Search Results - "MCGREGOR, Christopher G. A"

Porcine to Human Heart Transplantation: Is Clinical Application Now Appropriate? by McGregor, Christopher G. A., Byrne, Guerard W.

“…Cardiac xenotransplantation (CXTx) is a promising solution to the chronic shortage of donor hearts. Recent advancements in immune suppression have greatly…”
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Cardiac xenotransplantation technology provides materials for improved bioprosthetic heart valves by McGregor, Christopher G.A., MB, FRCS, MD(Hons), Carpentier, Alain, MD, PhD, Lila, Nermine, DVM, PhD, Logan, John S., PhD, Byrne, Guerard W., PhD

“…Objectives Human subjects and Old World primates have high levels of antibody to galactose-α-1,3 galactose β-1,4-N-acetylglucosamine (α-Gal). Commercially…”
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Cloning and expression of porcine β1,4 N-acetylgalactosaminyl transferase encoding a new xenoreactive antigen by Byrne, Guerard W., Du, Zeji, Stalboerger, Paul, Kogelberg, Heide, McGregor, Christopher G. A.

“…Background Xenograft rejection of pigs organs with an engineered mutation in the GGTA‐1 gene (GTKO) remains a predominantly antibody mediated process which is…”
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Human CD55 Expression Blocks Hyperacute Rejection and Restricts Complement Activation in Gal Knockout Cardiac Xenografts by MCGREGOR, Christopher G. A, RICCI, Davide, MIYAGI, Naoto, STALBOERGER, Paul G, ZEJI DU, OEHLER, Elise A, TAZELAAR, Henry D, BYRNE, Guerard W

“…Transgenic expression of human complement regulatory proteins reduces the frequency of hyperacute rejection (HAR) in Gal-positive cardiac xenotransplantation…”
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Identification of New Carbohydrate and Membrane Protein Antigens in Cardiac Xenotransplantation by BYRNE, Guerard W, STALBOERGER, Paul G, ZEJI DU, DAVIS, Tessa R, MCGREGO, Christopher G. A

“…α1,3-Galactosyltransferase gene knockout (GTKO) pigs reduced the significance of antibody to galactose alpha 1,3-galactose (Gal) antigens but did not eliminate…”
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Current status of pig heart xenotransplantation by Mohiuddin, Muhammad M, Reichart, Bruno, Byrne, Guerard W, McGregor, Christopher G.A

“…Abstract Significant progress in understanding and overcoming cardiac xenograft rejection using a clinically relevant large animal pig-to-baboon model has…”
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Recent investigations into pig antigen and anti-pig antibody expression by Byrne, Guerard W, McGregor, Christopher G.A, Breimer, Michael E

“…Abstract Genetic engineering of donor pigs to eliminate expression of the dominant xenogeneic antigen galactose α1,3 galactose (Gal) has created a sea change…”
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Mammalian mismatches in nucleotide metabolism: implications for xenotransplantation by Khalpey, Zain, Yuen, Ada H. Y, Lavitrano, Marialuisa, McGregor, Christopher G. A, Kalsi, Kameljit K, Yacoub, Magdi H, Smolenski, Ryszard T

“…Acute humoral rejection (AHR) limits the clinical application of animal organs for xenotransplantation. Mammalian disparities in nucleotide metabolism may…”
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Prognostication of survival using cardiac troponins and N-terminal pro-brain natriuretic peptide in patients with primary systemic amyloidosis undergoing peripheral blood stem cell transplantation by Dispenzieri, Angela, Gertz, Morie A., Kyle, Robert A., Lacy, Martha Q., Burritt, Mary F., Therneau, Terry M., McConnell, Joseph P., Litzow, Mark R., Gastineau, Dennis A., Tefferi, Ayalew, Inwards, David J., Micallef, Ivana N., Ansell, Stephen M., Porrata, Luis F., Elliott, Michelle A., Hogan, William J., Rajkumar, S. Vincent, Fonseca, Rafael, Greipp, Philip R., Witzig, Thomas E., Lust, John A., Zeldenrust, Steven R., Snow, Denise S., Hayman, Susan R., McGregor, Christopher G.A., Jaffe, Allan S.

“…Primary systemic amyloidosis (AL) is a fatal plasma cell disorder. Pilot data suggest survival is better in patients undergoing peripheral blood stem cell…”
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Early and medium‐term outcomes of Alfieri mitral valve repair in the management of systolic anterior motion during septal myectomy by Collis, Richard, Watkinson, Oliver, Pantazis, Antonis, Tome‐Esteban, Maria, Elliott, Perry M., McGregor, Christopher G. A.

“…Background This report studies the early and medium‐term clinical and echocardiographic outcomes of the Alfieri edge‐to‐edge mitral valve repair, as adjunctive…”
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Cardiac xenotransplantation: progress and challenges by Byrne, Guerard W, McGregor, Christopher G A

“…Cardiac xenotransplantation (CXTx) remains a promising approach to alleviate the chronic shortage of donor hearts. This review summarizes recent results of…”
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Efficient and Durable Gene Transfer to Transplanted Heart Using Adeno-associated Virus 9 Vector by Miyagi, Naoto, MD, Rao, Vinay P., MD, Ricci, Davide, MD, Du, Zeji, MD, PhD, Byrne, Guerard W., PhD, Bailey, Kent R., PhD, Nakai, Hiroyuki, MD, PhD, Russell, Stephen J., MD, PhD, McGregor, Christopher G.A., MB, FRCS, MD (Hons)

“…Background In this investigation we studied the efficacy and durability of recombinant adeno-associated virus serotype 9 (rAAV9) vector–mediated gene transfer…”
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Comparison of Gal and Non-Gal-Mediated Cardiac Xenograft Rejection by TAZELAAR, Henry D, BYRNE, Guerard W, MCGREGOR, Christopher G. A

“…This study compares the pathologic condition of delayed xenograft rejection in Gal-positive and Gal-knockout cardiac xenografts after pig-to-baboon heterotopic…”
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Gal knockout pig pericardium: New source of material for heart valve bioprostheses by Lila, Nermine, DVM, PhD, McGregor, Christopher G.A., MD, PhD, Carpentier, Sophie, PhD, Rancic, Jeanne, Byrne, Guerard W., PhD, Carpentier, Alain, MD, PhD

“…Background Although glutaraldehyde fixation is known to reduce immunogenicity and degeneration of heart valve bioprostheses, some degree of immunogenicity…”
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Incidence and clinical characteristics of ocular infections after heart transplantation: a retrospective cohort study by Del Pozo, Jose L., Van De Beek, Diederik, Daly, Richard C., Pulido, Jose S., McGregor, Christopher G.A., Patel, Robin

“…:  Background:  Ocular infections associated with organ transplantation are well documented following renal and liver transplantation; however, few studies…”
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Autologous Stem Cell Transplant after Heart Transplant for Light Chain (AL) Amyloid Cardiomyopathy by Lacy, Martha Q., MD, Dispenzieri, Angela, MD, Hayman, Suzanne R., MD, Kumar, Shaji, MD, Kyle, Robert A., MD, Rajkumar, S. Vincent, MD, Edwards, Brooks S., MD, Rodeheffer, Richard J., MD, Frantz, Robert P., MD, Kushwaha, Sudhir S., MD, Clavell, Alfredo L., MD, Dearani, Joseph A., MD, Sundt, Thoralf M., MD, Daly, Richard C., MD, McGregor, Christopher G.A., MD, Gastineau, Dennis A., MD, Litzow, Mark R., MD, Gertz, Morie A., MD

“…Background Historically, patients with AL amyloidosis and overt congestive heart failure have had an ominous prognosis with median survival of approximately 6…”
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Changes in cardiac gene expression after pig-to-primate orthotopic xenotransplantation by Byrne, Guerard W., Du, Zeji, Sun, Zhifu, Asmann, Yan W., McGregor, Christopher G. A.

“…Byrne GW, Du Z, Sun Z, Asmann YW, McGregor CGA. Changes in cardiac gene expression after pig‐to‐primate orthotopic xenotransplantation. Xenotransplantation…”
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Effect of neurologic complications on outcome after heart transplant by van de Beek, Diederik, Kremers, Walter, Daly, Richard C, Edwards, Brooks S, Clavell, Alfredo L, McGregor, Christopher G A, Wijdicks, Eelco F M

“…To study neurologic complications after heart transplant. Retrospective cohort study. Cardiac transplant program at Mayo Clinic, Rochester, Minnesota. We…”
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Anti‐pig antibodies in swine veterinarian serum: Implications for clinical xenotransplantation by Byrne, Guerard W., McGregor, Christopher G. A.

“…Recent clinical xenotransplantation and human decedent studies demonstrate that clinical hyperacute rejection of genetically engineered porcine organs can be…”
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Increased immunosuppression, not anticoagulation, extends cardiac xenograft survival by BYRNE, Guerard W, DAVIES, William R, KEIJI OI, RAO, Vinay P, TEOTIA, Sumeet S, RICCI, David, TAZELAAR, Henry D, WALKER, Randall C, LOGAN, John S, MCGREGOR, Christopher G. A

“…Cardiac xenograft function is lost due to delayed xenograft rejection (DXR) characterized by microvascular thrombosis and myocardial necrosis. The cause of DXR…”
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