Search Results - "MCGUIRE, Kathleen L"

VAX014, an Oncolytic Therapy, Reduces Adenomas and Modifies Colon Microenvironment in Mouse Model of CRC by Grenier, Shea F, Khan, Mohammad W, Reil, Katherine A, Sawaged, Savannah, Tsuji, Shingo, Giacalone, Matthew J, Tian, Mengxi, McGuire, Kathleen L

“…Colorectal cancer (CRC) remains the third most common form of cancer and, despite its reduced mortality, results in over 50,000 deaths annually, highlighting…”
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Influence of race on microsatellite instability and CD8+ T cell infiltration in colon cancer by Carethers, John M, Murali, Bhavya, Yang, Bing, Doctolero, Ryan T, Tajima, Akihiro, Basa, Ranor, Smith, E Julieta, Lee, Monte, Janke, Ryan, Ngo, Tina, Tejada, Ruth, Ji, Ming, Kinseth, Matthew, Cabrera, Betty L, Miyai, Katsumi, Keku, Temitope O, Martin, Christopher F, Galanko, Joseph A, Sandler, Robert S, McGuire, Kathleen L

“…African American patients with colorectal cancer show higher mortality than their Caucasian counterparts. Biology might play a partial role, and prior studies…”
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Decreased Anti-Tumor Cytotoxic Immunity among Microsatellite-Stable Colon Cancers from African Americans by Basa, Ranor C B, Davies, Vince, Li, Xiaoxiao, Murali, Bhavya, Shah, Jinel, Yang, Bing, Li, Shi, Khan, Mohammad W, Tian, Mengxi, Tejada, Ruth, Hassan, Avan, Washington, Jr, Allen, Mukherjee, Bhramar, Carethers, John M, McGuire, Kathleen L

“…Colorectal cancer is a leading cause of cancer related deaths in the U.S., with African-Americans having higher incidence and mortality rates than…”
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Intralesional administration of VAX014 facilitates in situ immunization and potentiates immune checkpoint blockade in immunologically cold tumors by Reil, Katherine A, Tsuji, Shingo, Molina, Elsa, Nelson, Kinsey L, McGuire, Kathleen L, Giacalone, Matthew J

“…BackgroundImmunologically cold tumors with an ‘immune desert’ phenotype lack tumor-infiltrating lymphocytes (TILs) and are typically impervious to systemic…”
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Expression differences between African American and Caucasian prostate cancer tissue reveals that stroma is the site of aggressive changes by Kinseth, Matthew A., Jia, Zhenyu, Rahmatpanah, Farahnaz, Sawyers, Anne, Sutton, Manuel, Wang‐Rodriguez, Jessica, Mercola, Dan, McGuire, Kathleen L.

“…In prostate cancer, race/ethnicity is the highest risk factor after adjusting for age. African Americans have more aggressive tumors at every clinical stage of…”
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A new method for discovering EMAST sequences in animal models of cancer by Bhaskaran, Nitya, Luu, Jennifer, Kelley, Scott T., Khan, Mohammad W., Mamindla, Priyadarshini, McGuire, Kathleen L.

“…Elevated Microsatellite Alterations at Selected Tetranucleotide repeats (EMAST) occur in up to 60% of colorectal cancers and may associate with aggressive and…”
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A Single Intravesical Instillation of VAX014 Inhibits Orthotopic Superficial Bladder Tumor Implantation to Increase Survival by Hancock, Bryan M, McGuire, Kathleen L, Tsuji, Shingo, Reil, Katherine, Hernandez, Veronica, Giacalone, Matthew J, Godbey, W T

“…VAX014 minicells (VAX014) have been previously characterized as an integrin-specific oncolytic biotherapeutic agent. The present study was designed to evaluate…”
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Relationship of EMAST and Microsatellite Instability Among Patients with Rectal Cancer by Devaraj, Bikash, Lee, Aaron, Cabrera, Betty L., Miyai, Katsumi, Luo, Linda, Ramamoorthy, Sonia, Keku, Temitope, Sandler, Robert S., McGuire, Kathleen L., Carethers, John M.

“…Background Elevated microsatellite instability at selected tetranucleotide repeats (EMAST) is a genetic signature identified in 60% of sporadic colon cancers…”
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1116 VAX014 as a novel oncolytic agent for STING and RIG-I-positive solid tumors by Nelson, Kinsey, Parikh, Amanda, Tsuji, Shingo, Reil, Katherine A, House, Carrie D, McGuire, Kathleen L, Giacalone, Matthew

“…BackgroundOncolytic virus (OV)-based therapies have demonstrated considerable promise for treating various solid tumor types. However, mounting evidence…”
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Comprehensive Study of Sansalvamide A Derivatives and their Structure–Activity Relationships against Drug-Resistant Colon Cancer Cell Lines by Otrubova, Katerina, Lushington, Gerald, Vander Velde, David, McGuire, Kathleen L, McAlpine, Shelli R

“…We report an extensive structure–activity relationship (SAR) of 62 compounds active against two drug-resistant colon cancer cell lines. Our comprehensive…”
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Microsatellite Instability, EMAST, and Morphology Associations with T Cell Infiltration in Colorectal Neoplasia by Lee, Sun-Young, Miyai, Katsuya, Han, Hye Seung, Hwang, Dae-Yong, Seong, Moo Kyung, Chung, Heekyung, Jung, Barbara H., Devaraj, Bikash, McGuire, Kathleen L., Carethers, John M.

“…Background and Objectives Colorectal tumors are often observed with tumor infiltrating lymphocytes, presumably as a host-immune response, and patterns may…”
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Scaffold Targeting Drug-Resistant Colon Cancers by Otrubova, Katerina, McGuire, Kathleen L, McAlpine, Shelli R

“…We have identified five derivatives of the natural product sansalvamide A that are potent against multiple drug-resistant colon cancer cell lines. These…”
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Identification of Sansalvamide a analog potent against pancreatic cancer cell lines by Pan, Po-Shen, McGuire, Kathleen L., McAlpine, Shelli R.

“…The potency of 31 Sansalvamide A derivatives in two pancreatic cancer cell lines is reported. Thirty-one Sansalvamide A peptide derivatives were synthesized…”
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Macrophages influence Salmonella host-specificity in vivo by Xu, Tong, Maloy, Stanley, McGuire, Kathleen L.

“…The generalist Salmonella enterica serovar Typhimurium causes disease in many animal species, but the closely related host-specific serovar Typhi only causes…”
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Repression of IL-2 Promoter Activity by the Novel Basic Leucine Zipper p21SNFT Protein by Iacobelli, Milena, Wachsman, William, McGuire, Kathleen L

“…IL-2 is the major autocrine and paracrine growth factor produced by T cells upon T cell stimulation. The inducible expression of IL-2 is highly regulated by…”
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IL-2 activation of a PI3K-dependent STAT3 serine phosphorylation pathway in primary human T cells by Fung, Michelle M., Rohwer, Forest, McGuire, Kathleen L.

“…Interleukin-2 (IL-2) is the major growth factor of activated T lymphocytes. By inducing cell cycle progression and protection from apoptosis in these cells,…”
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Role of complementary proteins in autoimmunity: an old idea re-emerges with new twists by McGuire, Kathleen L., Holmes, David S.

“…It has been suggested that complementary proteins are involved in autoimmunity through a network involving idiotype–anti-idiotype reactions termed ‘autoantigen…”
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Synthesis of Sansalvamide A derivatives and their cytotoxicity in the MSS colon cancer cell line HT-29 by Styers, Thomas J., Kekec, Ahmet, Rodriguez, Rodrigo, Brown, Joseph D., Cajica, Julia, Pan, Po-Shen, Parry, Emily, Carroll, Chris L., Medina, Irene, Corral, Ricardo, Lapera, Stephanie, Otrubova, Katerina, Pan, Chung-Mao, McGuire, Kathleen L., McAlpine, Shelli R.

“…We report the synthesis of thirty-six Sansalvamide A derivatives, and their biological activity against colon cancer HT-29 cell line, a microsatellite stable…”
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Synthesis and novel structure-activity relationships of potent sansalvamide A derivatives by Otrubova, Katerina, Styers, Thomas J, Pan, Po-Shen, Rodriguez, Rodrigo, McGuire, Kathleen L, McAlpine, Shelli R

“…Synthesis of twelve Sansalvamide A derivatives and their SAR against colon cancer (HT-29)…”
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IL-2- and STAT5-regulated cytokine gene expression in cells expressing the Tax protein of HTLV-1 by FUNG, Michelle M, CHU, Yen-Lin, FINK, J. Lynn, WALLACE, Anne, MCGUIRE, Kathleen L

“…Interleukin-2 (IL-2) mediates cell cycle progression and antiapoptosis in human T cells via several signal transduction pathways. The Tax protein of the human…”
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