Search Results - "MCDAID, John"

Ca2+ Dyshomeostasis Disrupts Neuronal and Synaptic Function in Alzheimer’s Disease by McDaid, John, Mustaly-Kalimi, Sarah, Stutzmann, Grace E.

“…Ca2+ homeostasis is essential for multiple neuronal functions and thus, Ca2+ dyshomeostasis can lead to widespread impairment of cellular and synaptic…”
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Spleen tyrosine kinase inhibition attenuates autoantibody production and reverses experimental autoimmune GN by McAdoo, Stephen P, Reynolds, John, Bhangal, Gurjeet, Smith, Jennifer, McDaid, John P, Tanna, Anisha, Jackson, William D, Masuda, Esteban S, Cook, H Terence, Pusey, Charles D, Tam, Frederick W K

“…Spleen tyrosine kinase (SYK) has an important role in immunoreceptor signaling, and SYK inhibition has accordingly attenuated immune-mediated injury in several…”
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Human-Induced Neurons from Presenilin 1 Mutant Patients Model Aspects of Alzheimer's Disease Pathology by Schrank, Sean, McDaid, John, Briggs, Clark A, Mustaly-Kalimi, Sarah, Brinks, Deanna, Houcek, Aiden, Singer, Oded, Bottero, Virginie, Marr, Robert A, Stutzmann, Grace E

“…Traditional approaches to studying Alzheimer's disease (AD) using mouse models and cell lines have advanced our understanding of AD pathogenesis. However, with…”
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Spleen tyrosine kinase is important in the production of proinflammatory cytokines and cell proliferation in human mesangial cells following stimulation with IgA1 isolated from IgA nephropathy patients by Kim, Min Jeong, McDaid, John P, McAdoo, Stephen P, Barratt, Jonathan, Molyneux, Karen, Masuda, Esteban S, Pusey, Charles D, Tam, Frederick W K

“…IgA immune complexes are capable of inducing human mesangial cell (HMC) activation, resulting in release of proinflammatory and profibrogenic mediators. The…”
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Selective Targeting of a Disease-Related Conformational Isoform of Macrophage Migration Inhibitory Factor Ameliorates Inflammatory Conditions by Thiele, Michael, Kerschbaumer, Randolf J, Tam, Frederick W K, Völkel, Dirk, Douillard, Patrice, Schinagl, Alexander, Kühnel, Harald, Smith, Jennifer, McDaid, John P, Bhangal, Gurjeet, Yu, Mei-Ching, Pusey, Charles D, Cook, H Terence, Kovarik, Josef, Magelky, Erica, Bhan, Atul, Rieger, Manfred, Mudde, Geert C, Ehrlich, Hartmut, Jilma, Bernd, Tilg, Herbert, Moschen, Alexander, Terhorst, Cox, Scheiflinger, Friedrich

“…Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine and counterregulator of glucocorticoids, is a potential therapeutic target. MIF is…”
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Sustained Hippocampal Synaptic Pathophysiology Following Single and Repeated Closed-Head Concussive Impacts by McDaid, John, Briggs, Clark A, Barrington, Nikki M, Peterson, Daniel A, Kozlowski, Dorothy A, Stutzmann, Grace E

“…Traumatic brain injury (TBI), and related diseases such as chronic traumatic encephalopathy (CTE) and Alzheimer's (AD), are of increasing concern in part due…”
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Bruton's Tyrosine Kinase Is Required for TLR2 and TLR4-Induced TNF, but Not IL-6, Production by Horwood, Nicole J, Page, Theresa H, McDaid, John P, Palmer, Christine D, Campbell, Jamie, Mahon, Tara, Brennan, Fionula M, Webster, David, Foxwell, Brian M. J

“…Bruton's tyrosine kinase (Btk), the gene mutated in the human immunodeficiency X-linked agammaglobulinemia, is activated by LPS and is required for LPS-induced…”
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A Spleen Tyrosine Kinase Inhibitor Reduces the Severity of Established Glomerulonephritis by SMITH, Jennifer, MCDAID, John P, BHANGAL, Gurjeet, CHAWANASUNTORAPOJ, Ratana, MASUDA, Esteban S, COOK, H. Terence, PUSEY, Charles D, TAM, Frederick W. K

“…Antibody-mediated glomerulonephritis, including that resulting from immune complexes, is an important cause of renal failure and is in need of more specific…”
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A Role for Dopamine-Mediated Learning in the Pathophysiology and Treatment of Parkinson’s Disease by Beeler, Jeff A., Frank, Michael J., McDaid, John, Alexander, Erin, Turkson, Susie, Sol Bernandez, Maria, McGehee, Daniel S., Zhuang, Xiaoxi

“…Dopamine contributes to corticostriatal plasticity and motor learning. Dopamine denervation profoundly alters motor performance, as in Parkinson’s disease…”
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Bruton's tyrosine kinase is required for lipopolysaccharide-induced tumor necrosis factor alpha production by Horwood, Nicole J, Mahon, Tara, McDaid, John P, Campbell, Jamie, Mano, Hiroyuki, Brennan, Fionula M, Webster, David, Foxwell, Brian M J

“…Lipopolysaccharide (LPS), a product of Gram-negative bacteria, is potent mediator of tumor necrosis factor (TNF)alpha production by myeloid/macrophage cells…”
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Persistent upregulation of brain phospho‐tau is accompanied by elevated hippocampal synaptic excitability and altered Ca 2+ handling, following single or repeated closed‐head concussive impacts: Developing topics by McDaid, John

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Persistent upregulation of brain phospho‐tau is accompanied by elevated hippocampal synaptic excitability and altered Ca2+ handling, following single or repeated closed‐head concussive impacts by McDaid, John

“…Background Traumatic brain injury (TBI) is of widespread clinical concern and a significant risk factor for Alzheimer’s‐like dementia (AD). Notably, repeated…”
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SYK inhibition in experimental autoimmune vasculitis and its glomerular expression in ANCA-associated vasculitis by McAdoo, Stephen P, Dr, Tanna, Anisha, MBBS, McDaid, John, PhD, Bhangal, Gurjeet, BSc, Masuda, Esteban S, PhD, Cook, H Terence, Prof, Pusey, Charles D, Prof, Tam, Frederick W K, FRCP

“…Abstract Background The anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitides (AAV) are a group of life-threatening multisystemic diseases…”
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Mice with defective Fas ligand are protected from crescentic glomerulonephritis by Tarzi, Ruth M, Sharp, Phoebe E H, McDaid, John P, Fossati-Jimack, Liliane, Herbert, Paul E, Pusey, Charles D, Cook, H Terence, Warrens, Anthony N

“…Fas ligand is a well-known inducer of apoptosis in cells expressing its receptor Fas; it also prevents autoimmunity by inducing apoptosis of activated T cells…”
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Ethanol interaction with α3β4 nicotinic acetylcholine receptors in neurons of the laterodorsal tegmentum by Abburi, Chandrika, McDaid, John

“…Background Nicotinic acetylcholine receptors (nAChRs) play a key role in the rewarding effects of ethanol (EtOH), and while several nAChR subtypes have been…”
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P2X7 Deficiency Attenuates Renal Injury in Experimental Glomerulonephritis by TAYLOR, Simon R. J, TURNER, Clare M, PUSEY, Charles D, UNWIN, Robert J, TAM, Frederick W. K, ELLIOTT, James I, MCDAID, John, HEWITT, Reiko, SMITH, Jennifer, PICKERING, Matthew C, WHITEHOUSE, Darren L, TERENCE COOK, H, BURNSTOCK, Geoffrey

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A Role for Dopamine-Mediated Learning in the Pathophysiology and Treatment of Parkinson’s Disease by Beeler, Jeff A., Frank, Michael J., McDaid, John, Alexander, Erin, Turkson, Susie, Bernardez Sarria, Maria Sol, McGehee, Daniel S., Zhuang, Xiaoxi

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Genes expressed by both mesangial cells and bone marrow-derived cells underlie genetic susceptibility to crescentic glomerulonephritis in the rat by SMITH, Jennifer, LAI, Ping-Chin, BEHMOARAS, Jacques, ROUFOSSE, Candice, BHANGAL, Gurjeet, MCDAID, John P, AITMAN, Timothy, TARN, Frederick W. K, PUSEY, Charles D, COOK, H. Terence

“…The Wistar-Kyoto (WKY) rat shows marked susceptibility to crescentic glomerulonephritis. In the model of nephrotoxic nephritis (NTN) that is induced by a small…”
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The effects of long chain-length n-alcohols on the firing frequency of dopaminergic neurons of the ventral tegmental area by Appel, Sarah B, Wise, Leon, McDaid, John, Koyama, Susumu, McElvain, Maureen A, Brodie, Mark S

“…The dopaminergic neurons of the ventral tegmental area (DA VTA neurons) have been implicated in the reinforcing properties of drugs of abuse, including ethanol…”
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Maternal choline supplementation protects against age-associated cholinergic and GABAergic basal forebrain neuron degeneration in the Ts65Dn mouse model of down syndrome and Alzheimer's disease by Gautier, Megan K., Kelley, Christy M., Lee, Sang Han, Alldred, Melissa J., McDaid, John, Mufson, Elliott J., Stutzmann, Grace E., Ginsberg, Stephen D.

“…Down syndrome (DS) is a genetic disorder caused by triplication of human chromosome 21. In addition to intellectual disability, DS is defined by a premature…”
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