Search Results - "MCKENNA, W"

Oxidative Phosphorylation as an Emerging Target in Cancer Therapy by Ashton, Thomas M, McKenna, W Gillies, Kunz-Schughart, Leoni A, Higgins, Geoff S

“…Cancer cells have upregulated glycolysis compared with normal cells, which has led many to the assumption that oxidative phosphorylation (OXPHOS) is…”
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Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair by Vaz, Bruno, Popovic, Marta, Newman, Joseph A., Fielden, John, Aitkenhead, Hazel, Halder, Swagata, Singh, Abhay Narayan, Vendrell, Iolanda, Fischer, Roman, Torrecilla, Ignacio, Drobnitzky, Neele, Freire, Raimundo, Amor, David J., Lockhart, Paul J., Kessler, Benedikt M., McKenna, Gillies W., Gileadi, Opher, Ramadan, Kristijan

“…The cytotoxicity of DNA-protein crosslinks (DPCs) is largely ascribed to their ability to block the progression of DNA replication. DPCs frequently occur in…”
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Gemcitabine-Induced TIMP1 Attenuates Therapy Response and Promotes Tumor Growth and Liver Metastasis in Pancreatic Cancer by D'Costa, Zenobia, Jones, Keaton, Azad, Abul, van Stiphout, Ruud, Lim, Su Y, Gomes, Ana L, Kinchesh, Paul, Smart, Sean C, Gillies McKenna, W, Buffa, Francesca M, Sansom, Owen J, Muschel, Ruth J, O'Neill, Eric, Fokas, Emmanouil

“…Gemcitabine constitutes one of the backbones for chemotherapy treatment in pancreatic ductal adenocarcinoma (PDAC), but patients often respond poorly to this…”
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Targeting ATR in vivo using the novel inhibitor VE-822 results in selective sensitization of pancreatic tumors to radiation by Fokas, E, Prevo, R, Pollard, J R, Reaper, P M, Charlton, P A, Cornelissen, B, Vallis, K A, Hammond, E M, Olcina, M M, Gillies McKenna, W, Muschel, R J, Brunner, T B

“…Combined radiochemotherapy is the currently used therapy for locally advanced pancreatic ductal adenocarcinoma (PDAC), but normal tissue toxicity limits its…”
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Impacts of combining anti-PD-L1 immunotherapy and radiotherapy on the tumour immune microenvironment in a murine prostate cancer model by Philippou, Yiannis, Sjoberg, Hanna T., Murphy, Emma, Alyacoubi, Said, Jones, Keaton I., Gordon-Weeks, Alex N., Phyu, Su, Parkes, Eileen E., Gillies McKenna, W., Lamb, Alastair D., Gileadi, Uzi, Cerundolo, Vincenzo, Scheiblin, David A., Lockett, Stephen J., Wink, David A., Mills, Ian G., Hamdy, Freddie C., Muschel, Ruth J., Bryant, Richard J.

“…Background Radiotherapy enhances innate and adaptive anti-tumour immunity. It is unclear whether this effect may be harnessed by combining immunotherapy with…”
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Tumor Vascular Changes Mediated by Inhibition of Oncogenic Signaling by QAYUM, Naseer, MUSCHEL, Ruth J, JAE HONG IM, BALATHASAN, Lukxmi, KOCH, Cameron J, PATEL, Sonal, GILLIES MCKENNA, W, BERNHARD, Eric J

“…Many inhibitors of the epidermal growth factor receptor (EGFR)-RAS-phosphatidylinositol 3-kinase (PI3K)-AKT signaling pathway are in clinical use or under…”
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Targeting radiation-resistant hypoxic tumour cells through ATR inhibition by Pires, I M, Olcina, M M, Anbalagan, S, Pollard, J R, Reaper, P M, Charlton, P A, McKenna, W G, Hammond, E M

“…Background: Most solid tumours contain regions of sub-optimal oxygen concentration (hypoxia). Hypoxic cancer cells are more resistant to radiotherapy and…”
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Dual Inhibition of the PI3K/mTOR Pathway Increases Tumor Radiosensitivity by Normalizing Tumor Vasculature by FOKAS, Emmanouil, JAE HONG IM, MUSCHEL, Ruth J, HILL, Sally, YAMEEN, Sabira, STRATFORD, Michael, BEECH, John, HACKL, Wolfgang, MAIRA, Sauveur-Michel, BEMHARD, Eric J, GILLIES MCKENNA, W

“…The aberrant vascular architecture of solid tumors results in hypoxia that limits the efficacy of radiotherapy. Vascular normalization using antiangiogenic…”
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CDK1 inhibition sensitizes normal cells to DNA damage in a cell cycle dependent manner by Prevo, Remko, Pirovano, Giacomo, Puliyadi, Rathi, Herbert, Katharine J., Rodriguez-Berriguete, Gonzalo, O'Docherty, Alice, Greaves, William, McKenna, W. Gillies, Higgins, Geoff S.

“…Cyclin-dependent kinase 1 (CDK1) orchestrates the transition from the G2 phase into mitosis and as cancer cells often display enhanced CDK1 activity, it has…”
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The impact of tumor microenvironment on cancer treatment and its modulation by direct and indirect antivascular strategies by Fokas, Emmanouil, McKenna, W. Gillies, Muschel, Ruth J.

“…Tumor cells exploit their microenvironment by growth factors and cytokines such as vascular endothelial growth factor (VEGF) to stimulate abnormal vessel…”
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Characteristics of Individualized Education Programs for Students With Learning Disabilities: A Systematic Review by McKenna, John W., Solis, Michael, Garwood, Justin, Parenti, Melissa

“…Students in the United States who receive special education services are entitled to receive an Individualized Education Program (IEP) that provides an…”
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Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases by Caforio, Alida L P, Pankuweit, Sabine, Arbustini, Eloisa, Basso, Cristina, Gimeno-Blanes, Juan, Felix, Stephan B, Fu, Michael, Heliö, Tiina, Heymans, Stephane, Jahns, Roland, Klingel, Karin, Linhart, Ales, Maisch, Bernhard, McKenna, William, Mogensen, Jens, Pinto, Yigal M, Ristic, Arsen, Schultheiss, Heinz-Peter, Seggewiss, Hubert, Tavazzi, Luigi, Thiene, Gaetano, Yilmaz, Ali, Charron, Philippe, Elliott, Perry M

“…In this position statement of the ESC Working Group on Myocardial and Pericardial Diseases an expert consensus group reviews the current knowledge on clinical…”
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Impact of co‐teaching on general educator self‐reported knowledge and use of inclusive practices for students with emotional and behavioral disabilities: A pilot investigation by McKenna, John W., Newton, Xiaoxia, Brigham, Frederick

“…This pilot study examined the self‐reported knowledge and implementation of recommended practices for supporting students with emotional and/or behavioral…”
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The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy by Prevo, Remko, Fokas, Emmanouil, Reaper, Philip M., Charlton, Peter A., Pollard, John R., McKenna, W. Gillies, Muschel, Ruth J., Brunner, Thomas B.

“…DNA damaging agents such as radiotherapy and gemcitabine are frequently used for the treatment of pancreatic cancer. However, these treatments typically…”
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Guidelines for preclinical and early phase clinical assessment of novel radiosensitisers by Harrington, K J, Billingham, L J, Brunner, T B, Burnet, N G, Chan, C S, Hoskin, P, Mackay, R I, Maughan, T S, Macdougall, J, McKenna, W G, Nutting, C M, Oliver, A, Plummer, R, Stratford, I J, Illidge, T

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Video-assisted thoracic surgery versus open lobectomy for lung cancer: A secondary analysis of data from the American College of Surgeons Oncology Group Z0030 randomized clinical trial by Scott, Walter J., MD, FACS, Allen, Mark S., MD, Darling, Gail, MD, FRCSC, FACS, Meyers, Bryan, MD, Decker, Paul A., MS, Putnam, Joe B., MD, Mckenna, Robert W., MD, Landrenau, Rodney J., MD, Jones, David R., MD, Inculet, Richard I., MD, Malthaner, Richard A., MD

“…Objective Video-assisted thoracoscopic lobectomy remains controversial. We compared outcomes from participants in a randomized study comparing lymph node…”
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Evaluation of a Stochastic Mixing Scheme in the Deep Convective Gray Zone Using a Tropical Oceanic Deep Convection Case Study by Stanford, McKenna W., Varble, Adam C., Morrison, Hugh

“…A stochastic horizontal subgrid‐scale mixing scheme is evaluated in ensemble simulations of a tropical oceanic deep convection case using a horizontal grid…”
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The prognostic role of desmoplastic stroma in pancreatic ductal adenocarcinoma by Wang, Lai Mun, Silva, Michael A, D'Costa, Zenobia, Bockelmann, Robin, Soonawalla, Zahir, Liu, Stanley, O'Neill, Eric, Mukherjee, Somnath, McKenna, W Gillies, Muschel, Ruth, Fokas, Emmanouil

“…Pancreatic ductal adenocarcinoma (PDAC) is characterized by an abundant desmoplastic stroma. We examined the prognostic value of stroma density and activity in…”
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Phase I Trial of the Human Immunodeficiency Virus Protease Inhibitor Nelfinavir and Chemoradiation for Locally Advanced Pancreatic Cancer by BRUNNER, Thomas B, GEIGER, Matthias, GRABENBAUER, Gerhard G, LANG-WELZENBACH, Marga, MANTONI, Tine S, CAVALLARO, Alexander, SAUER, Rolf, HOHENBERGER, Werner, GILLIES MCKENNA, W

“…Preclinically, HIV protease inhibitors radiosensitize tumors with activated PI3-kinase/Akt pathway. We determined the toxicity of nelfinavir chemoradiotherapy…”
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Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels by Harada, Hiroshi, Inoue, Masahiro, Itasaka, Satoshi, Hirota, Kiichi, Morinibu, Akiyo, Shinomiya, Kazumi, Zeng, Lihua, Ou, Guangfei, Zhu, Yuxi, Yoshimura, Michio, McKenna, W. Gillies, Muschel, Ruth J., Hiraoka, Masahiro

“…Tumour recurrence frequently occurs after radiotherapy, but the characteristics, intratumoural localization and post-irradiation behaviour of radioresistant…”
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