (TMAO) is a gut microbiota-dependent metabolite of dietary choline, L-carnitine, and phosphatidylcholine-rich foods. On the…”
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Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium by Guan, Weihua, Steffen, Brian T, Lemaitre, Rozenn N, Wu, Jason H Y, Tanaka, Toshiko, Manichaikul, Ani, Foy, Millennia, Rich, Stephen S, Wang, Lu, Nettleton, Jennifer A, Tang, Weihong, Gu, Xiangjun, Bandinelli, Stafania, King, Irena B, McKnight, Barbara, Psaty, Bruce M, Siscovick, David, Djousse, Luc, Chen, Yii-Der Ida, Ferrucci, Luigi, Fornage, Myriam, Mozafarrian, Dariush, Tsai, Michael Y, Steffen, Lyn M

“…Omega6 (n6) polyunsaturated fatty acids (PUFAs) and their metabolites are involved in cell signaling, inflammation, clot formation, and other crucial…”
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Circulating ceramides and sphingomyelins and the risk of incident cardiovascular disease among people with diabetes: the strong heart study by Jensen, Paul N, Fretts, Amanda M, Hoofnagle, Andrew N, McKnight, Barbara, Howard, Barbara V, Umans, Jason G, Sitlani, Colleen M, Siscovick, David S, King, Irena B, Sotoodehnia, Nona, Lemaitre, Rozenn N

“…Plasma ceramides and sphingomyelins have been independently linked to diabetes risk, glucose and insulin levels, and the risk of several cardiovascular (CVD)…”
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Circulating Very Long-Chain Saturated Fatty Acids and Heart Failure: The Cardiovascular Health Study by Lemaitre, Rozenn N, McKnight, Barbara, Sotoodehnia, Nona, Fretts, Amanda M, Qureshi, Waqas T, Song, Xiaoling, King, Irena B, Sitlani, Colleen M, Siscovick, David S, Psaty, Bruce M, Mozaffarian, Dariush

“…Background Circulating very-long-chain saturated fatty acids ( VLSFAs ) are integrated biomarkers of diet and metabolism that may point to new risk pathways…”
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Large-scale whole-exome sequencing association studies identify rare functional variants influencing serum urate levels by Tin, Adrienne, Li, Yong, Brody, Jennifer A., Nutile, Teresa, Chu, Audrey Y., Huffman, Jennifer E., Yang, Qiong, Chen, Ming-Huei, Robinson-Cohen, Cassianne, Macé, Aurélien, Liu, Jun, Demirkan, Ayşe, Sorice, Rossella, Sedaghat, Sanaz, Swen, Melody, Yu, Bing, Ghasemi, Sahar, Teumer, Alexanda, Vollenweider, Peter, Ciullo, Marina, Li, Meng, Uitterlinden, André G., Kraaij, Robert, Amin, Najaf, van Rooij, Jeroen, Kutalik, Zoltán, Dehghan, Abbas, McKnight, Barbara, van Duijn, Cornelia M., Morrison, Alanna, Psaty, Bruce M., Boerwinkle, Eric, Fox, Caroline S., Woodward, Owen M., Köttgen, Anna

“…Elevated serum urate levels can cause gout, an excruciating disease with suboptimal treatment. Previous GWAS identified common variants with modest effects on…”
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A comparison of prehospital lactate and systolic blood pressure for predicting the need for resuscitative care in trauma transported by ground by Guyette, Francis X, Meier, Eric N, Newgard, Craig, McKnight, Barbara, Daya, Mohamud, Bulger, Eileen M, Powell, Judy L, Brasel, Karen J, Kerby, Jeffery D, Egan, Debra, Sise, Michael, Coimbra, Raul, Fabian, Timothy C, Hoyt, David B

“…Reliance on prehospital trauma triage guidelines misses patients with serious injury. Lactate is a biomarker capable of identifying high-risk trauma patients…”
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Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis by Holliday, Elizabeth G, Smith, Albert V, Cornes, Belinda K, Buitendijk, Gabriëlle H S, Jensen, Richard A, Sim, Xueling, Aspelund, Thor, Aung, Tin, Baird, Paul N, Boerwinkle, Eric, Cheng, Ching Yu, van Duijn, Cornelia M, Eiriksdottir, Gudny, Gudnason, Vilmundur, Harris, Tamara, Hewitt, Alex W, Inouye, Michael, Jonasson, Fridbert, Klein, Barbara E K, Launer, Lenore, Li, Xiaohui, Liew, Gerald, Lumley, Thomas, McElduff, Patrick, McKnight, Barbara, Mitchell, Paul, Psaty, Bruce M, Rochtchina, Elena, Rotter, Jerome I, Scott, Rodney J, Tay, Wanting, Taylor, Kent, Teo, Yik Ying, Uitterlinden, André G, Viswanathan, Ananth, Xie, Sophia, Vingerling, Johannes R, Klaver, Caroline C W, Tai, E Shyong, Siscovick, David, Klein, Ronald, Cotch, Mary Frances, Wong, Tien Y, Attia, John, Wang, Jie Jin

“…Genetic factors explain a majority of risk variance for age-related macular degeneration (AMD). While genome-wide association studies (GWAS) for late AMD…”
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Plasma Ceramides and Sphingomyelins in Relation to Atrial Fibrillation Risk: The Cardiovascular Health Study by Jensen, Paul N, Fretts, Amanda M, Hoofnagle, Andrew N, Sitlani, Colleen M, McKnight, Barbara, King, Irena B, Siscovick, David S, Psaty, Bruce M, Heckbert, Susan R, Mozaffarian, Dariush, Sotoodehnia, Nona, Lemaitre, Rozenn N

“…Background Ceramides exhibit multiple biological activities that may influence the pathophysiological characteristics of atrial fibrillation (AF). Whether the…”
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Circulating sphingolipids, fasting glucose, and impaired fasting glucose: The Strong Heart Family Study by Jensen, Paul N., Fretts, Amanda M., Yu, Chaoyu, Hoofnagle, Andrew N., Umans, Jason G., Howard, Barbara V., Sitlani, Colleen M., Siscovick, David S., King, Irena B., Sotoodehnia, Nona, McKnight, Barbara, Lemaitre, Rozenn N.

“…Animal studies suggest sphingolipids as an early marker of impaired glucose metabolism; however, research in humans is limited. We evaluated whether individual…”
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Cooking for Health: a healthy food budgeting, purchasing, and cooking skills randomized controlled trial to improve diet among American Indians with type 2 diabetes by Hawley, Caitlin N, Huber, Corrine M, Best, Lyle G, Howard, Barbara V, Umans, Jason, Beresford, Shirley A A, McKnight, Barbara, Hager, Arlette, O'Leary, Marcia, Thorndike, Anne N, Ornelas, India J, Brown, Meagan C, Fretts, Amanda M

“…The prevalence of poor diet quality and type 2 diabetes are exceedingly high in many rural American Indian (AI) communities. Because of limited resources and…”
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Serial Plasma Phospholipid Fatty Acids in the De Novo Lipogenesis Pathway and Total Mortality, Cause-Specific Mortality, and Cardiovascular Diseases in the Cardiovascular Health Study by Lai, Heidi T M, de Oliveira Otto, Marcia C, Lee, Yujin, Wu, Jason H Y, Song, Xiaoling, King, Irena B, Psaty, Bruce M, Lemaitre, Rozenn N, McKnight, Barbara, Siscovick, David S, Mozaffarian, Dariush

“…Background Synthesized fatty acids (FAs) from de novo lipogenesis may affect cardiometabolic health, but longitudinal associations between serially measured de…”
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