Search Results - "MCFARLAND, H. F"

Differential diagnosis of suspected multiple sclerosis: a consensus approach by Miller, DH, Weinshenker, BG, Filippi, M, Banwell, BL, Cohen, JA, Freedman, MS, Galetta, SL, Hutchinson, M, Johnson, RT, Kappos, L, Kira, J, Lublin, FD, McFarland, HF, Montalban, X, Panitch, H, Richert, JR, Reingold, SC, Polman, CH

“…Background and objectives Diagnosis of multiple sclerosis (MS) requires exclusion of diseases that could better explain the clinical and paraclinical findings…”
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The role of magnetic resonance techniques in understanding and managing multiple sclerosis by MILLER, D. H, GROSSMAN, R. I, REINGOLD, S. C, MCFARLAND, H. F

“…Magnetic resonance (MR) techniques have had a major impact in the last 10-15 years in understanding and managing multiple sclerosis. This review summarizes the…”
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Expression profiling identifies responder and non‐responder phenotypes to interferon‐β in multiple sclerosis by Stürzebecher, S., Wandinger, K. P., Rosenwald, A., Sathyamoorthy, M., Tzou, A., Mattar, P., Frank, J. A., Staudt, L., Martin, R., McFarland, H. F.

“…Autoimmune diseases such as multiple sclerosis are characterized by complex genetic traits and pathomechanisms that translate into clinical heterogeneity. This…”
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Thalamic Involvement and Its Impact on Clinical Disability in Patients with Multiple Sclerosis: A Diffusion Tensor Imaging Study at 3T by Tovar-Moll, F, Evangelou, I.E, Chiu, A.W, Richert, N.D, Ostuni, J.L, Ohayon, J.M, Auh, S, Ehrmantraut, M, Talagala, S.L, McFarland, H.F, Bagnato, F

“…Several studies suggest that grey matter involvement may play a role in multiple sclerosis (MS) pathology. Diffusion tensor imaging (DTI) at 3T was used to…”
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MRI as a marker for disease heterogeneity in multiple sclerosis by BIELEKOVA, B, KADOM, N, MARTIN, R, CUTTER, G, MCFARLAND, H. F, FISHER, E, JEFFRIES, N, OHAYON, J, RICHERT, N, HOWARD, T, BASH, C. N, FRANK, J. A, STONE, L

“…Whereas recent data from imaging studies challenge the prevailing notion that multiple sclerosis (MS) is purely an inflammatory disease, pathologic studies…”
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Magnetic resonance imaging as a surrogate outcome for multiple sclerosis relapses by Petkau, J, Reingold, SC, Held, U, Cutter, GR, Fleming, TR, Hughes, MD, Miller, DH, McFarland, HF, Wolinsky, JS

“…Background Magnetic resonance imaging (MRI) of lesions in the brain may be the best current candidate for a surrogate biological marker of clinical outcomes in…”
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The contribution of magnetic resonance imaging to the diagnosis of multiple sclerosis by FAZEKAS, F, BARKHOF, F, MILLER, D. H, FILIPPI, M, GROSSMAN, R. I, LI, D. K. B, MCDONALD, W. I, MCFARLAND, H. F, PATY, D. W, SIMON, J. H, WOLINSKY, J. S

“…MRI is very sensitive in showing MS lesions throughout the CNS. Using MRI for diagnostic purposes, however useful, is a complex issue because of limited…”
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In Vivo Detection of Cortical Plaques by MR Imaging in Patients with Multiple Sclerosis by Bagnato, F, Butman, J.A, Gupta, S, Calabrese, M, Pezawas, L, Ohayon, J.M, Tovar-Moll, F, Riva, M, Cao, M.M, Talagala, S.L, McFarland, H.F

“…In vivo detection of cortical lesions in patients with multiple sclerosis (MS) by MR imaging is hampered by several factors. Among them is the low contrast…”
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Ring and nodular multiple sclerosis lesions: A retrospective natural history study by DAVIS, M, AUH, S, RIVA, M, RICHERT, N. D, FRANK, J. A, MCFARLAND, H. F, BAGNATO, F

“…In patients with multiple sclerosis (MS), contrast-enhancing lesions (CELs) on postcontrast MRI are considered markers of the inflammatory responses associated…”
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Relationship between inflammatory lesions and cerebral atrophy in multiple sclerosis by RICHERT, N. D, HOWARD, T, FRANK, J. A, STONE, R, OSTUNI, J, OHAYON, J, BASH, C, MCFARLAND, H. F

“…To investigate the temporal relationship between inflammation and cerebral atrophy in a longitudinal study of 19 patients with relapsing-remitting multiple…”
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The role of MRI as a surrogate outcome measure in multiple sclerosis by McFarland, H F, Barkhof, F, Antel, J, Miller, D H

“…The need for more specific and more sensitive outcome measures for use in testing new therapies in multiple sclerosis (MS) is generally accepted. This need has…”
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Guidelines for using quantitative measures of brain magnetic resonance imaging abnormalities in monitoring the treatment of multiple sclerosis by Filippi, M, Horsfield, M A, Adèr, H J, Barkhof, F, Bruzzi, P, Evans, A, Frank, J A, Grossman, R I, McFarland, H F, Molyneux, P, Paty, D W, Simon, J, Tofts, P S, Wolinsky, J S, Miller, D H

“…The change of brain lesion load, measured on T2-weighted magnetic resonance imaging (MRI) using computer-assisted techniques, is a widely used secondary…”
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Phase 1 trial of transforming growth factor beta 2 in chronic progressive MS by CALABRESI, P. A, FIELDS, N. S, MCFARLAND, H. F, RACKE, M. K, MALONI, H. W, HANHAM, A, CARLINO, J, MOORE, J, LEVIN, M. C, DHIB-JALBUT, S, TRANQUILL, L. R, AUSTIN, H

“…Transforming growth factor (TGF)-beta2 is a pleiotropic cytokine associated with remissions in multiple sclerosis (MS) and amelioration of allergic…”
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VLA-4 expression on peripheral blood lymphocytes is downregulated after treatment of multiple sclerosis with interferon beta by CALABRESI, P. A, PELFREY, C. M, TRANQUILL, L. R, MALONI, H, MCFARLAND, H. F

“…Adhesion molecules are likely to play a critical role in the immunopathogenesis of multiple sclerosis (MS). The interaction of vascular cell adhesion…”
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Characterization of MRI response to treatment with interferon beta-1b : Contrast-enhancing MRI lesion frequency as a primary outcome measure by STONE, L. A, FRANK, J. A, ALBERT, P. S, BASH, C. N, CALABRESI, P. A, MALONI, H, MCFARLAND, H. F

“…MRI is a valuable tool to examine the pathophysiology and natural history of multiple sclerosis (MS), and several large multicenter trials have utilized MRI as…”
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A case study on the effect of neutralizing antibodies to interferon beta 1b in multiple sclerosis patients followed for 3 years with monthly imaging by Chiu, A. W., Ehrmantraut, M., Richert, N. D., Ikonomidou, V. N., Pellegrini, S., McFarland, H. F., Frank, J. A., Bagnato, F.

“…Summary Interferon beta (IFN‐β) is among the first‐line treatment options for patients with multiple sclerosis (MS). A potential caveat of therapy, however, is…”
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Immunological Aspects of Demyelinating Diseases by Martin, Roland, McFarland, Henry F, McFarlin, Dale E

“…Primary demyelination in the central nervous system results from damage to the myelin sheath or oligodendroglia and can be produced by a variety of mechanisms,…”
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Interferon beta results in immediate reduction of contrast-enhanced MRI lesions in multiple sclerosis patients followed by weekly MRI by CALABRESI, P. A, STONE, L. A, BASH, C. N, FRANK, J. A, MCFARLAND, H. F

“…Interferon beta-1a and -1b reduce the frequency and severity of clinical exacerbations, and reduce both T2-weighted and contrast-enhanced MRI activity in…”
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Clinical worsening in multiple sclerosis is associated with increased frequency and area of gadopentetate dimeglumine-enhancing magnetic resonance imaging lesions by Smith, M E, Stone, L A, Albert, P S, Frank, J A, Martin, R, Armstrong, M, Maloni, H, McFarlin, D E, McFarland, H F

“…It is now well established that clinically stable patients with relapsing-remitting multiple sclerosis have ongoing disease activity when evaluated by serial…”
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Increased lymphoproliferative response to human herpesvirus type 6A variant in multiple sclerosis patients by Soldan, Samantha S., Leist, Thomas P., Juhng, K. Newton, McFarland, Henry F., Jacobson, Steven

“…Several reports have suggested an association of human herpevirus 6 (HHV‐6) and multiple sclerosis (MS) based on immunohistochemical demonstration of HHV‐6 DNA…”
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