Search Results - "MCKEE, K"

Precise small-molecule cleavage of an r(CUG) repeat expansion in a myotonic dystrophy mouse model by Angelbello, Alicia J., Rzuczek, Suzanne G., Mckee, Kendra K., Chen, Jonathan L., Olafson, Hailey, Cameron, Michael D., Moss, Walter N., Wang, Eric T., Disney, Matthew D.

“…Myotonic dystrophy type 1 (DM1) is an incurable neuromuscular disorder caused by an expanded CTG repeat that is transcribed into r(CUG)exp. The RNA repeat…”
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Mangrove Sedimentation and Response to Relative Sea-Level Rise by Woodroffe, C.D, Rogers, K, McKee, K.L, Lovelock, C.E, Mendelssohn, I.A, Saintilan, N

“…Mangroves occur on upper intertidal shorelines in the tropics and subtropics. Complex hydrodynamic and salinity conditions, related primarily to elevation and…”
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The effect of dietary sodium octanoate on Ghrelin concentration and feed intake in chickens and turkeys: a comparative study by Taofeek, N., Thompson, D., Rowland, J., Sanmartin, P., Ceron-Romero, N., Vroonland, E., Cintron, O., Rushing, M., McKee, K., Lopez, S., Blake, K., Shackelford, L., Baker, M., Verghese, M., Vizcarra, J.

“…Active ghrelin (AG) is produced through the post-translational addition of n-octanoic acid to the amino residue Ser-3, making it the natural ligand for the…”
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Bispecific Antibodies Targeting Different Epitopes on the HIV-1 Envelope Exhibit Broad and Potent Neutralization by Asokan, M, Rudicell, R S, Louder, M, McKee, K, O'Dell, S, Stewart-Jones, G, Wang, K, Xu, L, Chen, X, Choe, M, Chuang, G, Georgiev, I S, Joyce, M G, Kirys, T, Ko, S, Pegu, A, Shi, W, Todd, J P, Yang, Z, Bailer, R T, Rao, S, Kwong, P D, Nabel, G J, Mascola, J R

“…The potency and breadth of the recently isolated neutralizing human monoclonal antibodies to HIV-1 have stimulated interest in their use to prevent or to treat…”
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Ecological function maintained despite mesomammal declines by McKee, Rebecca K., Taillie, Paul J., Hart, Kristen M., Lopez, Christopher L., Sanjar, Adam, McCleery, Robert A.

“…Mid-sized mammals (i.e., mesomammals) fulfill important ecological roles, serving as essential scavengers, predators, pollinators, and seed dispersers in the…”
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Author Correction: Ecological function maintained despite mesomammal declines by McKee, Rebecca K., Taillie, Paul J., Hart, Kristen M., Lopez, Christopher L., Sanjar, Adam, McCleery, Robert A.

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Whole Transcriptome Analysis of Notochord-Derived Cells during Embryonic Formation of the Nucleus Pulposus by Peck, Sun H., McKee, Kendra K., Tobias, John W., Malhotra, Neil R., Harfe, Brian D., Smith, Lachlan J.

“…Recapitulation of developmental signals represents a promising strategy for treating intervertebral disc degeneration. During development, embryonic…”
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A mutation affecting laminin alpha 5 polymerisation gives rise to a syndromic developmental disorder by Jones, Lynelle K, Lam, Rachel, McKee, Karen K, Aleksandrova, Maya, Dowling, John, Alexander, Stephen I, Mallawaarachchi, Amali, Cottle, Denny L, Short, Kieran M, Pais, Lynn, Miner, Jeffery H, Mallett, Andrew J, Simons, Cas, McCarthy, Hugh, Yurchenco, Peter D, Smyth, Ian M

“…Laminin alpha 5 (LAMA5) is a member of a large family of proteins that trimerise and then polymerise to form a central component of all basement membranes…”
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The association between the physical environment and the well‐being of older people in residential care facilities: A multilevel analysis by Nordin, Susanna, McKee, Kevin, Wijk, Helle, Elf, Marie

“…Aims To investigate the associations between the quality of the physical environment and the psychological and social well‐being of older people living in…”
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Micro-RNA-195 and -451 regulate the LKB1/AMPK signaling axis by targeting MO25 by Chen, Hao, Untiveros, Gustavo M, McKee, Laurel A K, Perez, Jessica, Li, Jing, Antin, Parker B, Konhilas, John P

“…Recently, MicroRNAs (miR) and AMP-kinase (AMPK) have emerged as prominent players in the development of cardiac hypertrophy and heart failure. We hypothesized…”
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Pathogenicity of a Human Laminin β2 Mutation Revealed in Models of Alport Syndrome by Funk, Steven D., Bayer, Raymond H., Malone, Andrew F., McKee, Karen K., Yurchenco, Peter D., Miner, Jeffrey H.

“…Pierson syndrome is a congenital nephrotic syndrome with eye and neurologic defects caused by mutations in laminin β 2 ( LAMB2 ), a major component of the…”
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Structural decoding of netrin-4 reveals a regulatory function towards mature basement membranes by Reuten, Raphael, Patel, Trushar R., McDougall, Matthew, Rama, Nicolas, Nikodemus, Denise, Gibert, Benjamin, Delcros, Jean-Guy, Prein, Carina, Meier, Markus, Metzger, Stéphanie, Zhou, Zhigang, Kaltenberg, Jennifer, McKee, Karen K., Bald, Tobias, Tüting, Thomas, Zigrino, Paola, Djonov, Valentin, Bloch, Wilhelm, Clausen-Schaumann, Hauke, Poschl, Ernst, Yurchenco, Peter D., Ehrbar, Martin, Mehlen, Patrick, Stetefeld, Jörg, Koch, Manuel

“…Netrins, a family of laminin-related molecules, have been proposed to act as guidance cues either during nervous system development or the establishment of the…”
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Chimeric protein identification of dystrophic, Pierson and other laminin polymerization residues by McKee, Karen K., Aleksandrova, Maya, Yurchenco, Peter D.

“…Laminin polymerization is a key step of basement membrane self-assembly that depends on the binding of the three different N-terminal globular LN domains…”
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A deletion in the N-terminal polymerizing domain of laminin β2 is a new mouse model of chronic nephrotic syndrome by Funk, Steven D, Bayer, Raymond H, McKee, Karen K, Okada, Kazushi, Nishimune, Hiroshi, Yurchenco, Peter D, Miner, Jeffrey H

“…The importance of the glomerular basement membrane (GBM) in glomerular filtration is underscored by the manifestations of Alport and Pierson syndromes, caused…”
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A cytokine and angiogenic factor (CAF) analysis in plasma for selection of sorafenib therapy in patients with metastatic renal cell carcinoma by Zurita, A.J., Jonasch, E., Wang, X., Khajavi, M., Yan, S., Du, D.Z., Xu, L., Herynk, M.H., McKee, K.S., Tran, H.T., Logothetis, C.J., Tannir, N.M., Heymach, J.V.

“…We investigated cytokines and angiogenic factors (CAFs) in patients with metastatic renal cell carcinoma (mRCC) treated in a randomized phase II clinical trial…”
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Role of Laminin Terminal Globular Domains in Basement Membrane Assembly by McKee, Karen K., Harrison, David, Capizzi, Stephanie, Yurchenco, Peter D.

“…Laminins contribute to basement membrane assembly through interactions of their N- and C-terminal globular domains. To further analyze this process,…”
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Chimeric protein repair of laminin polymerization ameliorates muscular dystrophy phenotype by McKee, Karen K, Crosson, Stephanie C, Meinen, Sarina, Reinhard, Judith R, Rüegg, Markus A, Yurchenco, Peter D

“…Mutations in laminin α2-subunit (Lmα2, encoded by LAMA2) are linked to approximately 30% of congenital muscular dystrophy cases. Mice with a homozygous…”
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Linker Protein Repair of LAMA2 Dystrophic Neuromuscular Basement Membranes by Yurchenco, Peter D, McKee, Karen K

“…An understanding of basement membrane (BM) assembly at a molecular level provides a foundation with which to develop repair strategies for diseases with…”
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Exogenous laminin exhibits a unique vascular pattern in the brain via binding to dystroglycan and integrins by Ruan, Jingsong, McKee, Karen K, Yurchenco, Peter D, Yao, Yao

“…Unlike other proteins that exhibit a diffusion pattern after intracerebral injection, laminin displays a vascular pattern. It remains unclear if this unique…”
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The Effect of Nutrient Enrichment on Growth, Photosynthesis and Hydraulic Conductance of Dwarf Mangroves in Panamá by Lovelock, C. E., Feller, I. C., McKee, K. L., Engelbrecht, B. M. J., Ball, M. C.

“…1. Dwarf stands of the mangrove Rhizophora mangle L. are extensive in the Caribbean. We fertilized dwarf trees in Almirante Bay, Bocas del Toro Province,…”
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