Search Results - "MCGLINCHEY, K"

Self-Generated Magnetic Fields in the Stagnation Phase of Indirect-Drive Implosions on the National Ignition Facility by Walsh, C A, Chittenden, J P, McGlinchey, K, Niasse, N P L, Appelbe, B D

“…Three-dimensional extended-magnetohydrodynamic simulations of the stagnation phase of inertial confinement fusion implosion experiments at the National…”
Get full text

Correlation of pharmacokinetics with the antitumor activity of Cetuximab in nude mice bearing the GEO human colon carcinoma xenograft by LUO, F. R, YANG, Z, ROSE, W. C, KRAMER, R. A, WILD, R, LEE, F. Y, DONG, H, CAMUSO, A, MCGLINCHEY, K, FAGER, K, FLEFLEH, C, KAN, D, INIGO, I, CASTANEDA, S

“…The epidermal growth factor receptor (EGFR), a protein tyrosine kinase expressed in many types of human cancers including colon and breast, has been strongly…”
Get full text

Cetuximab preclinical antitumor activity (monotherapy and combination based) is not predicted by relative total or activated epidermal growth factor receptor tumor expression levels by Wild, Robert, Fager, Krista, Flefleh, Christine, Kan, David, Inigo, Ivan, Castaneda, Stephen, Luo, Feng Roger, Camuso, Amy, McGlinchey, Kelly, Rose, William C

“…Although Erbitux (cetuximab) has proven therapeutic benefit in the clinical setting, the molecular determinants predicting responsiveness to this agent are…”
Get full text

Preclinical efficacy evaluation of ixabepilone (BMS-247550) in combination with cetuximab or capecitabine in human colon and lung carcinoma xenografts by Lee, F. Y., Camuso, A., Castenada, S., Flefleh, C., Ingio, I., Kan, D., McGlinchey, K., Menard, K., Rose, W.

“…Abstract only 12017 Background: Ixabepilone belongs to a class of structurally novel, microtubule-stabilizing agents that exert their antimitotic action by…”
Get full text

Prediction of Active Drug Plasma Concentrations Achieved in Cancer Patients by Pharmacodynamic Biomarkers Identified from the Geo Human Colon Carcinoma Xenograft Model by LUO, Feng R, ZHENG YANG, WONG, Tai W, KRAMER, Robert A, WILD, Robert, LEE, Francis Y, HUIJIN DONG, CAMUSO, Amy, MCGLINCHEY, Kelly, FAGER, Krista, FLEFLEH, Christine, KAN, David, INIGO, Ivan, CASTANEDA, Stephen

“…Purpose: Epidermal growth factor receptor (EGFR), a protein tyrosine kinase expressed in many types of human cancers, has been strongly associated with tumor…”
Get full text

Design, synthesis, and structure–activity relationships of tetrahydroquinoline-based farnesyltransferase inhibitors by Lombardo, Louis J., Camuso, Amy, Clark, John, Fager, Krista, Gullo-Brown, Johnni, Hunt, John T., Inigo, Ivan, Kan, David, Koplowitz, Barry, Lee, Francis, McGlinchey, Kelly, Qian, Ligang, Ricca, Carolyn, Rovnyak, George, Traeger, Sarah, Tokarski, John, Williams, David K., Wu, Laurence I., Zhao, Yufen, Manne, Veeraswamy, Bhide, Rajeev S.

“…Tetrahydroquinoline-based small molecule inhibitors of farnesyltransferase (FT) have been identified. Lead compounds were shown to have nanomolar to…”
Get full text

Burn regimes in the hydrodynamic scaling of perturbed inertial confinement fusion hotspots by Tong, J. K, McGlinchey, K, Appelbe, B. D, Walsh, C. A, Crilly, A. J, Chittenden, J. P

“…We present simulations of ignition and burn based on the Highfoot and High-Density Carbon indirect drive designs of the National Ignition Facility for three…”
Get full text