Search Results - "MCKINNEY, Brett A"

Consensus features nested cross-validation by Parvandeh, Saeid, Yeh, Hung-Wen, Paulus, Martin P, McKinney, Brett A

“…Abstract Summary Feature selection can improve the accuracy of machine-learning models, but appropriate steps must be taken to avoid overfitting. Nested…”
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A Nonlinear Simulation Framework Supports Adjusting for Age When Analyzing BrainAGE by Le, Trang T, Kuplicki, Rayus T, McKinney, Brett A, Yeh, Hung-Wen, Thompson, Wesley K, Paulus, Martin P

“…Several imaging modalities, including T1-weighted structural imaging, diffusion tensor imaging, and functional MRI can show chronological age related changes…”
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Theoretical properties of distance distributions and novel metrics for nearest-neighbor feature selection by Dawkins, Bryan A, Le, Trang T, McKinney, Brett A

“…The performance of nearest-neighbor feature selection and prediction methods depends on the metric for computing neighborhoods and the distribution properties…”
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Correction: Tissue-Specific Expressed Antibody Variable Gene Repertoires by Briney, Bryan S, Willis, Jordan R, Finn, Jessica A, McKinney, Brett A, Crowe, Jr, James E

“…[This corrects the article DOI: 10.1371/journal.pone.0100839.]…”
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Exploring the role of neuronal-enriched extracellular vesicle miR-93 and interoception in major depressive disorder by Burrows, Kaiping, Figueroa-Hall, Leandra K., Stewart, Jennifer L., Alarbi, Ahlam M., Kuplicki, Rayus, Hannafon, Bethany N., Tan, Chibing, Risbrough, Victoria B., McKinney, Brett A., Ramesh, Rajagopal, Victor, Teresa A., Aupperle, Robin, Savitz, Jonathan, Teague, T. Kent, Khalsa, Sahib S., Paulus, Martin P.

“…Major depressive disorder (MDD) is associated with interoceptive processing dysfunctions, but the molecular mechanisms underlying this dysfunction are poorly…”
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The role of systems biology approaches in determining molecular signatures for the development of more effective vaccines by Pezeshki, Abdulmohammad, Ovsyannikova, Inna G, McKinney, Brett A, Poland, Gregory A, Kennedy, Richard B

“…Emerging infectious diseases are a major threat to public health, and while vaccines have proven to be one of the most effective preventive measures for…”
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Mathematical and Stability Analysis of Dengue–Malaria Co-Infection with Disease Control Strategies by Butt, Azhar Iqbal Kashif, Imran, Muhammad, McKinney, Brett A, Batool, Saira, Aftab, Hassan

“…Historically, humans have been infected by mosquito-borne diseases, including dengue fever and malaria fever. There is an urgent need for comprehensive methods…”
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Tissue-specific expressed antibody variable gene repertoires by Briney, Bryan S, Willis, Jordan R, Finn, Jessica A, McKinney, Brett A, Crowe, Jr, James E

“…Recent developments in genetic technologies allow deep analysis of the sequence diversity of immune repertoires, but little work has been reported on the…”
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Differential expression of MDGA1 in major depressive disorder by Li, Yijie (Jamie), Kresock, Elizabeth, Kuplicki, Rayus, Savitz, Jonathan, McKinney, Brett A.

“…The identification of gene expression-based biomarkers for major depressive disorder (MDD) continues to be an important challenge. In order to identify…”
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Common Data Elements, Scalable Data Management Infrastructure, and Analytics Workflows for Large-Scale Neuroimaging Studies by Kuplicki, Rayus, Touthang, James, Al Zoubi, Obada, Mayeli, Ahmad, Misaki, Masaya, Aupperle, Robin L, Teague, T Kent, McKinney, Brett A, Paulus, Martin P, Bodurka, Jerzy

“…Neuroscience studies require considerable bioinformatic support and expertise. Numerous high-dimensional and multimodal datasets must be preprocessed and…”
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Nearest-Neighbor Projected Distance Regression for Epistasis Detection in GWAS With Population Structure Correction by Arabnejad, Marziyeh, Montgomery, Courtney G., Gaffney, Patrick M., McKinney, Brett A.

“…Nearest-neighbor Projected-Distance Regression (NPDR) is a feature selection technique that uses nearest-neighbors in high dimensional data to detect complex…”
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Capturing the spectrum of interaction effects in genetic association studies by simulated evaporative cooling network analysis by McKinney, Brett A, Crowe, James E, Guo, Jingyu, Tian, Dehua

“…Evidence from human genetic studies of several disorders suggests that interactions between alleles at multiple genes play an important role in influencing…”
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The Integration of Epistasis Network and Functional Interactions in a GWAS Implicates RXR Pathway Genes in the Immune Response to Smallpox Vaccine by McKinney, Brett A, Lareau, Caleb, Oberg, Ann L, Kennedy, Richard B, Ovsyannikova, Inna G, Poland, Gregory A

“…Although many diseases and traits show large heritability, few genetic variants have been found to strongly separate phenotype groups by genotype. Complex…”
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ReliefSeq: a gene-wise adaptive-K nearest-neighbor feature selection tool for finding gene-gene interactions and main effects in mRNA-Seq gene expression data by McKinney, Brett A, White, Bill C, Grill, Diane E, Li, Peter W, Kennedy, Richard B, Poland, Gregory A, Oberg, Ann L

“…Relief-F is a nonparametric, nearest-neighbor machine learning method that has been successfully used to identify relevant variables that may interact in…”
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Genetic Basis for Adverse Events after Smallpox Vaccination by Reif, David M., McKinney, Brett A., Motsinger, Alison A., Chanock, Stephen J., Edwards, Kathryn M., Rock, Michael T., Moore, Jason H., Crowe, James E.

“…Identifying genetic factors associated with the development of adverse events might allow screening before vaccinia virus administration. Two independent…”
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Multi-Level Model to Predict Antibody Response to Influenza Vaccine Using Gene Expression Interaction Network Feature Selection by Parvandeh, Saeid, Poland, Greg A, Kennedy, Richard B, McKinney, Brett A

“…Vaccination is an effective prevention of influenza infection. However, certain individuals develop a lower antibody response after vaccination, which may lead…”
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Alternative contingency table measures improve the power and detection of multifactor dimensionality reduction by Bush, William S, Edwards, Todd L, Dudek, Scott M, McKinney, Brett A, Ritchie, Marylyn D

“…Multifactor Dimensionality Reduction (MDR) has been introduced previously as a non-parametric statistical method for detecting gene-gene interactions. MDR…”
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EpistasisRank and EpistasisKatz: interaction network centrality methods that integrate prior knowledge networks by Parvandeh, Saeid, McKinney, Brett A

“…An important challenge in gene expression analysis is to improve hub gene selection to enrich for biological relevance or improve classification accuracy for a…”
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dcVar: a method for identifying common variants that modulate differential correlation structures in gene expression data by Lareau, Caleb A, White, Bill C, Montgomery, Courtney G, McKinney, Brett A

“…Recent studies have implicated the role of differential co-expression or correlation structure in gene expression data to help explain phenotypic differences…”
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STatistical Inference Relief (STIR) feature selection by Le, Trang T, Urbanowicz, Ryan J, Moore, Jason H, McKinney, Brett A

“…Abstract Motivation Relief is a family of machine learning algorithms that uses nearest-neighbors to select features whose association with an outcome may be…”
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