Search Results - "MCGLYNN, Liane M"

SIRT3 & SIRT7: Potential Novel Biomarkers for Determining Outcome in Pancreatic Cancer Patients by McGlynn, Liane M, McCluney, Simon, Jamieson, Nigel B, Thomson, Jackie, MacDonald, Alasdair I, Oien, Karin, Dickson, Euan J, Carter, C Ross, McKay, Colin J, Shiels, Paul G

“…The sirtuin gene family has been linked with tumourigenesis, in both a tumour promoter and suppressor capacity. Information regarding the function of sirtuins…”
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Pre-transplant CDKN2A expression in kidney biopsies predicts renal function and is a future component of donor scoring criteria by Gingell-Littlejohn, Marc, McGuinness, Dagmara, McGlynn, Liane M, Kingsmore, David, Stevenson, Karen S, Koppelstaetter, Christian, Clancy, Marc J, Shiels, Paul G

“…CDKN2A is a proven and validated biomarker of ageing which acts as an off switch for cell proliferation. We have demonstrated previously that CDKN2A is the…”
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Accelerated telomere attrition is associated with relative household income, diet and inflammation in the pSoBid cohort by Shiels, Paul G, McGlynn, Liane M, MacIntyre, Alan, Johnson, Paul C D, Batty, G David, Burns, Harry, Cavanagh, Jonathan, Deans, Kevin A, Ford, Ian, McConnachie, Alex, McGinty, Agnes, McLean, Jennifer S, Millar, Keith, Sattar, Naveed, Tannahill, Carol, Velupillai, Yoga N, Packard, Chris J

“…It has previously been hypothesized that lower socio-economic status can accelerate biological ageing, and predispose to early onset of disease. This study…”
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Cellular senescence in pretransplant renal biopsies predicts postoperative organ function by McGlynn, Liane M., Stevenson, Karen, Lamb, Kelly, Zino, Samer, Brown, Michaela, Prina, Alberto, Kingsmore, David, Shiels, Paul G.

“…Summary Older and marginal donors have been used to meet the shortfall in available organs for renal transplantation. Post‐transplant renal function and…”
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Ras/Raf-1/MAPK Pathway Mediates Response to Tamoxifen but not Chemotherapy in Breast Cancer Patients by McGlynn, Liane M, Kirkegaard, Tove, Edwards, Joanne, Tovey, Sian, Cameron, David, Twelves, Chris, Bartlett, John M S, Cooke, Timothy G

“…Purpose: The expression and activation of the Ras/Raf-1/mitogen-activated protein kinase (MAPK) pathway plays an important role in the development and…”
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Is telomere length socially patterned? Evidence from the West of Scotland Twenty-07 Study by Robertson, Tony, Batty, G David, Der, Geoff, Green, Michael J, McGlynn, Liane M, McIntyre, Alan, Shiels, Paul G, Benzeval, Michaela

“…Lower socioeconomic status (SES) is strongly associated with an increased risk of morbidity and premature mortality, but it is not known if the same is true…”
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Amplified in Breast Cancer 1 in Human Epidermal Growth Factor Receptor–Positive Tumors of Tamoxifen-Treated Breast Cancer Patients by KIRKEGAARD, Tove, MCGLYNN, Liane M, CAMPBELL, Fiona M, MULLER, Sven, TOVEY, Sian M, DUNNE, Barbara, NIELSEN, Kirsten V, COOKE, Timothy G, BARTLETT, John M. S

“…Purpose: Amplified in breast cancer 1 (AIB1) is a member of the p160/steroid receptor coactivators family and is involved in estrogen-dependent gene…”
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Socio-economic status is associated with epigenetic differences in the pSoBid cohort by MCGUINNESS, Dagmara, MCGLYNN, Liane M, MCGINTY, Agnes, MCLEAN, Jennifer S, MILLAR, Keith, PACKARD, Chris J, SATTAR, Naveed A, TANNAHILL, Carol, VELUPILLAI, Yoga N, SHIELS, Paul G, JOHNSON, Paul Cd, MACINTYRE, Alan, BATTY, G. David, BURNS, Harry, CAVANAGH, Jonathan, DEANS, Kevin A, FORD, Ian, MCCONNACHIE, Alex

“…Epigenetic programming and epigenetic mechanisms driven by environmental factors are thought to play an important role in human health and ageing. Global DNA…”
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SIRT2: Tumour suppressor or tumour promoter in operable breast cancer? by McGlynn, Liane M, Zino, Samer, MacDonald, Alasdair I, Curle, Jennifer, Reilly, Justice E, Mohammed, Zahra M.A, McMillan, Donald C, Mallon, Elizabeth, Payne, Anthony P, Edwards, Joanne, Shiels, Paul G

“…Abstract Purpose Sirtuins comprise a family of genes involved in cellular stress, survival and damage responses. They have been implicated in a range of…”
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AKT activation predicts outcome in breast cancer patients treated with tamoxifen by Kirkegaard, Tove, Witton, Caroline J, McGlynn, Liane M, Tovey, Sian M, Dunne, Barbara, Lyon, Alison, Bartlett, John MS

“…Oestrogen receptor (ERα) expression is a strong predictor of response to endocrine therapy. The PI3K/AKT/mTOR signal transduction pathway has been implicated…”
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Interactions between MAP kinase and oestrogen receptor in human breast cancer by McGlynn, Liane M, Tovey, Sian, Bartlett, John M.S, Doughty, Julie, Cooke, Timothy G, Edwards, Joanne

“…Abstract Purpose The oestrogen receptor (ERα) may be activated in a ligand-dependent manner, via oestrogen, or in a ligand-independent manner, via signal…”
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Telomere Attrition and Decreased Fetuin-A Levels Indicate Accelerated Biological Aging and Are Implicated in the Pathogenesis of Colorectal Cancer by MAXWELL, Fraser, MCGLYNN, Liane M, MUIR, Hannah C, TALWAR, Dinesh, BENZEVAL, Michaela, ROBERTSON, Tony, ROXBURGH, Campbell S, MCMILLAN, Donald C, HORGAN, Paul G, SHIELS, Paul G

“…Increasing chronological age is a risk factor for many types of cancer including colorectal. An understanding of the biology of aging and factors which…”
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Pathfinder cells provide a novel therapeutic intervention for acute kidney injury by McGlynn, Liane M, Eller, Kathrin, MacDonald, Alasdair I, Macintyre, Alan, Russell, David, Koppelstaetter, Christian, Davies, R W, Shiels, Paul G

“…Pathfinder cells (PCs) are a novel class of adult-derived cells that facilitate functional repair of host tissue. We used rat PCs to demonstrate that they…”
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High Expression of Sphingosine 1-Phosphate Receptors, S1P1 and S1P3 , Sphingosine Kinase 1, and Extracellular Signal-Regulated Kinase-1/2 Is Associated with Development of Tamoxifen Resistance in Estrogen Receptor-Positive Breast Cancer Patients by Watson, Carol, Long, Jaclyn S, Orange, Clare, Tannahill, Claire L, Mallon, Elizabeth, McGlynn, Liane M, Pyne, Susan, Pyne, Nigel J, Edwards, Joanne

“…Various studies in cell lines have previously demonstrated that sphingosine kinase 1 (SK1) and extracellular signal-regulated kinase 1/2 (ERK-1/2) interact in…”
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Pancreatic-derived pathfinder cells enable regeneration of critically damaged adult pancreatic tissue and completely reverse streptozotocin-induced diabetes by Stevenson, Karen, Chen, Daxin, MacIntyre, Alan, McGlynn, Liane M, Montague, Paul, Charif, Rawiya, Subramaniam, Murali, George, W D, Payne, Anthony P, Davies, R Wayne, Dorling, Anthony, Shiels, Paul G

“…We demonstrate that intravenous delivery of human, or rat, pancreas-derived pathfinder (PDP) cells can totally regenerate critically damaged adult tissue and…”
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An increase in N-Ras expression is associated with development of hormone refractory prostate cancer in a subset of patients by Traynor, Pamela, McGlynn, Liane M, Mukhergee, Rono, Grimsley, Samuel J S, Bartlett, John M S, Edwards, Joanne

“…Protein expression of H, K and N-Ras was assessed in hormone sensitive and hormone refractory prostate tumour pairs from 61 patients by immunohistochemistry…”
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O-56 High expression of sphingosine 1-phosphate receptors, S1P1 and S1P3 , sphingosine kinase 1 and ERK-1/2 is associated with development of tamoxifen resistance in ER positive breast cancer patients by Watson, Carol, Long, Jaclyn S, Orange, Clare, Tannahill, Claire L, Mallon, Elizabeth, McGlynn, Liane M, Pyne, Susan, Pyne, Nigel J, Edwards, Joanne

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High Expression of Sphingosine 1-Phosphate Receptors, S1P 1 and S1P 3, Sphingosine Kinase 1, and Extracellular Signal-Regulated Kinase-1/2 Is Associated with Development of Tamoxifen Resistance in Estrogen Receptor-Positive Breast Cancer Patients by Watson, Carol, Long, Jaclyn S., Orange, Clare, Tannahill, Claire L., Mallon, Elizabeth, McGlynn, Liane M., Pyne, Susan, Pyne, Nigel J., Edwards, Joanne

“…Various studies in cell lines have previously demonstrated that sphingosine kinase 1 (SK1) and extracellular signal-regulated kinase 1/2 (ERK-1/2) interact in…”
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Ras/Raf-1/MAPK Pathway Mediates Response toTamoxifen but not Chemotherapy in Breast Cancer Patients by MCGLYNN, Liane M, KIRKEGAARD, Tove, EDWARDS, Joanne, TOVEY, Sian, CAMERON, David, TWELVES, Chris, BARTLETT, John M. S, COOKE, Timothy G

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