Search Results - "MCKINNEY, Steven"

Dynamics of breast-cancer relapse reveal late-recurring ER-positive genomic subgroups by Rueda, Oscar M., Sammut, Stephen-John, Seoane, Jose A., Chin, Suet-Feung, Caswell-Jin, Jennifer L., Callari, Maurizio, Batra, Rajbir, Pereira, Bernard, Bruna, Alejandra, Ali, H. Raza, Provenzano, Elena, Liu, Bin, Parisien, Michelle, Gillett, Cheryl, McKinney, Steven, Green, Andrew R., Murphy, Leigh, Purushotham, Arnie, Ellis, Ian O., Pharoah, Paul D., Rueda, Cristina, Aparicio, Samuel, Caldas, Carlos, Curtis, Christina

“…The rates and routes of lethal systemic spread in breast cancer are poorly understood owing to a lack of molecularly characterized patient cohorts with…”
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CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours by Xu, Hong, Di Antonio, Marco, McKinney, Steven, Mathew, Veena, Ho, Brandon, O’Neil, Nigel J., Santos, Nancy Dos, Silvester, Jennifer, Wei, Vivien, Garcia, Jessica, Kabeer, Farhia, Lai, Daniel, Soriano, Priscilla, Banáth, Judit, Chiu, Derek S., Yap, Damian, Le, Daniel D., Ye, Frank B., Zhang, Anni, Thu, Kelsie, Soong, John, Lin, Shu-chuan, Tsai, Angela Hsin Chin, Osako, Tomo, Algara, Teresa, Saunders, Darren N., Wong, Jason, Xian, Jian, Bally, Marcel B., Brenton, James D., Brown, Grant W., Shah, Sohrab P., Cescon, David, Mak, Tak W., Caldas, Carlos, Stirling, Peter C., Hieter, Phil, Balasubramanian, Shankar, Aparicio, Samuel

“…G-quadruplex DNAs form four-stranded helical structures and are proposed to play key roles in different cellular processes. Targeting G-quadruplex DNAs for…”
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TP53 Mutation Spectrum in Breast Cancer Is Subtype Specific and Has Distinct Prognostic Relevance by SILWAL-PANDIT, Laxmi, MOEN VOLLAN, Hans Kristian, CALDAS, Carlos, LANGERØD, Anita, CHIN, Suet-Feung, RUEDA, Oscar M, MCKINNEY, Steven, OSAKO, Tomo, QUIGLEY, David A, KRISTENSEN, Vessela N, APARICIO, Samuel, BØRRESEN-DALE, Anne-Lise

“…In breast cancer, the TP53 gene is frequently mutated and the mutations have been associated with poor prognosis. The prognostic impact of the different types…”
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Basal-Like Breast Cancer Defined by Five Biomarkers Has Superior Prognostic Value than Triple-Negative Phenotype by CHEANG, Maggie C. U, VODUC, David, BAJDIK, Chris, LEUNG, Samuel, MCKINNEY, Steven, CHIA, Stephen K, PEROU, Charles M, NIELSEN, Torsten O

“…Purpose: Basal-like breast cancer is associated with high grade, poor prognosis, and younger patient age. Clinically, a triple-negative phenotype definition…”
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Integrated structural variation and point mutation signatures in cancer genomes using correlated topic models by Funnell, Tyler, Zhang, Allen W, Grewal, Diljot, McKinney, Steven, Bashashati, Ali, Wang, Yi Kan, Shah, Sohrab P

“…Mutation signatures in cancer genomes reflect endogenous and exogenous mutational processes, offering insights into tumour etiology, features for prognostic…”
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Ovarian carcinoma subtypes are different diseases: implications for biomarker studies by Köbel, Martin, Kalloger, Steve E, Boyd, Niki, McKinney, Steven, Mehl, Erika, Palmer, Chana, Leung, Samuel, Bowen, Nathan J, Ionescu, Diana N, Rajput, Ashish, Prentice, Leah M, Miller, Dianne, Santos, Jennifer, Swenerton, Kenneth, Gilks, C Blake, Huntsman, David

“…Although it has long been appreciated that ovarian carcinoma subtypes (serous, clear cell, endometrioid, and mucinous) are associated with different natural…”
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Ubiquitin-mediated DNA damage response is synthetic lethal with G-quadruplex stabilizer CX-5461 by Masud, Tehmina, Soong, Charles, Xu, Hong, Biele, Justina, Bjornson, Saelin, McKinney, Steven, Aparicio, Samuel

“…CX-5461 is a G-quadruplex (G4) ligand currently in trials with initial indications of clinical activity in cancers with defects in homologous recombination…”
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Transcriptome analysis of the normal human mammary cell commitment and differentiation process by Raouf, Afshin, Zhao, Yun, To, Karen, Stingl, John, Delaney, Allen, Barbara, Mary, Iscove, Norman, Jones, Steven, McKinney, Steven, Emerman, Joanne, Aparicio, Samuel, Marra, Marco, Eaves, Connie

“…Mature mammary epithelial cells are generated from undifferentiated precursors through a hierarchical process, but the molecular mechanisms involved,…”
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Evidence from Multiplex Molecular Assays for Complex Multipathogen Interactions in Acute Respiratory Infections by Brunstein, John D, Cline, Christy L, McKinney, Steven, Thomas, Eva

“…While most diagnostic processes cease with the detection of the first relevant infectious agent, newer multiplexed molecular methods which provide simultaneous…”
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Accurate determination of CRISPR-mediated gene fitness in transplantable tumours by Eirew, Peter, O’Flanagan, Ciara, Ting, Jerome, Salehi, Sohrab, Brimhall, Jazmine, Wang, Beixi, Biele, Justina, Algara, Teresa, Lee, So Ra, Hoang, Corey, Yap, Damian, McKinney, Steven, Bates, Cherie, Kong, Esther, Lai, Daniel, Beatty, Sean, Andronescu, Mirela, Zaikova, Elena, Funnell, Tyler, Ceglia, Nicholas, Chia, Stephen, Gelmon, Karen, Mar, Colin, Shah, Sohrab, Roth, Andrew, Bouchard-Côté, Alexandre, Aparicio, Samuel

“…Assessing tumour gene fitness in physiologically-relevant model systems is challenging due to biological features of in vivo tumour regeneration, including…”
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CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor by Funnell, Tyler, Tasaki, Shinya, Oloumi, Arusha, Araki, Shinsuke, Kong, Esther, Yap, Damian, Nakayama, Yusuke, Hughes, Christopher S., Cheng, S.-W. Grace, Tozaki, Hirokazu, Iwatani, Misa, Sasaki, Satoshi, Ohashi, Tomohiro, Miyazaki, Tohru, Morishita, Nao, Morishita, Daisuke, Ogasawara-Shimizu, Mari, Ohori, Momoko, Nakao, Shoichi, Karashima, Masatoshi, Sano, Masaya, Murai, Aiko, Nomura, Toshiyuki, Uchiyama, Noriko, Kawamoto, Tomohiro, Hara, Ryujiro, Nakanishi, Osamu, Shumansky, Karey, Rosner, Jamie, Wan, Adrian, McKinney, Steven, Morin, Gregg B., Nakanishi, Atsushi, Shah, Sohrab, Toyoshiba, Hiroyoshi, Aparicio, Samuel

“…CDC-like kinase phosphorylation of serine/arginine-rich proteins is central to RNA splicing reactions. Yet, the genomic network of CDC-like kinase-dependent…”
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Amplification of 11q13 in ovarian carcinoma by Brown, Lindsay A., Kalloger, Steve E., Miller, Melinda A., Shih, Ie-Ming, McKinney, Steven E., Santos, Jennifer L., Swenerton, Ken, Spellman, Paul T., Gray, Joe, Gilks, C. Blake, Huntsman, David G.

“…Amplification at the 11q13 locus is commonly observed in breast, ovarian, head and neck, oral, and esophageal cancer. Studies of this region led to the…”
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P-cadherin expression as a prognostic biomarker in a 3992 case tissue microarray series of breast cancer by Turashvili, Gulisa, McKinney, Steven E, Goktepe, Ozge, Leung, Samuel C, Huntsman, David G, Gelmon, Karen A, Los, Gerrit, Rejto, Paul A, Aparicio, Samuel A J R

“…P-cadherin is a calcium-dependent cell–cell adhesion glycoprotein. P-cadherin expression is restricted to the myoepithelial cells in normal breast tissue, and…”
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Nucleic acid quantity and quality from paraffin blocks: Defining optimal fixation, processing and DNA/RNA extraction techniques by Turashvili, Gulisa, Yang, Winnie, McKinney, Steven, Kalloger, Steve, Gale, Nadia, Ng, Ying, Chow, Katie, Bell, Lynda, Lorette, Julie, Carrier, Melinda, Luk, Margaret, Aparicio, Samuel, Huntsman, David, Yip, Stephen

“…Although the extraction and analysis of nucleic acids from formalin-fixed paraffin-embedded tissues is a routine and growing part of pathology practice, no…”
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Synthetic Lethality Screens Reveal RPS6 and MST1R as Modifiers of Insulin-like Growth Factor-1 Receptor Inhibitor Activity in Childhood Sarcomas by POTRATZ, Jenny C, SAUNDERS, Darren N, APARICIO, Samuel A, SORENSEN, Poul H. B, WAI, Daniel H, NG, Tony L, MCKINNEY, Steven E, CARBONI, Joan M, GOTTARDIS, Marco M, TRICHE, Timothy J, JÜRGENS, Heribert, POLLAK, Michael N

“…The insulin-like growth factor-1 receptor (IGF1R) is emerging as a promising therapeutic target in human cancers. In the high-risk childhood sarcomas Ewing…”
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Combined Use of Gene Expression Modeling and siRNA Screening Identifies Genes and Pathways Which Enhance the Activity of Cisplatin When Added at No Effect Levels to Non-Small Cell Lung Cancer Cells In Vitro by Leung, Ada W Y, Hung, Stacy S, Backstrom, Ian, Ricaurte, Daniel, Kwok, Brian, Poon, Steven, McKinney, Steven, Segovia, Romulo, Rawji, Jenna, Qadir, Mohammed A, Aparicio, Samuel, Stirling, Peter C, Steidl, Christian, Bally, Marcel B

“…Platinum-based combination chemotherapy is the standard treatment for advanced non-small cell lung cancer (NSCLC). While cisplatin is effective, its use is not…”
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Mll5 is required for normal spermatogenesis by Yap, Damian B, Walker, David C, Prentice, Leah M, McKinney, Steven, Turashvili, Gulisa, Mooslehner-Allen, Katrin, de Algara, Teresa Ruiz, Fee, John, de Tassigny, Xavier d'Anglemont, Colledge, William H, Aparicio, Samuel

“…Mll5 is currently a member of the Mll family of SET domain histone methyltransferase proteins but studies have also showed that it could be part of the SET3…”
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Mutation of the Salt Bridge-forming Residues in the ETV6-SAM Domain Interface Blocks ETV6-NTRK3-induced Cellular Transformation by Cetinbas, Naniye, Huang-Hobbs, Helen, Tognon, Cristina, Leprivier, Gabriel, An, Jianghong, McKinney, Steven, Bowden, Mary, Chow, Connie, Gleave, Martin, McIntosh, Lawrence P., Sorensen, Poul H.

“…The ETV6-NTRK3 (EN) chimeric oncogene is expressed in diverse tumor types. EN is generated by a t(12;15) translocation, which fuses the N-terminal SAM (sterile…”
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Kisspeptin and GPR54 immunoreactivity in a cohort of 518 patients defines favourable prognosis and clear cell subtype in ovarian carcinoma by Prentice, Leah M, Klausen, Christian, Kalloger, Steve, Köbel, Martin, McKinney, Steven, Santos, Jennifer L, Kenney, Challayne, Mehl, Erika, Gilks, C Blake, Leung, Peter, Swenerton, Ken, Huntsman, David G, Aparicio, Samuel A J

“…Kisspeptins and their G-protein coupled receptor, GPR54 are required for GnRH release and have been associated with anti-metastatic tumour cell behaviour in…”
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The testosterone-dependent and independent transcriptional networks in the hypothalamus of Gpr54 and Kiss1 knockout male mice are not fully equivalent by Prentice, Leah M, d'Anglemont de Tassigny, Xavier, McKinney, Steven, Ruiz de Algara, Teresa, Yap, Damian, Turashvili, Gulisa, Poon, Steven, Sutcliffe, Margaret, Allard, Pat, Burleigh, Angela, Fee, John, Huntsman, David G, Colledge, William H, Aparicio, Samuel A J

“…Humans and mice with loss of function mutations in GPR54 (KISS1R) or kisspeptin do not progress through puberty, caused by a failure to release GnRH. The…”
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