Search Results - "MCINTOSH, Stuart"

Minimally invasive treatment of early, good prognosis breast cancer-is this feasible? by Mactier, Mhairi, McIntosh, Stuart A, Sharma, Nisha

“…Breast cancer screening programmes frequently detect early, good prognosis breast cancers with significant treatment burden for patients, and associated…”
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Understanding Patient Experiences to Inform Future Studies to Optimize Personalization of Treatment for Early Breast Cancer by McIntosh, Stuart A., Mactier, Mhairi, Fairhurst, Katherine, Gath, Jacqui, Stobart, Hilary, Potter, Shelley

“…Background Breast cancer treatment is multimodal, but not all patients benefit from each treatment, and many experience morbidities significantly impacting…”
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ASO Visual Abstract: Understanding Patient Experiences to Inform Future Studies to Optimize Personalization of Treatment for Early Breast Cancer by McIntosh, Stuart A., Mactier, Mhairi, Fairhurst, Katherine, Gath, Jacqui, Stobart, Hilary, Potter, Shelley

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Randomized Phase II Study Evaluating Palbociclib in Addition to Letrozole as Neoadjuvant Therapy in Estrogen Receptor-Positive Early Breast Cancer: PALLET Trial by Johnston, Stephen, Puhalla, Shannon, Wheatley, Duncan, Ring, Alistair, Barry, Peter, Holcombe, Chris, Boileau, Jean Francois, Provencher, Louise, Robidoux, André, Rimawi, Mothaffar, McIntosh, Stuart A, Shalaby, Ibrahim, Stein, Robert C, Thirlwell, Michael, Dolling, David, Morden, James, Snowdon, Claire, Perry, Sophie, Cornman, Chester, Batten, Leona M, Jeffs, Lisa K, Dodson, Andrew, Martins, Vera, Modi, Arjun, Osborne, C Kent, Pogue-Geile, Katherine L, Cheang, Maggie Chon U, Wolmark, Norman, Julian, Thomas B, Fisher, Kate, MacKenzie, Mairead, Wilcox, Maggie, Huang Bartlett, Cynthia, Koehler, Maria, Dowsett, Mitch, Bliss, Judith M, Jacobs, Samuel A

“…CDK4/6 inhibitors are used to treat estrogen receptor (ER)-positive metastatic breast cancer (BC) in combination with endocrine therapy. PALLET is a phase II…”
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Identifying research priorities for improving information and support for patients undergoing breast cancer surgery: a UK patient-centred priority setting project by Johnston, Emma, Cowan, Katherine, MacKenzie, Mairead, Patton, Sonia, Turner, Lesley, Fairbrother, Patricia, McIntosh, Stuart A., Potter, Shelley

“…Purpose To use robust consensus methods with individuals with lived breast cancer experience to agree the top 10 research priorities to improve information and…”
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The DNA damage induced immune response: Implications for cancer therapy by Barros, Eliana M., McIntosh, Stuart A., Savage, Kienan I.

“…Genomic instability is a hallmark of tumourigenesis, influencing tumour development and progression. In particular, defects in the DNA damage response (DDR)…”
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Homologous recombination deficiency in breast cancer: Implications for risk, cancer development, and therapy by Ali, Rayhaan M. M., McIntosh, Stuart A., Savage, Kienan I.

“…An underlying cause of breast cancers has been largely attributed to defects in the DNA damage response (DDR) pathway. In particular, the homologous…”
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Locoregional recurrence in studies of primary systemic therapy in early invasive breast cancer by Chen, Luqi, McIntosh, Stuart A., Tyagi, Siddharth, Dodwell, David

“…The use of primary systemic therapy (PST) in early invasive breast cancer is routine but there are concerns about risk of locoregional recurrence. We conducted…”
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Global trends in psycho‐oncology research investments 2016–2020: A content analysis by Conti, Isabella, Davidson, Mitchell, Cutress, Ramsey I., McIntosh, Stuart A., Head, Michael G.

“…Objective An estimated one‐third of cancer patients experience a clinically significant psychological disorder, however it is unclear to what extent this is…”
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Phase III, Randomized, Placebo-Controlled Study of Docetaxel in Combination With Zibotentan in Patients With Metastatic Castration-Resistant Prostate Cancer by FIZAZI, Karim S, HIGANO, Celestia S, NELSON, Joel B, GLEAVE, Martin, MILLER, Kurt, MORRIS, Thomas, NATHAN, Faith E, MCINTOSH, Stuart, PEMBERTON, Kristine, MOUL, Judd W

“…PURPOSE As part of the ENTHUSE (Endothelin A Use) program, the efficacy and safety of zibotentan (ZD4054), an oral specific endothelin A receptor antagonist,…”
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Cancer-specific mortality in breast cancer patients with hypothyroidism: a UK population-based study by McVicker, Lauren, Cardwell, Christopher R., McIntosh, Stuart A., McMenamin, Úna C.

“…Purpose Epidemiological studies have indicated a higher prevalence of hypothyroidism in breast cancer patients, possibly related to shared risk factors and…”
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FKBPL and its peptide derivatives inhibit endocrine therapy resistant cancer stem cells and breast cancer metastasis by downregulating DLL4 and Notch4 by McClements, Lana, Annett, Stephanie, Yakkundi, Anita, O'Rourke, Martin, Valentine, Andrea, Moustafa, Nermeen, Alqudah, Abdelrahim, Simões, Bruno M, Furlong, Fiona, Short, Amy, McIntosh, Stuart A, McCarthy, Helen O, Clarke, Robert B, Robson, Tracy

“…Optimising breast cancer treatment remains a challenge. Resistance to therapy is a major problem in both ER- and ER+ breast cancer. Tumour recurrence after…”
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Global funding for cancer research between 2016 and 2020: a content analysis of public and philanthropic investments by McIntosh, Stuart A, Alam, Fareeha, Adams, Laura, Boon, Ian S, Callaghan, Jonathan, Conti, Isabella, Copson, Ellen, Carson, Victoria, Davidson, Mitchell, Fitzgerald, Helen, Gautam, Ashram, Jones, Christopher M, Kargbo, Saffron, Lakshmipathy, Gokul, Maguire, Hannah, McFerran, Kathryn, Mirandari, Amatta, Moore, Natasha, Moore, Ross, Murray, Aidan, Newman, Lydia, Robinson, Stephen D, Segaran, Ashvina, Soong, Chin Nam, Walker, Andrew, Wijayaweera, Kusal, Atun, Rifat, Cutress, Ramsey I, Head, Michael G

“…Cancer is a leading cause of disease burden globally, with more than 19·3 million cases and 10 million deaths recorded in 2020. Research is crucial to…”
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The musculoskeletal consequences of latissmus dorsi breast reconstruction in women following mastectomy for breast cancer by Blackburn, Nicole E, Mc Veigh, Joseph G, Mc Caughan, Eilis M, Kennedy, Richard D, McIntosh, Stuart A, Wilson, Iseult M

“…Current evidence suggests that patients who have latissimus dorsi (LD) breast reconstruction following mastectomy for breast cancer can experience long-term…”
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BRCA1 Deficiency Exacerbates Estrogen-Induced DNA Damage and Genomic Instability by SAVAGE, Kienan I, MATCHETT, Kyle B, POWELL, Alexander, MANTI, Lorenzo, MCDADE, Simon S, BEN HO PARK, PRISE, Kevin M, MCINTOSH, Stuart A, SALTO-TELLEZ, Manuel, RICHARD, Derek J, ELLIOTT, Christopher T, HARKIN, D. Paul, BARROS, Eliana M, COOPER, Kevin M, IRWIN, Gareth W, GORSKI, Julia J, ORR, Katy S, VOHHODINA, Jekaterina, KAVANAGH, Joy N, MADDEN, Angelina F

“…Germline mutations in BRCA1 predispose carriers to a high incidence of breast and ovarian cancers. BRCA1 functions to maintain genomic stability through…”
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Identifying research priorities in breast cancer surgery: a UK priority setting partnership with the James Lind Alliance by Potter, Shelley, Fairhurst, Katherine, Cowan, Katherine, Vincent, Simon, Lewis, Ian, Cutress, Ramsey I., Stobart, Hilary, Fairbrother, Patricia, Turner, Sophia, Davies-Crowley, Kayleigh, Jeevan, Ranjeet, Rattay, Tim, O’Connell, Rachel, Bundred, Nigel, McIntosh, Stuart A.

“…Purpose A James Lind Alliance priority setting partnership was developed to identify research priorities in breast cancer surgery from individuals with lived…”
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The Lancet Breast Cancer Commission by Coles, Charlotte E, Earl, Helena, Anderson, Benjamin O, Barrios, Carlos H, Bienz, Maya, Bliss, Judith M, Cameron, David A, Cardoso, Fatima, Cui, Wanda, Francis, Prudence A, Jagsi, Reshma, Knaul, Felicia Marie, McIntosh, Stuart A, Phillips, Kelly-Anne, Radbruch, Lukas, Thompson, Mareike K, André, Fabrice, Abraham, Jean E, Bhattacharya, Indrani S, Franzoi, Maria Alice, Drewett, Lynsey, Fulton, Alexander, Kazmi, Farasat, Inbah Rajah, Dharrnesha, Mutebi, Miriam, Ng, Dianna, Ng, Szeyi, Olopade, Olufunmilayo I, Rosa, William E, Rubasingham, Jeffrey, Spence, Dingle, Stobart, Hilary, Vargas Enciso, Valentina, Vaz-Luis, Ines, Villarreal-Garza, Cynthia, Arreola-Ornelas, Hector, Bhadelia, Afsan, Boughey, Judy C, Chatterjee, Sanjoy, Dodwell, David, Doubova, Svetlana, Du Plooy, Dorothy, Essue, Beverley, Goel, Neha, Gralow, Julie, Hawley, Sarah, Kiely, Belinda, Mann, Ritse, Mertz, Shirley, Palmieri, Carlo, Poortmans, Philip, Spanic, Tanja, Stephen, Lesley, Symmans, Fraser, Towns, Catherine, Verhoeven, Didier, Vinnicombe, Sarah, Watkins, David, Yip, Cheng-Har, Zikmund-Fisher, Brian

“…Over a 2-year period, we brainstormed ideas, scoped the literature, obtained funding for dedicated pilot research that provided new data, and produced this…”
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Dose escalation and expansion cohorts in patients with advanced breast cancer in a Phase I study of the CDK7-inhibitor samuraciclib by Coombes, R. C., Howell, Sacha, Lord, Simon R., Kenny, Laura, Mansi, Janine, Mitri, Zahi, Palmieri, Carlo, Chap, Linnea I., Richards, Paul, Gradishar, William, Sardesai, Sagar, Melear, Jason, O’Shaughnessy, Joyce, Ward, Patrick, Chalasani, Pavani, Arkenau, Tobias, Baird, Richard D., Jeselsohn, Rinath, Ali, Simak, Clack, Glen, Bahl, Ashwani, McIntosh, Stuart, Krebs, Matthew G.

“…Samuraciclib is a selective oral CDK7-inhibitor. A multi-modular, open-label Phase I study to evaluate safety and tolerability of samuraciclib in patients with…”
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A multidisciplinary team and patient perspective on omission of surgery after neoadjuvant systemic therapy for early breast cancer: A European Society of Surgical Oncology (ESSO) Research Academy survey by Caballero, Carmela, Lundon, Dara J., Vasileva-Slaveva, Mariela, Montagna, Giacomo, Bonci, Eduard-Alexandru, Brandl, Andreas, Smith, Henry, Kok, Johnn Henry Herrera, Holmberg, Carl-Jacob, Sayyed, Raza, Santrac, Nada, Suppan, Ina, Kaul, Pallvi, Vassos, Nikolaos, Lorenzon, Laura, Murphy, Marlena, Ceelen, Wim, de Azambuja, Evandro, McIntosh, Stuart A., Rubio, Isabel T.

“…Surgical de-escalation aims to reduce morbidity without compromising oncological outcomes. Trials to de-escalate breast cancer (BC) surgery among exceptional…”
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Post-diagnostic antipsychotic use and cancer mortality: a population based cohort study by Hicks, Blánaid M, Busby, John, Mills, Ken, O'Neil, Francis A, McIntosh, Stuart A, Zhang, Shu-Dong, Liberante, Fabio Giuseppe, Cardwell, Chris R

“…Many antipsychotics elevate prolactin, a hormone implicated in breast cancer aetiology however no studies have investigated antipsychotic use in patients with…”
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