Search Results - "MCKINNON, P. J"

Loss of suppressor-of-fused function promotes tumorigenesis by LEE, Y, KAWAGOE, R, SASAI, K, LI, Y, RUSSELL, H. R, CURRAN, T, MCKINNON, P. J

“…The Sonic Hedgehog (SHH) signaling pathway is indispensable for development, and functions to activate a transcriptional program modulated by the GLI…”
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Requirement for Atm in Ionizing Radiation-Induced Cell Death in the Developing Central Nervous System by Herzog, Karl-Heinz, Chong, Miriam J., Kapsetaki, Manuela, Morgan, James I., McKinnon, Peter J.

“…Ataxia telangiectasia (AT) is characterized by progressive neurodegeneration that results from mutation of the ATM gene. However, neither the normal function…”
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Rint1 inactivation triggers genomic instability, ER stress and autophagy inhibition in the brain by Grigaravicius, P, Kaminska, E, Hübner, C A, McKinnon, P J, von Deimling, A, Frappart, P-O

“…Endoplasmic reticulum (ER) stress, defective autophagy and genomic instability in the central nervous system are often associated with severe developmental…”
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Gustducin is a taste-cell-specific G protein closely related to the transducins by McLaughlin, Susan K, McKinnon Margolskee, Peter J. Robert F

“…A novel G protein alpha-subunit (alpha-gustducin) has been identified and cloned from taste tissue. alpha-Gustducin messenger RNA is expressed in taste buds of…”
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ATM dependent apoptosis in the nervous system by Lee, Y, McKinnon, P J

“…Ataxia-telangiectasia is a human syndrome resulting from mutations of the ATM protein kinase that is characterized by radiation sensitivity and…”
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Loss of the ARF tumor suppressor reverses premature replicative arrest but not radiation hypersensitivity arising from disabled atm function by KAMIJO, T, DE KAMP, E. V, CHONG, M. J, ZINDY, F, DIEHL, J. A, SHERR, C. J, MCKINNON, P. J

“…The alternative reading frame product (p19ARF) of the mouse INK4a/ARF locus is induced by oncoproteins such as Myc and E1A as part of a checkpoint response…”
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DNA double-strand break repair and development by Phillips, E R, McKinnon, P J

“…Normal development of an organism requires the ability to respond to DNA damage. A particularly deleterious lesion is a DNA double-strand break (DSB). The…”
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Atm expression patterns suggest a contribution from the peripheral nervous system to the phenotype of ataxia–telangiectasia by Soares, H.D, Morgan, J.I, McKinnon, P.J

“…Ataxia–telangiectasia is a human autosomal recessive disease characterized by neurodegeneration, cancer predisposition and sensitivity to ionizing radiation…”
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Ataxia-telangiectasia: an inherited disorder of ionizing-radiation sensitivity in man: progress in the elucidation of the underlying biochemical defect by MCKINNON, P. J

“…This review summarizes the current research on the biochemical defect leading to ataxia-telangiectasia (AT). A DNA repair defect has been linked to AT,…”
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Cross-species epigenetics identifies a critical role for VAV1 in SHH subgroup medulloblastoma maintenance by Lindsey, J C, Kawauchi, D, Schwalbe, E C, Solecki, D J, Selby, M P, McKinnon, P J, Olson, J M, Hayden, J T, Grundy, R G, Ellison, D W, Williamson, D, Bailey, S, Roussel, M F, Clifford, S C

“…The identification of key tumorigenic events in Sonic Hedgehog (SHH) subgroup medulloblastomas (MB SHH ) will be essential for the development of…”
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Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway by Kitagawa, Risa, Bakkenist, Christopher J, McKinnon, Peter J, Kastan, Michael B

“…The ATM protein kinase is activated by intermolecular autophosphorylation in response to DNA damage and initiates cellular signaling pathways that facilitate…”
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Puma is an essential mediator of p53-dependent and -independent apoptotic pathways by Jeffers, John R., Parganas, Evan, Lee, Youngsoo, Yang, Chunying, Wang, JinLing, Brennan, Jennifer, MacLean, Kirsteen H., Han, Jiawen, Chittenden, Thomas, Ihle, James N., McKinnon, Peter J., Cleveland, John L., Zambetti, Gerard P.

“…Puma encodes a BH3-only protein that is induced by the p53 tumor suppressor and other apoptotic stimuli. To assess its physiological role in apoptosis, we…”
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Responding to DNA double strand breaks in the nervous system by Lee, Y, McKinnon, P.J

“…Abstract Within the nervous system appropriate responses to DNA damage are required to maintain homeostasis and prevent disease. In this tissue, DNA…”
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Pineal Opsin: A Nonvisual Opsin Expressed in Chick Pineal by Max, Marianna, McKinnon, Peter J., Seidenman, Kenneth J., Barrett, R. Keith, Applebury, Meredithe L., Takahashi, Joseph S., Margolskee, Robert F.

“…Pineal opsin (P-opsin), an opsin from chick that is highly expressed in pineal but is not detectable in retina, was cloned by the polymerase chain reaction. It…”
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Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development by Lagutin, Oleg V, Zhu, Changqi C, Kobayashi, Daisuke, Topczewski, Jacek, Shimamura, Kenji, Puelles, Luis, Russell, Helen R C, McKinnon, Peter J, Solnica-Krezel, Lilianna, Oliver, Guillermo

“…In vertebrate embryos, formation of anterior neural structures requires suppression of Wnt signals emanating from the paraxial mesoderm and midbrain territory…”
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Ataxia telangiectasia mutated deficiency affects astrocyte growth but not radiosensitivity by GOSINK, E. C, CHONG, M. J, MCKINNON, P. J

“…The cancer-prone neurodegenerative disorder, ataxia telangiectasia (A-T), results from mutations of ATM (ataxia telangiectasia mutated). Individuals with A-T…”
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DNA ligase IV suppresses medulloblastoma formation by LEE, Youngsoo, MCKINNON, Peter J

“…Substantial neural defects are often present in mice with targeted inactivation of DNA repair factors such as DNA ligase IV (Lig4). Whereas Lig4(-/-) mice…”
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SC1: a marker for astrocytes in the adult rodent brain is upregulated during reactive astrocytosis by McKinnon, Peter J., Margolskee, Robert F.

“…Astrocytes are the most abundant cell type in the mammalian central nervous system (CNS), and are involved in many processes critical for normal CNS…”
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Linking DNA damage and neurodegeneration by Rolig, Rhonda L, McKinnon, Peter J

“…Many human pathological conditions with genetic defects in DNA damage responses are also characterized by neurological deficits. These neurological deficits…”
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Ataxia Telangiectasia Mutated-Dependent Apoptosis after Genotoxic Stress in the Developing Nervous System Is Determined by Cellular Differentiation Status by Lee, Youngsoo, Chong, Miriam J, McKinnon, Peter J

“…Ataxia-telangiectasia (A-T) is a neurodegenerative syndrome resulting from dysfunction of ATM (ataxia telangiectasia mutated). The molecular details of ATM…”
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