Search Results - "MCGINNIS, John P"

Randomized Trial of Liposomal Amikacin for Inhalation in Nontuberculous Mycobacterial Lung Disease by Olivier, Kenneth N, Griffith, David E, Eagle, Gina, McGinnis, 2nd, John P, Micioni, Liza, Liu, Keith, Daley, Charles L, Winthrop, Kevin L, Ruoss, Stephen, Addrizzo-Harris, Doreen J, Flume, Patrick A, Dorgan, Daniel, Salathe, Matthias, Brown-Elliott, Barbara A, Gupta, Renu, Wallace, Jr, Richard J

“…Lengthy, multidrug, toxic, and low-efficacy regimens limit management of pulmonary nontuberculous mycobacterial disease. In this phase II study, we…”
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Cerebral microdialysis and glucopenia in traumatic brain injury: A review by Sharma, Himanshu, McGinnis, John P, Kabotyanski, Katherine E, Gopinath, Shankar P, Goodman, Jerry C, Robertson, Claudia, Cruz Navarro, Jovany

“…Traditionally, intracranial pressure (ICP) and partial brain tissue oxygenation (PbtO ) have been the primary invasive intracranial measurements used to guide…”
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Irreversible Inhibitors of the EGF Receptor May Circumvent Acquired Resistance to Gefitinib by Kwak, Eunice L., Sordella, Raffaella, Bell, Daphne W., Godin-Heymann, Nadia, Okimoto, Ross A., Brannigan, Brian W., Harris, Patricia L., Driscoll, David R., Fidias, Panos, Lynch, Thomas J., Rabindran, Sridhar K., McGinnis, John P., Wissner, Allan, Sharma, Sreenath V., Isselbacher, Kurt J., Settleman, Jeffrey, Haber, Daniel A.

“…Non-small cell lung cancers (NSCLCs) with activating mutations in the kinase domain of the epidermal growth factor receptor (EGFR) demonstrate dramatic, but…”
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Stereotactic Radiosurgery Hypophysectomy for Palliative Treatment of Refractory Cancer Pain: A Historical Review and Update by Larkin, M Benjamin, Karas, Patrick J, McGinnis, John P, McCutcheon, Ian E, Viswanathan, Ashwin

“…Medically refractory pain in those with advanced cancer significantly reduces one's quality of life. Therefore, palliative interventions to mitigate cancer…”
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The Effect of EDS-FLU on Objective and Patient-Reported Subjective Outcomes for Patients with Chronic Rhinosinusitis with Nasal Polyps by Ow, Randall A, McGinnis, 2nd, John P, Sacks, Harry J, Mehle, Mark E

“…Exhalation delivery system with fluticasone (EDS-FLU) delivers medication high and deep in the nasal passages and has been shown to reduce nasal polyp (NP)…”
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Neuroablative central lateral thalamotomy for chronic neuropathic pain by Allam, Anthony K., Larkin, M. Benjamin, McGinnis, John P., Viswanathan, Ashwin

“…Chronic neuropathic pain refractory to medical management can be debilitating and can seriously affect one's quality of life. The interest of ablative surgery…”
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Amikacin liposome inhalation suspension for chronic Pseudomonas aeruginosa infection in cystic fibrosis by Bilton, Diana, Pressler, Tacjana, Fajac, Isabelle, Clancy, John Paul, Sands, Dorota, Minic, Predrag, Cipolli, Marco, Galeva, Ivanka, Solé, Amparo, Quittner, Alexandra L, Liu, Keith, McGinnis, John P, Eagle, Gina, Gupta, Renu, Konstan, Michael W

“…AbstractBackgroundShortcomings of inhaled antibiotic treatments for Pseudomonas aeruginosa infection in patients with cystic fibrosis (CF) include poor drug…”
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Immediate perception of a reward is distinct from the reward's long-term salience by McGinnis, John P, Jiang, Huoqing, Agha, Moutaz Ali, Sanchez, Consuelo Perez, Lange, Jeff, Yu, Zulin, Marion-Poll, Frederic, Si, Kausik

“…Reward perception guides all aspects of animal behavior. However, the relationship between the perceived value of a reward, the latent value of a reward, and…”
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Inhibition of tumor cell proliferation by thieno[2,3- d]pyrimidin-4(1 H)-one-based analogs by Wang, Yanong D., Johnson, Steven, Powell, Dennis, McGinnis, John P., Miranda, Miriam, Rabindran, Sridhar K.

“…The synthesis of a series of novel tricyclic thieno[2,3- d]pyrimidin-4(1 H)-one-based analogs and their anti-proliferative activities are described. On the…”
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Validation of cyclin D1/CDK4 as an anticancer drug target in MCF-7 breast cancer cells : Effect of regulated overexpression of cyclin D1 and siRNA-mediated inhibition of endogenous cyclin D1 and CDK4 expression by GRILLO, Mary, BOTT, Matthew J, KHANDKE, Neha, MCGINNIS, John P, MIRANDA, Miriam, MEYYAPPAN, Muthupalaniappan, ROSFIORD, Edward C, RABINDRAN, Sridhar K

“…We have examined the role of cyclin D1 and cyclin-dependent kinase-4 (CDK4) in the cell cycle progression and proliferation of MCF-7 breast cancer cells…”
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Parallel synthesis and biological evaluation of 5,6,7,8-tetrahydrobenzothieno[2,3- d]pyrimidin-4(3H)-one cytotoxic agents selective for p21-deficient cells by Jennings, Lee D., Kincaid, Scott L., Wang, Yanong D., Krishnamurthy, Girija, Beyer, Carl F., McGinnis, John P., Miranda, Miriam, Discafani, Carolyn M., Rabindran, Sridhar K.

“…A novel series of anti-proliferative agents containing the thieno[2,3- d]pyrimidin-4-one scaffold and the structure–activity relationship studies to improve…”
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Pediatric Vagus Nerve Stimulation: Case Series Outcomes and Future Directions by LoPresti, Melissa A, Katlowitz, Kalman A, Sharma, Himanshu, McGinnis, John P, Weiner, Howard L

“…Vagus nerve stimulation (VNS) is a neuromodulatory procedure most extensively studied as an adjunct to medically refractory epilepsy. Despite widespread…”
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Neurostimulation for treatment-resistant posttraumatic stress disorder: an update on neurocircuitry and therapeutic targets by Larkin, M Benjamin, McGinnis, John P, Snyder, Rita I, Storch, Eric A, Goodman, Wayne K, Viswanathan, Ashwin, Sheth, Sameer A

“…Posttraumatic stress disorder (PTSD) is a widespread and often devastating psychiatric condition. Core symptoms include intrusive and distressing thoughts,…”
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Symptomatic obstructive hydrocephalus caused by choroid plexus hyperplasia in a pediatric patient: illustrative case by Alvarez, Ana Sofia, McGinnis, John P, Patel, Rajan, Weiner, Howard L

“…BACKGROUND Choroid plexus hyperplasia has been described as a rare cause of communicating hydrocephalus due to cerebrospinal fluid (CSF) overproduction…”
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Discovery of 4-(Benzylaminomethylene)isoquinoline-1,3-(2H,4H)-diones and 4-[(Pyridylmethyl)aminomethylene]isoquinoline-1,3-(2H,4H)-diones as Potent and Selective Inhibitors of the Cyclin-Dependent Kinase 4 by Tsou, Hwei-Ru, Liu, Xiaoxiang, Birnberg, Gary, Kaplan, Joshua, Otteng, Mercy, Tran, Tritin, Kutterer, Kristina, Tang, Zhilian, Suayan, Ron, Zask, Arie, Ravi, Malini, Bretz, Angela, Grillo, Mary, McGinnis, John P, Rabindran, Sridhar K, Ayral-Kaloustian, Semiramis, Mansour, Tarek S

“…The series of 4-(benzylaminomethylene)isoquinoline-1,3-(2H,4H)-dione and 4-[(pyridylmethyl)aminomethylene]isoquinoline-1,3-(2H,4H)-dione derivatives reported…”
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Nitric oxide synthase interneurons in the monkey cerebral cortex are subsets of the somatostatin, neuropeptide Y, and calbindin cells by Smiley, John F, McGinnis, John P, Javitt, Daniel C

“…Neuronal nitric oxide synthase (nNOS) is expressed most densely in two types of cortical interneurons. Large nitric oxide (LNOS) interneurons express dense…”
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4-(Phenylaminomethylene)isoquinoline-1,3(2H,4H)-diones as Potent and Selective Inhibitors of the Cyclin-Dependent Kinase 4 (CDK4) by Tsou, Hwei-Ru, Otteng, Mercy, Tran, Tritin, Floyd, M. Brawner, Reich, Marvin, Birnberg, Gary, Kutterer, Kristina, Ayral-Kaloustian, Semiramis, Ravi, Malini, Nilakantan, Ramaswamy, Grillo, Mary, McGinnis, John P, Rabindran, Sridhar K

“…The cyclin-dependent kinases (CDKs), as complexes with their respective partners, the cyclins, are critical regulators of cell cycle progression. Because…”
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Synthesis, SAR study and biological evaluation of novel pyrazolo[1,5- a]pyrimidin-7-yl phenyl amides as anti-proliferative agents by Wang, Yanong D., Honores, Erick, Wu, Biqi, Johnson, Steve, Powell, Dennis, Miranda, Miriam, McGinnis, John P., Discafani, Carolyn, Rabindran, Sridhar K., Cheng, Wendy, Krishnamurthy, Girija

“…Checkpoint deficiency of malignant cells can be exploited in cancer drug discovery. Compounds that selectively kill checkpoint-deficient cells versus…”
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Pyrazolo[1,5- a]pyrimidin-7-yl phenyl amides as novel antiproliferative agents: Exploration of core and headpiece structure–activity relationships by Powell, Dennis, Gopalsamy, Ariamala, Wang, Yanong D., Zhang, Nan, Miranda, Miriam, McGinnis, John P., Rabindran, Sridhar K.

“…A novel series of antiproliferative agents containing a pyrazolo[1,5- a]pyrimidine scaffold and the structure–activity relationship studies of the headpiece,…”
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Pyrazolo[1,5- a]pyrimidin-7-yl phenyl amides as novel anti-proliferative agents: parallel synthesis for lead optimization of amide region by Gopalsamy, Ariamala, Yang, Hui, Ellingboe, John W., Tsou, Hwei-Ru, Zhang, Nan, Honores, Erick, Powell, Dennis, Miranda, Miriam, McGinnis, John P., Rabindran, Sridhar K.

“…A novel series of anti-proliferative agents containing a pyrazolo[1,5- a]pyrimidine scaffold and the structure–activity relationship studies to improve potency…”
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