Search Results - "MCIVOR, R. S"

Visualization of spinal afferent innervation in the mouse colon by AAV8‐mediated GFP expression by Schuster, D. J., Dykstra, J. A., Riedl, M. S., Kitto, K. F., Honda, C. N., McIvor, R. S., Fairbanks, C. A., Vulchanova, L.

“…Background  Primary afferent neurons whose cell bodies reside in thoracolumbar and lumbosacral dorsal root ganglia (DRG) innervate colon and transmit sensory…”
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Increased longevity and metabolic correction following syngeneic BMT in a murine model of mucopolysaccharidosis type I by Wolf, D A, Lenander, A W, Nan, Z, Braunlin, E A, Podetz-Pedersen, K M, Whitley, C B, Gupta, P, Low, W C, McIvor, R S

“…Mucopolysaccharidosis type I (MPS I) is an autosomal recessive inherited disease caused by deficiency of the glycosidase α- L -iduronidase (IDUA). Deficiency…”
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High-titer lentiviral vectors stimulate fetal calf serum-specific human CD4 T-cell responses: implications in human gene therapy by Bao, L, Guo, H, Huang, X, Tammana, S, Wong, M, McIvor, R S, Zhou, X

“…Human immunodeficiency virus-1-derived lentiviral vectors have been increasingly used for gene delivery in both pre-clinical and clinical models. Numerous…”
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The Sleeping Beauty transposon system: a non-viral vector for gene therapy: Gene Therapy by ARONOVICH, Elena L, MCIVOR, R. Scott, HACKETT, Perry B

“…Over the past decade, the Sleeping Beauty (SB) transposon system has been developed as the leading non-viral vector for gene therapy. This vector combines the…”
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In vivo selection of human embryonic stem cell-derived cells expressing methotrexate-resistant dihydrofolate reductase by Gori, J L, Tian, X, Swanson, D, Gunther, R, Shultz, L D, McIvor, R S, Kaufman, D S

“…Human embryonic stem cells (hESCs) provide a novel source of hematopoietic and other cell populations suitable for gene therapy applications. Preclinical…”
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Retroviral vector design studies toward hematopoietic stem cell gene therapy for mucopolysaccharidosis type I by PAN, D, ARONOVICH, E, MCIVOR, R. S, WHITLEY, C. B

“…To optimize a gene transfer system for hematopoietic stem cell gene therapy of patients with mucopolysaccharidosis (MPS) type I, 10 retroviral vectors were…”
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Protection of Mice From Lethal Doses of Methotrexate by Transplantation With Transgenic Marrow Expressing Drug-Resistant Dihydrofolate Reductase Activity by May, Chad, Gunther, Roland, Mclvor, R.Scott

“…Marrow cells from previously established lines of transgenic mice expressing either of two different methotrexate (MTX)-resistant dihydrofolate reductases…”
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Drug-resistant dihydrofolate reductases: generation, expression and therapeutic application by McIvor, R S

“…Although methotrexate (MTX) and other antifolates are effective antitumor chemotherapeutic agents, their utility is limited by toxicity for normal…”
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Metabolic Correction and Cross-Correction of Mucopolysaccharidosis Type II (Hunter Syndrome) by Retroviral-Mediated Gene Transfer and Expression of Human Iduronate-2-Sulfatase by Braun, Stephen E., Aronovich, Elena L., Anderson, Rose Ann, Crotty, Paul L., McIvor, R. Scott, Whitley, Chester B.

“…To explore the possibility of using gene transfer to provide iduronate-2-sulfatase (IDS; EC 3.1.6.13) enzyme activity for treatment of Hunter syndrome, an…”
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Maintenance of differential methotrexate toxicity between cells expressing drug-resistant and wild-type dihydrofolate reductase activities in the presence of nucleosides through nucleoside transport inhibition by Warlick, Christopher A, Sweeney, Colin L, McIvor, R.Scott

“…Methotrexate (MTX), a potent inhibitor of dihydrofolate reductase (DHFR), has been used widely as a chemotherapeutic agent and as a selective agent for cells…”
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Methotrexate resistance conferred by transplantation of drug-resistant transgenic marrow cells fractionated by counterflow elutriation by JAMES, R. I, MAY, C, DIERS, M. D, WAGNER, J. E, MCIVOR, R. S

“…Introduction of genes conferring drug resistance into hematopoietic cells may allow for improved chemotherapy by protection of normally drug-sensitive cells…”
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Enzymatic correction and cross-correction of mucopolysaccharidosis type I fibroblasts by adeno-associated virus-mediated transduction of the alpha-L-iduronidase gene by Hartung, S D, Reddy, R G, Whitley, C B, McIvor, R S

“…Mucopolysaccharidosis type I (MPS I), a deficiency in the lysosomal enzyme alpha-L-iduronidase (IDUA), is characterized by skeletal abnormalities,…”
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Human purine nucleoside phosphorylase and adenosine deaminase: gene transfer into cultured cells and murine hematopoietic stem cells by using recombinant amphotropic retroviruses by MCIVOR, R. S, JOHNSON, M. J, MILLER, A. D, PITTS, S, WILLIAMS, S. R, VALERIO, D, MARTIN, D. W. JR, VERMA, I. M

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Selective expression of methotrexate-resistant dihydrofolate reductase (DHFR) activity in mice transduced with DHFR retrovirus and administered methotrexate by Vinh, D B, McIvor, R S

“…To determine the effect of in vivo pharmacological selective pressure on the insertion and expression of new gene sequences, retroviral-mediated transfer of a…”
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Transgenic mice expressing the tyr22 variant of murine DHFR: protection of transgenic marrow transplant recipients from lethal doses of methotrexate by James, R I, May, C, Vagt, M D, Studebaker, R, McIvor, R S

“…Expression of the arg22, drug-resistant variant of dihydrofolate reductase (DHFR) in hematopoietic cells has been demonstrated to confer resistance to…”
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Intron requirement for expression of the human purine nucleoside phosphorylase gene by JONSSON, J. J, FORESMAN, M. D, WILSON, N, MCIVOR, R. S

“…Abbreviated purine nucleoside phosphorylase (PNP) genes were engineered to determine the effect of introns on human PNP gene expression. PNP minigenes…”
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Isolation and characterization of a variant dihydrofolate reductase cDNA from methotrexate-resistant murine L5178Y cells by MCIVOR, R. S, SIMONSEN, C. C

“…Dihydrofolate reductase (DHFR) cDNA sequences were isolated from a methotrexate-resistant mouse L5178Y cell line previously shown to contain…”
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A human purine nucleoside phosphorylase deficiency caused by a single base change by Williams, S.R., Gekeler, V., McIvor, R.S., Martin, D.W.

“…Purine nucleoside phosphorylase (PNP) deficiency in humans is associated with a severe defect in T-lymphocyte function. The mutant gene was cloned from one…”
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Methotrexate dose-escalation studies in transgenic mice and marrow transplant recipients expressing drug-resistant dihydrofolate reductase activity by May, C, James, R I, Gunther, R, McIvor, R S

“…Methotrexate (MTX) dose-escalation studies were conducted in two inbred lines of FVB/N transgenic mice expressing distinct drug-resistant dihydrofolate…”
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Interleukin-2 gene transfer into murine neuroblastoma decreases tumorigenicity and enhances systemic immunity causing regression of preestablished retroperitoneal tumors by Katsanis, E, Orchard, P J, Bausero, M A, Gorden, K B, McIvor, R S, Blazar, B R

“…Murine neuroblastoma, neuro-2a, was transduced with the retroviral vector LIL-2SN in order to examine the influence of localized interleukin (IL)-2 production…”
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