Search Results - "MCKEAGE, M. J"

Randomised phase II study of ASA404 combined with carboplatin and paclitaxel in previously untreated advanced non-small cell lung cancer by McKeage, M J, Von Pawel, J, Reck, M, Jameson, M B, Rosenthal, M A, Sullivan, R, Gibbs, D, Mainwaring, P N, Serke, M, Lafitte, J-J, Chouaid, C, Freitag, L, Quoix, E

“…ASA404 (5,6-dimethylxanthenone-4-acetic acid or DMXAA) is a small-molecule tumour-vascular disrupting agent (Tumour-VDA). This randomised phase II study…”
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Oxaliplatin causes selective atrophy of a subpopulation of dorsal root ganglion neurons without inducing cell loss by JAMIESON, S. M. F, LIU, J, CONNOR, B, MCKEAGE, M. J

“…Peripheral neuropathy is induced by multiple doses of oxaliplatin and interferes with the clinical utility of the drug in patients with colorectal cancer. In…”
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Relationships between hydrophobicity, reactivity, accumulation and peripheral nerve toxicity of a series of platinum drugs by SCRENCI, D, MCKEAGE, M. J, GALETTIS, P, HAMBLEY, T. W, PALMER, B. D, BAGULEY, B. C

“…Previous work has shown platinum drugs to differ in their effects on the peripheral nervous system. To test whether their differential toxicity was due to…”
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Nucleolar damage correlates with neurotoxicity induced by different platinum drugs by MCKEAGE, M. J, HSU, T, SCRENCI, D, HADDAD, G, BAGULEY, B. C

“…Platinum-based drugs are very useful in cancer therapy but are associated with neurotoxicity in the clinic. To investigate the mechanism of neurotoxicity,…”
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Mass balance, excretion and metabolism of [14C] ASA404 in cancer patients in a phase I trial by McKeage, M. J., Fong, P. C., Hong, X., Flarakos, J., Mangold, J., Du, Y., Tanaka, C., Schran, H.

“…Purpose To determine the mass balance, excretion and metabolism of the small molecule flavonoid tumour vascular disrupting agent ASA404 in patients with…”
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Lobaplatin: a new antitumour platinum drug by McKeage, M J

“…Lobaplatin (D-19466) is a diastereometric mixture of platinum(II) complexes containing a 1,2-bis(aminomethyl)cyclobutane stable ligand and lactic acid as the…”
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Nucleolar enlargement, nuclear eccentricity and altered cell body immunostaining characteristics of large-sized sensory neurons following treatment of rats with paclitaxel by Jamieson, S.M.F., Liu, J.J., Connor, B., Dragunow, M., McKeage, M.J.

“…Paclitaxel-induced sensory neuropathy is a problematic side-effect of cancer chemotherapy. Previous studies in rodents have shown paclitaxel treatment to have…”
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Comparative adverse effect profiles of platinum drugs by MCKEAGE, M. J

“…Since the discovery of the biologically active platinum complexes 30 years ago, 2 agents have become widely established in clinical oncology practice. Both…”
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Phase I and pharmacokinetic study of an oral platinum complex given daily for 5 days in patients with cancer by McKeage, M J, Raynaud, F, Ward, J, Berry, C, O'Dell, D, Kelland, L R, Murrer, B, Santabárabara, P, Harrap, K R, Judson, I R

“…We aimed to determine the maximum-tolerated dose (MTD) clinical toxicities, pharmacokinetics, and pharmacodynamics of oral JM216 given once daily for 5 days to…”
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Paclitaxel induces nucleolar enlargement in dorsal root ganglion neurons in vivo reducing oxaliplatin toxicity by JAMIESON, S. M. F, LIU, J, HSU, T, BAGULEY, B. C, MCKEAGE, M. J

“…Paclitaxel and oxaliplatin are promising drugs for combination trials but both induce peripheral neurotoxicity. To investigate this toxicity, 10-week-old…”
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Preclinical antitumor evaluation of bis-acetato-ammine-dichloro-cyclohexylamine platinum(IV) : an orally active platinum drug by KELLAND, L. R, ABEL, G, MCKEAGE, M. J, JONES, M, GODDARD, P. M, VALENTI, M, MURRER, B. A, HARRAP, K. R

“…The cytotoxicity of a novel platinum(IV) complex, bis-acetato-amminedichloro-cyclohexylamine platinum(IV) (JM216), has been evaluated in vitro against a panel…”
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Stereoselective peripheral sensory neurotoxicity of diaminocyclohexane platinum enantiomers related to ormaplatin and oxaliplatin by SCRENCI, D, ER, H. M, HAMBLEY, T. W, GALETTIS, P, BROUWER, W, MCKEAGE, M. J

“…The diaminocyclohexane platinum (Pt(DACH)) derivatives ormaplatin and oxaliplatin have caused severe and dose-limiting peripheral sensory neurotoxicity in a…”
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Preparation, DNA binding, and in vitro cytotoxicity of a pair of enantiomeric platinum(II) complexes, [(R)- and (S)-3-aminohexahydroazepine]dichloroplatinum(II). Crystal structure of the S enantiomer by FENTON, R. R, EASDALE, W. J, ER, H. M, O'MARA, S. M, MCKEAGE, M. J, RUSSELL, P. J, HAMBLEY, T. W

“…A pair of enantiomeric Pt(II) complexes, [Pt(R-ahaz)Cl2] and [Pt(S-ahaz)Cl2] (ahaz = 3-aminohexahydroazepine), has been investigated for their ability to bind…”
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Lack of nephrotoxicity of oral ammine/amine platinum (IV) dicarboxylate complexes in rodents by MCKEAGE, M. J, MORGAN, S. E, BOXALL, F. E, MURRER, B. A, HARD, G. C, HARRAP, K. R

“…The comparative nephrotoxicity of i.v. cisplatin, i.v. carboplatin and six p.o. ammine/amine Pt(IV) dicarboxylates was studied in rodents following single MTD…”
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Preparation, Characterization, DNA Binding, and in Vitro Cytotoxicity of the Enantiomers of the Platinum(II) Complexes N-Methyl-, N-Ethyl- and N,N-Dimethyl-(R)- and -(S)-3-aminohexahydroazepinedichloroplatinum(II) by Rezler, Evonne M, Fenton, Ronald R, Esdale, Warren J, McKeage, Mark J, Russell, Pamela J, Hambley, Trevor W

“…A series of chiral diaminedichloroplatinum(II) complexes derived from [Pt(ahaz)Cl2] (ahaz = 3-aminohexahydroazepine) have been synthesized and tested for…”
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Phase I study of paclitaxel and oral etoposide in previously untreated non-small-cell and extensive small-cell lung cancer by Boyer, M. J., Zalcberg, J., Olver, I. N., Millward, M. J., Richardson, G., McKeage, M. J.

“…Purpose: This phase I study of paclitaxel and oral etoposide was performed to determine the safety of the combination in patients with advanced lung cancer who…”
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Platinum neurotoxicity: clinical profiles, experimental models and neuroprotective approaches by Screnci, Daniela, McKeage, Mark J

“…This paper reviews the neurotoxic side-effects associated with platinum drugs, experimental approaches to studying this toxicity and attempts to use…”
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Lack of neurotoxicity of oral bisacetatoamminedichlorocyclohexylamine-platinum(IV) in comparison to cisplatin and tetraplatin in the rat by MCKEAGE, M. J, BOXALL, F. E, JONES, M, HARRAP, K. R

“…This study compared the effect on sensory nerve conduction velocity in the hind limb of chronically treated age-matched rats of a novel lipophilic p.o…”
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Overview of docetaxel (Taxotere)/cisplatin combination in non-small cell lung cancer by Le Chevalier, T, Bérille, J, Zalcberg, J R, Millward, M J, Monnier, A, Douillard, J Y, McKeage, M J, James, R, Soulas, F, Loret, C, Bougon, N, Bizzari, J P

“…Cisplatin-based chemotherapy is effective in non-small cell lung cancer (NSCLC), although it prolongs survival only modestly. Single-agent docetaxel (Taxotere;…”
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Mechanism of action of an orally administered platinum complex [ammine bis butyrato cyclohexylamine dichloroplatinum (IV) (JM221)] in intrinsically cisplatin-resistant human ovarian carcinoma in vitro by MCKEAGE, M. J, ABEL, G, KELLAND, L. R, HARRAP, K. R

“…Intrinsic resistance to existing clinical platinum drugs is a major cause of treatment failure; moreover, these agents have the drawbacks of cross-resistance…”
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