Search Results - "MCDAID, John P"

Spleen tyrosine kinase inhibition attenuates autoantibody production and reverses experimental autoimmune GN by McAdoo, Stephen P, Reynolds, John, Bhangal, Gurjeet, Smith, Jennifer, McDaid, John P, Tanna, Anisha, Jackson, William D, Masuda, Esteban S, Cook, H Terence, Pusey, Charles D, Tam, Frederick W K

“…Spleen tyrosine kinase (SYK) has an important role in immunoreceptor signaling, and SYK inhibition has accordingly attenuated immune-mediated injury in several…”
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Spleen tyrosine kinase is important in the production of proinflammatory cytokines and cell proliferation in human mesangial cells following stimulation with IgA1 isolated from IgA nephropathy patients by Kim, Min Jeong, McDaid, John P, McAdoo, Stephen P, Barratt, Jonathan, Molyneux, Karen, Masuda, Esteban S, Pusey, Charles D, Tam, Frederick W K

“…IgA immune complexes are capable of inducing human mesangial cell (HMC) activation, resulting in release of proinflammatory and profibrogenic mediators. The…”
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Selective Targeting of a Disease-Related Conformational Isoform of Macrophage Migration Inhibitory Factor Ameliorates Inflammatory Conditions by Thiele, Michael, Kerschbaumer, Randolf J, Tam, Frederick W K, Völkel, Dirk, Douillard, Patrice, Schinagl, Alexander, Kühnel, Harald, Smith, Jennifer, McDaid, John P, Bhangal, Gurjeet, Yu, Mei-Ching, Pusey, Charles D, Cook, H Terence, Kovarik, Josef, Magelky, Erica, Bhan, Atul, Rieger, Manfred, Mudde, Geert C, Ehrlich, Hartmut, Jilma, Bernd, Tilg, Herbert, Moschen, Alexander, Terhorst, Cox, Scheiflinger, Friedrich

“…Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine and counterregulator of glucocorticoids, is a potential therapeutic target. MIF is…”
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Bruton's Tyrosine Kinase Is Required for TLR2 and TLR4-Induced TNF, but Not IL-6, Production by Horwood, Nicole J, Page, Theresa H, McDaid, John P, Palmer, Christine D, Campbell, Jamie, Mahon, Tara, Brennan, Fionula M, Webster, David, Foxwell, Brian M. J

“…Bruton's tyrosine kinase (Btk), the gene mutated in the human immunodeficiency X-linked agammaglobulinemia, is activated by LPS and is required for LPS-induced…”
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A Spleen Tyrosine Kinase Inhibitor Reduces the Severity of Established Glomerulonephritis by SMITH, Jennifer, MCDAID, John P, BHANGAL, Gurjeet, CHAWANASUNTORAPOJ, Ratana, MASUDA, Esteban S, COOK, H. Terence, PUSEY, Charles D, TAM, Frederick W. K

“…Antibody-mediated glomerulonephritis, including that resulting from immune complexes, is an important cause of renal failure and is in need of more specific…”
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Bruton's tyrosine kinase is required for lipopolysaccharide-induced tumor necrosis factor alpha production by Horwood, Nicole J, Mahon, Tara, McDaid, John P, Campbell, Jamie, Mano, Hiroyuki, Brennan, Fionula M, Webster, David, Foxwell, Brian M J

“…Lipopolysaccharide (LPS), a product of Gram-negative bacteria, is potent mediator of tumor necrosis factor (TNF)alpha production by myeloid/macrophage cells…”
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Mice with defective Fas ligand are protected from crescentic glomerulonephritis by Tarzi, Ruth M, Sharp, Phoebe E H, McDaid, John P, Fossati-Jimack, Liliane, Herbert, Paul E, Pusey, Charles D, Cook, H Terence, Warrens, Anthony N

“…Fas ligand is a well-known inducer of apoptosis in cells expressing its receptor Fas; it also prevents autoimmunity by inducing apoptosis of activated T cells…”
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Genes expressed by both mesangial cells and bone marrow-derived cells underlie genetic susceptibility to crescentic glomerulonephritis in the rat by SMITH, Jennifer, LAI, Ping-Chin, BEHMOARAS, Jacques, ROUFOSSE, Candice, BHANGAL, Gurjeet, MCDAID, John P, AITMAN, Timothy, TARN, Frederick W. K, PUSEY, Charles D, COOK, H. Terence

“…The Wistar-Kyoto (WKY) rat shows marked susceptibility to crescentic glomerulonephritis. In the model of nephrotoxic nephritis (NTN) that is induced by a small…”
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Bmx tyrosine kinase regulates TLR4-induced IL-6 production in human macrophages independently of p38 MAPK and NFκB activity by Palmer, Christine D., Mutch, Brenda E., Workman, Sarita, McDaid, John P., Horwood, Nicole J., Foxwell, Brian M.J.

“…Chronic inflammation, as seen in conditions such as rheumatoid arthritis and Crohn disease, is in part driven by discordant production of inflammatory…”
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Bmx tyrosine kinase regulates TLR4-induced IL-6 production in human macrophages independently of p38 MAPK and NFkapp}B activity by Palmer, Christine D, Mutch, Brenda E, Workman, Sarita, McDaid, John P, Horwood, Nicole J, Foxwell, Brian M J

“…Chronic inflammation, as seen in conditions such as rheumatoid arthritis and Crohn disease, is in part driven by discordant production of inflammatory…”
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Bmx tyrosine kinase regulates TLR4-induced IL-6 production in human macrophages independently of p38 MAPK and NFKB activity by PALMER, Christine D, MUTCH, Brenda E, WORKMAN, Sarita, MCDAID, John P, HORWOOD, Nicole J, FOXWELL, Brian M. J

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