Search Results - "MCILLERON, Helen"

Global tuberculosis drug development pipeline: the need and the reality by Ma, Zhenkun, Dr, Lienhardt, Christian, PhD, McIlleron, Helen, PhD, Nunn, Andrew J, Prof, Wang, Xiexiu, Prof

“…Summary Drugs for tuberculosis are inadequate to address the many inherent and emerging challenges of treatment. In the past decade, ten compounds have…”
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High-Dose Rifapentine with Moxifloxacin for Pulmonary Tuberculosis by Jindani, Amina, Harrison, Thomas S, Nunn, Andrew J, Phillips, Patrick P.J, Churchyard, Gavin J, Charalambous, Salome, Hatherill, Mark, Geldenhuys, Hennie, McIlleron, Helen M, Zvada, Simbarashe P, Mungofa, Stanley, Shah, Nasir A, Zizhou, Simukai, Magweta, Lloyd, Shepherd, James, Nyirenda, Sambayawo, van Dijk, Janneke H, Clouting, Heather E, Coleman, David, Bateson, Anna L.E, McHugh, Timothy D, Butcher, Philip D, Mitchison, Denny A

“…In this report from sub-Saharan Africa, a 4-month regimen of moxifloxacin and rifapentine for pulmonary tuberculosis was not as beneficial as two 6-month…”
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Rifapentine Population Pharmacokinetics and Dosing Recommendations for Latent Tuberculosis Infection by Hibma, Jennifer E, Radtke, Kendra K, Dorman, Susan E, Jindani, Amina, Dooley, Kelly E, Weiner, Marc, McIlleron, Helen M, Savic, Radojka M

“…Rifapentine has been investigated at various doses, frequencies, and dosing algorithms but clarity on the optimal dosing approach is lacking. In this…”
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Optimizing Dosing and Fixed-Dose Combinations of Rifampicin, Isoniazid, and Pyrazinamide in Pediatric Patients With Tuberculosis: A Prospective Population Pharmacokinetic Study by Denti, Paolo, Wasmann, Roeland E, van Rie, Annelies, Winckler, Jana, Bekker, Adrie, Rabie, Helena, Hesseling, Anneke C, van der Laan, Louvina E, Gonzalez-Martinez, Carmen, Zar, Heather J, Davies, Gerry, Wiesner, Lubbe, Svensson, Elin M, McIlleron, Helen M

“…Abstract Background In 2010, the World Health Organization (WHO) revised dosing guidelines for treatment of childhood tuberculosis. Our aim was to investigate…”
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Pharmacokinetics and Safety of Moxifloxacin in Children With Multidrug-Resistant Tuberculosis by Thee, Stephanie, Garcia-Prats, Anthony J., Draper, Heather R., McIlleron, Helen M., Wiesner, Lubbe, Castel, Sandra, Schaaf, H. Simon, Hesseling, Anneke C.

“…Background. Moxifloxacin is currently recommended at a dose of 7.5–10 mg/kg for children with multidrug-resistant (MDR) tuberculosis, but pharmacokinetic and…”
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Pharmacokinetics of once-daily darunavir/ritonavir in second-line treatment in African children with HIV by Tsirizani, Lufina, Mohsenian Naghani, Shaghayegh, Waalewijn, Hylke, Szubert, Alexander, Mulenga, Veronica, Chabala, Chishala, Bwakura-Dangarembizi, Mutsa, Chitsamatanga, Moses, Rutebarika, Diana A, Musiime, Victor, Kasozi, Mariam, Lugemwa, Abbas, Monkiewicz, Lara N, McIlleron, Helen M, Burger, David M, Gibb, Diana M, Denti, Paolo, Wasmann, Roeland E, Colbers, Angela

“…Darunavir is a potent HIV protease inhibitor with a high barrier to resistance. We conducted a nested pharmacokinetic sub-study within CHAPAS-4 to evaluate…”
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Mycobacterium tuberculosis precursor rRNA as a measure of treatment-shortening activity of drugs and regimens by Walter, Nicholas D., Born, Sarah E. M., Robertson, Gregory T., Reichlen, Matthew, Dide-Agossou, Christian, Ektnitphong, Victoria A., Rossmassler, Karen, Ramey, Michelle E., Bauman, Allison A., Ozols, Victor, Bearrows, Shelby C., Schoolnik, Gary, Dolganov, Gregory, Garcia, Benjamin, Musisi, Emmanuel, Worodria, William, Huang, Laurence, Davis, J. Lucian, Nguyen, Nhung V., Nguyen, Hung V., Nguyen, Anh T. V., Phan, Ha, Wilusz, Carol, Podell, Brendan K., Sanoussi, N’ Dira, de Jong, Bouke C., Merle, Corinne S., Affolabi, Dissou, McIlleron, Helen, Garcia-Cremades, Maria, Maidji, Ekaterina, Eshun-Wilson, Franceen, Aguilar-Rodriguez, Brandon, Karthikeyan, Dhuvarakesh, Mdluli, Khisimuzi, Bansbach, Cathy, Lenaerts, Anne J., Savic, Radojka M., Nahid, Payam, Vásquez, Joshua J., Voskuil, Martin I.

“…There is urgent need for new drug regimens that more rapidly cure tuberculosis (TB). Existing TB drugs and regimens vary in treatment-shortening activity, but…”
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Levofloxacin Population Pharmacokinetics in South African Children Treated for Multidrug-Resistant Tuberculosis by Denti, Paolo, Garcia-Prats, Anthony J, Draper, Heather R, Wiesner, Lubbe, Winckler, Jana, Thee, Stephanie, Dooley, Kelly E, Savic, Rada M, McIlleron, Helen M, Schaaf, H Simon, Hesseling, Anneke C

“…Levofloxacin is increasingly used in the treatment of multidrug-resistant tuberculosis (MDR-TB). There are limited pediatric pharmacokinetic data to inform…”
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Pharmacokinetics of Isoniazid, Pyrazinamide, and Ethambutol in Newly Diagnosed Pulmonary TB Patients in Tanzania by Denti, Paolo, Jeremiah, Kidola, Chigutsa, Emmanuel, Faurholt-Jepsen, Daniel, PrayGod, George, Range, Nyagosya, Castel, Sandra, Wiesner, Lubbe, Hagen, Christian Munch, Christiansen, Michael, Changalucha, John, McIlleron, Helen, Friis, Henrik, Andersen, Aase Bengaard

“…Exposure to lower-than-therapeutic levels of anti-tuberculosis drugs is likely to cause selection of resistant strains of Mycobacterium tuberculosis and…”
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First Pharmacokinetic Data of Tenofovir Alafenamide Fumarate and Tenofovir With Dolutegravir or Boosted Protease Inhibitors in African Children: A Substudy of the CHAPAS-4 Trial by Waalewijn, Hylke, Szubert, Alexander J, Wasmann, Roeland E, Wiesner, Lubbe, Chabala, Chishala, Bwakura-Dangarembizi, Mutsa, Makumbi, Shafic, Nangiya, Joan, Mumbiro, Vivian, Mulenga, Veronica, Musiime, Victor, Monkiewicz, Lara N, Griffiths, Anna L, Bamford, Alasdair, Doerholt, Katja, Denti, Paolo, Burger, David M, Gibb, Diana M, McIlleron, Helen M, Colbers, Angela

“…Abstract Background We evaluated the pharmacokinetics of tenofovir alafenamide fumarate (TAF) and tenofovir in a subset of African children enrolled in the…”
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Neuropsychiatric toxicity and cycloserine concentrations during treatment for multidrug-resistant tuberculosis by Court, Richard, Centner, Chad M., Chirehwa, Maxwell, Wiesner, Lubbe, Denti, Paolo, de Vries, Nihal, Harding, Joseph, Gumbo, Tawanda, Maartens, Gary, McIlleron, Helen

“…•Neuropsychiatric events are common in patients with multidrug-resistant tuberculosis treated with cycloserine.•Cycloserine clearance is significantly…”
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Evaluating pediatric tuberculosis dosing guidelines: A model-based individual data pooled analysis by Galileya, Lufina Tsirizani, Wasmann, Roeland E, Chabala, Chishala, Rabie, Helena, Lee, Janice, Njahira Mukui, Irene, Hesseling, Anneke, Zar, Heather, Aarnoutse, Rob, Turkova, Anna, Gibb, Diana, Cotton, Mark F, McIlleron, Helen, Denti, Paolo

“…The current World Health Organization (WHO) pediatric tuberculosis dosing guidelines lead to suboptimal drug exposures. Identifying factors altering the…”
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Pharmacogenetics of plasma efavirenz exposure in HIV‐infected adults and children in South Africa by Sinxadi, Phumla Z., Leger, Paul D., McIlleron, Helen M., Smith, Peter J., Dave, Joel A., Levitt, Naomi S, Maartens, Gary, Haas, David W.

“…Aims Genetic factors, notably CYP2B6 516G→T [rs3745274] and 983T→C [rs28399499], explain much of the interindividual variability in efavirenz pharmacokinetics,…”
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A Population Pharmacokinetic Analysis Shows that Arylacetamide Deacetylase (AADAC) Gene Polymorphism and HIV Infection Affect the Exposure of Rifapentine by Francis, Jose, Zvada, Simbarashe P, Denti, Paolo, Hatherill, Mark, Charalambous, Salome, Mungofa, Stanley, Dawson, Rodney, Dorman, Susan, Gupte, Nikhil, Wiesner, Lubbe, Jindani, Amina, Harrison, Thomas S, Olagunju, Adeniyi, Egan, Deirdre, Owen, Andrew, McIlleron, Helen M

“…Rifapentine is a rifamycin used to treat tuberculosis. As is the case for rifampin, plasma exposures of rifapentine are associated with the treatment response…”
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SLCO1B1 rs4149032 Polymorphism Is Highly Prevalent in South Africans and Is Associated with Reduced Rifampin Concentrations: Dosing Implications by Chigutsa, Emmanuel, Visser, Marianne E, Swart, Elizabeth C, Denti, Paolo, Pushpakom, Sudeep, Egan, Deirdre, Holford, Nicholas H. G, Smith, Peter J, Maartens, Gary, Owen, Andrew, McIlleron, Helen

“…Among patients with tuberculosis, rifampin plasma concentrations and sputum conversion rates have been reported to be lower in Africans. Rifampin is a…”
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Reduced Antituberculosis Drug Concentrations in HIV-Infected Patients Who Are Men or Have Low Weight: Implications for International Dosing Guidelines by MCLLLERON, Helen, RUSTOMJEE, Roxana, VAHEDI, Mahnaz, MTHIYANE, Thuli, DENTI, Paolo, CONNOLLY, Catherine, RIDA, Wasima, PYM, Alexander, SMITH, Peter J, ONYEBUJOH, Philip C

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Effects of rifampin-based antituberculosis therapy on plasma efavirenz concentrations in children vary by CYP2B6 genotype by MCILLERON, Helen M, SCHOMAKER, Michael, HAAS, David W, MAARTENS, Gary, YUAN REN, SINXADI, Phumla, NUTTALL, James J. C, GOUS, Hermien, MOULTRIE, Harry, ELEY, Brian, MERRY, Concepta, SMITH, Peter

“…An efavirenz-based antiretroviral therapy (ART) regimen is preferred for children more than 3 years of age with tuberculosis. However, rifampin, a key…”
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Rifabutin pharmacokinetics and safety among TB/HIV-coinfected children receiving lopinavir/ritonavir-containing second-line ART by Rawizza, Holly E, Oladokun, Regina, Ejeliogu, Emeka, Oguche, Stephen, Ogunbosi, Babatunde O, Agbaji, Oche, Odaibo, Georgina, Imade, Godwin, Olaleye, David, Wiesner, Lubbe, Darin, Kristin M, Okonkwo, Prosper, Kanki, Phyllis J, Scarsi, Kimberly K, McIlleron, Helen M

“…Abstract Background Treatment options are limited for TB/HIV-coinfected children who require PI-based ART. Rifabutin is the preferred rifamycin for adults on…”
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Impact of alcohol consumption on tuberculosis treatment outcomes: a prospective longitudinal cohort study protocol by Myers, Bronwyn, Bouton, Tara C, Ragan, Elizabeth J, White, Laura F, McIlleron, Helen, Theron, Danie, Parry, Charles D H, Horsburgh, C Robert, Warren, Robin M, Jacobson, Karen R

“…An estimated 10% of tuberculosis (TB) deaths are attributable to problematic alcohol use globally, however the causal pathways through which problem alcohol…”
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Moxifloxacin Population Pharmacokinetics and Model-Based Comparison of Efficacy between Moxifloxacin and Ofloxacin in African Patients by ZVADA, Simbarashe P, DENTI, Paolo, HARRISON, Thomas, MCILLERON, Helen M, SIRGEL, Frederick A, CHIGUTSA, Emmanuel, HATHERILL, Mark, CHARALAMBOUS, Salome, MUNGOFA, Stanley, WIESNER, Lubbe, SIMONSSON, Ulrika S. H, JINDANI, Amina

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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