Search Results - "MCINTYRE, W"

Randomized clinical trial of dialysate cooling and effects on brain white matter by Eldehni, Mohamed T, Odudu, Aghogho, McIntyre, Christopher W

“…Hemodialysis is associated with significant circulatory stress that could produce recurrent and cumulative ischemic insults to multiple organs, such as the…”
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Ischemic brain injury in hemodialysis patients: which is more dangerous, hypertension or intradialytic hypotension? by McIntyre, Christopher W, Goldsmith, David J

“…Abnormalities of cognitive function and high levels of depression incidence are characteristic of hemodialysis patients. Although previously attributed to the…”
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Analyzing RNA posttranscriptional modifications to decipher the epitranscriptomic code by Deng, L., Kumar, J., Rose, R., McIntyre, W., Fabris, Daniele

“…The discovery of RNA silencing has revealed that non‐protein‐coding sequences (ncRNAs) can cover essential roles in regulatory networks and their malfunction…”
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Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165 by Wrobleski, Stephen T, Moslin, Ryan, Lin, Shuqun, Zhang, Yanlei, Spergel, Steven, Kempson, James, Tokarski, John S, Strnad, Joann, Zupa-Fernandez, Adriana, Cheng, Lihong, Shuster, David, Gillooly, Kathleen, Yang, Xiaoxia, Heimrich, Elizabeth, McIntyre, Kim W, Chaudhry, Charu, Khan, Javed, Ruzanov, Max, Tredup, Jeffrey, Mulligan, Dawn, Xie, Dianlin, Sun, Huadong, Huang, Christine, D’Arienzo, Celia, Aranibar, Nelly, Chiney, Manoj, Chimalakonda, Anjaneya, Pitts, William J, Lombardo, Louis, Carter, Percy H, Burke, James R, Weinstein, David S

“…Small molecule JAK inhibitors have emerged as a major therapeutic advancement in treating autoimmune diseases. The discovery of isoform selective JAK…”
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Randomized Controlled Trial of Individualized Dialysate Cooling for Cardiac Protection in Hemodialysis Patients by Odudu, Aghogho, Eldehni, Mohamed Tarek, McCann, Gerry P, McIntyre, Christopher W

“…Cardiovascular disease is the most common cause of death in patients on hemodialysis (HD). HD-associated cardiomyopathy is appreciated to be driven by exposure…”
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Antiseizure effects of the cannabinoids in the amygdala‐kindling model by Fallah, Merrick S., Dlugosz, Lukasz, Scott, Brian W., Thompson, Miles D., Burnham, W. McIntyre

“…Objective Focal impaired awareness seizures (FIASs) are the most common seizure type in adults and are often refractory to medication. Management of FIASs is…”
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Intradialytic Cardiac Magnetic Resonance Imaging to Assess Cardiovascular Responses in a Short-Term Trial of Hemodiafiltration and Hemodialysis by Buchanan, Charlotte, Mohammed, Azharuddin, Cox, Eleanor, Köhler, Katrin, Canaud, Bernard, Taal, Maarten W, Selby, Nicholas M, Francis, Susan, McIntyre, Chris W

“…Hemodynamic stress during hemodialysis (HD) results in recurrent segmental ischemic injury (myocardial stunning) that drives cumulative cardiac damage. We…”
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CHOGM 2022: Rwanda hosts a well-organised revival of Commonwealth rituals by McIntyre, W. David

“…After postponements in 2020 and 2021 because of the pandemic, the Commonwealth Heads of Government Meeting (CHOGM) was finally held for two days on 24-25 June…”
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Hemodialysis-Induced Cardiac Injury: Determinants and Associated Outcomes by Burton, James O, Jefferies, Helen J, Selby, Nicholas M, McIntyre, Christopher W

“…Hemodialysis (HD)-induced myocardial stunning driven by ischemia is a recognized complication of HD, which can be ameliorated by HD techniques that improve…”
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The clinical utility and cost impact of cystatin C measurement in the diagnosis and management of chronic kidney disease: A primary care cohort study by Shardlow, Adam, McIntyre, Natasha J, Fraser, Simon D S, Roderick, Paul, Raftery, James, Fluck, Richard J, McIntyre, Christopher W, Taal, Maarten W

“…To reduce over-diagnosis of chronic kidney disease (CKD) resulting from the inaccuracy of creatinine-based estimates of glomerular filtration rate (GFR), UK…”
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Influence of Dialysate Sodium Prescription on Skin and Muscle Sodium Concentration by Lemoine, Sandrine, Salerno, Fabio R., Akbari, Alireza, McIntyre, Christopher W.

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Estimated incidence of previously undetected atrial fibrillation on a 14-day continuous electrocardiographic monitor and associated risk of stroke: comment-Authors' reply by McIntyre, W F, Healey, J S

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Hemodialysis-Induced Repetitive Myocardial Injury Results in Global and Segmental Reduction in Systolic Cardiac Function by Burton, James O, Jefferies, Helen J, Selby, Nicholas M, McIntyre, Christopher W

“…Hemodialysis (HD)-induced regional wall motion abnormalities (RWMAs) are common in HD patients and driven by ischemia. In nondialysis patients, repeated…”
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Frequent Hemodialysis Schedules Are Associated with Reduced Levels of Dialysis-induced Cardiac Injury (Myocardial Stunning) by Jefferies, Helen J, Virk, Bhupinder, Schiller, Brigitte, Moran, John, McIntyre, Christopher W

“…Recurrent hemodialysis (HD)-induced ischemic cardiac injury (myocardial stunning) is common and associated with high ultrafiltration (UF) requirements,…”
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Impact of Compliance with a Care Bundle on Acute Kidney Injury Outcomes: A Prospective Observational Study by Kolhe, Nitin V, Staples, David, Reilly, Timothy, Merrison, Daniel, Mcintyre, Christopher W, Fluck, Richard J, Selby, Nicholas M, Taal, Maarten W

“…A recent report has highlighted suboptimal standards of care for acute kidney injury (AKI) patients in England. The objective of this study was to ascertain if…”
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Bruton's tyrosine kinase inhibitor BMS-986142 in experimental models of rheumatoid arthritis enhances efficacy of agents representing clinical standard-of-care by Gillooly, Kathleen M, Pulicicchio, Claudine, Pattoli, Mark A, Cheng, Lihong, Skala, Stacey, Heimrich, Elizabeth M, McIntyre, Kim W, Taylor, Tracy L, Kukral, Daniel W, Dudhgaonkar, Shailesh, Nagar, Jignesh, Banas, Dana, Watterson, Scott H, Tino, Joseph A, Fura, Aberra, Burke, James R

“…Bruton's tyrosine kinase (BTK) regulates critical signal transduction pathways involved in the pathobiology of rheumatoid arthritis (RA) and other autoimmune…”
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Hemodialysis-Related Acute Brain Injury Demonstrated by Application of Intradialytic Magnetic Resonance Imaging and Spectroscopy by Anazodo, Udunna C, Wong, Dickson Y, Théberge, Jean, Dacey, Madeleine, Gomes, Janice, Penny, Jarrin D, van Ginkel, Michael, Poirier, Stefan E, McIntyre, Christopher W

“…Hemodialysis (HD) results in reduced brain blood flow, and HD-related circulatory stress and regional ischemia are associated with brain injury over time…”
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Redefining the concept of residual renal function with kidney sodium MRI: a pilot study by Lemoine, Sandrine, Akbari, Alireza, Brahm, Gary, Dorie, Justin, Tamasi, Tanya, Penny, Jarrin, McIntyre, Christopher W

“…The concept of residual kidney function (RKF) is exclusively based upon urine volume and small solute clearance, making RKF challenging to assess in clinical…”
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Use of Electronic Results Reporting to Diagnose and Monitor AKI in Hospitalized Patients by Selby, Nicholas M, Crowley, Lisa, Fluck, Richard J, McIntyre, Christopher W, Monaghan, John, Lawson, Nigel, Kolhe, Nitin V

“…Many patients with AKI are cared for by non-nephrologists. This can result in variable standards of care that contribute to poor outcomes. To improve AKI…”
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Progesterone, 5a-dihydropogesterone and allopregnanolone's effects on seizures: A review of animal and clinical studies by Wu, Yinhao Violet, Burnham, W. McIntyre

“…•Progesterone's anti-seizure effects are mediated by its metabolites: DHP and ALLO.•Progesterone, DHP and ALLO suppress non-absence seizures in…”
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